Caretaker Brca1: Keeping the genome in the straight and narrow

Breast Cancer Research

Volumn 2, Issue 2, 2000, Pages 82-85

  Yu, V ^a  

^a WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

Author keywords

Brca1; Brca2; Breast cancer; Double strand break; Homologous recombination; Nonhomologous end joining; Rad51; RecA

Indexed keywords

BRCA1 PROTEIN; DNA; DOUBLE STRANDED DNA;

BREAST CANCER; CANCER RISK; CELL FUNCTION; CONTROLLED STUDY; DNA REPAIR; DNA STRAND BREAKAGE; GENE MUTATION; GENE TARGETING; GENETIC RECOMBINATION; GENOME; HUMAN; HUMAN TISSUE; MUTAGENICITY; NOTE; ONCOGENE; OVARY CANCER; TRANSCRIPTION INITIATION;

BRCA1 PROTEIN; BREAST NEOPLASMS; CELL LINE; CHROMOSOMES; DNA DAMAGE; DNA REPAIR; DNA-BINDING PROTEINS; FEMALE; HUMANS; RAD51 RECOMBINASE; REC A RECOMBINASES; RECOMBINATION, GENETIC; RETINOBLASTOMA PROTEIN; STEM CELLS; TRANSFECTION;

EID: 0034468241     PISSN: 14655411     EISSN: None     Source Type: Journal    
DOI: 10.1186/bcr37     Document Type: Note

References (39)

1. Brca2 is coordinately regulated with Brca1 during proliferation and differentiation in mammary epithelial cells
2. Transcriptional activation by BRCA1
3. BRCA1 protein is linked to the RNA polymerase II holoenzyme complex via RNA helicase A
4. Transcriptional activation functions in BRCA2
5. BRCA1 interacts with components of the histone deacetylase complex
6. BRCA2 associates with acetyltransferase activity when bound to P/CAF
7. 2-M cell cycle checkpoint induce genetic instability in BRCA1 exon11 isoform-deficient cells
8. Absence of Brca2 causes genome instability by chromosome breakage and loss associated with centrosome amplification
9. Induction of GADD45 and JNK/SAPK-dependent apoptosis following inducible expression of BRCA1
10. BRCA1 required for transcription-coupled repair of oxidative DNA damage
11. A targeted disruption of the murine Brca1 gene causes gamma-irradiation hypersensitivity and genetic instability
12. Brca1 controls homology-directed DNA repair
13. Involvement of Brca2 in DNA repair
14. Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities
15. Inactivation of the mouse Brca1 gene leads to failure in the morphogenesis of the egg cylinder in early postimplantation development
16. The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse
17. Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2
18. Targeted mutations of breast cancer susceptibility gene homologs in mice: Lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos
19. RAD51 interacts with the evolutionarily conserved BRC motifs in the human breast cancer susceptibility gene brca2
20. Association of BRCA1 with Rad51 in mitotic and meiotic cells
21. Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells
22. Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage
23. Homology-directed repair is a major double-strand break repair pathway in mammalian cells
24. DNA end-joining: From yeast to man
25. Genetic manipulation of genomes with rare-cutting endonucleases
26. Universal code equivalent of a yeast mitochondrial intron reading frame is expressed into E. coli as a specific double strand endonuclease
27. Chromosomal rearrangements occur in S-cerevisiae rfa1 mutator mutants due to mutagenic lesions processed by double-strand-break repair
28. Gross chromosomal rearrangements in Saccharomyces cerevisiae replication and recombination defective mutants
29. Characterization of a breast cancer cell line derived from a germ-line BRCA1 mutation carrier
30. Chromosome instability syndromes: Lessons for carcinogenesis
31. Cancer-susceptibility genes. Gatekeepers and caretakers
32. Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response
33. Requirement of ATM dependent phosphorylation of Brca1 in the DNA damage response to double-strand breaks
34. Breast cancer genes and DNA repair
35. XRCC3 promotes homology-directed repair of DNA damage in mammalian cells
36. Mammalian XRCC2 promotes the repair of DNA double-strand breaks by homologous recombination
37. Isolation and cross-sensitivity of X-ray sensitive mutants of V79-4 hamster cells
38. XRCC2 and XRCC3, new human Rad51-family members, promote chromosome stability and protect against DNA cross-links and other damages
39. Radiation-induced chromosome damage in X-ray-sensitive mutants (xrs) of the Chinese hamster ovary cell line