Ibuprofen and lipoic acid codrug 1 control Alzheimer's disease progression by down-regulating protein kinase C ε-mediated metalloproteinase 2 and 9 levels in β-amyloid infused Alzheimer's disease rat model

Brain Research

Volumn 1412, Issue , 2011, Pages 79-87

  Zara, S ^a   Rapino, M ^b   Sozio, P ^a   Di Stefano, A ^a   Nasuti, C ^c   Cataldi, A ^a  

^a UNIVERSITY OF CHIETI   (Italy)

^b Istituto di Genetica Molecolare Del CNR   (Italy)

^c UNIVERSITY OF CAMERINO   (Italy)

Author keywords

Alzheimer's disease; Codrug 1; Ibuprofen; Lipoic acid; Metalloproteinases; PKCs

Indexed keywords

AMYLOID BETA PROTEIN[1-40]; GELATINASE A; GELATINASE B; IBUPROFEN; PROTEIN KINASE C EPSILON; THIOCTIC ACID;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CONTROLLED STUDY; DISEASE COURSE; DOWN REGULATION; MALE; NERVE CELL NECROSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; CEREBRAL CORTEX; CYCLOOXYGENASE INHIBITORS; DISEASE PROGRESSION; DOWN-REGULATION; DRUG COMBINATIONS; IBUPROFEN; MALE; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; PEPTIDE FRAGMENTS; PROTEIN KINASE C-EPSILON; RATS; RATS, WISTAR; THIOCTIC ACID;

MUS; RATTUS;

EID: 80052034783     PISSN: 00068993     EISSN: 18726240     Source Type: Journal    
DOI: 10.1016/j.brainres.2011.07.022     Document Type: Article

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