A glutathione S-transferase π-activated prodrug causes kinase activation concurrent with S-glutathionylation of proteins

Molecular Pharmacology

Volumn 69, Issue 2, 2006, Pages 501-508

  Townsend, Danyelle M ^a   Findlay, Victoria J ^b   Fazilev, Farit ^c   Ogle, Molly ^b   Fraser, Jacob ^b   Saavedra, Joseph E ^d   Ji, Xinhua ^e   Keefer, Larry K ^e   Tew, Kenneth D ^a,b  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^c FOX CHASE CANCER CENTER   (United States)

^d SAIC FREDERICK INC   (United States)

^e NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; ALPHA GLUCOSIDASE AB; BETA LACTATE DEHYDROGENASE; CHAPERONIN; DRUG METABOLITE; ELONGATION FACTOR 2; GLUCOSIDASE; GLUTATHIONE TRANSFERASE P1; GUANINE NUCLEOTIDE DISSOCIATION INHIBITOR; JS 39 93; JS 42 25; JS 43 19; LACTATE DEHYDROGENASE; MONOCLONAL ANTIBODY; MULTIDRUG RESISTANCE PROTEIN 1; NITRIC OXIDE; NUCLEOPHOSMIN; O 2 [2,4 DINITRO 5 [4 (N METHYLAMINO)BENZOYLOXY]PHENYL] 1 (N,N DIMETHYLAMINO)DIAZEN 1 IUM 1,2 DIOLATE; PHOSPHOTRANSFERASE; PRODRUG; PROTEIN; PROTEIN DISULFIDE ISOMERASE; PROTEIN TYROSINE PHOSPHATASE 1B; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; RHO FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL DEATH; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG MECHANISM; EMBRYO; ENZYME ACTIVATION; ENZYME INACTIVATION; FEMALE; HALF LIFE TIME; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IN VITRO STUDY; IN VIVO STUDY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; METABOLITE; MOUSE; NITRATION; NITROSYLATION; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN INTERACTION; STRESS; TOXICITY;

4-AMINOBENZOIC ACID; ANIMALS; AZO COMPOUNDS; CELLS, CULTURED; ENZYME ACTIVATION; GLUTATHIONE; GLUTATHIONE S-TRANSFERASE PI; HUMANS; MICE; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; NITRIC OXIDE; PRODRUGS; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN-TYROSINE-PHOSPHATASE; PROTEINS;

EID: 31044436627     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.105.018523     Document Type: Article

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