Metabolism of vertebrate amino sugars with N-glycolyl groups: Resistance of α2-8-linked N-glycolylneuraminic acid to enzymatic cleavage

Journal of Biological Chemistry

Volumn 287, Issue 34, 2012, Pages 28917-28931

  Davies, Leela R L ^a   Pearce, Oliver M T ^a   Tessier, Matthew B ^b   Assar, Siavash ^a   Smutova, Victoria ^c   Pajunen, Maria ^d   Sumida, Mizuki ^e   Sato, Chihiro ^e   Kitajima, Ken ^e   Finne, Jukka ^d   Gagneux, Pascal ^a   Pshezhetsky, Alexey ^c   Woodss, Robert ^b,f   Varki, Ajit ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF GEORGIA   (United States)

^c UNIVERSITY OF MONTREAL   (Canada)

^d UNIVERSITY OF HELSINKI   (Finland)

^e NAGOYA UNIVERSITY   (Japan)

^f NATIONAL UNIVERSITY OF IRELAND   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

ACID-CATALYZED HYDROLYSIS; ADDITIONAL SAMPLES; ENZYMATIC ACTIVITIES; ENZYMATIC CLEAVAGE; EVOLUTIONARY CONSERVATIONS; IN-VITRO; LOW LEVEL; MOLECULAR DYNAMICS MODELING; N-ACETYLNEURAMINIC ACID; N-GLYCOLYLNEURAMINIC ACID; OXYGEN ATOM; POLYSIALIC ACID; SIALIC ACIDS; SIALIDASES; SYNTHETIC POLYMERS; VARIABLE FRACTIONS; VERTEBRATE BRAINS; VERTEBRATE EVOLUTION;

CARBOXYLIC ACIDS; CONSERVATION; HYDROLYSIS; MAMMALS; MOLECULAR DYNAMICS; SUGARS; THREE DIMENSIONAL; TISSUE;

POLYMERS;

ALPHA 2-8 LINKED N GLYCOLYLNEURAMINIC ACID; AMINOSUGAR; N GLYCOLOYLNEURAMINIC ACID; POLYSIALIC ACID; SIALIC ACID; SIALIDASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN DEVELOPMENT; BRAIN FUNCTION; CARBOHYDRATE METABOLISM; CARBOHYDRATE SYNTHESIS; CARBOHYDRATE TRANSPORT; CHEMICAL BOND; CHEMICAL COMPOSITION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME CLEAVAGE; ENZYME MODIFICATION; ENZYME SUBSTRATE COMPLEX; GLYCOSIDATION; HUMAN; HUMAN CELL; HUMAN TISSUE; HYDROLYSIS; HYDROPHOBICITY; MOLECULAR DYNAMICS; MOLECULAR EVOLUTION; MOUSE; NONHUMAN; PH; PRIORITY JOURNAL; RAT; TISSUE SPECIFICITY;

AMINO SUGARS; ANIMALS; BACTERIA; BRAIN; BRAIN CHEMISTRY; CARBOHYDRATE CONFORMATION; CATTLE; DOLPHINS; ELEPHANTS; EVOLUTION, MOLECULAR; HYDROLYSIS; MICE; N-ACETYLNEURAMINIC ACID; NERVE TISSUE PROTEINS; NEURAMINIC ACIDS; NEURAMINIDASE; PAN TROGLODYTES; RATS; SPECIES SPECIFICITY; SWINE;

EID: 84865211588     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.365056     Document Type: Article

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