In vitro and in vivo evaluation of donepezil-sustained release microparticles for the treatment of Alzheimer's disease

Biomaterials

Volumn 28, Issue 10, 2007, Pages 1882-1888

  Zhang, Pengcheng ^a   Chen, Lingli ^a   Gu, Wangwen ^a   Xu, Zhenghong ^a   Gao, Yu ^a   Li, Yaping ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Acetylcholinesterase inhibitor; Donepezil; Microparticles; PLGA; Sustained release

Indexed keywords

ACETYLCHOLINESTERASE INHIBITORS; DONEPEZIL; MICROPARTICLES; PLGA; SUSTAINED RELEASE;

CONTROLLED DRUG DELIVERY; DRUG THERAPY; EMULSION POLYMERIZATION; PARTICLE SIZE ANALYSIS; PH EFFECTS; POLYESTERS;

DRUG PRODUCTS;

1 BENZYL 4 [2 [(5,6 DIMETHOXY 1 INDANON) 2 YL]ETHYL]PIPERIDINE; ACETYLCHOLINESTERASE; CHOLINESTERASE INHIBITOR; DONEPEZIL; PHOSPHATE BUFFERED SALINE; PIPERIDINE DERIVATIVE; POLYGLACTIN; UNCLASSIFIED DRUG; WATER; WATER OIL CREAM;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; CHOLINESTERASE INHIBITION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM COMPARISON; DRUG FORMULATION; DRUG INFUSION; DRUG MECHANISM; DRUG SCREENING; DRUG SYNTHESIS; EVAPORATION; FRONTAL CORTEX; HIPPOCAMPUS; IN VITRO STUDY; IN VIVO STUDY; MAZE TEST; MEMORY DISORDER; NONHUMAN; PARTICLE SIZE; PH; PRIORITY JOURNAL; RAT; SOLVENT EXTRACTION; SUSTAINED DRUG RELEASE;

ALZHEIMER DISEASE; ANIMALS; CAPSULES; CHOLINESTERASE INHIBITORS; COGNITION DISORDERS; DELAYED-ACTION PREPARATIONS; DIFFUSION; DRUG EVALUATION, PRECLINICAL; INDANS; PARTICLE SIZE; PIPERIDINES; RATS; TREATMENT OUTCOME;

RATTUS;

EID: 33846317458     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2006.12.016     Document Type: Article

References (23)

1. Cheng D.H., and Tang X.C. Comparative studies of Huperzine A, E2020, and Tacrine on behavior and cholinesterase activities. Pharmacol Biochem Behav 60 (1998) 377-386
2. Kosasa T., Kuriya Y., Matsui K., and Yarnanishi Y. Inhibitory effects of donepezil hydrochloride (E2020) on cholinesterase activity in brain and peripheral tissues of young and aged rats. Eur J Pharmacol 386 (1999) 7-13
3. Kosasa T., Kuriya Y., Matsui K., and Yamanishi Y. Inhibitory effect of orally administered donepezil hydrochloride (E2020), a novel treatment for Alzheimer's disease, on cholinesterase activity in rats. Eur J Pharmacol 389 (2000) 173-179
4. Yamada K., Takayanagi M., Kamei H., Nagai T., Dohniwa M., Kobayashi K., et al. Effects of memantine and donepezil on amyloid β-induced memory impairment in a delayed-matching to position task in rats. Behav Brain Res 162 (2005) 191-199
5. Perry E.K., Tomlinson B.E., Blessed G., Bergman K., Gibson P.H., and Perry R.H. Correlation of cholinergic abnormalities with senile senile plaques and mental test scores in senile dementia. Br Med J 2 (1978) 1457-1459
6. Sugimoto H., Iimura Y., Yamanishi Y., and Yamatsu K. Syntheses and structure-activity relationships of acetylcholinesterase inhibitors: 1-benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl] piperidine hydrochloride and related compounds. J Med Chem 38 (1995) 4821-4829
7. Rogers S.L., and Friedhoff L.T. Long-term efficacy and safety of donepezil in the treatment of Alzheimer's disease: an interim analysis of the results of a US multicenter open label extension study. Eur Neuropsychopharmacol 8 (1998) 67-75
8. Rogers SL, Yamanishi Y, Yamatsu K. E2020: the pharmacology of a piperidine cholinesterase inhibitor. In: Becker R, Giacobini E, editors. Cholinergic basis for Alzheimer therapy. Boston, MA: Birkhäuser. p. 314-20.
9. Christodoulou C., Melville P., Scherl W.F., MacAllister W.S., Elkins L.E., and Krupp L.B. Effects of donepezil on memory and cognition in multiple sclerosis. J Neurol Sci 245 (2006) 127-136
10. Gander B., Meinel M., Walter E., and Merkle H.P. Polymers as a platform for drug delivery: reviewing our current portfolio on poly(lactide-co-glycolide) (PLGA) microspheres. Chimia 55 (2001) 212-217
11. Ciftci K., Kas H.S., Hincal A.A., Ercan T.M., Güven O., and Ruacan S. In vitro and in vivo evaluation of PLAGA (50/50) microspheres containing 5-fluorouracil prepared by a solvent evaporation method. Int J Pharm 131 (1996) 73-82
12. Morris R. Developments of a water-maze procedure for studying spatial learning in the rat. J Neurosci Methods 11 (1984) 47-60
13. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72 (1976) 248-254
14. Yao R.S., Dong A.J., and Liu Y.Q. Macromolecule materials in pharmaceutics, 1st ed (2003), Chemistry Industry Press, Beijing p. 178
15. Li Y.P., Pei Y.Y., Zhou Z.H., Zhang X.Y., Gu Z.H., Ding J., et al. PEGylated polycyanoacrylate nanoparticles as tumor necrosis factor-α carriers. J Control Release 71 (2001) 287-296
16. Fang K.T. Uniform design-application of number theory method in experimental design. Acta Math Appl Sin 3 (1980) 363-372
17. Huang J., Liu H.Q., Gu W.W., Yan Z., Xu Z.H., Yang Y.X., et al. A delivery strategy for rotenone microspheres in an animal model of Parkinson's disease. Biomaterials 26 (2006) 937-946
18. Suzuki N., Kasahara K., Hasegawa H., and Kawasaki T. Physical property of troglitazone, an equal mixture of four stereoisomers. Int J Pharm 248 (2002) 71-80
19. Faisant N., Akiki J., Siepmann F., Benoit J.P., and Siepmann J. Effects of the type of release medium on drug release from PLGA-based microparticles: experiment and theory. Int J Pharm 314 (2006) 189-197
20. Tsuchiya M., Sako K., Yura S., and Yonemasu Y. Local cerebral glucose utilization following acute and chronic bilateral carotid artery ligation in Wistar rats: relation to changes in local cerebral blood flow. Exp Brain Res 95 (1993) 1-7
21. Ni J.W., Matsumoto K., Li H.B., Murakami Y., and Watanabe H. Neuronal damage and decrease of central acetylcholine level following permanent occlusion bilateral common carotid arteries in rats. Brain Res 673 (1995) 290-296
22. Liao Y., Wang R., and Tang X.C. Centrophenoxine improves chronic cerebral ischemia induced cognitive deficit and neuronal degeneration in rats. Acta Pharmacol Sin 12 (2004) 1590-1596
23. Huang J., Mei Y., and Sun L. Experimental study on the treatment of vascular dementia with aricept. Acta Med Univ Sci Technol Huazhong 34 (2005) 719-722