Amiodarone reduces transmural heterogeneity of repolarization in the human heart

Journal of the American College of Cardiology

Volumn 32, Issue 4, 1998, Pages 1063-1067

  Drouin, Emmanuel ^a   Lande, Gilles ^a   Charpentier, Flavien ^a  

^a NANTES UNIVERSITY HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AMIODARONE; ANTIARRHYTHMIC AGENT;

ACTION POTENTIAL; ARTICLE; HEART FAILURE; HEART LEFT VENTRICLE CONTRACTION; HEART MUSCLE CELL; HEART REPOLARIZATION; HUMAN; HUMAN CELL; HUMAN TISSUE; MICROELECTRODE; PRIORITY JOURNAL; TORSADE DES POINTES;

ACTION POTENTIALS; ADOLESCENT; ADULT; AMIODARONE; ANTI-ARRHYTHMIA AGENTS; ELECTROPHYSIOLOGY; ENDOCARDIUM; FEMALE; HEART; HEART FAILURE, CONGESTIVE; HEART VENTRICLES; HUMANS; MALE; MIDDLE AGED; PERICARDIUM;

EID: 0032191405     PISSN: 07351097     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0735-1097(98)00330-1     Document Type: Article

References (25)

1. Hohnloser S.H., Singh B.N. Proarrhythmia with class III antiarrhythmic drugs definition, electrophysiologic mechanisms, incidence, predisposing factors and clinical implications . J Cardiovasc Electrophysiol. 6:1995;920-936.
2. Nguyen P.T., Scheinman M.M., Seger J. Polymorphous ventricular tachycardia clinical characterization, therapy and the QT interval . Circulation. 74:1986;340-349.
3. Lazzara R. Amiodarone and torsade de pointes. Ann Intern Med. 111:1989;549-551.
4. Antzelevitch C., Sicouri S., Litovsky S.H., et al. Heterogeneity within the ventricular wall. Electrophysiology and pharmacology of epicardial endocardial and M cells. Circ Res. 69:1991;1427-1449.
5. el-Sherif N., Caref E.B., Yin H., Restivo M. The electrophysiological mechanism of ventricular arrhythmias in the long QT syndrome. Tridimensional mapping of activation and recovery patterns. Circ Res. 79:1996;474-492.
6. Antzelevitch C. The M cell. Invited Editorial Comment. J Cardiovasc Pharmacol Ther. 2:1997;73-76.
7. Wit A.L., Rosen M.R. Afterdepolarizations and triggered activity. Fozzard H.A., Haber E., Jennings R.B., et al. The Heart and Cardiovascular System. 1986;1449-1491 Raven Press, New York.
8. Pertsov A.M., Davidenko J.M., Salomonsz R., Baxter W.T., Jalife J. Spiral waves of excitation underlie reentrant activity in isolated cardiac muscle. Circ Res. 72:1993;631-650.
9. Sicouri S., Antzelevitch C. Drug-induced afterdepolarizations and triggered activity occur in a discrete subpopulation of ventricular muscle cell (M cells) in the canine heart quinidine and digitalis . J Cardiovasc Electrophysiol. 4:1993;48-58.
10. Antzelevitch C., Sicouri S. Clinical relevance of cardiac arrhythmias generated by afterdepolarizations role of M cells in the generation of U waves, triggered activity and torsade de pointes . J Am Coll Cardiol. 23:1994;259-277.
11. Drouin E., Charpentier F., Gauthier C., Laurent K., Le Marec H. Electrophysiological characteristics of cells spanning the left ventricular wall of human heart evidence for the presence of M cells . J Am Coll Cardiol. 26:1995;185-192.
12. Cui G., Sen L., Sager P., Uppal P., Singh B.N. Effects of amiodarone, sematilide, and sotalol on QT dispersion. Am J Cardiol. 74:1994;896-900.
13. Lepeschkin E., Surawicz B. The measurement of the QT interval of the electrocardiogram. Circulation. 6:1952;378-388.
14. Puddu P.E., Jouve R., Mariotti S., et al. Evaluation of 10 QT prediction formulas in 881 middle-aged men from the seven countries study emphasis on the cubic root Fridericia's equation . J Electrocardiol. 21:1988;219-229.
15. Le Coz F., Funck-Brentano C., Morell T., Ghadanfar M.M., Jaillon P. Pharmacokinetic and pharmacodynamic modeling of the effects of oral and intravenous administrations of dofetilide on ventricular repolarization. Clin Pharmacol Ther. 57:1995;533-542.
16. Nattel S., Talajic M., Fermini B., Roy D. Amiodarone pharmacology, clinical actions, and relationships between them . J Cardiovasc Electrophysiol. 3:1992;266-280.
17. Singh B.N., Nademanee K. Control of cardiac arrhythmias by selective lengthening of cardiac repolarization theoretic considerations and clinical observations . Am Heart J. 109:1985;421-430.
18. Sicouri S., Moro S., Litovsky S., Elizari M.V., Antzelevitch C. Chronic amiodarone reduces transmural dispersion of repolarization in the canine heart. J Cardiovasc Electrophysiol. 8:1997;1269-1279.
19. Yabek S.M., Kato R., Singh B.N. Acute effects of amiodarone on the electrophysiologic properties of isolated neonatal and adult cardiac fibers. J Am Coll Cardiol. 5:1985;1109-1115.
20. Peeters G.A., Sanguinetti M.C., Eki Y., Konarzewska H., et al. Method for isolation of human ventricular myocytes from single endocardial and epicardial biopsies. Am J Physiol. 268:1995;H1757-H1764.
21. Singh B.N. Antiarrhythmic actions of amiodarone a profile of a paradoxical agent . Am J Cardiol. 78:1996;41-53.
22. Pollack P.T., Sharma A.D., Carruthers S.G. Correlation of amiodarone dosage, heart rate, QT interval and corneal microdeposits with serum amiodarone and desethylamiodarone concentrations. Am J Cardiol. 64:1989;1138-1143.
23. Debbas N.M., du-Cailar C., Bexton R.S., Demaille J.G., Camm A.J., Puech P. The QT interval a predictor of the plasma and myocardial concentrations of amiodarone . Br Heart J. 51:1984;316-320.
24. Greenberg M.L., Lerman B.B., Shipe J.R., Kaiser D.L., DiMarco J.P. Relation between amiodarone and desethylamiodarone plasma concentrations and electrophysiologic effects, efficacy and toxicity. J Am Coll Cardiol. 9:1987;1148-1155.
25. Nademanee K., Hendrickson J.A., Cannom D.S., Goldreyer B.N., Singh B.N. Control of refractory life-threatening ventricular tachyarrhythmias by amiodarone. Am Heart J. 101:1981;759-768.