The microclimate pH in poly(D,L-lactide-co-hydroxymethyl glycolide) microspheres during biodegradation

Biomaterials

Volumn 33, Issue 30, 2012, Pages 7584-7593

  Liu, Yajun ^a   Ghassemi, Amir H ^b   Hennink, Wim E ^b   Schwendeman, Steven P ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Confocal laser scanning microscopy; Hydrophilic polyesters; Microclimate pH; Microsphere; PH distribution; Poly(lactic co glycolic acid)

Indexed keywords

ACID DEGRADATION; ACID-LABILE; BIOEROSION; CONFOCAL LASER SCANNING MICROSCOPY; COPOLYMER COMPOSITIONS; DEGRADATION TIME; FLUORESCENT PROBES; GLYCOLIDE; HYDROPHILIC POLYMERS; MATRIX DIFFUSION; PH DISTRIBUTION; PHYSIOLOGICAL CONDITION; PLGA MICROSPHERES; POLY LACTIC-CO-GLYCOLIC ACID; RAPID RELEASE; RATIOMETRIC;

BIODEGRADATION; CONFOCAL MICROSCOPY; DEGRADATION; ESTERS; HYDROPHILICITY; METHANOL; MICROBIOLOGY; MOLECULES; PH;

MICROSPHERES;

BORON DERIVATIVE; FLUORESCENT DYE; MICROSPHERE; POLY(DEXTRO, LEVO LACTIDE CO HYDROXYMETHYL GLYCOLIDE); POLYESTER; POLYGLACTIN; POLYMER; UNCLASSIFIED DRUG;

ACIDIFICATION; ARTICLE; BIODEGRADATION; CONFOCAL LASER MICROSCOPY; HYDROPHILICITY; MICROCLIMATE; MOLECULAR WEIGHT; PH; PRIORITY JOURNAL;

ACIDS; BIODEGRADATION, ENVIRONMENTAL; BORON COMPOUNDS; CHEMISTRY, PHARMACEUTICAL; DIFFUSION; HYDROGEN-ION CONCENTRATION; KINETICS; LACTIC ACID; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON, SCANNING; MICROSPHERES; POLYESTERS; POLYGLYCOLIC ACID; SOLUBILITY; SOLUTIONS; WATER;

EID: 84864969640     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2012.06.013     Document Type: Article

References (32)

1. Hiroaki O., Masaki Y., Toshiro H., Yayoi I., Shigeru K., Yasuaki O., et al. Drug delivery using biodegradable microspheres. J Control Release 1994, 28:121-129.
2. Mehta R.C., Jeyanthi R., Calls S., Thanoo B., Burton K.W., DeLuca P.P. Biodegradable microspheres as depot system for parenteral delivery of peptide drugs. J Control Release 1994, 29:375-384.
3. Johnson O.F.L., Cleland J.L., Lee H.J., Charnis M., Duenas E., Jaworowicz W., et al. A month-long effect from a single injection of microencapsulated human growth hormone. Nat Med 1996, 2:795-799.
4. Putney S.D., Burke P.A. Improving protein therapeutics with sustained-release formulations. Nat Biotechnol 1998, 16:153-157.
5. Jiang W., Gupta R.K., Deshpande M.C., Schwendeman S.P. Biodegradable poly (lactic-co-glycolic acid) microparticles for injectable delivery of vaccine antigens. Adv Drug Deliv Rev 2005, 57:391-410.
6. Slütter B., Bal S., Keijzer C., Mallants R., Hagenaars N., Que I., et al. Nasal vaccination with N-trimethyl chitosan and PLGA based nanoparticles: nanoparticle characteristics determine quality and strength of the antibody response in mice against the encapsulated antigen. Vaccine 2010, 28:6282-6291.
7. Vert M., Schwach G., Engel R., Coudane J. Something new in the field of PLA/GA bioresorbable polymers?. J Control Release 1998, 53:85-92.
8. Fu K., Pack D.W., Klibanov A.M., Langer R. Visual evidence of acidic environment within degrading poly (lactic-co-glycolic acid)(PLGA) microspheres. Pharm Res 2000, 17:100-106.
9. Shenderova A., Burke T.G., Schwendeman S.P. The acidic microclimate in poly (lactide-co-glycolide) microspheres stabilizes camptothecins. Pharm Res 1999, 16:241-248.
10. Ding A.G., Schwendeman S.P. Acidic microclimate pH distribution in PLGA microspheres monitored by confocal laser scanning microscopy. Pharm Res 2008, 25:2041-2052.
11. Schwendeman S.P. Recent advances in the stabilization of proteins encapsulated in injectable PLGA delivery systems. Crit Rev Ther Drug Carrier Syst 2002, 19:73-98.
12. van de Weert M., Hennink W.E., Jiskoot W. Protein instability in poly (lactic-co-glycolic acid) microparticles. Pharm Res 2000, 17:1159-1167.
13. Zhu G., Schwendeman S.P. Stabilization of proteins encapsulated in cylindrical poly (lactide-co-glycolide) implants: mechanism of stabilization by basic additives. Pharm Res 2000, 17:351-357.
14. Kang J., Schwendeman S.P. Comparison of the effects of Mg (OH)2 and sucrose on the stability of bovine serum albumin encapsulated in injectable poly (d, l-lactide-co-glycolide) implants. Biomaterials 2002, 23:239-245.
15. Zhu G., Mallery S.R., Schwendeman S.P. Stabilization of proteins encapsulated in injectable poly (lactide-co-glycolide). Nat Biotechnol 2000, 18:52-57.
16. Jiang W., Schwendeman S.P. Stabilization of tetanus toxoid encapsulated in PLGA microspheres. Mol Pharm 2008, 5:808-817.
17. Jiang W., Schwendeman S.P. Stabilization and controlled release of bovine serum albumin encapsulated in poly (d, l-lactide) and poly (ethylene glycol) microsphere blends. Pharm Res 2001, 18:878-885.
18. Kang J., Lambert O., Ausborn M., Schwendeman S.P. Stability of proteins encapsulated in injectable and biodegradable poly (lactide-co-glycolide)-glucose millicylinders. Int J Pharm 2008, 357:235-243.
19. Jiang G., Woo B.H., Kang F., Singh J., DeLuca P.P. Assessment of protein release kinetics, stability and protein polymer interaction of lysozyme encapsulated poly (d, l-lactide-co-glycolide) microspheres. J Control Release 2002, 79:137-145.
20. Kim H.K., Park T.G. Microencapsulation of dissociable human growth hormone aggregates within poly (d, l-lactic-co-glycolic acid) microparticles for sustained release. Int J Pharm 2001, 229:107-116.
21. Noga D.E., Petrie T.A., Kumar A., Weck M., García A.J., Collard D.M. Synthesis and modification of functional poly (lactide) copolymers: toward biofunctional materials. Biomacromolecules 2008, 9:2056-2062.
22. Ghassemi A., Van Steenbergen M., Talsma H., Van Nostrum C., Jiskoot W., Crommelin D., et al. Preparation and characterization of protein loaded microspheres based on a hydroxylated aliphatic polyester, poly (lactic-co-hydroxymethyl glycolic acid). J Control Release 2009, 138:57-63.
23. Ghassemi A.H., van Steenbergen M.J., Talsma H., van Nostrum C.F., Crommelin D.J.A., Hennink W.E. Hydrophilic polyester microspheres: effect of molecular weight and copolymer composition on release of BSA. Pharm Res 2010, 27:2008-2017.
24. Leemhuis M., Van Nostrum C., Kruijtzer J., Zhong Z., Ten Breteler M., Dijkstra P., et al. Functionalized poly (α-hydroxy acid)s via ring-opening polymerization: toward hydrophilic polyesters with pendant hydroxyl groups. Macromolecules 2006, 39:3500-3508.
25. Ghassemi A.H., Van Steenbergen M.J., Barendregt A., Talsma H., Kok R.J., Van Nostrum C.F., et al. Controlled release of octreotide and assessment of peptide acylation from poly (d, l-lactide-co-hydroxymethyl glycolide) compared to PLGA microspheres. Pharm Res 2011, 1-11.
26. Lavelle E., Yeh M.K., Coombes A., Davis S. The stability and immunogenicity of a protein antigen encapsulated in biodegradable microparticles based on blends of lactide polymers and polyethylene glycol. Vaccine 1999, 17:512-529.
27. Kang J., Schwendeman S.P. Determination of diffusion coefficient of a small hydrophobic probe in poly (lactide-co-glycolide) microparticles by laser scanning confocal microscopy. Macromolecules 2003, 36:1324-1330.
28. Li L., Schwendeman S.P. Mapping neutral microclimate pH in PLGA microspheres. J Control Release 2005, 101:163-173.
29. Leemhuis M., Kruijtzer J.A.W., van Nostrum C.F., Hennink W.E. In vitro hydrolytic degradation of hydroxyl-functionalized poly (α-hydroxy acid)s. Biomacromolecules 2007, 8:2943-2949.
30. Ding A.G., Shenderova A., Schwendeman S.P. Prediction of microclimate pH in poly (lactic-co-glycolic acid) films. J Am Chem Soc 2006, 128:5384-5390.
31. Blasi P., D'Souza S.S., Selmin F., DeLuca P.P. Plasticizing effect of water on poly (lactide-co-glycolide). J Control Release 2005, 108:1-9.
32. Yang Y.Y., Chung T.S., Ping Ng N. Morphology, drug distribution, and in vitro release profiles of biodegradable polymeric microspheres containing protein fabricated by double-emulsion solvent extraction/evaporation method. Biomaterials 2001, 22:231-241.