pPKCα-mediated effect on in vitro Aβ production in response to γ secretase inhibitor LY411575 in rat CTXTNA2 astrocytes

Journal of Biological Regulators and Homeostatic Agents

Volumn 26, Issue 2, 2012, Pages 245-251

  Sozio, P ^a   Rapino, M ^a   Di Valerio, V ^a   Laserra, S ^a   Pacella, S ^a   Di Stefano, A ^a   Cataldi, A ^a  

^a UNIVERSITY OF CHIETI   (Italy)

Author keywords

amyloid plaques; Alzheimer's disease; iNOS; LY411575; pPKC

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BETA TUBULIN; GAMMA SECRETASE; INDUCIBLE NITRIC OXIDE SYNTHASE; N2 [2 (3,5 DIFLUOROPHENYL) 2 HYDROXYACETYL] N1 (6,7 DIHYDRO 5 METHYL 6 OXO 5H DIBENZ[B,D]AZEPIN 7 YL)ALANINAMIDE; NEURONAL NITRIC OXIDE SYNTHASE; PROTEIN BAX; PROTEIN KINASE C ALPHA;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; ASTROCYTE; BRAIN CORTEX; CELL LINE; CELL STRAIN CTXTNA2; CELL VIABILITY; COGNITIVE DEFECT; CONTROLLED STUDY; DRUG MECHANISM; MEMORY DISORDER; NONHUMAN; PROTEIN EXPRESSION; RAT;

ALANINE; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASTROCYTES; AZEPINES; CELLS, CULTURED; PROTEIN KINASE C-ALPHA; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION;

EID: 84865030416     PISSN: 0393974X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Agostinho P, Cunha RA, Oliveira C. Neuroinflammation, oxidative stress and the pathogenesis of Alzheimer's disease. Curr Pharm Des 2010; 16:2766-78.
2. Vincent AJ, Gasperini R, Foa L. Astrocytes in Alzheimer's disease: emerging roles in calcium dysregulation and synaptic plasticity. J Alzheimers Dis 2010; 223:699-714.
3. Busciglio J, Gabuzda BH, Matsudaira P. Generation of β-amyloid in the secretory pathway in neuronal and non-neuronal cells, Proc Natl Acad Sci USA 1993; 90:2092-6. (Pubitemid 23070004)
4. Siman R, Card J, Nelson R. Expression of β amyloid precursor protein in reactive astrocytes following neuronal damage. Neuron 1989; 3:275-85.
5. Selkoe DJ. The cell biology of β amyloid precursor protein and pre-senilin in Alzheimer's disease. Trends Cell Biol 1998; 8:447-53.
6. Vassar R, Bennett BD, Babu-Khan S. β secretase cleavage of Alzheimer's amyloid precursor protein by the trans membrane aspartic protease BACE. Science 1999; 286: 735-41.
7. Elvang AB, Volbracht C, Pedersen LO. Differential effects of γ secretase and BACE1 inhibition on brain Aβ levels in vitro and in vivo. J Neurochem 2009; 110:1377-87.
8. Pepicelli O, Raiteri M, Fedele E. The NOS/sGC pathway in the rat central nervous system: a microdialysis overview. Neurochem Int 2004; 45:787-97. (Pubitemid 39108051)
9. Zara S, Di Stefano A, Nasuti C, Rapino M, Patruno A, Pesce M, Sozio P, Cerasa LS, Cataldi A. Morphological and molecular modifications in rats infused with Aβ (1-40),as a model of Alzheimer's disease, in response to a new lipophilic molecular combination codrug-1. Exp Gerontol 2010; 464:273-81.
10. Simic G, Lucassen PJ, Krsnik Z. nNOS expression in reactive astrocytes correlates with increased cell death related DNA damage in the hippocampus and entorhinal cortex in Alzheimer's disease. Exp Neurol 2010; 16:512-26.
11. Shaul PW. Regulation of endothelial nitric oxide synthase: location, location, location. Annu Rev Physiol 2002; 64:749-74. (Pubitemid 34259248)
12. Buskila Y, Amitai Y. Astrocytic iNOS-dependent enhancement of synaptic release in mouse neocortex. J Neurophysiol 2010; 103:1322-8.
13. Lüth HJ, Holzer M, Gärtner U, Staufenbiel M, Arendt T. Expression of endothelial and inducible NOS-isoforms is increased in Alzheimer's disease, in APP23 transgenic mice and after experimental brain lesion in rat: evidence for an induction by amyloid pathology. Brain Res 2001; 14:57-67.
14. Alkon DL, Sun MK, Nelson TJ. PKC signalling deficits: a mechanistic hypothesis for the origins of Alzheimer's disease, Trends Pharmacol Sci 2007; 28:51-60. (Pubitemid 46161834)
15. de Barry J, Liegeois CM, Janoshazi A. Protein Kinase C as a peripheral biomarker for Alzheimer's disease. Exp Gerontol 2010; 45:64-69.
16. Rashid G, Bernheim J, Green J. Parathyroid hormone stimulates the endothelial nitric oxide synthase through protein kinase A and C pathways. Nephrol Dial Transplant 2007; 22:2831-7. (Pubitemid 350093420)
17. Haass C, Selkoe DJ. Soluble protein oligomers in neurodegeneration: lessons form the Alzheimer's amyloid beta peptide. Nat Rev Mol Cell Biol 2007; 8:101-12. (Pubitemid 46432529)
18. Sheng B, Gong K, Miu YN. Inhibition of γ secretase activity reduces Aβ production, reduces oxidative stress, increases mitochondrial activity and leads to reduced vulnerability to apoptosis: implications for the treatment of Alzheimer's disease. Free Rad Biol Med 2009; 46:1362-75.
19. Panelos J, Massi D. Emerging role of Notch signaling in epidermal differentiation and skin cancer. Cancer Biol Ther 2009; 8:1986-93.
20. Michener MS, Holahan MA, Gilberto DB, et al. Nonhuman primate model for prediction of human Aβ effects. Targeting γ-secretase; effects of enzyme inhibition vs. modulation of cleavage specificity on CSF and plasma Aβ in conscious rhesus monkeys. Alzheimer's Dementia 2006; 2:S252.
21. Costa RM, Drew C, Silva AJ. Notch to remember. Trends Neurosci 2005; 28:429-35. (Pubitemid 40982556)
22. Oehlrich D, Berthelot DJ, Gijsen HJ. γ-Secretase Modulators as potential disease modifying anti-Alzheimer's drugs. J Med Chem 2011; 54:669-98.
23. Skovronsky DM, Moore DB, Milla ME. Protein kinase C-dependent alpha-secretase competes with beta-secretase for cleavage of amyloid-beta precursor protein in the trans-golgi network. J Biol Chem 2000; 275:2568-75. (Pubitemid 30082022)
24. Díaz-Rodríguez E, Montero JC, Esparís-Ogando A. Extracellular signal-regulated kinase phosphorylates tumor necrosis factor alpha-converting enzyme at threonine 735: a potential role in regulated shedding. Mol Biol Cell 2002; 6:2031-44.
25. Zara S, Rapino M, Sozio P, Di Stefano A, Nasuti C, Cataldi A. Ibuprofen and lipoic acid codrug 1 control Alzheimer's disease progression by down-regulating Protein Kinase C ε - mediated Metalloproteinase 2 and 9 levels in β-amyloid infused Alzheimer's disease rat model. Brain Research 2011; 1412:79-87.
26. Wu WL, Zhang L. γ secretase inhibitors for the treatment of Alzheimer's disease. Drug Dev Res 2009; 7:94-100.
27. Nelson TJ, Sun MK, Hongpaisan J. Insulin, PKC signaling pathways and synaptic remodelling during memory storage and neuronal repair. Europ J Pharmacol 2008; 58:76-87
28. Sun MK, Alkon DL Protein kinase C activators as synaptogenic and memory therapeutics. Arch Pharm 2009; 342:689-98.
29. Pascale A, Amadio M, Govoni S. The aging brain, a key target for the future : the protein kinase C involvement. Pharmacol Res 2007; 55:560-9. (Pubitemid 46962312)