-
1
-
-
79651470475
-
Docking, synthesis, and in vitro evaluation of antimitotic estrone analogues
-
10.1111/j.1747-0285.2010.01064.x, 21244635
-
Stander A, Joubert F, Joubert A. Docking, synthesis, and in vitro evaluation of antimitotic estrone analogues. Chem Biol Drug Des 2011, 77:173-181. 10.1111/j.1747-0285.2010.01064.x, 21244635.
-
(2011)
Chem Biol Drug Des
, vol.77
, pp. 173-181
-
-
Stander, A.1
Joubert, F.2
Joubert, A.3
-
2
-
-
0028220858
-
Schweigerer: The endogenous oestrogen metabolite 2-methoxyestradiol inhibits angiogenesis and suppresses tumor growth
-
10.1038/368237a0, 7511798
-
Fotsis T, Zhang Y, Pepper MS, Aldercreutz H, Montesano R, Nawroth PP. Schweigerer: The endogenous oestrogen metabolite 2-methoxyestradiol inhibits angiogenesis and suppresses tumor growth. Nature 1994, 368:237-239. 10.1038/368237a0, 7511798.
-
(1994)
Nature
, vol.368
, pp. 237-239
-
-
Fotsis, T.1
Zhang, Y.2
Pepper, M.S.3
Aldercreutz, H.4
Montesano, R.5
Nawroth, P.P.6
-
3
-
-
79951998753
-
ELR5010444, a novel microtubule disruptor with multiple mechanisms of action
-
Risinger AL, Westbrook CD, Encinas M, Mülbaier M, Schultes CM, Wawro S, Lewis JD, Janssen B, Giles FJ, Moolberry SL. ELR5010444, a novel microtubule disruptor with multiple mechanisms of action. Pharmacol Exp Ther 2011, 6:652-660.
-
(2011)
Pharmacol Exp Ther
, vol.6
, pp. 652-660
-
-
Risinger, A.L.1
Westbrook, C.D.2
Encinas, M.3
Mülbaier, M.4
Schultes, C.M.5
Wawro, S.6
Lewis, J.D.7
Janssen, B.8
Giles, F.J.9
Moolberry, S.L.10
-
4
-
-
34247604099
-
In vivo inhibition of angiogenesis by sulphamoylated derivatives of 2-methoxyestradiol
-
2360171, 17426705
-
Chander SK, Foster PA, Leese MP, Newman SP, Potter BVL, Purohit A, Reed MJ. In vivo inhibition of angiogenesis by sulphamoylated derivatives of 2-methoxyestradiol. Br J Cancer 2007, 96:1368-1376. 2360171, 17426705.
-
(2007)
Br J Cancer
, vol.96
, pp. 1368-1376
-
-
Chander, S.K.1
Foster, P.A.2
Leese, M.P.3
Newman, S.P.4
Potter, B.V.L.5
Purohit, A.6
Reed, M.J.7
-
5
-
-
85047688876
-
2-Methoxyestradiol-bis-sulfamate induces apoptosis and autophagy in a tumorigenic breast epithelial cell line
-
10.1007/s11010-011-0905-3, 21656128
-
Visagie MH, Joubert AM. 2-Methoxyestradiol-bis-sulfamate induces apoptosis and autophagy in a tumorigenic breast epithelial cell line. Mol Cell Biochem 2011, 357:343-352. 10.1007/s11010-011-0905-3, 21656128.
-
(2011)
Mol Cell Biochem
, vol.357
, pp. 343-352
-
-
Visagie, M.H.1
Joubert, A.M.2
-
6
-
-
78649717886
-
The in vitro effects of 2-Methoxyestradiol-bis-sulphamate on cell numbers, membrane integrity and cell morphology, and the possible induction of apoptosis and autophagy in a non-tumorigenic breast epithelial cell line
-
10.2478/s11658-010-0030-4, 20697831
-
Visagie MH, Joubert AM. The in vitro effects of 2-Methoxyestradiol-bis-sulphamate on cell numbers, membrane integrity and cell morphology, and the possible induction of apoptosis and autophagy in a non-tumorigenic breast epithelial cell line. Cell Mol Biol Lett 2010, 15:564-581. 10.2478/s11658-010-0030-4, 20697831.
-
(2010)
Cell Mol Biol Lett
, vol.15
, pp. 564-581
-
-
Visagie, M.H.1
Joubert, A.M.2
-
7
-
-
1642319678
-
Pharmacokinetics and efficacy of 2-methoxyoestradiol and 2-methoxyoestradiol-bis-sulphamate in vivo in rodents
-
10.1038/sj.bjc.6601591, 2410173, 14970876
-
Ireson CR, Chander SK, Purohit A, Perera S, Newman SP, Parish D, Leese MP, Smith AC, Potter BVL, Reed MJ. Pharmacokinetics and efficacy of 2-methoxyoestradiol and 2-methoxyoestradiol-bis-sulphamate in vivo in rodents. Br J Cancer 2004, 90:932-937. 10.1038/sj.bjc.6601591, 2410173, 14970876.
-
(2004)
Br J Cancer
, vol.90
, pp. 932-937
-
-
Ireson, C.R.1
Chander, S.K.2
Purohit, A.3
Perera, S.4
Newman, S.P.5
Parish, D.6
Leese, M.P.7
Smith, A.C.8
Potter, B.V.L.9
Reed, M.J.10
-
8
-
-
0037321793
-
Inhibition of MCF-7 breast cancer cell proliferation and in vivo steroid sulphatase activity by 2-methoxyestradiol-bis-sulphamate
-
10.1016/S0960-0760(03)00049-9, 12711022
-
Raobaikady B, Purohit A, Chander SK, Woo LWL, Leese MP, Potter BVL, Reed MJ. Inhibition of MCF-7 breast cancer cell proliferation and in vivo steroid sulphatase activity by 2-methoxyestradiol-bis-sulphamate. J Steroid Biochem Mol Biol 2003, 84:351-358. 10.1016/S0960-0760(03)00049-9, 12711022.
-
(2003)
J Steroid Biochem Mol Biol
, vol.84
, pp. 351-358
-
-
Raobaikady, B.1
Purohit, A.2
Chander, S.K.3
Woo, L.W.L.4
Leese, M.P.5
Potter, B.V.L.6
Reed, M.J.7
-
9
-
-
0037319954
-
Growth inhibition of multi-drug-resistant breast cancer cells by 2-methoxyoestradiol-bis-sulphamate and 2-ethyloestradiol-bis-sulphamate
-
10.1016/S0960-0760(03)00035-9, 12711013
-
Suzuki RN, Newman SP, Purohit A, Leese MP, Potter BV, Reed MJ. Growth inhibition of multi-drug-resistant breast cancer cells by 2-methoxyoestradiol-bis-sulphamate and 2-ethyloestradiol-bis-sulphamate. J Steroid Biochem Mol Biol 2003, 84:269-278. 10.1016/S0960-0760(03)00035-9, 12711013.
-
(2003)
J Steroid Biochem Mol Biol
, vol.84
, pp. 269-278
-
-
Suzuki, R.N.1
Newman, S.P.2
Purohit, A.3
Leese, M.P.4
Potter, B.V.5
Reed, M.J.6
-
10
-
-
45949110337
-
A comparison of two orally bioavailable anti-cancer angents, IRC-110160 and STX140
-
Foster PA, Stengel C, Ali T, Leese MP, Potter BV, Reed MJ, Purohit A, Newman SP. A comparison of two orally bioavailable anti-cancer angents, IRC-110160 and STX140. Anticancer Res 2008, 28:1483-1491.
-
(2008)
Anticancer Res
, vol.28
, pp. 1483-1491
-
-
Foster, P.A.1
Stengel, C.2
Ali, T.3
Leese, M.P.4
Potter, B.V.5
Reed, M.J.6
Purohit, A.7
Newman, S.P.8
-
11
-
-
24344456018
-
Inhibition of MDA-MB-231 cell cycle progression and cell proliferation by C-2-substituted oestradiol mono- and bis-3-O-sulphamates
-
10.1002/ijc.21066, 15880363
-
Raobaikady B, Reed MJ, Leese MP, Potter BVL, Purohit A. Inhibition of MDA-MB-231 cell cycle progression and cell proliferation by C-2-substituted oestradiol mono- and bis-3-O-sulphamates. Int J Cancer 2005, 117:150-159. 10.1002/ijc.21066, 15880363.
-
(2005)
Int J Cancer
, vol.117
, pp. 150-159
-
-
Raobaikady, B.1
Reed, M.J.2
Leese, M.P.3
Potter, B.V.L.4
Purohit, A.5
-
12
-
-
59649101811
-
BCRP expression does not result in resistance to STX140 in vivo, despite the increased expression of BCRP in A2780 cells in vitro after long-term STX140 exposure
-
10.1038/sj.bjc.6604873, 2658539, 19156141
-
Day JM, Foster PA, Tutill HJ, Newman SP, Ho YT, Leese MP, Potter BV, Reed MJ, Purohit A. BCRP expression does not result in resistance to STX140 in vivo, despite the increased expression of BCRP in A2780 cells in vitro after long-term STX140 exposure. Br J Cancer 2009, 100:476-486. 10.1038/sj.bjc.6604873, 2658539, 19156141.
-
(2009)
Br J Cancer
, vol.100
, pp. 476-486
-
-
Day, J.M.1
Foster, P.A.2
Tutill, H.J.3
Newman, S.P.4
Ho, Y.T.5
Leese, M.P.6
Potter, B.V.7
Reed, M.J.8
Purohit, A.9
-
13
-
-
1542510122
-
Inhibition of in vitro angiogenesis by 2-Methoxy- and 2-ethyl-estrogen sulfamates
-
10.1002/ijc.20045, 14991574
-
Newman SP, Leese MP, Purohit A, James DRC, Rennie CE, Potter BVL. Inhibition of in vitro angiogenesis by 2-Methoxy- and 2-ethyl-estrogen sulfamates. Int J Cancer 2004, 109:533-540. 10.1002/ijc.20045, 14991574.
-
(2004)
Int J Cancer
, vol.109
, pp. 533-540
-
-
Newman, S.P.1
Leese, M.P.2
Purohit, A.3
James, D.R.C.4
Rennie, C.E.5
Potter, B.V.L.6
-
14
-
-
37049031003
-
The therapeutic potential of a series of bioavailable anti-angiogenic microtubule disruptors as therapy for hormone-independent prostate and breast cancers
-
10.1038/sj.bjc.6604100, 2360283, 18026194
-
Newman SP, Foster PA, Ho YT, Day JM, Raibaikady B, Kasprzyk PG, Leese MP, Potter BV, Reed MJ, Purohit A. The therapeutic potential of a series of bioavailable anti-angiogenic microtubule disruptors as therapy for hormone-independent prostate and breast cancers. Br J Cancer 2007, 97:1673-1682. 10.1038/sj.bjc.6604100, 2360283, 18026194.
-
(2007)
Br J Cancer
, vol.97
, pp. 1673-1682
-
-
Newman, S.P.1
Foster, P.A.2
Ho, Y.T.3
Day, J.M.4
Raibaikady, B.5
Kasprzyk, P.G.6
Leese, M.P.7
Potter, B.V.8
Reed, M.J.9
Purohit, A.10
-
15
-
-
3242808959
-
Packham Gl: 2-MeOE2bisMATE induces caspase-dependent apoptosis in CAL51 breast cancer cells and overcomes resistance to TRAIL via cooperative activation of caspases
-
Wood L, Leese MP, Mouzakiti A, Purohit A, Potter BV, Reed MJ. Packham Gl: 2-MeOE2bisMATE induces caspase-dependent apoptosis in CAL51 breast cancer cells and overcomes resistance to TRAIL via cooperative activation of caspases. Apoptosis 2004, 9:323-332.
-
(2004)
Apoptosis
, vol.9
, pp. 323-332
-
-
Wood, L.1
Leese, M.P.2
Mouzakiti, A.3
Purohit, A.4
Potter, B.V.5
Reed, M.J.6
-
16
-
-
18144409797
-
The effects of 2-methoxyoestrogen sulphamates on the in vitro and in vivo proliferation of breast cancer cells
-
10.1016/j.jsbmb.2005.01.022, 15862969
-
Utsumi T, Leese MP, Chander SK, Gaukroger K, Purohit A, Newman SP, Potter BV, Reed MJ. The effects of 2-methoxyoestrogen sulphamates on the in vitro and in vivo proliferation of breast cancer cells. J Steroid Biochem Mol Biol 2005, 94:219-227. 10.1016/j.jsbmb.2005.01.022, 15862969.
-
(2005)
J Steroid Biochem Mol Biol
, vol.94
, pp. 219-227
-
-
Utsumi, T.1
Leese, M.P.2
Chander, S.K.3
Gaukroger, K.4
Purohit, A.5
Newman, S.P.6
Potter, B.V.7
Reed, M.J.8
-
17
-
-
41649119942
-
Structure-activity relationship of C-17 cyano-substituted estratriene as anticancer agents
-
10.1021/jm701319c, 18260615
-
Leese LP, Jourdan FL, Gaokroger K, Mahon MF, Newman SP, Foster PA, Stengel C, Regis-Lydi S, Di Fiore A, De Simone G, Supuran CT, Purohit A, Reed MJ, Potter BVL. Structure-activity relationship of C-17 cyano-substituted estratriene as anticancer agents. J Med Chem 2008, 51:1295-1308. 10.1021/jm701319c, 18260615.
-
(2008)
J Med Chem
, vol.51
, pp. 1295-1308
-
-
Leese, L.P.1
Jourdan, F.L.2
Gaokroger, K.3
Mahon, M.F.4
Newman, S.P.5
Foster, P.A.6
Stengel, C.7
Regis-Lydi, S.8
Di Fiore, A.9
De Simone, G.10
Supuran, C.T.11
Purohit, A.12
Reed, M.J.13
Potter, B.V.L.14
-
18
-
-
77950564911
-
Synthesis, antitubulin, and antiproliferative SAR of analogues of 2-methoxyestradiol-3-17-O, O-bis-sulfamate
-
10.1021/jm9018806, 20225862
-
Jourdan F, Leese MP, Dohle W, Hamel E, Ferrandism E, Newman SP, Purohit A, Rees MJ, Potter BVL. Synthesis, antitubulin, and antiproliferative SAR of analogues of 2-methoxyestradiol-3-17-O, O-bis-sulfamate. J Med Chem 2010, 53:2942-2951. 10.1021/jm9018806, 20225862.
-
(2010)
J Med Chem
, vol.53
, pp. 2942-2951
-
-
Jourdan, F.1
Leese, M.P.2
Dohle, W.3
Hamel, E.4
Ferrandism, E.5
Newman, S.P.6
Purohit, A.7
Rees, M.J.8
Potter, B.V.L.9
-
19
-
-
31544434859
-
The role of 17β-hydroxysteriod dehydrogenase in modulating the activity of 2-methoxyestradiol in breast cancer cells
-
10.1158/0008-5472.CAN-05-2391, 16397246
-
Newman SP, Ireson CR, Tutill HJ. The role of 17β-hydroxysteriod dehydrogenase in modulating the activity of 2-methoxyestradiol in breast cancer cells. Cancer Res 2006, 66:324-330. 10.1158/0008-5472.CAN-05-2391, 16397246.
-
(2006)
Cancer Res
, vol.66
, pp. 324-330
-
-
Newman, S.P.1
Ireson, C.R.2
Tutill, H.J.3
-
20
-
-
79952708659
-
Mitochondrialouter membrane permeabilization during apoptosis: the role of mitochondrial fission
-
10.1016/j.bbamcr.2011.01.021, 21277336
-
Landes T, Martinou JC. Mitochondrialouter membrane permeabilization during apoptosis: the role of mitochondrial fission. Biochim Biophys Acta 2011, 1813:540-545. 10.1016/j.bbamcr.2011.01.021, 21277336.
-
(2011)
Biochim Biophys Acta
, vol.1813
, pp. 540-545
-
-
Landes, T.1
Martinou, J.C.2
-
21
-
-
0034329418
-
LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing
-
10.1093/emboj/19.21.5720, 305793, 11060023
-
Kabeya Y, Mizushima N, Ueno T, Yamamoto A, Kirisako T, Noda T, Kominami E, Ohsumi Y, Yoshimori T. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. Embo J 2000, 19:5720-5728. 10.1093/emboj/19.21.5720, 305793, 11060023.
-
(2000)
Embo J
, vol.19
, pp. 5720-5728
-
-
Kabeya, Y.1
Mizushima, N.2
Ueno, T.3
Yamamoto, A.4
Kirisako, T.5
Noda, T.6
Kominami, E.7
Ohsumi, Y.8
Yoshimori, T.9
-
22
-
-
0035911162
-
Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells
-
10.1083/jcb.152.4.657, 2195787, 11266458
-
Mizushima N, Yamamoto A, Hatano M, Kobayashi Y, Kabeya Y, Suzuki K, Tokuhisa T, Ohsumi Y, Yoshimori T. Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells. J Cell Biol 2001, 152:657-667. 10.1083/jcb.152.4.657, 2195787, 11266458.
-
(2001)
J Cell Biol
, vol.152
, pp. 657-667
-
-
Mizushima, N.1
Yamamoto, A.2
Hatano, M.3
Kobayashi, Y.4
Kabeya, Y.5
Suzuki, K.6
Tokuhisa, T.7
Ohsumi, Y.8
Yoshimori, T.9
-
23
-
-
79952812631
-
Influence of estradiol analogue on cell growth, morphology and death in esophageal carcinoma cells
-
Mqoco T, Joubert A. Influence of estradiol analogue on cell growth, morphology and death in esophageal carcinoma cells. Biocell 2010, 34.
-
(2010)
Biocell
, vol.34
-
-
Mqoco, T.1
Joubert, A.2
-
24
-
-
77956863614
-
In vitro effects of 2-methoxyestradiol-bis-sulphamate on the non-tumorigenic MCF-12A cell line
-
Vorster CJJ, Joubert AM. In vitro effects of 2-methoxyestradiol-bis-sulphamate on the non-tumorigenic MCF-12A cell line. Cell Biochem Func 2010, 28:412-419.
-
(2010)
Cell Biochem Func
, vol.28
, pp. 412-419
-
-
Vorster, C.J.J.1
Joubert, A.M.2
-
25
-
-
83155178480
-
In vitro effects of 2-methoxyestradiol-bis-sulphamate on reactive oxygen species and possible apoptosis induction in a breast adenocarcinoma cell line
-
10.1186/1475-2867-11-1, 3022788, 21214935
-
Visagie MH, Joubert AM. In vitro effects of 2-methoxyestradiol-bis-sulphamate on reactive oxygen species and possible apoptosis induction in a breast adenocarcinoma cell line. Cancer Cell Int 2011, 11:1-7. 10.1186/1475-2867-11-1, 3022788, 21214935.
-
(2011)
Cancer Cell Int
, vol.11
, pp. 1-7
-
-
Visagie, M.H.1
Joubert, A.M.2
-
26
-
-
46649120102
-
Reactive oxygen species and nitric oxide regulate mitochondrial-dependent apoptosis and autophagy in evodiamine-treated human cervix carcinoma HeLa cells
-
10.1080/10715760802112791, 18484413
-
Yang J, Wu LJ, Tashino SI, Onodera S, Ikejima T. reactive oxygen species and nitric oxide regulate mitochondrial-dependent apoptosis and autophagy in evodiamine-treated human cervix carcinoma HeLa cells. Free Radic Res 2008, 42:492-504. 10.1080/10715760802112791, 18484413.
-
(2008)
Free Radic Res
, vol.42
, pp. 492-504
-
-
Yang, J.1
Wu, L.J.2
Tashino, S.I.3
Onodera, S.4
Ikejima, T.5
-
27
-
-
76049083966
-
Reactive oxygen species, cellular redox systems, and apoptosis
-
10.1016/j.freeradbiomed.2009.12.022, 2823977, 20045723
-
Circu ML, Aw TY. reactive oxygen species, cellular redox systems, and apoptosis. Free Rad Biol Med 2010, 48:749-762. 10.1016/j.freeradbiomed.2009.12.022, 2823977, 20045723.
-
(2010)
Free Rad Biol Med
, vol.48
, pp. 749-762
-
-
Circu, M.L.1
Aw, T.Y.2
-
28
-
-
84859583241
-
Generation of reactive oxygen species by grape seed extract causes irreparable DNA damage leading to G2/M arrest and apoptosis selectively in head and neck sqamous cell carcinoma cells
-
in press
-
Shrotriya S, Deep G, Gu M, Kaur M, Jain AK, Inturi S, Agarwal R, Agarwal C. generation of reactive oxygen species by grape seed extract causes irreparable DNA damage leading to G2/M arrest and apoptosis selectively in head and neck sqamous cell carcinoma cells. Carcimogenesis 2012, in press.
-
(2012)
Carcimogenesis
-
-
Shrotriya, S.1
Deep, G.2
Gu, M.3
Kaur, M.4
Jain, A.K.5
Inturi, S.6
Agarwal, R.7
Agarwal, C.8
-
29
-
-
60749108379
-
Regulation of autophagy by reactive oxygen species (ROS): implications for cancer progression and cancer
-
Azad MB, Chen Y, Gibson B. Regulation of autophagy by reactive oxygen species (ROS): implications for cancer progression and cancer. Antioxid Redox Signal 2009, 11(4):1-14.
-
(2009)
Antioxid Redox Signal
, vol.11
, Issue.4
, pp. 1-14
-
-
Azad, M.B.1
Chen, Y.2
Gibson, B.3
|