Mesenchymal stem cells overexpressing GCP-2 improve heart function through enhanced angiogenic properties in a myocardial infarction model

Cardiovascular Research

Volumn 95, Issue 4, 2012, Pages 495-506

  Kim, Sung Whan ^a,b   Lee, Dong Won ^c   Yu, Long Hao ^a,b   Zhang, Hong Zhe ^a,b   Kim, Chae Eun ^b   Kim, Jong Min ^a   Park, Tae Ho ^a   Cha, Kwang Soo ^c   Seo, Su Yeong ^a   Roh, Mee Sook ^a   Lee, Keun Cheol ^a   Jung, Jin Sup ^c   Kim, Moo Hyun ^a,b  

^a Dong A University   (South Korea)

^b Dong A University College of Medicine   (South Korea)

^c Pusan National University School of Medicine   (South Korea)

Author keywords

Angiogenesis; GCP 2; Mesenchymal stem cells; Myocardial infarction

Indexed keywords

GRANULOCYTE CHEMOTACTIC PROTEIN 2; INTERLEUKIN 8; SCATTER FACTOR; SOMATOMEDIN C; VASCULOTROPIN A;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ASSAY; CELL DIFFERENTIATION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DISEASE MODEL; ENDOTHELIUM CELL; FIBROBLAST; HEART FUNCTION; HEART INFARCTION; HEART INFARCTION SIZE; IN VITRO STUDY; IN VIVO STUDY; MESENCHYMAL STEM CELL; MICROVASCULAR ENDOTHELIAL CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION;

ANIMALS; APOPTOSIS; CELL DIFFERENTIATION; CELL LINE; CELL MOVEMENT; CELL PROLIFERATION; CELL SURVIVAL; CHEMOKINE CXCL6; CULTURE MEDIA, CONDITIONED; DISEASE MODELS, ANIMAL; ENDOTHELIAL CELLS; FIBROBLASTS; GENETIC THERAPY; HEPATOCYTE GROWTH FACTOR; HUMANS; INSULIN-LIKE GROWTH FACTOR I; INTERLEUKIN-8; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMAL CELLS; MICE; MICE, INBRED NOD; MICE, SCID; MYOCARDIAL INFARCTION; MYOCARDIUM; NEOVASCULARIZATION, PHYSIOLOGIC; PROTO-ONCOGENE PROTEINS C-AKT; REAL-TIME POLYMERASE CHAIN REACTION; RECOVERY OF FUNCTION; TIME FACTORS; TRANSFECTION; UP-REGULATION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84865212543     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvs224     Document Type: Article

References (36)

1. Lloyd-Jones D, Adams R, Carnethon M, De Simone G, Ferguson TB, Flegal K et al. Heart disease and stroke statistics-2009 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 2009;119:480-486.
2. Zuk PA, Zhu M, Mizuno H, Huang J, Futrell JW, Katz AJ et al. Multilineage cells from human adipose tissue: implications for cell-based therapies. Tissue Eng 2001;7: 211-228.
3. Lee RH, Kim B, Choi I, Kim H, Choi HS, Suh K et al. Characterization and expression analysis of mesenchymal stem cells from human bone marrow and adipose tissue. Cell Physiol Biochem 2004;14:311-324.
4. Rehman J, Traktuev D, Li J, Merfeld-Clauss S, Temm-Grove CJ, Bovenkerk JE et al. Secretion of angiogenic and antiapoptotic factors by human adipose stromal cells. Circulation 2004;109:1292-1298.
5. Moon MH, Kim SY, Kim YJ, Kim SJ, Lee JB, Bae YC et al. Human adipose tissue-derived mesenchymal stem cells improve postnatal neovascularization in a mouse model of hindlimb ischemia. Cell Physiol Biochem 2006;17:279-290.
6. Byun KH, Kim SW. Is stem cell-based therapy going on or out for cardiac disease? Korean Circ J 2009;39:87-92.
7. Shake JG, Gruber PJ, Baumgartner WA, Senechal G, Meyers J, Redmond JM et al. Mesenchymal stem cell implantation in a swine myocardial infarct model: engraftment and functional effects. Ann Thorac Surg 2002;73:1919-1925. discussion 1926.
8. Toma C, Pittenger MF, Cahill KS, Byrne BJ, Kessler PD. Human mesenchymal stem cells differentiate to a cardiomyocyte phenotype in the adult murine heart. Circulation 2002;105:93-98.
9. Cho HJ, Lee N, Lee JY, Choi YJ, Ii M, Wecker A et al. Role of host tissues for sustained humoral effects after endothelial progenitor cell transplantation into the ischemic heart. J Exp Med 2007;204:3257-3269.
10. Kang HJ, Kim JY, Lee HJ, Kim KH, Kim TY, Lee CS et al. Magnetic bionanoparticle enhances homing of endothelial progenitor cells in mouse hindlimb ischemia. Korean Circ J 2012;42:390-396.
11. Baggiolini M. Chemokines in pathology and medicine. J Intern Med 2001;250:91-104.
12. Rot A, von Andrian UH. Chemokines in innate and adaptive host defense: basic che-mokinese grammar for immune cells. Annu Rev Immunol 2004;22:891-928.
13. Wuyts A, Struyf S, Gijsbers K, Schutyser E, Put W, Conings R et al. The CXC chemo-kine GCP-2/CXCL6 is predominantly induced in mesenchymal cells by interleukin-1 beta and is down-regulated by interferon-gamma: comparison with interleukin-8/CXCL8. Lab Invest 2003;83:23-34.
14. Van Coillie E, Van Aelst I, Wuyts A, Vercauteren R, Devos R, De Wolf-Peeters C et al. Tumor angiogenesis induced by granulocyte chemotactic protein-2 as a countercur-rent principle. Am J Pathol 2001;159:1405-1414.
15. Gijsbers K, Gouwy M, Struyf S, Wuyts A, Proost P, Opdenakker G et al. GCP-2/CXCL6 synergizes with other endothelial cell-derived chemokines in neutrophil mobilization and is associated with angiogenesis in gastrointestinal tumors. Exp Cell Res 2005;303:331-342.
16. Cho HH, Kim YJ, Kim JT, Song JS, Shin KK, Bae YC et al. The role of chemokines in proangiogenic action induced by human adipose tissue-derived mesenchymal stem cells in the murine model of hindlimb ischemia. Cell Physiol Biochem 2009;24:511-518.
17. Kim SW, Kim H, Cho HJ, Lee JU, Levit R, Yoon YS. Human peripheral blood-derived CD31+ Cells have robust angiogenic and vasculogenic properties and are effective for treating ischemic vascular disease. J Am Coll Cardiol 2010;56:593-607.
18. Kim MH, Zhang HZ, Kim SW. Combined growth factors enhanced angiogenic potential of cord blood-derived mononuclear cells transplanted to ischemic limbs. J Mol Cell Cardiol 2011;51:702-712.
19. Zhang C, Fu L, Fu J, Hu L, Yang H, Rong TH et al. Fibroblast growth factor receptor 2-positive fibroblasts provide a suitable microenvironment for tumor development and progression in esophageal carcinoma. Clin Cancer Res 2009;15:4017-4027.
20. Yu LH, Kim MH, Park TH, Cha KS, Kim YD, Quan ML et al. Improvement of cardiac function and remodeling by transplanting adipose tissue-derived stromal cells into a mouse model of acute myocardial infarction. Int J Cardiol 2010;139:166-172.
21. Gao D, Nolan DJ, Mellick AS, Bambino K, McDonnell K, Mittal V. Endothelial progenitor cells control the angiogenic switch in mouse lung metastasis. Science 2008;319:195-198.
22. Strieter RM, Polverini PJ, Arenberg DA, Kunkel SL. The role of CXC chemokines as regulators of angiogenesis. Shock 1995;4:155-160.
23. Proost P, De Wolf-Peeters C, Conings R, Opdenakker G, Billiau A, Van Damme J. Identification of a novel granulocyte chemotactic protein (GCP-2) from human tumor cells. In vitro and in vivo comparison with natural forms of GRO, IP-10, and IL-8. J Immunol 1993;150:1000-1010.
24. Strieter RM, Polverini PJ, Kunkel SL, Arenberg DA, Burdick MD, Kasper J et al. The functional role of the ELR motif in CXC chemokine-mediated angiogenesis. J Biol Chem 1995;270:27348-27357.
25. Koch AE, Polverini PJ, Kunkel SL, Harlow LA, DiPietro LA, Elner VM et al. Interleukin-8 as a macrophage-derived mediator of angiogenesis. Science 1992;258: 1798-1801.
26. Lamalice L, Le Boeuf F, Huot J. Endothelial cell migration during angiogenesis. Circ Res 2007;100:782-794.
27. Ausprunk DH, Knighton DR, Folkman J. Vascularization of normal and neoplastic tissues grafted to the chick chorioallantois. Role of host and preexisting graft blood vessels. Am J Pathol 1975;79:597-618.
28. Smith LE, Shen W, Perruzzi C, Soker S, Kinose F, Xu X et al. Regulation of vascular endothelial growth factor-dependent retinal neovascularization by insulin-like growth factor-1 receptor. Nat Med 1999;5:1390-1395.
29. Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, Hu LS et al. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 1999;96: 857-868.
30. Mangi AA, Noiseux N, Kong D, He H, Rezvani M, Ingwall JS et al. Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts. Nat Med 2003;9:1195-1201.
31. Li A, Dubey S, Varney ML, Dave BJ, Singh RK. IL-8 directly enhanced endothelial cell survival, proliferation, and matrix metalloproteinases production and regulated angio-genesis. J Immunol 2003;170:3369-3376.
32. Ziegelhoeffer T, Fernandez B, Kostin S, Heil M, Voswinckel R, Helisch A et al. Bone marrow-derived cells do not incorporate into the adult growing vasculature. Circ Res 2004;94:230-238.
33. Au P, Tam J, Fukumura D, Jain RK. Bone marrow-derived mesenchymal stem cells facilitate engineering of long-lasting functional vasculature. Blood 2008;111: 4551-4558.
34. Breitbach M, Bostani T, Roell W, Xia Y, Dewald O, Nygren JM et al. Potential risks of bone marrow cell transplantation into infarcted hearts. Blood 2007;110:1362-1369.
35. Gnecchi M, He H, Liang OD, Melo LG, Morello F, Mu H et al. Paracrine action accounts for marked protection of ischemic heart by Akt-modified mesenchymal stem cells. Nat Med 2005;11:367-368.
36. Millauer B, Wizigmann-Voos S, Schnurch H, Martinez R, Moller NP, Risau W et al. High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis. Cell 1993;72:835-846.