A fatal case of Human Herpesvirus 6 chronic myocarditis in an immunocompetent adult

Journal of Clinical Virology

Volumn 52, Issue 2, 2011, Pages 142-145

  Leveque, Nicolas ^a   Boulagnon, Camille ^a   Brasselet, Camille ^a   Lesaffre, François ^a   Boutolleau, David ^b   Metz, Damien ^a   Fornes, Paul ^a   Andreoletti, Laurent ^a  

^a REIMS UNIVERSITY HOSPITAL   (France)

^b PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

Author keywords

Endomyocardial biopsy; Human Herpesvirus 6; Immunocompetent; Immunohistochemistry; Real time PCR assay; Viral myocarditis

Indexed keywords

ACETYLSALICYLIC ACID; ADRENALIN; DOBUTAMINE; ENALAPRIL; FUROSEMIDE; VIRUS GLYCOPROTEIN;

ADULT; ARTICLE; CASE REPORT; CELL INFILTRATION; CYTOLYTIC HEPATITIS; DRUG MEGADOSE; ECHOCARDIOGRAPHY; ENDOTHELIUM CELL; FEMALE; FIBROSIS; HEART; HEART DILATATION; HEART FAILURE; HEART LEFT VENTRICLE FILLING PRESSURE; HEART MUSCLE BIOPSY; HERPES VIRUS INFECTION; HISTOPATHOLOGY; HUMAN; HUMAN HERPESVIRUS 6; HYPOKINESIA; IMMUNOCOMPROMISED PATIENT; IMMUNOHISTOCHEMISTRY; LEUKOCYTOSIS; LOW DRUG DOSE; MONONUCLEAR CELL; NEUTROPHILIA; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PERICARDIAL EFFUSION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN SYNTHESIS; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCAR FORMATION; T LYMPHOCYTE; TISSUE DOPPLER IMAGING; VIRUS MYOCARDITIS; VIRUS REPLICATION;

BIOPSY; CELL LINE, TUMOR; CHRONIC DISEASE; FATAL OUTCOME; FEMALE; HERPESVIRUS 6, HUMAN; HUMANS; IMMUNOCOMPETENCE; MIDDLE AGED; MYOCARDITIS; MYOCARDIUM; ROSEOLOVIRUS INFECTIONS;

EID: 80052704858     PISSN: 13866532     EISSN: 18735967     Source Type: Journal    
DOI: 10.1016/j.jcv.2011.06.017     Document Type: Article

References (27)

1. Kühl U., Pauschinger M., Noutsias M., Seeberg B., Bock T., Lassner D., et al. High prevalence of viral genomes and multiple viral infections in the myocardium of adults with idiopathic left ventricular dysfunction. Circulation 2005, 111:887-893.
2. Kühl U., Pauschinger M., Seeberg B., Lassner D., Noutsias M., Poller W., et al. Viral persistence in the myocardium is associated with progressive cardiac dysfunction. Circulation 2005, 112:1965-1970.
3. Mahrholdt H., Wagner A., Deluigi C.C., Kispert E., Hager S., Meinhardt G., et al. Presentation, patterns of myocardial damage, and clinical course of viral myocarditis. Circulation 2006, 114:1581-1590.
4. Cooper L.T., Baughman K.L., Feldman A.M., Frustaci A., Jessup M., Kuhl U., et al. The role of endomyocardial biopsy in the management of cardiovascular disease: a scientific statement from the American Heart Association, the American College of Cardiology, and the European Society of Cardiology. Endorsed by the Heart Failure Society of America and the Heart Failure Association of the European Society of Cardiology. J Am Coll Cardiol 2007, 50:1914-1931.
5. Candotti D., Etiz N., Parsyan A., Allain J.P. Identification and characterization of persistent human erythrovirus infection in blood donor samples. J Virol 2004, 78:12169-12178.
6. Fafi-Kremer S., Brengel-Pesce K., Barguès G., Bourgeat M.J., Genoulaz O., Seigneurin J.M., et al. Assessment of automated DNA extraction coupled with real-time PCR for measuring Epstein-Barr virus load in whole blood, peripheral mononuclear cells and plasma. J Clin Virol 2004, 30:157-164.
7. Heim A., Ebnet C., Harste G., Pring-Akerblom P. Rapid and quantitative detection of human adenovirus DNA by real-time PCR. J Med Virol 2003, 70:228-239.
8. Kares S., Lönnrot M., Vuorinen P., Oikarinen S., Taurianen S., Hyöty H. Real-time PCR for rapid diagnosis of entero- and rhinovirus infections using LightCycler. J Clin Virol 2004, 29:99-104.
9. Najioullah F., Thouvenot D., Lina B. Development of a real-time PCR procedure including an internal control for the measurement of HCMV viral load. J Virol Methods 2001, 92:55-64.
10. Gautheret-Dejean A., Manichanh C., Thien-Ah-Koon F., Fillet A.M., Mangeney N., Vidaud M., et al. Development of a real-time polymerase chain reaction assay for the diagnosis of human herpesvirus-6 infection and application to bone marrow transplant patients. J Virol Methods 2002, 100:27-35.
11. Fillet A.M., Reux I., Joberty C., Fournier J.G., Hauw J.J., Le Hoang P., et al. Detection of human herpes virus 6 in AIDS-associated retinitis by means of in situ hybridization, polymerase chain reaction and immunohistochemistry. J Med Virol 1996, 49:289-295.
12. Okuno T., Shao H., Asada H., Shiraki K., Takahashi M., Yamanishi K. Analysis of human herpesvirus 6 glycoproteins recognized by monoclonal antibody OHV1. J Gen Virol 1992, 73:443-447.
13. Chang Y.L., Parker M.E., Nuovo G., Miller J.B. Human herpesvirus 6-related fulminant myocarditis and hepatitis in an immunocompetent adult with fatal outcome. Hum Pathol 2009, 40:740-745.
14. Yoshikawa T., Ihira M., Suzuki K., Suga S., Kito H., Iwasaki T., et al. Fatal acute myocarditis in an infant with human herpesvirus 6 infection. J Clin Pathol 2001, 54:792-795.
15. Fukae S., Ashizawa N., Morikawa S., Yano K. A fatal case of fulminant myocarditis with human herpesvirus-6 infection. Intern Med 2000, 39:632-636.
16. Andreoletti L., Leveque N., Boulagnon C., Brasselet C., Fornes P. Viral causes of human myocarditis. Arch Cardiovasc Dis 2009, 102:559-568.
17. Cooper L.T. Myocarditis. N Engl J Med 2009, 360:1526-1538.
18. Dennert R., Crijns H.J., Heymans S. Acute viral myocarditis. Eur Heart J 2008, 29:2073-2082.
19. Yajima T., Knowlton K.U. Viral myocarditis: from the perspective of the virus. Circulation 2009, 119:2615-2624.
20. Maron B.J., Towbin J.A., Thiene G., Antzelevitch C., Corrado D., Arnett D., et al. Contemporary definitions and classification of the cardiomyopathies: an American Heart Association Scientific Statement from the Council on Clinical Cardiology, Heart Failure and Transplantation Committee; Quality of Care and Outcomes Research and Functional Genomics and Translational Biology Interdisciplinary Working Groups; and Council on Epidemiology and Prevention. Circulation 2006, 113:1807-1816.
21. Bowles N.E., Ni J., Kearney D.L., Pauschinger M., Schultheiss H.P., McCarthy R., et al. Detection of viruses in myocardial tissues by polymerase chain reaction. Evidence of adenovirus as a common cause of myocarditis in children and adults. J Am Coll Cardiol 2003, 42:466-472.
22. Li Y., Bourlet T., Andreoletti L., Mosnier J.F., Peng T., Yang Y., et al. Enteroviral capsid protein VP1 is present in myocardial tissues from some patients with myocarditis or dilated cardiomyopathy. Circulation 2000, 101:231-234.
23. Braun D.K., Dominguez G., Pellett P.E. Human herpesvirus 6. Clin Microbiol Rev 1997, 10:521-567.
24. Bigalke B., Klingel K., May A.E., Kandolf R., Gawaz M.G. Human herpesvirus 6 subtype A-associated myocarditis with 'apical ballooning'. Can J Cardiol 2007, 23:393-395.
25. Gazziero A., Guzzardo V., Aldighieri E., Fassina A. Morphological quality and nucleic acid preservation in cytopathology. J Clin Pathol 2009, 62:429-434.
26. Caruso A., Rotola A., Comar M., Favilli F., Galvan M., Tosetti M., et al. HHV-6 infects human aortic and heart microvascular endothelial cells, increasing their ability to secrete proinflammatory chemokines. J Med Virol 2002, 67:528-533.
27. Kindermann I., Kindermann M., Kandolf R., Klingel K., Bültmann B., Müller T., et al. Predictors of outcome in patients with suspected myocarditis. Circulation 2008, 118:639-648.