Macromolecular HPMA-based nanoparticles with cholesterol for solid-tumor targeting: Detailed study of the inner structure of a highly efficient drug delivery system

Biomacromolecules

Volumn 13, Issue 8, 2012, Pages 2594-2604

  Filippov, Sergey K ^a   Chytil, Petr ^a   Konarev, Petr V ^b   Dyakonova, Margarita ^c   Papadakis, Christinem ^c   Zhigunov, Alexander ^a   Plestil, Josef ^a   Stepanek, Petr ^a   Etrych, Tomas ^a   Ulbrich, Karel ^a   Svergun, Dmitri I ^b  

^a INSTITUTE OF MACROMOLECULAR CHEMISTRY   (Czech Republic)

^b EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AB INITIO CALCULATIONS; AGGREGATION NUMBERS; ANTICANCER DRUG; BASIC STRUCTURE; CHOLESTEROL CONTENT; DOXORUBICIN; DRUG-CONJUGATES; EFFICIENT DRUG DELIVERY; HPMA COPOLYMERS; HYDRAZONE BONDS; INNER STRUCTURE; METHACRYLAMIDES; NANOCARRIERS; PH SENSITIVE; SHELL SURFACE;

COPOLYMERS; DRUG DELIVERY; GEMS; HYDROPHILICITY; NANOPARTICLES;

CHOLESTEROL;

CHOLESTEROL; DOXORUBICIN; HYDRAZONE DERIVATIVE; N (2 HYDROXYPROPYL)METHACRYLAMIDE COPOLYMER; NANOCARRIER;

AB INITIO CALCULATION; ANISOTROPY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; HYDRODYNAMICS; HYDROPHILICITY; HYDROPHOBICITY; LIGHT SCATTERING; MACROMOLECULE; MOLECULAR WEIGHT; MOLECULARLY TARGETED THERAPY; NEUTRON SCATTERING; PARTICLE SIZE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; SMALL ANGLE SCATTERING; STRUCTURE ANALYSIS; SYNTHESIS;

ACRYLAMIDES; ALGORITHMS; ANISOTROPY; ANTIBIOTICS, ANTINEOPLASTIC; CHOLESTEROL; DOXORUBICIN; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; LIGHT; MACROMOLECULAR SUBSTANCES; MICELLES; MODELS, MOLECULAR; MOLECULAR CONFORMATION; NANOCAPSULES; NEUTRON DIFFRACTION; PARTICLE SIZE; SCATTERING, SMALL ANGLE; X-RAY DIFFRACTION;

EID: 84865001035     PISSN: 15257797     EISSN: 15264602     Source Type: Journal    
DOI: 10.1021/bm3008555     Document Type: Article

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