메뉴 건너뛰기




Volumn 287, Issue 33, 2012, Pages 27806-27812

Dopamine- and cAMP-regulated phosphoprotein of 32-kDa (DARPP-32)-dependent activation of extracellular signal-regulated kinase (ERK) and mammalian target of rapamycin complex 1 (mTORC1) signaling in experimental parkinsonism

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEX 1; EXTRACELLULAR SIGNAL-REGULATED KINASE; EXTRACELLULAR SIGNAL-REGULATED PROTEIN KINASE; HYPERPHOSPHORYLATION; MAMMALIAN TARGET; PHOSPHORYLATION SITES; PROTEIN KINASE; SIGNALING CASCADES;

EID: 84865016327     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.388413     Document Type: Article
Times cited : (68)

References (36)
  • 1
    • 0023874410 scopus 로고
    • Uneven pattern of dopamine loss in the striatum of patients with idiopathic Parkinson disease. Pathophysiologic and clinical implications
    • Kish, S. J., Shannak, K., and Hornykiewicz, O. (1988) Uneven pattern of dopamine loss in the striatum of patients with idiopathic Parkinson disease. Pathophysiologic and clinical implications. N. Engl. J. Med. 318, 876-880
    • (1988) N. Engl. J. Med. , vol.318 , pp. 876-880
    • Kish, S.J.1    Shannak, K.2    Hornykiewicz, O.3
  • 2
    • 0017342547 scopus 로고
    • Supersensitivity to apomorphine following destruction of the ascending dopamine neurons. Quantification using the rotational model
    • Marshall, J. F., and Ungerstedt, U. (1977) Supersensitivity to apomorphine following destruction of the ascending dopamine neurons. Quantification using the rotational model. Eur. J. Pharmacol. 41, 361-367
    • (1977) Eur. J. Pharmacol. , vol.41 , pp. 361-367
    • Marshall, J.F.1    Ungerstedt, U.2
  • 3
    • 0025572196 scopus 로고
    • D1 and D2 dopamine receptor-regulated gene expression of striatonigral and striatopallidal neurons
    • Gerfen, C. R., Engber, T. M., Mahan, L. C., Susel, Z., Chase, T. N., Monsma, F. J., Jr., and Sibley, D. R. (1990) D1 and D2 dopamine receptor-regulated gene expression of striatonigral and striatopallidal neurons. Science 250, 1429-1432
    • (1990) Science , vol.250 , pp. 1429-1432
    • Gerfen, C.R.1    Engber, T.M.2    Mahan, L.C.3    Susel, Z.4    Chase, T.N.5    Monsma Jr., F.J.6    Sibley, D.R.7
  • 5
    • 40749086042 scopus 로고    scopus 로고
    • Parkinson disease. Levodopa-induced dyskinesia and signal transduction
    • Santini, E., Valjent, E., and Fisone, G. (2008) Parkinson disease. Levodopa-induced dyskinesia and signal transduction. FEBS J. 275, 1392-1399
    • (2008) FEBS J. , vol.275 , pp. 1392-1399
    • Santini, E.1    Valjent, E.2    Fisone, G.3
  • 7
    • 34347357671 scopus 로고    scopus 로고
    • Critical involvement of cAMP/DARPP-32 and extracellular signal-regulated protein kinase signaling in L-DOPA-induced dyskinesia
    • Santini, E., Valjent, E., Usiello, A., Carta, M., Borgkvist, A., Girault, J. A., Hervé, D., Greengard, P., and Fisone, G. (2007) Critical involvement of cAMP/DARPP-32 and extracellular signal-regulated protein kinase signaling in L-DOPA-induced dyskinesia. J. Neurosci. 27, 6995-7005
    • (2007) J. Neurosci. , vol.27 , pp. 6995-7005
    • Santini, E.1    Valjent, E.2    Usiello, A.3    Carta, M.4    Borgkvist, A.5    Girault, J.A.6    Hervé, D.7    Greengard, P.8    Fisone, G.9
  • 8
    • 0035798093 scopus 로고    scopus 로고
    • The neurobiology of slow synaptic transmission
    • Greengard, P. (2001) The neurobiology of slow synaptic transmission. Science 294, 1024-1030
    • (2001) Science , vol.294 , pp. 1024-1030
    • Greengard, P.1
  • 10
    • 49049095114 scopus 로고    scopus 로고
    • Differences between dorsal and ventral striatum in Drd1a dopamine receptor coupling of dopamine- and cAMP-regulated phosphoprotein-32 to activation of extracellular signal-regulated kinase
    • Gerfen, C. R., Paletzki, R., and Worley, P. (2008) Differences between dorsal and ventral striatum in Drd1a dopamine receptor coupling of dopamine- and cAMP-regulated phosphoprotein-32 to activation of extracellular signal-regulated kinase. J. Neurosci. 28, 7113-7120
    • (2008) J. Neurosci. , vol.28 , pp. 7113-7120
    • Gerfen, C.R.1    Paletzki, R.2    Worley, P.3
  • 11
    • 29344434297 scopus 로고    scopus 로고
    • ERK phosphorylation and FosB expression are associated with L-DOPA-induced dyskinesia in hemiparkinsonian mice
    • Pavón, N., Martín, A. B., Mendialdua, A., and Moratalla, R. (2006) ERK phosphorylation and FosB expression are associated with L-DOPA-induced dyskinesia in hemiparkinsonian mice. Biol. Psychiatry 59, 64-74
    • (2006) Biol. Psychiatry , vol.59 , pp. 64-74
    • Pavón, N.1    Martín, A.B.2    Mendialdua, A.3    Moratalla, R.4
  • 12
    • 34047178328 scopus 로고    scopus 로고
    • Spatiotemporal pattern of striatal ERK1/2 phosphorylation in a rat model of L-DOPA-induced dyskinesia and the role of dopamine D1 receptors
    • Westin, J. E., Vercammen, L., Strome, E. M., Konradi, C., and Cenci, M. A. (2007) Spatiotemporal pattern of striatal ERK1/2 phosphorylation in a rat model of L-DOPA-induced dyskinesia and the role of dopamine D1 receptors. Biol. Psychiatry 62, 800-810
    • (2007) Biol. Psychiatry , vol.62 , pp. 800-810
    • Westin, J.E.1    Vercammen, L.2    Strome, E.M.3    Konradi, C.4    Cenci, M.A.5
  • 13
    • 70349572635 scopus 로고    scopus 로고
    • Inhibition of mTOR signaling in Parkinson disease prevents L-DOPA-induced dyskinesia
    • Santini, E., Heiman, M., Greengard, P., Valjent, E., and Fisone, G. (2009) Inhibition of mTOR signaling in Parkinson disease prevents L-DOPA-induced dyskinesia. Sci. Signal. 2, ra36
    • (2009) Sci. Signal. , vol.2
    • Santini, E.1    Heiman, M.2    Greengard, P.3    Valjent, E.4    Fisone, G.5
  • 14
    • 58149469090 scopus 로고    scopus 로고
    • Translational control of long lasting synaptic plasticity and memory
    • Costa-Mattioli, M., Sossin, W. S., Klann, E., and Sonenberg, N. (2009) Translational control of long lasting synaptic plasticity and memory. Neuron 61, 10-26
    • (2009) Neuron , vol.61 , pp. 10-26
    • Costa-Mattioli, M.1    Sossin, W.S.2    Klann, E.3    Sonenberg, N.4
  • 15
    • 1342289413 scopus 로고    scopus 로고
    • MAPK cascade signaling and synaptic plasticity
    • Thomas, G. M., and Huganir, R. L. (2004) MAPK cascade signaling and synaptic plasticity. Nat. Rev. Neurosci. 5, 173-183
    • (2004) Nat. Rev. Neurosci. , vol.5 , pp. 173-183
    • Thomas, G.M.1    Huganir, R.L.2
  • 16
    • 77957870263 scopus 로고    scopus 로고
    • Distinct changes in cAMP and extracellular signal-regulated protein kinase signalling in L-DOPA-induced dyskinesia
    • Santini, E., Sgambato-Faure, V., Li, Q., Savasta, M., Dovero, S., Fisone, G., and Bezard, E. (2010) Distinct changes in cAMP and extracellular signal-regulated protein kinase signalling in L-DOPA-induced dyskinesia. PLoS One 5, e12322
    • (2010) PLoS One , vol.5
    • Santini, E.1    Sgambato-Faure, V.2    Li, Q.3    Savasta, M.4    Dovero, S.5    Fisone, G.6    Bezard, E.7
  • 17
    • 43749109162 scopus 로고    scopus 로고
    • The 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor lovastatin reduces severity of L-DOPA-induced abnormal involuntary movements in experimental Parkinson disease
    • Schuster, S., Nadjar, A., Guo, J. T., Li, Q., Ittrich, C., Hengerer, B., and Bezard, E. (2008) The 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor lovastatin reduces severity of L-DOPA-induced abnormal involuntary movements in experimental Parkinson disease. J. Neurosci. 28, 4311-4316
    • (2008) J. Neurosci. , vol.28 , pp. 4311-4316
    • Schuster, S.1    Nadjar, A.2    Guo, J.T.3    Li, Q.4    Ittrich, C.5    Hengerer, B.6    Bezard, E.7
  • 18
    • 0034548879 scopus 로고    scopus 로고
    • Involvement of the extracellular signal-regulated kinase cascade for cocaine-rewarding properties
    • Valjent, E., Corvol, J. C., Pages, C., Besson, M. J., Maldonado, R., and Caboche, J. (2000) Involvement of the extracellular signal-regulated kinase cascade for cocaine-rewarding properties. J. Neurosci. 20, 8701-8709
    • (2000) J. Neurosci. , vol.20 , pp. 8701-8709
    • Valjent, E.1    Corvol, J.C.2    Pages, C.3    Besson, M.J.4    Maldonado, R.5    Caboche, J.6
  • 19
    • 48149108931 scopus 로고    scopus 로고
    • Cell type-specific regulation of DARPP-32 phosphorylation by psychostimulant and antipsychotic drugs
    • Bateup, H. S., Svenningsson, P., Kuroiwa, M., Gong, S., Nishi, A., Heintz, N., and Greengard, P. (2008) Cell type-specific regulation of DARPP-32 phosphorylation by psychostimulant and antipsychotic drugs. Nat. Neurosci. 11, 932-939
    • (2008) Nat. Neurosci. , vol.11 , pp. 932-939
    • Bateup, H.S.1    Svenningsson, P.2    Kuroiwa, M.3    Gong, S.4    Nishi, A.5    Heintz, N.6    Greengard, P.7
  • 22
    • 2342459797 scopus 로고    scopus 로고
    • A model of L-DOPA-induced dyskinesia in 6-hydroxydopamine lesioned mice. Relation to motor and cellular parameters of nigrostriatal function
    • Lundblad, M., Picconi, B., Lindgren, H., and Cenci, M. A. (2004) A model of L-DOPA-induced dyskinesia in 6-hydroxydopamine lesioned mice. Relation to motor and cellular parameters of nigrostriatal function. Neurobiol. Dis. 16, 110-123
    • (2004) Neurobiol. Dis. , vol.16 , pp. 110-123
    • Lundblad, M.1    Picconi, B.2    Lindgren, H.3    Cenci, M.A.4
  • 23
    • 0009482260 scopus 로고
    • Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets. Procedure and some applications
    • Towbin, H., Staehelin, T., and Gordon, J. (1979) Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets. Procedure and some applications. Proc. Natl. Acad. Sci. U.S.A. 76, 4350-4354
    • (1979) Proc. Natl. Acad. Sci. U.S.A. , vol.76 , pp. 4350-4354
    • Towbin, H.1    Staehelin, T.2    Gordon, J.3
  • 24
    • 0026755762 scopus 로고
    • Phosphorylation of DARPP-32 and protein phosphatase inhibitor-1 in rat choroid plexus. Regulation by factors other than dopamine
    • Snyder, G. L., Girault, J. A., Chen, J. Y., Czernik, A. J., Kebabian, J. W., Nathanson, J. A., and Greengard, P. (1992) Phosphorylation of DARPP-32 and protein phosphatase inhibitor-1 in rat choroid plexus. Regulation by factors other than dopamine. J. Neurosci. 12, 3071-3083
    • (1992) J. Neurosci. , vol.12 , pp. 3071-3083
    • Snyder, G.L.1    Girault, J.A.2    Chen, J.Y.3    Czernik, A.J.4    Kebabian, J.W.5    Nathanson, J.A.6    Greengard, P.7
  • 25
    • 0022450222 scopus 로고
    • DARPP-32, a dopamine- and adenosine 3′:5′-monophosphate- regulated phosphoprotein. Regional, tissue, and phylogenetic distribution
    • Hemmings, H. C., Jr., and Greengard, P. (1986) DARPP-32, a dopamine- and adenosine 3′:5′-monophosphate-regulated phosphoprotein. Regional, tissue, and phylogenetic distribution. J. Neurosci. 6, 1469-1481
    • (1986) J. Neurosci. , vol.6 , pp. 1469-1481
    • Hemmings Jr., H.C.1    Greengard, P.2
  • 26
    • 68949172388 scopus 로고    scopus 로고
    • Genetic inactivation of dopamine D1 but not D2 receptors inhibits L-DOPA-induced dyskinesia and histone activation
    • Darmopil, S., Martín, A. B., De Diego, I. R., Ares, S., and Moratalla, R. (2009) Genetic inactivation of dopamine D1 but not D2 receptors inhibits L-DOPA-induced dyskinesia and histone activation. Biol. Psychiatry 66, 603-613
    • (2009) Biol. Psychiatry , vol.66 , pp. 603-613
    • Darmopil, S.1    Martín, A.B.2    De Diego, I.R.3    Ares, S.4    Moratalla, R.5
  • 27
    • 58149333252 scopus 로고    scopus 로고
    • L-DOPA activates ERK signaling and phosphorylates histone H3 in the striatonigral medium spiny neurons of hemiparkinsonian mice
    • Santini, E., Alcacer, C., Cacciatore, S., Heiman, M., Hervé, D., Greengard, P., Girault, J. A., Valjent, E., and Fisone, G. (2009) L-DOPA activates ERK signaling and phosphorylates histone H3 in the striatonigral medium spiny neurons of hemiparkinsonian mice. J. Neurochem. 108, 621-633
    • (2009) J. Neurochem. , vol.108 , pp. 621-633
    • Santini, E.1    Alcacer, C.2    Cacciatore, S.3    Heiman, M.4    Hervé, D.5    Greengard, P.6    Girault, J.A.7    Valjent, E.8    Fisone, G.9
  • 28
    • 0037096360 scopus 로고    scopus 로고
    • D1 dopamine receptor supersensitivity in the dopamine-depleted striatum results from a switch in the regulation of ERK1/2/MAP kinase
    • Gerfen, C. R., Miyachi, S., Paletzki, R., and Brown, P. (2002) D1 dopamine receptor supersensitivity in the dopamine-depleted striatum results from a switch in the regulation of ERK1/2/MAP kinase. J. Neurosci. 22, 5042-5054
    • (2002) J. Neurosci. , vol.22 , pp. 5042-5054
    • Gerfen, C.R.1    Miyachi, S.2    Paletzki, R.3    Brown, P.4
  • 30
    • 33745150462 scopus 로고    scopus 로고
    • Ribosomal protein S6 phosphorylation: From protein synthesis to cell size
    • Ruvinsky, I., and Meyuhas, O. (2006) Ribosomal protein S6 phosphorylation: from protein synthesis to cell size. Trends Biochem. Sci. 31, 342-348
    • (2006) Trends Biochem. Sci. , vol.31 , pp. 342-348
    • Ruvinsky, I.1    Meyuhas, O.2
  • 32
    • 0021162349 scopus 로고
    • DARPP-32, a dopamine-regulated neuronal phosphoprotein, is a potent inhibitor of protein phosphatase-1
    • Hemmings, H. C., Jr., Greengard, P., Tung, H. Y., and Cohen, P. (1984) DARPP-32, a dopamine-regulated neuronal phosphoprotein, is a potent inhibitor of protein phosphatase-1. Nature 310, 503-505
    • (1984) Nature , vol.310 , pp. 503-505
    • Hemmings Jr., H.C.1    Greengard, P.2    Tung, H.Y.3    Cohen, P.4
  • 33
    • 77649179779 scopus 로고    scopus 로고
    • Striatal inhibition of PKA prevents levodopa-induced behavioral and molecular changes in the hemiparkinsonian rat
    • Lebel, M., Chagniel, L., Bureau, G., and Cyr, M. (2010) Striatal inhibition of PKA prevents levodopa-induced behavioral and molecular changes in the hemiparkinsonian rat. Neurobiol. Dis. 38, 59-67
    • (2010) Neurobiol. Dis. , vol.38 , pp. 59-67
    • Lebel, M.1    Chagniel, L.2    Bureau, G.3    Cyr, M.4
  • 34
    • 84860158569 scopus 로고    scopus 로고
    • Gα(olf) mutation allows parsing the role of cAMP-dependent and extracellular signal-regulated kinase-dependent signaling in L-3,4-dihy-droxyphenylalanine-induced dyskinesia
    • Alcacer, C., Santini, E., Valjent, E., Gaven, F., Girault, J. A., and Hervé, D. (2012) Gα(olf) mutation allows parsing the role of cAMP-dependent and extracellular signal-regulated kinase-dependent signaling in L-3,4-dihy-droxyphenylalanine-induced dyskinesia. J. Neurosci. 32, 5900-5910
    • (2012) J. Neurosci. , vol.32 , pp. 5900-5910
    • Alcacer, C.1    Santini, E.2    Valjent, E.3    Gaven, F.4    Girault, J.A.5    Hervé, D.6
  • 35
    • 17444431201 scopus 로고    scopus 로고
    • Phosphorylation and functional inactivation of TSC2 by ERK implications for tuberous sclerosis and cancer pathogenesis
    • Ma, L., Chen, Z., Erdjument-Bromage, H., Tempst, P., and Pandolfi, P. P. (2005) Phosphorylation and functional inactivation of TSC2 by ERK implications for tuberous sclerosis and cancer pathogenesis. Cell 121, 179-193
    • (2005) Cell , vol.121 , pp. 179-193
    • Ma, L.1    Chen, Z.2    Erdjument-Bromage, H.3    Tempst, P.4    Pandolfi, P.P.5
  • 36
    • 4544384577 scopus 로고    scopus 로고
    • Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase
    • Roux, P. P., Ballif, B. A., Anjum, R., Gygi, S. P., and Blenis, J. (2004) Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase. Proc. Natl. Acad. Sci. U.S.A. 101, 13489-13494
    • (2004) Proc. Natl. Acad. Sci. U.S.A. , vol.101 , pp. 13489-13494
    • Roux, P.P.1    Ballif, B.A.2    Anjum, R.3    Gygi, S.P.4    Blenis, J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.