ESI-MS/MS stability-indicating bioanalytical method development and validation for simultaneous estimation of donepezil, 5-desmethyl donepezil and 6-desmethyl donepezil in human plasma

Biomedical Chromatography

Volumn 26, Issue 5, 2012, Pages 636-649

  Khuroo, Arshad H ^a   Gurule, Sanjay J ^a   Monif, Tausif ^a   Goswami, Dipanjan ^a   Saha, Arabinda ^a   Singh, Santosh K ^a  

^a RANBAXY LABORATORIES LTD   (India)

Author keywords

Clinical impact; Donepezil and its metabolites; LC MS MS simultaneous method development; Plasma stability; Validation

Indexed keywords

LIQUID CHROMATOGRAPHY; PLASMA (HUMAN); PLASMA STABILITY;

BIOANALYTICAL METHODS; CLINICAL IMPACT; DONEPEZIL; DONEPEZIL AND ITS METABOLITE; ESI-MS-MS; LC-MS-MS; LC-MS/MS SIMULTANEOUS METHOD DEVELOPMENT; METHOD DEVELOPMENT; SIMULTANEOUS METHODS; VALIDATION;

METABOLITES;

5 DESMETHYL DONEPEZIL; 6 DESMETHYL DONEPEZIL; DONEPEZIL; DRUG METABOLITE; GALANTAMINE; UNCLASSIFIED DRUG;

ACCURACY; ANALYTIC METHOD; ARTICLE; CALIBRATION; CASE REPORT; CHEMICAL REACTION; CLINICAL STUDY; COLLISIONALLY ACTIVATED DISSOCIATION; CONTROLLED STUDY; DEOXYGENATION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG STABILITY; DRUG STRUCTURE; ELECTROSPRAY MASS SPECTROMETRY; HUMAN; LIQUID CHROMATOGRAPHY; MALE; NORMAL HUMAN; PH; PHARMACOKINETICS; PROTON TRANSPORT; SENSITIVITY ANALYSIS; SEPARATION TECHNIQUE; STORAGE TEMPERATURE;

EID: 84859442493     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.1709     Document Type: Article

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