L-DOPA activates ERK signaling and phosphorylates histone H3 in the striatonigral medium spiny neurons of hemiparkinsonian mice

Journal of Neurochemistry

Volumn 108, Issue 3, 2009, Pages 621-633

  Santini, Emanuela ^a   Alcacer, Cristina ^b,c,d   Cacciatore, Silvia ^a   Heiman, Myriam ^e   Hervé, Denis ^b,c,d   Greengard, Paul ^e   Girault, Jean Antoine ^b,c,d   Valjent, Emmanuel ^b,c,d   Fisone, Gilberto ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b INSERM   (France)

^c SORBONNE UNIVERSITÉ   (France)

^d INSTITUT DU FER À MOULIN   (France)

^e ROCKEFELLER UNIVERSITY   (United States)

Author keywords

Bacterial artificial chromosome; L DOPA induced dyskinesia; Mitogen and stress activated kinase 1; Parkinson's disease; Striatum; Transgenic mice

Indexed keywords

DOPAMINE 1 RECEPTOR; DOPAMINE 2 RECEPTOR; ENHANCED GREEN FLUORESCENT PROTEIN; HISTONE H3; LEVODOPA; MITOGEN ACTIVATED PROTEIN KINASE 1; OXIDOPAMINE; STRESS ACTIVATED PROTEIN KINASE 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; DYSKINESIA; ENZYME PHOSPHORYLATION; IMMUNOCYTOCHEMISTRY; IMMUNOFLUORESCENCE; MOUSE; NIGRONEOSTRIATAL SYSTEM; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE;

ANIMALS; ANTIPARKINSON AGENTS; BLOTTING, WESTERN; DYSKINESIAS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FLUORESCENT ANTIBODY TECHNIQUE; HISTONES; LEVODOPA; MALE; MICE; MICE, INBRED C57BL; NEOSTRIATUM; NEURONS; OXIDOPAMINE; PARKINSON DISEASE, SECONDARY; PHOSPHORYLATION; RECEPTORS, DOPAMINE D1; RECEPTORS, DOPAMINE D2; RIBOSOMAL PROTEIN S6 KINASES, 90-KDA; SIGNAL TRANSDUCTION; SUBSTANTIA NIGRA; SYMPATHOLYTICS;

BACTERIA (MICROORGANISMS); MUS; MUS MUSCULUS;

EID: 58149333252     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2008.05831.x     Document Type: Article

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