Dramatic reduction of dimensionality in large biochemical networks owing to strong pair correlations

Journal of the Royal Society Interface

Volumn 9, Issue 73, 2012, Pages 1824-1835

  Dworkin, Michael ^a   Mukherjee, Sayak ^a   Jayaprakash, Ciriyam ^a   Das, Jayajit ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

Biological networks; Dimension reduction; Gram determinant; Pair correlations

Indexed keywords

COVARIANCE MATRIX; EIGENVALUES AND EIGENFUNCTIONS; GENES; NETWORK ARCHITECTURE; RATE CONSTANTS; REACTION KINETICS;

BIO-CHEMICAL COMPOUNDS; BIOCHEMICAL NETWORK; BIOLOGICAL NETWORKS; CELL SIGNALLING; CHEMICAL SPECIES; COMPLEX KINETICS; DATA SETS; DATA-DRIVEN MODEL; DIMENSION REDUCTION; EIGENVALUE SPECTRA; ELEMENTARY DIFFERENTIALS; EXPERIMENTAL ANALYSIS; GRAM DETERMINANT; HIGH-THROUGHPUT; LINEAR COMBINATIONS; MASS ACTION KINETICS; MOLECULAR SPECIES; MULTIDIMENSIONALITY; NONLINEAR INTERACTIONS; PAIR CORRELATIONS; PRINCIPAL COMPONENTS; PROTEIN EXPRESSION LEVELS; REDUCTION OF DIMENSIONALITY; RELEVANT REACTIONS; STRONG CORRELATION; STRONG PAIR CORRELATION; SYSTEM TRAJECTORY; TEMPORAL CHANGE; TIME-SCALES;

CHEMICAL ANALYSIS;

ARTICLE; BIOCHEMISTRY; GENE CONTROL; GEOMETRY; HIGH THROUGHPUT SEQUENCING; HYDRODYNAMICS; KINETICS; MULTIFACTOR DIMENSIONALITY REDUCTION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; THERMODYNAMICS;

EID: 84865094962     PISSN: 17425689     EISSN: 17425662     Source Type: Journal    
DOI: 10.1098/rsif.2011.0896     Document Type: Article

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