A 24-color metaphase-based radiation assay discriminates heterozygous BRCA2 mutation carriers from controls by chromosomal radiosensitivity

Breast Cancer Research and Treatment

Volumn 135, Issue 1, 2012, Pages 167-175

  Becker, Alexandra A ^a   Graeser, Monika K ^a   Landwehr, Christina ^b,c   Hilger, Thomas ^a   Baus, Wolfgang ^a   Wappenschmidt, Barbara ^a   Meindl, Alfons ^d   Weber, Ruthild G ^b,e   Schmutzler, Rita K ^a  

^a UNIVERSITY HOSPITAL OF COLOGNE   (Germany)

^b UNIVERSITY OF BONN   (Germany)

^c Institute for Medical Diagnostics   (Germany)

^d TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^e HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

BRCA2; Hereditary breast cancer; Homologous recombination repair; Irradiation sensitivity; Unclassified variants

Indexed keywords

BRCA2 PROTEIN;

ADULT; AGED; ARTICLE; BRCA2 GENE; BREAST CANCER; BREAST CARCINOGENESIS; CHROMOSOME ABERRATION; CHROMOSOME ANALYSIS; CHROMOSOME DAMAGE; CLINICAL ARTICLE; CONTROLLED STUDY; DNA REPAIR; DOUBLE STRANDED DNA BREAK; FEMALE; GENE MUTATION; GENETIC VARIABILITY; HETEROZYGOSITY; HOMOLOGOUS RECOMBINATION; HUMAN; IRRADIATION; METAPHASE CHROMOSOME; PRIORITY JOURNAL; RADIOSENSITIVITY; TUMOR GENE;

BRCA2 PROTEIN; BREAST NEOPLASMS; CHROMOSOME BREAKAGE; CHROMOSOMES, HUMAN; DNA BREAKS, DOUBLE-STRANDED; DNA REPAIR; FEMALE; GENES, BRCA2; HETEROZYGOTE; HUMANS; MIDDLE AGED; MUTATION; RADIATION TOLERANCE; ULTRAVIOLET RAYS;

EID: 84865120489     PISSN: 01676806     EISSN: 15737217     Source Type: Journal    
DOI: 10.1007/s10549-012-2119-0     Document Type: Article

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