G0 and G2 chromosomal assays in the evaluation of radiosensitivity in a cohort of Italian breast cancer patients

Journal of Radiation Research

Volumn 51, Issue 5, 2010, Pages 615-619

  Poggioli, Tommaso ^a   Sterpone, Silvia ^b   Palma, Selena ^a   Cozzi, Renata ^b   Testa, Antonella ^a  

^a ENEA C R CASACCIA   (Italy)

^b ROMA TRE UNIVERSITY   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ASSAYS; CHROMOSOMES; DISEASES; PATIENT TREATMENT; RADIATION EFFECTS; RADIATION SHIELDING;

BREAST CANCER; BREAST CANCER RISK; CANCER PATIENTS; ENHANCED SENSITIVITY; HEALTHY CONTROLS; HEALTHY SUBJECTS; IN-VITRO; PERIPHERAL BLOOD LYMPHOCYTES; RADIATION SENSITIVITY; SPORADICS;

IONIZING RADIATION;

TUMOR MARKER;

ADULT; AGED; ARTICLE; BREAST TUMOR; CELL CYCLE G0 PHASE; CELL CYCLE G2 PHASE; CHROMOSOME ANALYSIS; FEMALE; HUMAN; ITALY; MIDDLE AGED; RADIATION DOSE; RADIATION EXPOSURE;

ADULT; AGED; BREAST NEOPLASMS; CYTOGENETIC ANALYSIS; FEMALE; G0 PHASE; G2 PHASE; HUMANS; ITALY; MIDDLE AGED; RADIATION TOLERANCE; TUMOR MARKERS, BIOLOGICAL;

EID: 77958565611     PISSN: 04493060     EISSN: 13499157     Source Type: Journal    
DOI: 10.1269/jrr.10052     Document Type: Article

References (28)

1. Glass A, et al (2007) Breast cancer incidence, 1980-2006: combined roles of menopausal hormone therapy, screening mammography, and estrogen receptor status. J Natl Cancer Inst 99: 1152-1161.
2. Peto J, et al (1999) Prevalence of BRCA1 and BRCA2 gene mutations in patients with early-onset breast cancer. J Natl Cancer Inst 91: 943-949.
3. Scott D, et al (1999) Increased chromosomal radiosensitivity in breast cancer patients: a comparison of two assays. Int J Radiat Biol 75: 1-10.
4. Peto J and Houlston R (2001) Genetics and the common cancers. Eur J Cancer 37 Suppl 8: S88-S96.
5. Terzoudi G, et al (2000) Increased G2 chromosomal radiosen-sitivity in cancer patients: the role of cdk1/cyclin-B activity level in the mechanisms involved. Int J Radiat Biol 76: 607- 615.
6. Howe O, et al (2005) Elevated G2 chromosomal radiosensi-tivity in Irish breast cancer patients: a comparison with other studies. Int J Radiat Biol 81: 373-378.
7. Alapetite C, et al (1999) Analysis by alkaline comet assay of cancer patients with severe reactions to radiotherapy: defective rejoining of radioinduced DNA strand breaks in lymphocytes of breast cancer patients. Int J Cancer 83: 83-90.
8. Djuzenova C, et al (1999) Identification of ataxia telangiectasia heterozygotes, a cancer-prone population, using the single-cell gel electrophoresis (Comet) assay. Lab Invest 79: 699-705.
9. Blasiak J, et al (2004) Basal, oxidative and alkylative DNA damage, DNA repair efficacy and mutagen sensitivity in breast cancer. Mutat Res 554: 139-148.
10. Colleu-Durel S, et al (2004) Alkaline single-cell gel electro-phoresis (comet assay): a simple technique to show genomic instability in sporadic breast cancer. Eur J Cancer 40: 445- 451.
11. Hussien M, et al (2005) Investigation of systemic folate status, impact of alcohol intake and levels of DNA damage in mono-nuclear cells of breast cancer patients. Br J Cancer 92: 1524- 1530.
12. Sterpone S, et al (2010a) DNA repair capacity and acute radiotherapy adverse effects in Italian breast cancer patients. Mutat Res 684: 43-48.
13. Dikomey E, et al (2003) Why recent studies relating normal tissue response to individual radiosensitivity might have failed and how new studies should be performed. Int J Radiat Oncol Biol Phys 56: 1194-1200.
14. Brock WA and Tucker SL (2000) In vitro radiosensitivity and normal tissue damage. Radiother Oncol 55: 93-94.
15. De Ruyck K, et al (2005) Radiation-induced damage to normal tissues after radiotherapy in patients treated for gynecologic tumors: association with single nucleotide polymorphisms in XRCC1, XRCC3, and OGG1 genes and in vitro chromosomal radiosensitivity in lymphocytes. Int J Radiat Oncol Biol Phys 62: 1140-1149.
16. Baeyens A, et al (2002) Chromosomal radiosensitivity in breast cancer patients with a known or putative genetic predisposition. Br J Cancer 87: 1379-1385.
17. Borgmann K, et al (2007) Genetic determination of chromosomal radiosensitivities in G0- and G2-phase human lymphocytes. Radiother Oncol 83: 196-202.
18. Vral A, et al (2002) The micronucleus and G2-phase assays for human blood lymphocytes as biomarkers of individual sensitivity to ionizing radiation: limitations imposed by intraindividual variability. Radiat Res 157: 472-477.
19. Smart V, et al (2003) Chromosomal radiosensitivity: a study of the chromosomal G(2) assay in human blood lymphocytes indicating significant inter-individual variability. Mutat Res 528: 105-110.
20. Hoeller U, et al (2003) Individual radiosensitivity measured with lymphocytes may be used to predict the risk of fibrosis after radiotherapy for breast cancer. Radiother Oncol 69: 137- 144.
21. Parshad R, et al (1996) Deficient DNA repair capacity, a predisposing factor in breast cancer. Br J Cancer 74: 1-5.
22. Sterpone S, et al (2010b) Single-nucleotide polymorphisms in BER and HRR genes, XRCC1 haplotypes and breast cancer risk in Caucasian women. J Cancer Res Clin Oncol 136: 631- 636.
23. Rothfuss A, et al (2000) Induced micronucleus frequencies in peripheral lymphocytes as a screening test for carriers of a BRCA1 mutation in breast cancer families. Cancer Res 60: 390-394.
24. Riches A, et al (2001) Chromosomal radiosensitivity in G2-phase lymphocytes identifies breast cancer patients with distinctive tumour characteristics. Br J Cancer 85: 1157-1161.
25. Smith T, et al (2003) DNA damage and breast cancer risk. Carcinogenesis 24: 883-889.
26. Scott D, et al (1994) Genetic predisposition in breast cancer. Lancet 344: 1444.
27. Lou J, et al (2008) Response of lymphocytes to radiation in untreated breast cancer patients as detected with three different genetic assays. Biomed Environ Sci 21: 499-508.
28. Ban S, et al (2004) Radiosensitivity of peripheral blood lymphocytes obtained from patients with cancers of the breast, head and neck or cervix as determined with a micronucleus assay. J Radiat Res (Tokyo) 45: 535-541.