Structure-based design, synthesis, and biological evaluation of dihydroquinazoline-derived potent β-secretase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 17, 2012, Pages 5460-5465

  Ghosh, Arun K ^a,b   Pandey, Satyendra ^a,b   Gangarajula, Sudhakar ^a,b   Kulkarni, Sarang ^a,b   Xu, Xiaoming ^a,b   Rao, Kalapala Venkateswara ^a,b   Huang, Xiangping ^c   Tang, Jordan ^c  

^a PURDUE UNIVERSITY   (United States)

^b PURDUE UNIVERSITY   (United States)

^c UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER   (United States)

Author keywords

Secretase; Alzheimer's disease; Design and synthesis; Dihydroquinazoline; Inhibitor; Memapsin 2

Indexed keywords

2 AMINO DIHYDROQUINAZOLINE DERIVATIVE; BETA SECRETASE INHIBITOR; PYRAZOLE; QUINAZOLINE DERIVATIVE; THIAZOLE; UNCLASSIFIED DRUG; URETHAN DERIVATIVE;

ARTICLE; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HYDROGEN BOND; HYDROGENATION; MOLECULAR INTERACTION; NEUROBLASTOMA CELL; SAPONIFICATION;

ALZHEIMER DISEASE; AMYLOID PRECURSOR PROTEIN SECRETASES; CATALYTIC DOMAIN; CELL LINE, TUMOR; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; MODELS, MOLECULAR; PYRAZOLES; QUINAZOLINES; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

EID: 84865152883     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.07.043     Document Type: Article

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