Intracytoplasmic epidermal growth factor receptor shows poor response to the cetuximab antitumor effect in irradiated non-small cell lung cancer cell lines

Lung Cancer

Volumn 77, Issue 3, 2012, Pages 482-487

  Ryu, Seung Hee ^a   Lee, Sang wook ^a   Yang, Youn Joo ^a   Song, Si Yeol ^a   Kim, Jong Hoon ^a   Choi, Eun Kyung ^a   Ahn, Seung Do ^a  

^a University of Ulsan College of Medicine   (South Korea)

Author keywords

Cetuximab; EGFR localization; Monoclonal antibody; Non small cell lung cancer; Radiosensitivity; Radiotherapy

Indexed keywords

CETUXIMAB; EPIDERMAL GROWTH FACTOR RECEPTOR;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER RADIOTHERAPY; CELL MEMBRANE; CELL MEMBRANE PERMEABILITY; CELLULAR DISTRIBUTION; CHEMORADIOTHERAPY; COLONY FORMATION; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOPLASM; CYTOSOL; DOSE RESPONSE; DRUG EFFICACY; FLOW CYTOMETRY; GOLGI COMPLEX; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; LUNG NON SMALL CELL CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RADIATION DOSE; RADIOSENSITIVITY; TREATMENT RESPONSE; WESTERN BLOTTING;

ANTIBODIES, MONOCLONAL; ANTINEOPLASTIC AGENTS; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; CELL SURVIVAL; CHEMORADIOTHERAPY; CYTOPLASM; DRUG RESISTANCE, NEOPLASM; HUMANS; LUNG NEOPLASMS; PROTEIN TRANSPORT; RADIATION TOLERANCE; RECEPTOR, EPIDERMAL GROWTH FACTOR;

EID: 84865182643     PISSN: 01695002     EISSN: 18728332     Source Type: Journal    
DOI: 10.1016/j.lungcan.2012.05.104     Document Type: Article

References (35)

1. Franovic A., Gunaratnam L., Smith K., Robert I., Patten D., Lee S. Translational up-regulation of the EGFR by tumor hypoxia provides a nonmutational explanation for its overexpression in human cancer. Proc Natl Acad Sci U S A 2007, 104:13092-13097.
2. Toulany M., Dittmann K., Kruger M., Baumann M., Rodemann H.P. Radioresistance of K-Ras mutated human tumor cells is mediated through EGFR-dependent activation of PI3K-AKT pathway. Radiother Oncol 2005, 76:143-150.
3. Rodemann H.P., Dittmann K., Toulany M. Radiation-induced EGFR-signaling and control of DNA-damage repair. Int J Radiat Biol 2007, 83:781-791.
4. Chen D.J., Nirodi C.S. The epidermal growth factor receptor: a role in repair of radiation-induced DNA damage. Clin Cancer Res 2007, 13:6555-6560.
5. Das A.K., Sato M., Story M.D., Peyton M., Graves R., Redpath S., et al. Non-small-cell lung cancers with kinase domain mutations in the epidermal growth factor receptor are sensitive to ionizing radiation. Cancer Res 2006, 66:9601-9608.
6. Mendelsohn J., Baselga J. The EGF receptor family as targets for cancer therapy. Oncogene 2000, 19:6550-6565.
7. Kris M.G., Natale R.B., Herbst R.S., Lynch T.J., Prager D., Belani C.P., et al. Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: a randomized trial. JAMA 2003, 290:2149-2158.
8. Perez-Soler R., Chachoua A., Hammond L.A., Rowinsky E.K., Huberman M., Karp D., et al. Determinants of tumor response and survival with erlotinib in patients with non-small-cell lung cancer. J Clin Oncol 2004, 22:3238-3247.
9. Raben D., Helfrich B., Chan D.C., Ciardiello F., Zhao L., Franklin W., et al. The effects of cetuximab alone and in combination with radiation and/or chemotherapy in lung cancer. Clin Cancer Res 2005, 11:795-805.
10. Rusch V., Klimstra D., Venkatraman E., Pisters P.W., Langenfeld J., Dmitrovsky E. Overexpression of the epidermal growth factor receptor and its ligand transforming growth factor alpha is frequent in resectable non-small cell lung cancer but does not predict tumor progression. Clin Cancer Res 1997, 3:515-522.
11. Fontanini G., De Laurentiis M., Vignati S., Chine S., Lucchi M., Silvestri V., et al. Evaluation of epidermal growth factor-related growth factors and receptors and of neoangiogenesis in completely resected stage I-IIIA non-small-cell lung cancer: amphiregulin and microvessel count are independent prognostic indicators of survival. Clin Cancer Res 1998, 4:241-249.
12. Ettinger D.S. Clinical implications of EGFR expression in the development and progression of solid tumors: focus on non-small cell lung cancer. Oncologist 2006, 11:358-373.
13. Huang S.M., Harari P.M. Modulation of radiation response after epidermal growth factor receptor blockade in squamous cell carcinomas: inhibition of damage repair, cell cycle kinetics, and tumor angiogenesis. Clin Cancer Res 2000, 6:2166-2174.
14. Milas L., Mason K., Hunter N., Petersen S., Yamakawa M., Ang K., et al. In vivo enhancement of tumor radioresponse by C225 antiepidermal growth factor receptor antibody. Clin Cancer Res 2000, 6:701-708.
15. Xie Y., Hung M.C. Nuclear localization of p185neu tyrosine kinase and its association with transcriptional transactivation. Biochem Biophys Res Commun 1994, 203:1589-1598.
16. Lin S.Y., Makino K., Xia W., Matin A., Wen Y., Kwong K.Y., et al. Nuclear localization of EGF receptor and its potential new role as a transcription factor. Nat Cell Biol 2001, 3:802-808.
17. Ni C.Y., Murphy M.P., Golde T.E., Carpenter G. γ-Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase. Science 2001, 294:2179-2181.
18. Lo H.W., Hsu S.C., Ali-Seyed M., Gunduz M., Xia W., Wei Y., et al. Nuclear interaction of EGFR and STAT3 in the activation of the iNOS/NO pathway. Cancer Cell 2005, 7:575-589.
19. Hung L.Y., Tseng J.T., Lee Y.C., Xia W., Wang Y.N., Wu M.L., et al. Nuclear epidermal growth factor receptor (EGFR) interacts with signal transducer and activator of transcription 5 (STAT5) in activating Aurora-A gene expression. Nucleic Acids Res 2008, 36:4337-4351.
20. Huang S.M., Bock J.M., Harari P.M. Epidermal growth factor receptor blockade with C225 modulates proliferation, apoptosis, and radiosensitivity in squamous cell carcinomas of the head and neck. Cancer Res 1999, 59:1935-1940.
21. Baselga J. The EGFR as a target for anticancer therapy-focus on cetuximab. Eur J Cancer 2001, 37(Suppl. 4):S16-S22.
22. Parra H.S., Cavina R., Latteri F., Zucali P.A., Campagnoli E., Morenghi E., et al. Analysis of epidermal growth factor receptor expression as a predictive factor for response to gefitinib ('Iressa', ZD1839) in non-small-cell lung cancer. Br J Cancer 2004, 91:208-212.
23. Cappuzzo F., Gregorc V., Rossi E., Cancellieri A., Magrini E., Paties C.T., et al. Gefitinib in pretreated non-small-cell lung cancer (NSCLC): analysis of efficacy and correlation with HER2 and epidermal growth factor receptor expression in locally advanced or metastatic NSCLC. J Clin Oncol 2003, 21:2658-2663.
24. Ang K.K., Berkey B.A., Tu X., Zhang H.Z., Katz R., Hammond E.H., et al. Impact of epidermal growth factor receptor expression on survival and pattern of relapse in patients with advanced head and neck carcinoma. Cancer Res 2002, 62:7350-7356.
25. Bentzen S.M., Atasoy B.M., Daley F.M., Dische S., Richman P.I., Saunders M.I., et al. Epidermal growth factor receptor expression in pretreatment biopsies from head and neck squamous cell carcinoma as a predictive factor for a benefit from accelerated radiation therapy in a randomized controlled trial. J Clin Oncol 2005, 23:5560-5567.
26. Eriksen J.G., Steiniche T., Overgaard J. The influence of epidermal growth factor receptor and tumor differentiation on the response to accelerated radiotherapy of squamous cell carcinomas of the head and neck in the randomized DAHANCA 6 and 7 study. Radiother Oncol 2005, 74:93-100.
27. Schmidt-Ullrich R.K., Contessa J.N., Dent P., Mikkelsen R.B., Valerie K., Reardon D.B., et al. Molecular mechanisms of radiation-induced accelerated repopulation. Radiat Oncol Investig 1999, 7:321-330.
28. Contessa J.N., Hampton J., Lammering G., Mikkelsen R.B., Dent P., Valerie K., et al. Ionizing radiation activates Erb-B receptor dependent Akt and p70 S6 kinase signaling in carcinoma cells. Oncogene 2002, 21:4032-4041.
29. Marti U., Wells A. The nuclear accumulation of a variant epidermal growth factor receptor (EGFR) lacking the transmembrane domain requires coexpression of a full-length EGFR. Mol Cell Biol Res Commun 2000, 3:8-14.
30. Lo H.W., Xia W., Wei Y., Ali-Seyed M., Huang S.F., Hung M.C. Novel prognostic value of nuclear epidermal growth factor receptor in breast cancer. Cancer Res 2005, 65:338-348.
31. Psyrri A., Yu Z., Weinberger P.M., Sasaki C., Haffty B., Camp R., et al. Quantitative determination of nuclear and cytoplasmic epidermal growth factor receptor expression in oropharyngeal squamous cell cancer by using automated quantitative analysis. Clin Cancer Res 2005, 11:5856-5862.
32. Xia W., Wei Y., Du Y., Liu J., Chang B., Yu Y.L., et al. Nuclear expression of epidermal growth factor receptor is a novel prognostic value in patients with ovarian cancer. Mol Carcinog 2009, 48:610-617.
33. Akashi Y., Okamoto I., Iwasa T., Yoshida T., Suzuki M., Hatashita E., et al. Enhancement of the antitumor activity of ionising radiation by nimotuzumab, a humanised monoclonal antibody to the epidermal growth factor receptor, in non-small cell lung cancer cell lines of differing epidermal growth factor receptor status. Br J Cancer 2008, 98:749-755.
34. Milas L., Fan Z., Andratschke N.H., Ang K.K. Epidermal growth factor receptor and tumor response to radiation: in vivo preclinical studies. Int J Radiat Oncol Biol Phys 2004, 58:966-971.
35. Gatei M., Zhou B.B., Hobson K., Scott S., Young D., Khanna K.K. Ataxia telangiectasia mutated (ATM) kinase and ATM and Rad3 related kinase mediate phosphorylation of Brca1 at distinct and overlapping sites. In vivo assessment using phospho-specific antibodies. J Biol Chem 2001, 276:17276-17280.