Mig-6 plays a critical role in the regulation of cholesterol homeostasis and bile acid synthesis

PLoS ONE

Volumn 7, Issue 8, 2012, Pages

  Ku, Bon Jeong ^a,b   Kim, Tae Hoon ^c   Lee, Jae Hee ^c   Buras, Eric D ^a   White, Lisa D ^a   Stevens, Robert D ^d   Ilkayeva, Olga R ^d   Bain, James R ^d   Newgard, Christopher B ^d   DeMayo, Francesco J ^a   Jeong, Jae Wook ^c  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b Chungnam National University   (South Korea)

^c MICHIGAN STATE UNIVERSITY   (United States)

^d DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; BILE ACID; CRE RECOMBINASE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE ACID SYNTHESIS; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL LIVER LEVEL; CHOLESTEROL METABOLISM; CONTROLLED STUDY; EARLY RESPONSE GENE; FATTY LIVER; FECES LEVEL; GENE EXPRESSION REGULATION; GENE FUNCTION; HEPATOMEGALY; LIPOGENESIS; LIVER METABOLISM; METABOLIC REGULATION; MITOGEN INDUCIBLE GENE 6; MOLECULAR PATHOLOGY; MOUSE; NONHUMAN; TISSUE SPECIFICITY;

ANIMALS; AZO COMPOUNDS; BILE ACIDS AND SALTS; BLOTTING, WESTERN; CARDIOVASCULAR DISEASES; CHOLESTEROL; FECES; GENE EXPRESSION REGULATION; HOMEOSTASIS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIVER; MICE; MICROARRAY ANALYSIS; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 84865081168     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0042915     Document Type: Article

References (52)

1. Yusuf S, Hawken S, Ounpuu S, Dans T, Avezum A, et al. (2004) Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study. Lancet 364: 937-952.
2. Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA 285: 2486-2497.
3. Stamler J, Daviglus ML, Garside DB, Dyer AR, Greenland P, et al. (2000) Relationship of baseline serum cholesterol levels in 3 large cohorts of younger men to long-term coronary, cardiovascular, and all-cause mortality and to longevity. JAMA 284: 311-318.
4. Nabel EG, (2003) Cardiovascular disease. N Engl J Med 349: 60-72.
5. Charlton-Menys V, Durrington PN, (2008) Human cholesterol metabolism and therapeutic molecules. Exp Physiol 93: 27-42.
6. Lefebvre P, Cariou B, Lien F, Kuipers F, Staels B, (2009) Role of bile acids and bile acid receptors in metabolic regulation. Physiol Rev 89: 147-191.
7. Hofmann AF, (1999) The continuing importance of bile acids in liver and intestinal disease. Arch Intern Med 159: 2647-2658.
8. Jeong JW, Lee KY, Kwak I, White LD, Hilsenbeck SG, et al. (2005) Identification of murine uterine genes regulated in a ligand-dependent manner by the progesterone receptor. Endocrinology 146: 3490-3505.
9. Jeong JW, Lee HS, Lee KY, White LD, Broaddus RR, et al. (2009) Mig-6 modulates uterine steroid hormone responsiveness and exhibits altered expression in endometrial disease. Proc Natl Acad Sci U S A 106: 8677-8682.
10. Makkinje A, Quinn DA, Chen A, Cadilla CL, Force T, et al. (2000) Gene 33/Mig-6, a transcriptionally inducible adapter protein that binds GTP-Cdc42 and activates SAPK/JNK. A potential marker transcript for chronic pathologic conditions, such as diabetic nephropathy. Possible role in the response to persistent stress. J Biol Chem 275: 17838-17847.
11. Saarikoski ST, Rivera SP, Hankinson O, (2002) Mitogen-inducible gene 6 (MIG-6), adipophilin and tuftelin are inducible by hypoxia. FEBS Lett 530: 186-190.
12. van Laar T, Schouten T, van der Eb AJ, Terleth C, (2001) Induction of the SAPK activator MIG-6 by the alkylating agent methyl methanesulfonate. Mol Carcinog 31: 63-67.
13. Wick M, Burger C, Funk M, Muller R, (1995) Identification of a novel mitogen-inducible gene (mig-6): regulation during G1 progression and differentiation. Exp Cell Res 219: 527-535.
14. Burbelo PD, Drechsel D, Hall A, (1995) A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases. J Biol Chem 270: 29071-29074.
15. Pirone DM, Carter DE, Burbelo PD, (2001) Evolutionary expansion of CRIB-containing Cdc42 effector proteins. Trends Genet 17: 370-373.
16. Amatschek S, Koenig U, Auer H, Steinlein P, Pacher M, et al. (2004) Tissue-wide expression profiling using cDNA subtraction and microarrays to identify tumor-specific genes. Cancer Res 64: 844-856.
17. Anastasi S, Sala G, Huiping C, Caprini E, Russo G, et al. (2005) Loss of RALT/MIG-6 expression in ERBB2-amplified breast carcinomas enhances ErbB-2 oncogenic potency and favors resistance to Herceptin. Oncogene 24: 4540-4548.
18. Ferby I, Reschke M, Kudlacek O, Knyazev P, Pante G, et al. (2006) Mig6 is a negative regulator of EGF receptor-mediated skin morphogenesis and tumor formation. Nat Med 12: 568-573.
19. Jin N, Gilbert JL, Broaddus RR, Demayo FJ, Jeong JW, (2007) Generation of a Mig-6 conditional null allele. Genesis 45: 716-721.
20. Tseng RC, Chang JW, Hsien FJ, Chang YH, Hsiao CF, et al. (2005) Genomewide loss of heterozygosity and its clinical associations in non small cell lung cancer. Int J Cancer 117: 241-247.
21. Zhang YW, Staal B, Su Y, Swiatek P, Zhao P, et al. (2007) Evidence that MIG-6 is a tumor-suppressor gene. Oncogene 26: 269-276.
22. Kim TH, Franco HL, Jung SY, Qin J, Broaddus RR, et al. (2010) The synergistic effect of Mig-6 and Pten ablation on endometrial cancer development and progression. Oncogene 29: 3770-3780.
23. Kim TH, Wang J, Lee KY, Franco HL, Broaddus RR, et al. (2010) The Synergistic Effect of Conditional Pten Loss and Oncogenic K-ras Mutation on Endometrial Cancer Development Occurs via Decreased Progesterone Receptor Action. J Oncol 2010: 139087.
24. Mahgoub MA, Abd-Elfattah AS, (1998) Diabetes mellitus and cardiac function. Mol Cell Biochem 180: 59-64.
25. Kent TA, Messina JL, Weinstock RS, Stein JP, (1994) Synergistic induction of gene 33 expression by retinoic acid and insulin. Endocrinology 134: 2237-2244.
26. Cadilla C, Isham KR, Lee KL, Ch'ang LY, Johnson AC, et al. (1992) Insulin increases transcription of rat gene 33 through cis-acting elements in 5′-flanking DNA. Gene 118: 223-229.
27. Mohn KL, Laz TM, Melby AE, Taub R, (1990) Immediate-early gene expression differs between regenerating liver, insulin-stimulated H-35 cells, and mitogen-stimulated Balb/c 3T3 cells. Liver-specific induction patterns of gene 33, phosphoenolpyruvate carboxykinase, and the jun, fos, and egr families. J Biol Chem 265: 21914-21921.
28. Keeton AB, Xu J, Franklin JL, Messina JL, (2004) Regulation of Gene33 expression by insulin requires MEK-ERK activation. Biochim Biophys Acta 1679: 248-255.
29. Li C, Wong WH, (2001) Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection. Proc Natl Acad Sci U S A 98: 31-36.
30. An J, Muoio DM, Shiota M, Fujimoto Y, Cline GW, et al. (2004) Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance. Nat Med 10: 268-274.
31. Millington DS, Kodo N, Norwood DL, Roe CR, (1990) Tandem mass spectrometry: a new method for acylcarnitine profiling with potential for neonatal screening for inborn errors of metabolism. J Inherit Metab Dis 13: 321-324.
32. Wu JY, Kao HJ, Li SC, Stevens R, Hillman S, et al. (2004) ENU mutagenesis identifies mice with mitochondrial branched-chain aminotransferase deficiency resembling human maple syrup urine disease. J Clin Invest 113: 434-440.
33. Chace DH, Hillman SL, Millington DS, Kahler SG, Roe CR, et al. (1995) Rapid diagnosis of maple syrup urine disease in blood spots from newborns by tandem mass spectrometry. Clin Chem 41: 62-68.
34. Zhang YW, Su Y, Lanning N, Swiatek PJ, Bronson RT, et al. (2005) Targeted disruption of Mig-6 in the mouse genome leads to early onset degenerative joint disease. Proc Natl Acad Sci U S A 102: 11740-11745.
35. Zhang YW, Vande Woude GF, (2007) Mig-6, signal transduction, stress response and cancer. Cell Cycle 6: 507-513.
36. Jin N, Gilbert JL, Broaddus RR, Demayo FJ, Jeong JW, (2007) Generation of a Mig-6 conditional null allele. Genesis 45: 716-721.
37. Postic C, Shiota M, Niswender KD, Jetton TL, Chen Y, et al. (1999) Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase. J Biol Chem 274: 305-315.
38. Dennis G Jr, Sherman BT, Hosack DA, Yang J, Gao W, et al. (2003) DAVID: Database for Annotation, Visualization, and Integrated Discovery. Genome Biol 4: P3.
39. Huang da W, Sherman BT, Lempicki RA, (2009) Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 4: 44-57.
40. Durrington P, (2003) Dyslipidaemia. Lancet 362: 717-731.
41. Bradbury MW, (2006) Lipid metabolism and liver inflammation. I. Hepatic fatty acid uptake: possible role in steatosis. Am J Physiol Gastrointest Liver Physiol 290: G194-198.
42. Bouche C, Serdy S, Kahn CR, Goldfine AB, (2004) The cellular fate of glucose and its relevance in type 2 diabetes. Endocr Rev 25: 807-830.
43. Chiang JY, (2002) Bile acid regulation of gene expression: roles of nuclear hormone receptors. Endocr Rev 23: 443-463.
44. Ikonen E, (2006) Mechanisms for cellular cholesterol transport: defects and human disease. Physiol Rev 86: 1237-1261.
45. Adams SH, Hoppel CL, Lok KH, Zhao L, Wong SW, et al. (2009) Plasma acylcarnitine profiles suggest incomplete long-chain fatty acid beta-oxidation and altered tricarboxylic acid cycle activity in type 2 diabetic African-American women. J Nutr 139: 1073-1081.
46. Fuchs M, (2003) Bile acid regulation of hepatic physiology: III. Regulation of bile acid synthesis: past progress and future challenges. Am J Physiol Gastrointest Liver Physiol 284: G551-557.
47. Packard CJ, Shepherd J, (1982) The hepatobiliary axis and lipoprotein metabolism: effects of bile acid sequestrants and ileal bypass surgery. J Lipid Res 23: 1081-1098.
48. Erickson SK, Lear SR, Deane S, Dubrac S, Huling SL, et al. (2003) Hypercholesterolemia and changes in lipid and bile acid metabolism in male and female cyp7A1-deficient mice. J Lipid Res 44: 1001-1009.
49. Pullinger CR, Eng C, Salen G, Shefer S, Batta AK, et al. (2002) Human cholesterol 7alpha-hydroxylase (CYP7A1) deficiency has a hypercholesterolemic phenotype. J Clin Invest 110: 109-117.
50. Goodwin B, Jones SA, Price RR, Watson MA, McKee DD, et al. (2000) A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis. Mol Cell 6: 517-526.
51. Chiang JY, (2009) Bile acids: regulation of synthesis. J Lipid Res 50: 1955-1966.
52. Li T, Owsley E, Matozel M, Hsu P, Novak CM, et al. Transgenic expression of cholesterol 7alpha-hydroxylase in the liver prevents high-fat diet-induced obesity and insulin resistance in mice. Hepatology 52: 678-690.