Impact of Na+ channel blockers on transmural dispersion of refractoriness and arrhythmic susceptibility in guinea-pig left ventricle

European Journal of Pharmacology

Volumn 691, Issue 1-3, 2012, Pages 173-181

  Osadchii, Oleg E ^a,b  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b AALBORG UNIVERSITY   (Denmark)

Author keywords

Cardiac arrhythmia; Na channel blockers; Refractoriness; Transmural heterogeneities

Indexed keywords

DOFETILIDE; FLECAINIDE; LIDOCAINE; MEXILETINE; PROCAINAMIDE; QUINIDINE; SODIUM CHANNEL BLOCKING AGENT;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DISPERSION; ENDOCARDIUM; EPICARDIUM; EVENT RELATED POTENTIAL; GUINEA PIG; HEART ARRHYTHMIA; HEART LEFT VENTRICLE WALL; HEART MUSCLE POTENTIAL; HEART MUSCLE REFRACTORY PERIOD; HEART REPOLARIZATION; HEART VENTRICLE TACHYCARDIA; NONHUMAN; PRIORITY JOURNAL; QT INTERVAL;

ANIMALS; ARRHYTHMIAS, CARDIAC; BASAL METABOLISM; DISEASE SUSCEPTIBILITY; ENDOCARDIUM; FEMALE; GUINEA PIGS; HEART VENTRICLES; MEMBRANE POTENTIALS; PERICARDIUM; REFRACTORY PERIOD, ELECTROPHYSIOLOGICAL; SODIUM CHANNEL BLOCKERS;

EID: 84864972296     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2012.07.015     Document Type: Article

References (53)

1. C. Antzelevitch, W. Shimizu, G.X. Yan, S. Sicouri, J. Weissenburger, V.V. Nesterenko, A. Burashnikov, J. Di Diego, J. Saffitz, and G.P. Thomas The M cell: its contribution to the ECG and to normal and abnormal electrical function of the heart J. Cardiovasc. Electrophysiol. 10 1999 1124 1152 (Pubitemid 29383677)
2. J.L. Anderson, E.V. Platia, A. Hallstrom, R.W. Henthorn, T.A. Buckingham, M.D. Carlson, and P.E. Carson Interaction of baseline characteristics with the hazard of encainide, flecainide, and moricizine therapy in patients with myocardial infarction Circulation 90 1994 2843 2852
3. S.M. Bryant, X. Wan, S.J. Shipsey, and G. Hart Regional differences in the delayed rectifier current (IKr and IKs) contribute to the differences in action potential duration in basal left ventricular myocytes in guinea-pig Cardiovasc. Res. 40 1998 322 331 (Pubitemid 28506043)
4. T.J. Campbell, and K.M. Williams Therapeutic drug monitoring: antiarrhythmic drugs Br. J. Clin. Pharmacol. 46 1998 307 319
5. X. Chen, J.D. Cass, J.A. Bradley, C.M. Dahm, Z. Sun, E. Kadyszewski, M.J. Engwall, and J. Zhou QT prolongation and proarrhythmia by moxifloxacin: concordance of preclinical models in relation to clinical outcome Br. J. Pharmacol. 146 2005 792 799 (Pubitemid 41622245)
6. X. Chen, J.S. Cordes, J.A. Bradley, Z. Sun, and J. Zhou Use of arterially perfused rabbit ventricular wedge in predicting arrhythmogenic potentials of drugs J. Pharmacol. Toxicol. Methods 54 2006 261 272 (Pubitemid 44636256)
7. P. Collste, and R. Nordlander Quinidine dosage, with special reference to an oral loading dose schedule Br. J. Clin. Pharmacol. 7 1979 293 297 (Pubitemid 9102838)
8. K.A. Conrad, B.L. Molk, and C.A. Chidsey Pharmacokinetic studies of quinidine in patients with arrhythmias Circulation 55 1977 1 7 (Pubitemid 8015582)
9. J. Davis, T. Matsubara, M.M. Scheinman, B. Katzung, and L.H. Hondeghem Use-dependent effects of lidocaine on conduction in canine myocardium: application of the modulated receptor hypothesis in vivo Circulation 74 1986 205 214 (Pubitemid 16092942)
10. S. Dhein, A. Muller, R. Gerwin, and W. Klaus Comparative study on the proarrhythmic effects of some antiarrhythmic drugs Circulation 87 1993 617 630 (Pubitemid 23040932)
11. E. Drouin, G. Lande, and F. Charpentier Amiodarone reduces transmural heterogeneity of repolarization in the human heart J. Am. Coll. Cardiol. 32 1998 1063 1067 (Pubitemid 28459600)
12. C.Y. Du, A. El Harchi, Y.H. Zhang, C.H. Orchard, and J.C. Hancox Pharmacological inhibition of the hERG potassium channel is modulated by extracellular but not intracellular acidosis J. Cardiovasc. Electrophysiol. 22 2011 1163 1170
13. S.O. Fagbemi, L. Chi, and B.R. Lucchesi Antifibrillatory and profibrillatory actions of selected class I antiarrhythmic agents J. Cardiovasc. Pharmacol. 21 1993 709 719 (Pubitemid 23121867)
14. G.C. Flaker, J.L. Blackshear, R. McBride, R.A. Kronmal, J.L. Halperin, and R.G. Hart Antiarrhythmic drug therapy and cardiac mortality in atrial fibrillation J. Am. Col. Cardiol. 20 1992 527 532
15. K, by flecainide and E-4031 in cat ventricular myocytes Circulation 82 1990 289 293 (Pubitemid 20216340)
16. N. Gaborit, S. Le Bouter, V. Szuts, A. Varro, D. Escande, S. Nattel, and S. Demolombe Regional and tissue specific transcript signatures of ion channel genes in the non-diseased human heart J. Physiol. 582 2007 675 693 (Pubitemid 47040552)
17. p-e/QT ratio as an index of arrhythmogenesis J. Electrocardiol. 41 2008 567 574
18. J.T. Hii, D.G. Wyse, A.M. Gillis, J.M Cohen, and L.B. Mitchell Propafenone-induced torsade de pointes: cross-reactivity with quinidine Pacing Clin. Electrophysiol. 14 1991 1568 1570
19. M. Hodges, J.M. Haugland, G. Granrud, G.J. Conard, R.W. Asinger, F.L. Mikell, and J. Krejci Suppression of ventricular ectopic depolarizations by flecainide acetate, a new antiarrhythmic agent Circulation 65 1982 879 885 (Pubitemid 12081311)
20. S.F. Hohnloser, A. van de Loo, and F. Baedeker Efficacy and proarrhythmic hazard of pharmacologic cardioversion of atrial fibrillation: prospective comparison of sotalol versus quinidine J. Am. Coll. Cardiol. 26 1995 852 858
21. L.M. Hondeghem Antiarrhythmic agents: modulated receptor applications Circulation 75 1987 514 520 (Pubitemid 17026039)
22. L.M. Hondeghem, L. Carlsson, and G. Duker Instability and triangulation of the action potential predict serious proarrhythmia, but action potential duration prolongation is antiarrhythmic Circulation 103 2001 2004 2013 (Pubitemid 32322230)
23. L.M. Hondeghem TRIad: foundation for proarrhythmia (triangulation, reverse use dependence and instability) Novartis Found. Symp. 266 2005 235 244
24. K.H. Kuck, R. Cappato, J. Siebels, and R. Ruppel Randomized comparison of antiarrhythmic drug therapy with implantable defibrillators in patients resuscitated from cardiac arrest: the Cardiac Arrest Study Hamburg (CASH) Circulation 102 2000 748 754 (Pubitemid 30648765)
25. T. Liu, B.S. Brown, Y. Wu, C. Antzelevitch, P.R. Kowey, and G.X. Yan Blinded validation of the isolated arterially perfused rabbit ventricular wedge in preclinical assessment of drug-induced proarrhythmias Heart Rhythm. 3 2006 948 956 (Pubitemid 44103507)
26. H.R. Lu, J. Rohrbacher, E. Vlaminckx, K.V. Ammel, G.X. Yan, and D. Gallacher Predicting drug-induced slowing of conduction and pro-arrhythmia: identifying the bad sodium current blockers Br. J. Pharmacol. 160 2010 60 76
27. M.C. Main, S.M. Bryant, and G. Hart Regional differences in action potential characteristics and membrane currents of guinea-pig left ventricular myocytes Exp. Physiol. 83 1998 747 761 (Pubitemid 28529001)
28. G. Michael, L. Xiao, X.Y Qi, D. Dobrev, and S. Nattel Remodelling of cardiac repolarization: how homeostatic responses can lead to arrhythmogenesis Cardiovasc. Res. 81 2009 491 499
29. J. Morganroth, and J.E. Goin Quinidine-related mortality in the short-to-medium-term treatment of ventricular arrhythmias Circulation 84 1991 1977 1983
30. A. Muller, and S. Dhein Sodium channel blockade enhances dispersion of the cardiac action potential duration Basic Res. Cardiol. 88 1993 11 22 (Pubitemid 23083866)
31. V.V. Nesterenko, A.A. Lastra, L.V. Rosenshtraukh, and C.F. Starmer A proarrhythmic response to sodium channel blockade: modulation of the vulnerable period in guinea-pig ventricular myocardium J. Cardiovasc. Pharmacol. 19 1992 810 820
32. J.M. Nerbonne, and R.S. Kass Molecular physiology of cardiac repolarization Physiol. Rev. 85 2005 1205 1253 (Pubitemid 41362269)
33. O. Osadchii, A. Woodiwiss, N. Alves, and G. Norton Mechanisms of preserved baseline cardiac systolic function in rats with adrenergic inotropic downregulation Life Sci. 78 2005 366 375 (Pubitemid 41597545)
34. O. Osadchii, G. Norton, D. Deftereos, and A. Woodiwiss Rat strain-related differences in myocardial adrenergic tone and the impact on cardiac fibrosis, adrenergic responsiveness and myocardial structure and function Pharmacol. Res. 55 2007 287 294 (Pubitemid 46518159)
35. O.E. Osadchii, E. Soltysinska, and S.P. Olesen Na channel distribution and electrophysiological heterogeneities in guinea-pig ventricular wall Am. J. Physiol. Heart Circ. Physiol. 300 2011 H989 H1002
36. E.N. Prystowsky Proarrhythmia during drug treatment of supraventricular tachycardia: paradoxical risk of sinus rhythm for sudden death Am. J. Cardiol. 78 Suppl. 8A 1996 35 41
37. S. Ranger, and S. Nattel Determinants and mechanisms of flecainide-induced promotion of ventricular tachycardia in anesthetized dogs Circulation 92 1995 1300 1311
38. C.A. Remme, A.O. Verkerk, W.M.H. Hoogaars, W.T.J. Aanhaanen, B.P. Scicluna, C. Annink, M.J.B. van den Hoff, A.A.M. Wilde, T.A.B. van Veen, M.W. Veldkamp, J.M.T. de Bakker, V.M. Christoffels, and C.R. Bezzina The cardiac sodium channel displays differential distribution in the conduction system and transmural heterogeneity in the murine ventricular myocardium Basic Res. Cardiol. 104 2009 511 522
39. D.M. Roden Ionic mechanisms for prolongation of refractoriness and their proarrhythmic and antiarrhythmic correlates Am. J. Cardiol. 78 1996 12 16 (Pubitemid 26287346)
40. D.M. Roden Long QT syndrome: reduced repolarization reserve and the genetic link J. Intern. Med. 259 2006 59 69
41. K activation in guinea-pig ventricular myocytes Circ. Res. 62 1988 1055 1058
42. B. Rosati, F. Grau, and D. McKinnon Regional variation in mRNA transcript abundance within the ventricular wall J. Mol. Cell Cardiol. 40 2006 295 302 (Pubitemid 43152385)
43. F.A. Scamps, A. Undrovinas, and G. Vassort Inhibition of ICa in single frog cardiac cells by quinidine, flecainide, ethmozin, and ethacizin Am. J. Physiol. Cell Physiol. 256 1989 C549 C559
44. W. Shimizu, and C. Antzelevitch Sodium channel block with mexiletine is effective in reducing dispersion of repolarization and preventing torsade de pointes in LQT2 and LQT3 models of the long QT syndrome Circulation 96 1997 2038 2047 (Pubitemid 27400769)
45. W. Shimizu, and C. Antzelevitch Cellular basis for the ECG features of the LQT1 form of the long QT syndrome Circulation 98 1998 2314 2322
46. S. Sicouri, M. Quist, and C. Antzelevitch Evidence for the presence of M cells in the guinea-pig ventricle J. Cardiovasc. Electrophysiol. 7 1996 503 511 (Pubitemid 26156421)
47. B. Strasberg, S. Sclarovsky, A. Erdberg, C.E. Duffy, W. Lam, S. Swiryn, J. Agmon, and K.M. Rosen Procainamide-induced polymorphous ventricular tachycardia Am. J. Cardiol. 47 1981 1309 1314 (Pubitemid 11126303)
48. C. Torp-Pedersen, M. Moller, P. Bloch-Thomsen, L. Kober, E. Sandoe, K. Egstrup, E. Agner, J. Carlsen, J. Videbaek, B. Marchant, and J. Camm Dofetilide in patients with congestive heart failure and left ventricular dysfunction N. Engl. J. Med. 341 1999 857 865 (Pubitemid 29427047)
49. A.L. Waldo, A.J. Camm, H. deRuyter, P.L. Friedman, D.J. MacNeil, J.F. Pauls, B. Pitt, C.M. Pratt, P.J. Schwartz, and E.P. Veltri Effect of d-sotalol on mortality in patients with left ventricular dysfunction after recent and remote myocardial infarction Lancet 348 1996 7 12 (Pubitemid 26237238)
50. J. Weissenburger, V.V. Nesterenko, and C. Antzelevitch Transmural heterogeneity of ventricular repolarization under baseline and long QT conditions in the canine heart in vivo: torsade de pointes develops with halothane but not pentobarbital anesthesia J. Cardiovasc. Electrophysiol. 11 2000 290 304 (Pubitemid 30165349)
51. L. Wu, S. Rajamani, H. Li, C.T. January, J.C. Shryock, and L. Belardinelli Reduction of repolarization reserve unmasks the proarrhythmic role of endogenous late Na current in the heart Am. J. Physiol. Heart Circ. Physiol. 297 2009 H1048 H1057
52. Y. Wu, L. Carlsson, T. Liu, P.R. Kowey, and G.X. Yan Assessment of the proarrhythmic potential of the novel antiarrhythmic agent AZD7009 and dofetilide in experimental models of torsades de pointes J. Cardiovasc. Electrophysiol. 16 2005 898 904 (Pubitemid 41623783)
53. M.G. Wyman, R.M. Wyman, D.S. Cannom, and J.M. Criley Prevention of primary fibrillation in acute myocardial infarction with prophylactic lidocaine Am. J. Cardiol. 94 2004 545 551 (Pubitemid 39165830)