VDAC channels differentiate between natural metabolites and synthetic molecules

Journal of Membrane Biology

Volumn 187, Issue 2, 2002, Pages 147-156

  Rostovtseva, T K ^a   Komarov, A ^b,c   Bezrukov, S M ^b,c   Colombini, M ^a  

^a Bldg 142   (United States)

^b EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^c PETERSBURG NUCLEAR PHYSICS INSTITUTE   (Russian Federation)

Author keywords

ATP; Current noise; Large channel; Mitochondria; Permeation; Planar membranes

Indexed keywords

1 HYDROXYPYRENE; ADENOSINE TRIPHOSPHATE; ANION; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; GLUTAMIC ACID DERIVATIVE; NUCLEOTIDE; POTASSIUM CHANNEL; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; SODIUM CHANNEL; SULFONIC ACID DERIVATIVE; URIDINE TRIPHOSPHATE; ARYLSULFONIC ACID DERIVATIVE; ION CHANNEL; NICOTINAMIDE ADENINE DINUCLEOTIDE; PORIN; PYRANINE; VOLTAGE DEPENDENT ANION CHANNEL;

ARTICLE; DIFFUSION COEFFICIENT; MEMBRANE CHANNEL; MEMBRANE CONDUCTANCE; MEMBRANE POTENTIAL; METABOLITE; MITOCHONDRIAL MEMBRANE; NEUROSPORA CRASSA; NONHUMAN; ARTIFICIAL MEMBRANE; CHANNEL GATING; CHEMICAL STRUCTURE; CHEMISTRY; ELECTROCHEMISTRY; ISOLATION AND PURIFICATION; METABOLISM; METHODOLOGY; SENSITIVITY AND SPECIFICITY; STRUCTURE ACTIVITY RELATION;

ADENOSINE TRIPHOSPHATE; ARYLSULFONATES; ELECTROCHEMISTRY; GLUTAMATES; ION CHANNEL GATING; ION CHANNELS; MEMBRANES, ARTIFICIAL; MODELS, MOLECULAR; NAD; NEUROSPORA CRASSA; PORINS; SENSITIVITY AND SPECIFICITY; STRUCTURE-ACTIVITY RELATIONSHIP; SUPPORT, U.S. GOV'T, NON-P.H.S.; URIDINE TRIPHOSPHATE; VOLTAGE-DEPENDENT ANION CHANNELS;

NEUROSPORA; NEUROSPORA CRASSA;

EID: 0037092536     PISSN: 00222631     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00232-001-0159-1     Document Type: Article

References (40)

1. Structure and orientation of two voltage-dependent anion-selective channel isoforms
2. Structure and function of porins from gram-negative bacteria
3. Inhibition of adenine nucleotide transport through the mitochondrial porin by a synthetic polyanion
4. Ion channels as molecular Coulter counters to probe metabolite transport
5. The charge state of an ion channel controls neutral polymer entry into its pore
6. Probing sugar translocation through maltoporin at the single channel level
7. Probing alamethicin channels with water-soluble polymers
8. Counting polymers moving through a single ion channel
9. Polyol permeability of the human red cell. Interpretation of glucose transport in terms of a pore
10. A candidate for the permeability pathway of the outer mitochondrial membrane
11. The pore size and properties of channels from mitochondria isolated from Neurospora crassa
12. Anion channels in the mitochondrial outer membrane
13. VDAC, a channel in the outer mitochondrial membrane
14. Qualitative and quantitative colometric determination of heptoses
15. Isolation and properties of the porin of the outer mitochondrial membrane from Neurospora crassa
16. Influence of the mitochondrial outer membrane and the binding of creatine kinase to the mitochondrial inner membrane on the compartmentation of adenine nucleotides in the intermembrane space of rat heart mitochondria
17. Cause and consequences of dynamic compartmentation of adenine nucleotides in the mitochondrial intermembrane space in respect to exchange of energy-rich phosphates between cytosol and mitochondria
18. Effect of macromolecules on the regulation of the mitochondrial outer membrane pore and the activity of adenylate kinase in the inter-membrane space
19. Protonation dynamics of the alpha-toxin channel from spectral analysis of pH dependent current fluctuations
20. A simple method for the determination of the pore radius of ion channels in a planar lipid bilayer membranes
21. The role of pyridine dinucleotides in regulating the permeability of the mitochondrial outer membrane
22. β-NADH decreases the permeability of the mitochondrial outer membrane to ADP by a factor of 6
23. Regulation of mitochondrial respiration by controlling the permeability of the outer membrane through the mitochondrial channel. VDAC
24. Structure of the outer mitochondrial membrane: Ordered arrays of pore-like subunits in outer-membrane fractions from Neurospora crassa mitochondria
25. Diameter of the mitochondrial outer membrane channel: Evidence from electron microscopy of frozen-hydrated membrane crystals
26. Formation of biomolecular membranes from lipid monolayers and a study of their electrical properties
27. Amino acid analysis: Aqueous dimethyl sulfoxide as solvent for the ninhydrin reaction
28. ATP flux is controlled by a voltage-gated channel from the mitochondrial outer membrane
29. VDAC channels mediate and gate the flow of ATP: Implications for the regulation of mitochondrial functions
30. ATP transport through a single mitochondrial channel, VDAC, studied by current fluctuation analysis
31. Dynamics of nucleotides in VDAC channels: Structure-specific noise generation
32. Structural basis for sugar translocation through maltoporin channels at 3.1 Angstrom resolution
33. Indication of a common folding pattern for VDAC channels from all sources
34. The sensor regions of VDAC are translocated from within the membrane to the surface during the gating processes
35. The topology of VDAC as probed by biotin modification
36. L Promotes the open configuration of VDAC and metabolite passage through the mitochondrial outer membrane
37. Mitochondrial outer membrane contains a protein producing nonspecific diffusion channels
38. Zero-current potentials in a large membrane channel: A simple theory accounts for complex behavior