Antiviral therapy of two patients with chromosomally-integrated human herpesvirus-6A presenting with cognitive dysfunction

Journal of Clinical Virology

Volumn 55, Issue 1, 2012, Pages 40-45

  Montoya, José G ^a   Neely, Michael N ^b   Gupta, Sudhir ^c   Lunn, Mitchell R ^d   Loomis, Kristin S ^e   Pritchett, Joshua C ^e   Polsky, Bruce ^f   Medveczky, Peter G ^g  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d BRIGHAM AND WOMEN S HOSPITAL   (United States)

^e The HHV 6 Foundation   (United States)

^f ST LUKE S ROOSEVELT HOSPITAL CENTER   (United States)

^g UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

Chromosomally integrated HHV 6; CIHHV 6; HHV 6; Human herpesvirus 6; Inherited HHV 6

Indexed keywords

FOSCARNET; IMMUNOGLOBULIN; MESSENGER RNA; TRICHOSTATIN A; VALGANCICLOVIR;

ADOLESCENT; ADULT; ARTICLE; CASE REPORT; CENTRAL NERVOUS SYSTEM INFECTION; COGNITIVE DEFECT; DRUG MEGADOSE; FEMALE; HERPES VIRUS INFECTION; HUMAN; HUMAN HERPESVIRUS 6; LOW DRUG DOSE; MALE; PATIENT MONITORING; PERSISTENT VIRUS INFECTION; PRIORITY JOURNAL; RECURRENT INFECTION; TREATMENT DURATION; TREATMENT OUTCOME; VIRUS DNA CELL DNA INTERACTION; VIRUS LOAD; VIRUS REACTIVATION;

ANTIVIRAL AGENTS; CHILD; COGNITION DISORDERS; DNA, VIRAL; ELECTROENCEPHALOGRAPHY; FEMALE; HERPESVIRUS 6, HUMAN; HUMANS; LEUKOCYTE COUNT; MALE; RNA, MESSENGER; ROSEOLOVIRUS INFECTIONS; SIBLINGS; VIRAL LOAD; VIRUS INTEGRATION; YOUNG ADULT;

EID: 84865161650     PISSN: 13866532     EISSN: 18735967     Source Type: Journal    
DOI: 10.1016/j.jcv.2012.05.016     Document Type: Article

References (47)

1. Ablashi D.V., Agut H., Berneman Z., Campadilli-Fiume G., Carrigan D., Ceccerini-Nelli L., et al. Human herpesvirus-6 strain groups: a nomenclature. Arch Virol 1993, 129(1-4):363-366.
2. Troy S.B., Blackburn B.G., Yeom K., Caulfield A.K., Bhangoo M.S., Montoya J.G. Severe encephalomyelitis in an immunocompetent adult with chromosomally integrated human herpesvirus 6 and clinical response to treatment with foscarnet plus ganciclovir. Clin Infect Dis 2008, 47(December (12)):e93-e96.
3. Yamashita N., Morishima T. HHV-6 and seizures. Herpes 2005, 12(October (2)):46-49.
4. Kuhl U., Pauschinger M., Noutsias M., Seeberg B., Bock T., Lassner D., et al. High prevalence of viral genomes and multiple viral infections in the myocardium of adults with " idiopathic" left ventricular dysfunction. Circulation 2005, 111(February (7)):887-893.
5. Mahrholdt H., Wagner A., Deluigi C.C., Kispert E., Hager S., Meinhardt G., et al. Presentation, patterns of myocardial damage, and clinical course of viral myocarditis. Circulation 2006, 114(October (15)):1581-1590.
6. Leveque N., Boulagnon C., Brasselet C., Lesaffre F., Boutolleau D., Metz D., et al. A fatal case of Human Herpesvirus 6 chronic myocarditis in an immunocompetent adult. J Clin Virol 2011, 52(October (2)):142-145.
7. Sairenji T., Yamanishi K., Tachibana Y., Bertoni G., Kurata T. Antibody responses to Epstein-Barr virus, human herpesvirus 6 and human herpesvirus 7 in patients with chronic fatigue syndrome. Intervirology 1995, 38(5):269-273.
8. Kogelnik A.M., Loomis K., Hoegh-Petersen M., Rosso F., Hischier C., Montoya J.G. Use of valganciclovir in patients with elevated antibody titers against Human Herpesvirus-6 (HHV-6) and Epstein-Barr Virus (EBV) who were experiencing central nervous system dysfunction including long-standing fatigue. J Clin Virol 2006, 37(December (Suppl. 1)):S33-S38.
9. Komaroff A.L. Is human herpesvirus-6 a trigger for chronic fatigue syndrome?. J Clin Virol 2006, 37(December (Suppl. 1)):S39-S46.
10. Soldan S.S., Berti R., Salem N., Secchiero P., Flamand L., Calabresi P.A., et al. Association of human herpes virus 6 (HHV-6) with multiple sclerosis: increased IgM response to HHV-6 early antigen and detection of serum HHV-6 DNA. Nat Med 1997, 3(December (12)):1394-1397.
11. Martinez A., Alvarez-Lafuente R., Mas A., Bartolome M., Garcia-Montojo M., de Las Heras V., et al. Environment-gene interaction in multiple sclerosis: human herpesvirus 6 and MHC2TA. Hum Immunol 2007, 68(August (8)):685-689.
12. Garcia-Montojo M., De Las Heras V., Dominguez-Mozo M., Bartolome M., Garcia-Martinez M.A., Arroyo R., et al. Human herpesvirus 6 and effectiveness of interferon beta1b in multiple sclerosis patients. Eur J Neurol 2011, 18(August (8)):1027-1035.
13. Virtanen J.O., Pietilainen-Nicklen J., Uotila L., Farkkila M., Vaheri A., Koskiniemi M. Intrathecal human herpesvirus 6 antibodies in multiple sclerosis and other demyelinating diseases presenting as oligoclonal bands in cerebrospinal fluid. J Neuroimmunol 2011, 237(August (1-2)):93-97.
14. Luppi M., Marasca R., Barozzi P., Ferrari S., Ceccherini-Nelli L., Batoni G., et al. Three cases of human herpesvirus-6 latent infection: integration of viral genome in peripheral blood mononuclear cell DNA. J Med Virol 1993, 40(May (1)):44-52.
15. Hall C.B., Caserta M.T., Schnabel K.C., Shelley L.M., Carnahan J.A., Marino A.S., et al. Transplacental congenital human herpesvirus 6 infection caused by maternal chromosomally integrated virus. J Infect Dis 2010, 201(February (4)):505-507.
16. Leong H.N., Tuke P.W., Tedder R.S., Khanom A.B., Eglin R.P., Atkinson C.E., et al. The prevalence of chromosomally integrated human herpesvirus 6 genomes in the blood of UK blood donors. J Med Virol 2007, 79(January (1)):45-51.
17. Pellett P.E., Ablashi D.V., Ambros P.F., Agut H., Caserta M.T., Descamps V., et al. Chromosomally integrated human herpesvirus 6: questions and answers. Rev Med Virol 2011, 22(3):144-155.
18. Arbuckle J.H., Medveczky M.M., Luka J., Hadley S.H., Luegmayr A., Ablashi D., et al. The latent human herpesvirus-6A genome specifically integrates in telomeres of human chromosomes in vivo and in vitro. Proc Natl Acad Sci U S A 2010, 107(March (12)):5563-5568.
19. Ahn H., Prichep L., John E.R., Baird H., Trepetin M., Kaye H. Developmental equations reflect brain dysfunctions. Science 1980, 210(December (4475)):1259-1262.
20. John E.R., Prichep L., Ahn H., Easton P., Fridman J., Kaye H. Neurometric evaluation of cognitive dysfunctions and neurological disorders in children. Prog Neurobiol 1983, 21(4):239-290.
21. Ahn H., Prichep L., John E.R. Electroncephalogram tests for brain dysfunation: a question of validity. Science 1982, 217(July (4554)):82.
22. Adler G., Bramesfeld A., Jajcevic A. Mild cognitive impairment in old-age depression is associated with increased EEG slow-wave power. Neuropsychobiology 1999, 40(November (4)):218-222.
23. Andraus M.E., Alves-Leon S.V. Non-epileptiform EEG abnormalities: an overview. Arq Neuropsiquiatr 2011, 69(October (5)):829-835.
24. De Clercq E., Naesens L., De Bolle L., Schols D., Zhang Y., Neyts J. Antiviral agents active against human herpesviruses HHV-6, HHV-7 and HHV-8. Rev Med Virol 2001, 11(November-December (6)):381-395.
25. Achour A., Boutolleau D., Slim A., Agut H., Gautheret-Dejean A. Human herpesvirus-6 (HHV-6) DNA in plasma reflects the presence of infected blood cells rather than circulating viral particles. J Clin Virol 2007, 38(April (4)):280-285.
26. Zerr D.M., Fann J.R., Breiger D., Boeckh M., Adler A.L., Xie H., et al. HHV-6 reactivation and its effect on delirium and cognitive functioning in hematopoietic cell transplantation recipients. Blood 2011, 117(May (19)):5243-5249.
27. Provenzale J.M., van Landingham K., White L.E. Clinical and imaging findings suggesting human herpesvirus 6 encephalitis. Pediatr Neurol 2010, 42(January (1)):32-39.
28. Sharland M., Luck S., Griffiths P., Cotton M. Antiviral therapy of CMV disease in children. Adv Exp Med Biol 2011, 697:243-260.
29. Deray G., Martinez F., Katlama C., Levaltier B., Beaufils H., Danis M., et al. Foscarnet nephrotoxicity: mechanism, incidence and prevention. Am J Nephrol 1989, 9(4):316-321.
30. Hubacek P., Maalouf J., Zajickova M., Kouba M., Cinek O., Hyncicova K., et al. Failure of multiple antivirals to affect high HHV-6 DNAaemia resulting from viral chromosomal integration in case of severe aplastic anaemia. Haematologica 2007, 92(October (10)):e98-e100.
31. Ward K.N., Thiruchelvam A.D., Couto-Parada X. Unexpected occasional persistence of high levels of HHV-6 DNA in sera: detection of variants A and B. J Med Virol 2005, 76(August (4)):563-570.
32. Wittekindt B., Berger A., Porto L., Vlaho S., Gruttner H.P., Becker M., et al. Human herpes virus-6 DNA in cerebrospinal fluid of children undergoing therapy for acute leukaemia. Br J Haematol 2009, 145(May (4)):542-545.
33. Kobayashi D., Kogawa K., Imai K., Tanaka T., Hiroi S., Satoh H., et al. Quantitation of human herpesvirus-6 (HHV-6) DNA in a cord blood transplant recipient with chromosomal integration of HHV-6. Transpl Infect Dis 2011, 13(December (6)):650-653.
34. Clark D.A., Nacheva E.P., Leong H.N., Brazma D., Li Y.T., Tsao E.H., et al. Transmission of integrated human herpesvirus 6 through stem cell transplantation: implications for laboratory diagnosis. J Infect Dis 2006, 193(April (7)):912-916.
35. Kamble R.T., Clark D.A., Leong H.N., Heslop H.E., Brenner M.K., Carrum G. Transmission of integrated human herpesvirus-6 in allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplant 2007, 40(September (6)):563-566.
36. Lee S.O., Brown R.A., Razonable R.R. Clinical significance of pretransplant chromosomally integrated human herpesvirus-6 in liver transplant recipients. Transplantation 2011, 92(July (2)):224-229.
37. Potenza L., Barozzi P., Rossi G., Riva G., Vallerini D., Zanetti E., et al. May the indirect effects of CIHHV-6 in transplant patients be exerted through the reactivation of the viral replicative machinery?. Transplantation 2011, 92(November (9)):e49-e51. author reply e-2.
38. Tanaka-Taya K., Sashihara J., Kurahashi H., Amo K., Miyagawa H., Kondo K., et al. Human herpesvirus 6 (HHV-6) is transmitted from parent to child in an integrated form and characterization of cases with chromosomally integrated HHV-6 DNA. J Med Virol 2004, 73(July (3)):465-473.
39. Kano Y., Inaoka M., Shiohara T. Association between anticonvulsant hypersensitivity syndrome and human herpesvirus 6 reactivation and hypogammaglobulinemia. Arch Dermatol 2004, 140(February (2)):183-188.
40. Kano Y., Hiraharas K., Sakuma K., Shiohara T. Several herpesviruses can reactivate in a severe drug-induced multiorgan reaction in the same sequential order as in graft-versus-host disease. Br J Dermatol 2006, 155(August (2)):301-306.
41. Shiohara T., Inaoka M., Kano Y. Drug-induced hypersensitivity syndrome (DIHS): a reaction induced by a complex interplay among herpesviruses and antiviral and antidrug immune responses. Allergol Int 2006, 55(March (1)):1-8.
42. Tohyama M., Hashimoto K., Yasukawa M., Kimura H., Horikawa T., Nakajima K., et al. Association of human herpesvirus 6 reactivation with the flaring and severity of drug-induced hypersensitivity syndrome. Br J Dermatol 2007, 157(November (5)):934-940.
43. Black J.B., Sanderlin K.C., Goldsmith C.S., Gary H.E., Lopez C., Pellett P.E. Growth properties of human herpesvirus-6 strain Z29. J Virol Methods 1989, 26(November (2)):133-145.
44. Ogata M., Kikuchi H., Satou T., Kawano R., Ikewaki J., Kohno K., et al. Human herpesvirus 6 DNA in plasma after allogeneic stem cell transplantation: incidence and clinical significance. J Infect Dis 2006, 193(January (1)):68-79.
45. Ogata M., Satou T., Kawano R., Takakura S., Goto K., Ikewaki J., et al. Correlations of HHV-6 viral load and plasma IL-6 concentration with HHV-6 encephalitis in allogeneic stem cell transplant recipients. Bone Marrow Transplant 2010, 45(January (1)):129-136.
46. Fujita A., Ihira M., Suzuki R., Enomoto Y., Sugiyama H., Sugata K., et al. Elevated serum cytokine levels are associated with human herpesvirus 6 reactivation in hematopoietic stem cell transplantation recipients. J Infect 2008, 57(September (3)):241-248.
47. Ichiyama T., Ito Y., Kubota M., Yamazaki T., Nakamura K., Furukawa S. Serum and cerebrospinal fluid levels of cytokines in acute encephalopathy associated with human herpesvirus-6 infection. Brain Dev 2009, 31(November (10)):731-738.