Dried blood spot analysis of donepezil in support of a GLP 3-month dose-range finding study in rats

International Journal of Toxicology

Volumn 31, Issue 4, 2012, Pages 337-347

  Meier Davis, Susan R ^a   Meng, Min ^b   Yuan, Weiwei ^b   Diehl, Lisa ^c   Arjmand, Fatima M ^a   Lucke, Rebecca M ^c   Huang, Betsy ^a   Wen, Jianye ^a   Shudo, Jutaro ^a   Nagata, Tetsuto ^a  

^a NEC Corporation of America   (United States)

^b Northwest Toxicology Inc   (United States)

^c CHARLES RIVER LABORATORIES   (United States)

Author keywords

donepezil; dose range finding; dried blood spot; GLP; topical

Indexed keywords

DONEPEZIL;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DRIED BLOOD SPOT TESTING; DRUG BLOOD LEVEL; DRUG CARCINOGENICITY; DRUG DETERMINATION; DRUG HALF LIFE; FEMALE; GOOD LABORATORY PRACTICE; LIMIT OF QUANTITATION; LIQUID CHROMATOGRAPHY; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; RAT; TANDEM MASS SPECTROMETRY; TIME TO MAXIMUM PLASMA CONCENTRATION;

ADMINISTRATION, ORAL; ADMINISTRATION, TOPICAL; ANIMALS; CHOLINESTERASE INHIBITORS; CHROMATOGRAPHY, LIQUID; DOSE-RESPONSE RELATIONSHIP, DRUG; DRIED BLOOD SPOT TESTING; FEMALE; INDANS; LABORATORIES; MALE; PIPERIDINES; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; TANDEM MASS SPECTROMETRY; TOXICITY TESTS;

EID: 84865014579     PISSN: 10915818     EISSN: 1092874X     Source Type: Journal    
DOI: 10.1177/1091581812447957     Document Type: Article

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