Protection against carbon tetrachloride hepatotoxicity by oleanolic acid is not mediated through metallothionein

Toxicology Letters

Volumn 95, Issue 2, 1998, Pages 77-85

  Liu, Yaping ^a   Hartley, Dylan P ^a   Liu, Jie ^a  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

Author keywords

Carbon tetrachloride; Dose response; Hepatoprotection; Hepatotoxicity; Metallothionein; MT null mice; Oleanolic acid; Time course

Indexed keywords

ALANINE AMINOTRANSFERASE; CARBON TETRACHLORIDE; CYCLINE; IDITOL DEHYDROGENASE; LIVER PROTECTIVE AGENT; METALLOTHIONEIN; OLEANOLIC ACID;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVITY; HISTOPATHOLOGY; IMMUNOCYTOCHEMISTRY; LIVER PROTECTION; LIVER TOXICITY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; CARBON TETRACHLORIDE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; LIVER; MALE; METALLOTHIONEIN; MICE; MICE, KNOCKOUT; OLEANOLIC ACID; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0032536731     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4274(98)00009-5     Document Type: Article

References (27)

1. Cagen, S.Z., Klaassen, C.D., 1979. Protection of carbon tetrachloride-induced hepatotoxicity by zinc: role of metallothionein. Toxicol. Appl. Pharmacol. 52, 107-116.
2. Calabrese, E.J., Baldwin, L.A., Mehendale, H.M., 1993. G2 subpopulation in rat liver induced into mitosis by low-level exposure to carbon tetrachloride: an adaptive response. Toxicol. Appl. Pharmacol. 121, 1-7.
3. Clarke, I.S., Lui, E.M., 1986. Interaction of metallothionein and carbon tetrachloride on the protective effect of zinc on hepatotoxicity. Can. J. Physiol. Pharmacol. 64, 1104-1110.
4. DiSilvestro, R.A., Carlson, G.P., 1992. Inflammation, an inducer of metallothionein, inhibits carbon tetrachloride-induced hepatotoxicity in rats. Toxicol. Lett. 60, 175-181.
5. Eaton, D.L., Toal, B.F., 1982. Evaluation of the Cdhemoglobin affinity assay for the rapid determination of metallothionein in biological tissues. Toxicol. Appl. Pharmacol. 66, 134-142.
6. Hooser, S.B., Rosengren, R.J., Hill, D.A., Mobley, S.A., Sipes, I.G., 1994. Vitamin A modulation of xenobiotic-induced hepatotoxicity in rodents. Environ. Health Perspect. 102 (Suppl. 9), 39-43.
7. Hunan Medical Institute, 1977. Effects of oleanolic acid on experimental liver injury and acute hepatitis in humans. Tradit. Med. 8, 32-37.
8. Kägi, J.H.R., 1993. Evolution, structure and chemical activity of class I metallothioneins: an overview. In: Suzuki, K.T., Imura, N., Kimura, M. (Eds.), Metallothionein III: Biological Roles and Medical Implications. Birkhauser Verlag, Berlin, pp. 29-56.
9. Klaassen, C.D., Cagen, S.Z., 1981. Metallothionein as a trap for reactive organic intermediates. Adv. Exp. Med. Biol. 136 Pt A, 633-646.
10. Klaassen, C.D., Liu, J., 1998. Induction of metallothionein as an adaptive mechanism affecting the magnitude and progression of toxicological injury. Environ. Health Perspect. 106 (Suppl.), 297-300.
11. Liu, Y-P., Kreppel, H., Liu, J., Choudhuri, S., Klaassen, C.D., 1993a. Oleanolic acid protects against cadmium hepatotoxicity by inducing metallothionein. J. Pharmacol. Exp. Ther. 266, 400-408.
12. Liu, J., Liu, Y-P., Madhu, C., Klaassen, C.D., 1993b. Protective effects of oleanolic acid on acetaminophen-induced hepatotoxicity in mice. J. Pharmacol. Exp. Ther. 266, 1607-1613.
13. Liu, J., Liu, Y-P., Mao, Q., Klaassen, C.D., 1994. The effects of 10 triterpenoid compounds on experimental liver injury in mice. Fundam. Appl. Toxicol. 22, 34-40.
14. Liu, J., Liu, Y-P., Klaassen, C.D., 1995a. Protective effect of oleanolic acid against chemical-induced acute necrotic liver injury in mice. Acta Pharmcol. Sin. 16, 97-102.
15. Liu, J., Liu, Y-P., Parkinson, A., Klaassen, C.D., 1995b. Effect of oleanolic acid on hepatic toxicant-activating and detoxifying systems in mice. J. Pharmacol. Exp. Ther. 275, 768-774.
16. Liu, J., Liu, Y-P., Michalska, A.E., Choo, K.H.A., Klaassen, C.D., 1996. Metallothionein plays less of a protective role in cadmium-metallothionein-induced nephrotoxicity than in cadmium chloride-induced hepatotoxicity. J. Pharmacol. Exp. Ther. 276, 1216-1223.
17. Liu, J., 1995. Pharmacology of oleanolic acid and ursolic acid. J. Ethnopharmacol. 49, 57-68.
18. Ma, X.H., Zhao, Y.C., Yin, L., Han, D.W., 1982. Studies on the effect of oleanolic acid on experimental liver injury. Acta Pharma. Sin. 17, 93-97.
19. Madhu, C., Klaassen, C.D., 1991. Protective effect of pregnenolone-16α-carbonitrile on acetaminophen-induced hepatotoxicity in hamsters. Toxicol. Appl. Pharmacol. 109, 305-313.
20. Madhu, C., Maziasz, T., Klaassen, C.D., 1992. Effect of pregnenolone-16α-carbonitrile and dexamethasone on acetaminophen-induced hepatotoxicity in mice. Toxicol. Appl. Pharmacol. 115, 191-198.
21. Masters, B.A., Kelly, E.J., Quaife, C.J., Brinster, R.L., Palmiter, R.D., 1994. Targeted disruption of metallothionein I and II genes increases sensitivity to cadmium. Proc. Natl. Acad. Sci. 91, 584-588.
22. Mehendale, H.M., Thakore, K.N., Rao, C.V., 1994. Autoprotection: stimulated tissue repair permits recovery from injury. J. Biochem. Toxicol. 9, 131-139.
23. Michalska, A.E., Choo, K.H.A., 1993. Targeting and germ-line transmission of a null mutation at the metallothionein I and II loci in mouse. Proc. Natl. Acad. Sci. 90, 8088-8092.
24. Min, K-S., Terano, Y., Onosaka, S., Tanaka, K., 1992. Induction of metallothionein synthesis by menadione or carbon tetrachloride is independent of free radical production. Toxicol. Appl. Pharmacol. 113, 74-79.
25. Raucy, J.L., Kraner, J.C., Lasker, J.M., 1993. Bioactivation of halogenated hydrocarbons by cytochrome P4502E1. Crit. Rev. Toxicol. 23, 1-20.
26. Recknagel, R.O., Glende, E.A. Jr., Dolak, J.A., Waller, R.L., 1989. Mechanisms of carbon tetrachloride toxicity. Pharmac. Ther. 43, 139-154.
27. Recknagel, R.O., Glende, E.A. Jr., Britton, R.S., 1991. Free radical damage and lipid peroxidation. In: Meeks, R.G., Harrison, S.D., Bull, R.J. (Eds.), Hepatotoxicity. CRC Press, Boston, pp. 401-436.