Xanthohumol prevents carbon tetrachloride-induced acute liver injury in rats

Food and Chemical Toxicology

Volumn 50, Issue 10, 2012, Pages 3405-3412

  Pinto, Carmen ^a   Duque, Antonio L ^a   Rodríguez Galdón, Beatriz ^a   Cestero, Juan J ^a   Macías, Pedro ^a  

^a UNIVERSITY OF EXTREMADURA   (Spain)

Author keywords

Antioxidant; CCl4; Hepatoprotection; Hepatotoxicity; Liver; Xanthohumol

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CARBON TETRACHLORIDE; CATALASE; GLUTAMIC ACID; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; GLUTATHIONE TRANSFERASE; HYDROGEN PEROXIDE; LACTATE DEHYDROGENASE; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; XANTHOHUMOL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARBON TETRACHLORIDE INDUCED ACUTE LIVER INJURY; DRUG STRUCTURE; ENZYME ACTIVITY; HISTOPATHOLOGY; INCIDENCE; LIPID PEROXIDATION; LIVER INJURY; LIVER PROTECTION; LIVER WEIGHT; NONHUMAN; OXIDATIVE STRESS; RAT;

ANIMALS; CARBON TETRACHLORIDE POISONING; DRUG-INDUCED LIVER INJURY; FLAVONOIDS; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; GLUTATHIONE TRANSFERASE; LIVER; MOLECULAR STRUCTURE; OXIDANTS; PROPIOPHENONES; RATS; RATS, WISTAR;

RATTUS;

EID: 84865082911     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2012.07.035     Document Type: Article

References (36)

1. Aebi H. Catalase. Methods of Enzymatic Analysis 1974, 673-684. Academic Press, New York and London. H.U. Bergmeyer (Ed.).
2. 4-induced liver injury by a single dose of retinol. Toxicol. Appl. Pharmacol. 1996, 141:507-519.
3. Bandele O.J., Santillo M.F., Ferguson M., Wiesenfel P.L. In vitro toxicity screening of chemical mixtures using HepG2/C3A Cells. Food Chem. Toxicol. 2012, 50:1653-1659.
4. Basu S. Carbon tetrachloride-induced lipid peroxidation: Eicosanoid formation and their regulation by antioxidant nutrients. Toxicology 2003, 189:113-127.
5. Bergmeyer U.H., Holder N. Stimation of GOT activity in serum. Ann. Biol. Clin. 1986, 44:497-501.
6. Bergmeyer U.H., Holder N. Determination of GPT activity in blood. Ann. Biol. Clin. 1986, 44:481-489.
7. Bhandarkar M.R., Khan A. Antihepatotoxic effect of Nymphaea stellata willd., against carbon tetrachloride-induced hepatic damage in albino rats. J. Ethnopharmacol. 2004, 91:61-64.
8. Cheeseman K.H., Albano E.F., Thomasi A., Slater T. Biochemical studies on the metabolic activation of halogenated alkanes. Environ. Health Perspect. 1985, 64:85-91.
9. Diaz G., Melis M., Batetta M., Angius F., Falchi A.M. Hydrophobic characterization of intracellular lipids in situ by Nile Red red/yellow emission ratio. Micron 2008, 39:819-824.
10. Dorn C., Bataille F., Gaebele E., Hailmann J., Hellerbrand C. Xanthohumol feeding does not impair organ function and homeostasis in mice. Food Chem. Toxicol. 2010, 48:1890-1897.
11. Ellman G.L. Tissue sulfhydryl groups. Arch. Biochem. Biophys. 1959, 82:70-77.
12. Ferk F., Huber W.W., Filipic M., Bichler J., Haslinger E., Misik M., Nersesyan A., Grasl-Kraupp B., Zegura B., Knasmüller S. Xanthohumol, a prenylated flavonoid contained in beer, prevents the induction of preneoplastic lesions and DNA damage in liver an colon induced by the heterocyclic aromatic amine amino-3-methyl-imidazol[4,5-f] quinoline (IQ). Mutat. Res. - Fund. Mol. M 2010, 691:17-22.
13. Galati G., Sabzevari O., Wilson J.X., O'Brien P.J. Prooxidant activity and cellular effects of the phenoxyl radicals of dietary flavonoids and other polyphenolics. Toxicol. 2002, 177:91-104.
14. Gerhauser C., Alt A., Heiss E., Gamal-Eldeen A., Klimo K., Knauft J., Neumann I., Scherft H.R., Frank N., Bartsh H., Becker H. Cancer chemopreventive activity of Xanthohumol, a natural product derived from hop. Mol. Cancer Ther. 2002, 1:959-969.
15. Habig W.H., Pabst M.J., Jakoby W.B. Glutathione S-transferases: The first enzymatic step in mercapturic acid formation. J. Biol. Chem. 1974, 249:7130-7139.
16. 4-induced hepatic damage in rats. Food Chem. Toxicol. 2006, 44:1424-1431.
17. Kornberg A. Lactic dehydrogenase of muscle. Methods in Enzymology 1955, vol. 1:441-443. Academic Press, New York.
18. Lee I.S., Lim J., Gal J., Kang J.C., Kim H.J., Kang B.Y., Choi H.J. Anti-inflammatory activity of xanthohumol involves heme oxygenase-1 induction via NRF2-ARE signaling in microglial BV2 cells. Neurochem. Int. 2011, 58:153-160.
19. Legette L., Ma L., Reed R.L., Miranda C.L., Christensen J.M., Rodriguez-Proteau R., Stevens J.F. Pharmacokinetics of xanthohumol and metabolites in rats after oral and intravenous administration. Mol. Nutr. Food Res. 2012, 56:466-474.
20. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the folin phenol reagent. J. Biol. Chem. 1951, 193:265-275.
21. Marklund S., Marklund G. Involvement of superoxide anion radical in autooxidation of pirogallol as convenient assay for superoxide dismutase. Eur. J. Biochem. 1974, 47:469-474.
22. McMillian M.K., Grant E.R., Zhong Z., Parker J.B., Li L., Zivin R.A., Burczynski M.E., Johnson M.D. Nile Red binding to HepG2 cells: an improved assay for in vitro studies of hepatoesteatosis. In Vitro Mol. Toxicol. 2001, 1483:177-190.
23. Mohandas J., Marshall J.J., Duggins G.G., Horvath J.S., Tiller D. Differential distribution of glutathione and glutathione related enzymes in rabbit kidney. Possible implications in analgesic neuropathy. Cancer Res. 1984, 44:5086-5091.
24. Ohkawa H., Ohishi N., Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem. 1979, 95:351-358.
25. Pick E., Keisari Y. A simple colorimetric method for the measurement of hydrogen peroxide produced by cells in culture. J. Immunol. Method. 1980, 38:161-170.
26. Planagun A., Claria J., Miquel R., Lopez-Parra M., Titos E., Masferrer J.L., Arroyo V., Rodes J. The selective cyclooxygenase-2 inhibitor SC-236 reduces liver fibrosis by mechanisms involving non-parenchymal cell apoptosis and PPAR gamma activation. FASEB J. 2005, 19:1120-1122.
27. Plazar I., Filipic M., Groothuis G.M. Antigenotoxic effects of Xanthohumol in rat liver slices. Toxicol. In Vitro 2008, 22:318-327.
28. Raja S., Nazer Ahmaed K.F.H., Kumar V., Mukherjee K., Bandyopadhyay A., Mukherjee P.K. Antioxidant effect of Cystisus scopiarius against carbon tetrachloride treated liver injury in rats. J. Ethnopharmacol. 2007, 109:41-47.
29. Ramachandran R., Kakar S. Histological patterns in drug induced liver disease. J. Clin. Pathol. 2009, 62:481-492.
30. Rodriguez R.J., Miranda C.L., Stevens J.F., Deinzer M.L., Buhler D.R. Influence of prenylated and non-prenylated flavonoids on the liver microsomal lipid peroxidation and oxidative injury in rats hepatocytes. Food Chem. Toxicol. 2001, 39:437-445.
31. 4-induced hepatic toxicity in rats. J. Agric. Food Chem. 2003, 51:1571-1577.
32. Stevens J.F., Page J.E. Xanthohumol and related prenylflavonoids from hops and beer: To your good health. Phytochemistry 2004, 65:1317-1330.
33. Teocharis S.E., Margelo A.P., Skaltsas S.D., Spiliopoulou C.A., Koutselinis A.S. Induction of metallothionein in the liver of carbon tetrachloride intoxicated rats: An inmunohistochemical study. Toxicology 2001, 161:129-138.
34. Vanhoecke B.W., Delporte F., Van B.E., Heyerick A., Depypere H.T., Nuytick M., De K.D., Bracke M.E. A safety study of oral tangeretin and xanthohumol administration to laboratory mice. In Vivo 2005, 19:103-107.
35. Wendel A. Glutathione peroxidase. Method. Enzymol. 1981, 77:325-333.
36. Zanoli P., Zavatti M. Pharmacognostic and pharmacological profile of Humulus lupulus L. J. Ethnopharmacol. 2008, 116:383-396.