-
1
-
-
0942290437
-
In self-defence: Hexokinase promotes voltage-dependent anion channel closure and prevents mitochondria-mediated apoptotic cell death
-
DOI 10.1042/BJ20031465
-
Azoulay-Zohar H, Israelson A, Abu-Hamad S, and Shoshan-Barmatz V (2004) In self-defence: hexokinase promotes voltage-dependent anion channel closure and prevents mitochondria-mediated apoptotic cell death. Biochem J 377:347-355. (Pubitemid 38142190)
-
(2004)
Biochemical Journal
, vol.377
, Issue.2
, pp. 347-355
-
-
Azoulay-Zohar, H.1
Israelson, A.2
Abu-Hamad, S.3
Shoshan-Barmatz, V.4
-
2
-
-
55749094704
-
Structure of the human voltage-dependent anion channel
-
Bayrhuber M, Meins T, Habeck M, Becker S, Giller K, Villinger S, Vonrhein C, Griesinger C, Zweckstetter M, and Zeth K (2008) Structure of the human voltage-dependent anion channel. Proc Natl Acad Sci U S A 105:15370-15375.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 15370-15375
-
-
Bayrhuber, M.1
Meins, T.2
Habeck, M.3
Becker, S.4
Giller, K.5
Villinger, S.6
Vonrhein, C.7
Griesinger, C.8
Zweckstetter, M.9
Zeth, K.10
-
3
-
-
0028969860
-
Mitochondrial VDAC can be phosphorylated by cyclic AMP-dependent protein kinase
-
Bera AK, Ghosh S, and Das S (1995) Mitochondrial VDAC can be phosphorylated by cyclic AMP-dependent protein kinase. Biochem Biophys Res Commun 209:213-217.
-
(1995)
Biochem Biophys Res Commun
, vol.209
, pp. 213-217
-
-
Bera, A.K.1
Ghosh, S.2
Das, S.3
-
4
-
-
0019815655
-
Energy metabolism of tumor cells. Requirement for a form of hexokinase with a propensity for mitochondrial binding
-
Bustamante E, Morris HP, and Pedersen PL (1981) Energy metabolism of tumor cells. Requirement for a form of hexokinase with a propensity for mitochondrial binding. J Biol Chem 256:8699-8704. (Pubitemid 12254812)
-
(1981)
Journal of Biological Chemistry
, vol.256
, Issue.16
, pp. 8699-8704
-
-
Bustamante, E.1
Morris, H.P.2
Pedersen, P.L.3
-
6
-
-
79955604131
-
Genetic insights into OXPHOS defect and its role in cancer
-
Chandra D and Singh KK (2011) Genetic insights into OXPHOS defect and its role in cancer. Biochim Biophys Acta 1807:620-625.
-
(2011)
Biochim Biophys Acta
, vol.1807
, pp. 620-625
-
-
Chandra, D.1
Singh, K.K.2
-
7
-
-
40749163248
-
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
-
DOI 10.1038/nature06734, PII NATURE06734
-
Christofk HR, Vander Heiden MG, Harris MH, Ramanathan A, Gerszten RE, Wei R, Fleming MD, Schreiber SL, and Cantley LC (2008) The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. Nature 452:230-233. (Pubitemid 351380249)
-
(2008)
Nature
, vol.452
, Issue.7184
, pp. 230-233
-
-
Christofk, H.R.1
Vander, H.M.G.2
Harris, M.H.3
Ramanathan, A.4
Gerszten, R.E.5
Wei, R.6
Fleming, M.D.7
Schreiber, S.L.8
Cantley, L.C.9
-
8
-
-
0018847077
-
Structure and mode of action of a voltage dependent anion-selective channel (VDAC) located in the outer mitochondrial membrane
-
Colombini M (1980) Structure and mode of action of a voltage dependent anion-selective channel (VDAC) located in the outer mitochondrial membrane. Ann NY Acad Sci 341:552-563.
-
(1980)
Ann NY Acad Sci
, vol.341
, pp. 552-563
-
-
Colombini, M.1
-
9
-
-
0842345400
-
VDAC: The channel at the interface between mitochondria and the cytosol
-
Colombini M (2004) VDAC: the channel at the interface between mitochondria and the cytosol. Mol Cell Biochem 256-257:107-115.
-
(2004)
Mol Cell Biochem
, vol.256-257
, pp. 107-115
-
-
Colombini, M.1
-
10
-
-
68249126139
-
The published 3D structure of the VDAC channel: Native or not?
-
Colombini M (2009) The published 3D structure of the VDAC channel: native or not? Trends Biochem Sci 34:382-389.
-
(2009)
Trends Biochem Sci
, vol.34
, pp. 382-389
-
-
Colombini, M.1
-
11
-
-
0023513271
-
The mitochondrial outer membrane channel, VDAC, is regulated by a synthetic polyanion
-
Colombini M, Yeung CL, Tung J, and König T (1987) The mitochondrial outer membrane channel, VDAC, is regulated by a synthetic polyanion. Biochim Biophys Acta 905:279-286. (Pubitemid 18004526)
-
(1987)
Biochimica et Biophysica Acta - Biomembranes
, vol.905
, Issue.2
, pp. 279-286
-
-
Colombini, M.1
Yeung, C.L.2
Tung, J.3
Konig, T.4
-
12
-
-
55449092939
-
Glycogen synthase kinase 3 inhibition slows mitochondrial adenine nucleotide transport and regulates voltage-dependent anion channel phosphorylation
-
Das S, Wong R, Rajapakse N, Murphy E, and Steenbergen C (2008) Glycogen synthase kinase 3 inhibition slows mitochondrial adenine nucleotide transport and regulates voltage-dependent anion channel phosphorylation. Circ Res 103:983-991.
-
(2008)
Circ Res
, vol.103
, pp. 983-991
-
-
Das, S.1
Wong, R.2
Rajapakse, N.3
Murphy, E.4
Steenbergen, C.5
-
13
-
-
78649701863
-
Transcriptional regulation in yeast during diauxic shift and stationary phase
-
Galdieri L, Mehrotra S, Yu S, and Vancura A (2010) Transcriptional regulation in yeast during diauxic shift and stationary phase. OMICS 14:629-638.
-
(2010)
OMICS
, vol.14
, pp. 629-638
-
-
Galdieri, L.1
Mehrotra, S.2
Yu, S.3
Vancura, A.4
-
14
-
-
0036717382
-
Molecular imaging of cancer with positron emission tomography
-
Gambhir SS (2002) Molecular imaging of cancer with positron emission tomography. Nat Rev Cancer 2:683-693.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 683-693
-
-
Gambhir, S.S.1
-
15
-
-
8144228566
-
Why do cancers have high aerobic glycolysis?
-
DOI 10.1038/nrc1478
-
Gatenby RA and Gillies RJ (2004) Why do cancers have high aerobic glycolysis? Nat Rev Cancer 4:891-899. (Pubitemid 39472955)
-
(2004)
Nature Reviews Cancer
, vol.4
, Issue.11
, pp. 891-899
-
-
Gatenby, R.A.1
Gillies, R.J.2
-
16
-
-
2942511577
-
Recently elucidated energy catabolism pathways provide opportunities for novel treatments in hepatocellular carcinoma
-
Geschwind JF, Georgiades CS, Ko YH, and Pedersen PL (2004) Recently elucidated energy catabolism pathways provide opportunities for novel treatments in hepatocellular carcinoma. Expert Rev Anticancer Ther 4:449-457. (Pubitemid 38745116)
-
(2004)
Expert Review of Anticancer Therapy
, vol.4
, Issue.3
, pp. 449-457
-
-
Geschwind, J.-F.1
Georgiades, C.S.2
Ko, Y.H.3
Pedersen, P.L.4
-
17
-
-
0036213162
-
REDOX regulation of early embryo development
-
Harvey AJ, Kind KL, and Thompson JG (2002) REDOX regulation of early embryo development. Reproduction 123:479-486. (Pubitemid 34303149)
-
(2002)
Reproduction
, vol.123
, Issue.4
, pp. 479-486
-
-
Harvey, A.J.1
Kind, K.L.2
Thompson, J.G.3
-
18
-
-
50649121583
-
Solution structure of the integral human membrane protein VDAC-1 in detergent micelles
-
Hiller S, Garces RG, Malia TJ, Orekhov VY, Colombini M, and Wagner G (2008) Solution structure of the integral human membrane protein VDAC-1 in detergent micelles. Science 321:1206-1210.
-
(2008)
Science
, vol.321
, pp. 1206-1210
-
-
Hiller, S.1
Garces, R.G.2
Malia, T.J.3
Orekhov, V.Y.4
Colombini, M.5
Wagner, G.6
-
19
-
-
84857757376
-
Ethanol suppresses ureagenesis in rat hepatocytes: Role of acetaldehyde
-
Holmuhamedov EL, Czerny C, Beeson CC, and Lemasters JJ (2012) Ethanol suppresses ureagenesis in rat hepatocytes: role of acetaldehyde. J Biol Chem 287:7692-7700.
-
(2012)
J Biol Chem
, vol.287
, pp. 7692-7700
-
-
Holmuhamedov, E.L.1
Czerny, C.2
Beeson, C.C.3
Lemasters, J.J.4
-
20
-
-
0028172237
-
β-NADH decreases the permeability of the mitochondrial outer membrane to ADP by a factor of 6
-
Lee AC, Zizi M, and Colombini M (1994) β-NADH decreases the permeability of the mitochondrial outer membrane to ADP by a factor of 6. J Biol Chem 269:30974-30980. (Pubitemid 24377586)
-
(1994)
Journal of Biological Chemistry
, vol.269
, Issue.49
, pp. 30974-30980
-
-
Lee, A.-C.1
Zizi, M.2
Colombini, M.3
-
21
-
-
84865185623
-
The voltage-dependent anion channel regulates mitochondrial function in HepG2 cells
-
Maldonado EN, DeHart DN, Patnaik JR, and Lemasters JJ (2011) The voltage-dependent anion channel regulates mitochondrial function in HepG2 cells. Hepatology 54:763A.
-
(2011)
Hepatology
, vol.54
-
-
Maldonado, E.N.1
DeHart, D.N.2
Patnaik, J.R.3
Lemasters, J.J.4
-
22
-
-
78650332649
-
Free tubulin modulates mitochondrial membrane potential in cancer cells
-
Maldonado EN, Patnaik J, Mullins MR, and Lemasters JJ (2010) Free tubulin modulates mitochondrial membrane potential in cancer cells. Cancer Res 70:10192-10201.
-
(2010)
Cancer Res
, vol.70
, pp. 10192-10201
-
-
Maldonado, E.N.1
Patnaik, J.2
Mullins, M.R.3
Lemasters, J.J.4
-
23
-
-
0036510541
-
Mitochondrial binding of hexokinase II inhibits Bax-induced cytochrome c release and apoptosis
-
DOI 10.1074/jbc.M109950200
-
Pastorino JG, Shulga N, and Hoek JB (2002) Mitochondrial binding of hexokinase II inhibits Bax-induced cytochrome c release and apoptosis. J Biol Chem 277:7610-7618. (Pubitemid 34953160)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.9
, pp. 7610-7618
-
-
Pastorino, J.G.1
Shulga, N.2
Hoek, J.B.3
-
24
-
-
35448964610
-
Warburg, me and Hexokinase 2: Multiple discoveries of key molecular events underlying one of cancers' most common phenotypes, the "Warburg Effect", i.e., elevated glycolysis in the presence of oxygen
-
Pedersen PL (2007) Warburg, me and Hexokinase 2: Multiple discoveries of key molecular events underlying one of cancers' most common phenotypes, the "Warburg Effect", i.e., elevated glycolysis in the presence of oxygen. J Bioenerg Biomembr 39:211-222.
-
(2007)
J Bioenerg Biomembr
, vol.39
, pp. 211-222
-
-
Pedersen, P.L.1
-
25
-
-
10644280072
-
pH difference across the outer mitochondrial membrane measured with a green fluorescent protein mutant
-
DOI 10.1016/j.bbrc.2004.11.105, PII S0006291X04026890
-
Porcelli AM, Ghelli A, Zanna C, Pinton P, Rizzuto R, and Rugolo M (2005) pH difference across the outer mitochondrial membrane measured with a green fluorescent protein mutant. Biochem Biophys Res Commun 326:799-804. (Pubitemid 39655990)
-
(2005)
Biochemical and Biophysical Research Communications
, vol.326
, Issue.4
, pp. 799-804
-
-
Porcelli, A.M.1
Ghelli, A.2
Zanna, C.3
Pinton, P.4
Rizzuto, R.5
Rugolo, M.6
-
26
-
-
0030947935
-
Vdac channels mediate and gate the flow of ATP: Implications for the regulation of mitochondrial function
-
Rostovtseva T and Colombini M (1997) VDAC channels mediate and gate the flow of ATP: implications for the regulation of mitochondrial function. Biophys J 72:1954-1962. (Pubitemid 27184425)
-
(1997)
Biophysical Journal
, vol.72
, Issue.5
, pp. 1954-1962
-
-
Rostovtseva, T.1
Colombini, M.2
-
27
-
-
1842640369
-
Bid, but Not Bax, Regulates VDAC Channels
-
DOI 10.1074/jbc.M310593200
-
Rostovtseva TK, Antonsson B, Suzuki M, Youle RJ, Colombini M, and Bezrukov SM (2004) Bid, but not Bax, regulates VDAC channels. J Biol Chem 279:13575-13583. (Pubitemid 38468883)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.14
, pp. 13575-13583
-
-
Rostovtseva, T.K.1
Antonsson, B.2
Suzuki, M.3
Youle, R.J.4
Colombini, M.5
Bezrukov, S.M.6
-
28
-
-
0037092536
-
VDAC channels differentiate between natural metabolites and synthetic molecules
-
DOI 10.1007/s00232-001-0159-1
-
Rostovtseva TK, Komarov A, Bezrukov SM, and Colombini M (2002) VDAC channels differentiate between natural metabolites and synthetic molecules. J Membr Biol 187:147-156. (Pubitemid 34526479)
-
(2002)
Journal of Membrane Biology
, vol.187
, Issue.2
, pp. 147-156
-
-
Rostovtseva, T.K.1
Komarov, A.2
Bezrukov, S.M.3
Colombini, M.4
-
29
-
-
57749084634
-
Tubulin binding blocks mitochondrial voltage-dependent anion channel and regulates respiration
-
Rostovtseva TK, Sheldon KL, Hassanzadeh E, Monge C, Saks V, Bezrukov SM, and Sackett DL (2008) Tubulin binding blocks mitochondrial voltage-dependent anion channel and regulates respiration. Proc Natl Acad Sci U S A 105:18746-18751.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 18746-18751
-
-
Rostovtseva, T.K.1
Sheldon, K.L.2
Hassanzadeh, E.3
Monge, C.4
Saks, V.5
Bezrukov, S.M.6
Sackett, D.L.7
-
30
-
-
0030856487
-
The murine voltage-dependent anion channel gene family. Conserved structure and function
-
DOI 10.1074/jbc.272.30.18966
-
Sampson MJ, Lovell RS, and Craigen WJ (1997) The murine voltage-dependent anion channel gene family. Conserved structure and function. J Biol Chem 272:18966-18973. (Pubitemid 27318251)
-
(1997)
Journal of Biological Chemistry
, vol.272
, Issue.30
, pp. 18966-18973
-
-
Sampson, M.J.1
Lovell, R.S.2
Craigen, W.J.3
-
31
-
-
80054052133
-
Phosphorylation of voltage-dependent anion channel by serine/threonine kinases governs its interaction with tubulin
-
Sheldon KL, Maldonado EN, Lemasters JJ, Rostovtseva TK, and Bezrukov SM (2011) Phosphorylation of voltage-dependent anion channel by serine/threonine kinases governs its interaction with tubulin. PLoS One 6:e25539.
-
(2011)
PLoS One
, vol.6
-
-
Sheldon, K.L.1
Maldonado, E.N.2
Lemasters, J.J.3
Rostovtseva, T.K.4
Bezrukov, S.M.5
-
32
-
-
34948846577
-
VDAC closure increases calcium ion flux
-
DOI 10.1016/j.bbamem.2007.06.002, PII S0005273607002131
-
Tan W and Colombini M (2007) VDAC closure increases calcium ion flux. Biochim Biophys Acta 1768:2510-2515. (Pubitemid 47532032)
-
(2007)
Biochimica et Biophysica Acta - Biomembranes
, vol.1768
, Issue.10
, pp. 2510-2515
-
-
Tan, W.1
Colombini, M.2
-
33
-
-
68749106797
-
Direct measurement of energy fluxes from mitochondria into cytoplasm in permeabilized cardiac cells in situ: Some evidence for mitochondrial interactosome
-
Timohhina N, Guzun R, Tepp K, Monge C, Varikmaa M, Vija H, Sikk P, Kaambre T, Sackett D, and Saks V (2009) Direct measurement of energy fluxes from mitochondria into cytoplasm in permeabilized cardiac cells in situ: some evidence for mitochondrial interactosome. J Bioenerg Biomembr 41:259-275.
-
(2009)
J Bioenerg Biomembr
, vol.41
, pp. 259-275
-
-
Timohhina, N.1
Guzun, R.2
Tepp, K.3
Monge, C.4
Varikmaa, M.5
Vija, H.6
Sikk, P.7
Kaambre, T.8
Sackett, D.9
Saks, V.10
-
34
-
-
56649099192
-
The crystal structure of mouse VDAC1 at 2.3 A resolution reveals mechanistic insights into metabolite gating
-
Ujwal R, Cascio D, Colletier JP, Faham S, Zhang J, Toro L, Ping P, and Abramson J (2008) The crystal structure of mouse VDAC1 at 2.3 A resolution reveals mechanistic insights into metabolite gating. Proc Natl Acad Sci U S A 105:17742-17747.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 17742-17747
-
-
Ujwal, R.1
Cascio, D.2
Colletier, J.P.3
Faham, S.4
Zhang, J.5
Toro, L.6
Ping, P.7
Abramson, J.8
-
35
-
-
66249108601
-
Understanding the Warburg effect: The metabolic requirements of cell proliferation
-
Vander Heiden MG, Cantley LC, and Thompson CB (2009) Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 324: 1029-1033.
-
(2009)
Science
, vol.324
, pp. 1029-1033
-
-
Vander Heiden, M.G.1
Cantley, L.C.2
Thompson, C.B.3
-
36
-
-
0034712944
-
Outer mitochondrial membrane permeability can regulate coupled respiration and cell survival
-
DOI 10.1073/pnas.090082297
-
Vander Heiden MG, Chandel NS, Li XX, Schumacker PT, Colombini M, and Thompson CB (2000) Outer mitochondrial membrane permeability can regulate coupled respiration and cell survival. Proc Natl Acad Sci U S A 97:4666-4671. (Pubitemid 30238615)
-
(2000)
Proceedings of the National Academy of Sciences of the United States of America
, vol.97
, Issue.9
, pp. 4666-4671
-
-
Vander, H.M.G.1
Chandel, N.S.2
Li, X.X.3
Schumacker, P.T.4
Colombini, M.5
Thompson, C.B.6
-
37
-
-
0035380462
-
Bcl-xL promotes the open configuration of the voltage-dependent anion channel and metabolite passage through the outer mitochondrial membrane
-
Vander Heiden MG, Li XX, Gottleib E, Hill RB, Thompson CB, and Colombini M (2001) Bcl-xL promotes the open configuration of the voltage-dependent anion channel and metabolite passage through the outer mitochondrial membrane. J Biol Chem 276:19414-19419.
-
(2001)
J Biol Chem
, vol.276
, pp. 19414-19419
-
-
Vander Heiden, M.G.1
Li, X.X.2
Gottleib, E.3
Hill, R.B.4
Thompson, C.B.5
Colombini, M.6
-
38
-
-
84865169609
-
Metabolic pathway alterations that support cell proliferation
-
Vander Heiden MG, Lunt SY, Dayton TL, Fiske BP, Israelsen WJ, Mattaini KR, Vokes NI, Stephanopoulos G, Cantley LC, Metallo CM, et al. (2011) Metabolic pathway alterations that support cell proliferation. Cold Spring Harb Symp Quant Biol 76:325-334.
-
(2011)
Cold Spring Harb Symp Quant Biol
, vol.76
, pp. 325-334
-
-
Vander Heiden, M.G.1
Lunt, S.Y.2
Dayton, T.L.3
Fiske, B.P.4
Israelsen, W.J.5
Mattaini, K.R.6
Vokes, N.I.7
Stephanopoulos, G.8
Cantley, L.C.9
Metallo, C.M.10
-
39
-
-
12444279265
-
On the origin of cancer cells
-
Warburg O (1956) On the origin of cancer cells. Science 123:309-314.
-
(1956)
Science
, vol.123
, pp. 309-314
-
-
Warburg, O.1
-
41
-
-
84858604270
-
Metabolic reprogramming: A cancer hallmark even Warburg did not anticipate
-
Ward PS and Thompson CB (2012) Metabolic reprogramming: a cancer hallmark even Warburg did not anticipate. Cancer Cell 21:297-308.
-
(2012)
Cancer Cell
, vol.21
, pp. 297-308
-
-
Ward, P.S.1
Thompson, C.B.2
|