Carbonylhydrazide-based molecular tongs inhibit wild-type and mutated HIV-1 protease dimerization

Journal of Medicinal Chemistry

Volumn 55, Issue 15, 2012, Pages 6762-6775

  Dufau, Laure ^b   Marques Ressurreição, Ana Sofia ^a   Fanelli, Roberto ^a   Kihal, Nadjib ^a   Vidu, Anamaria ^a   Milcent, Thierry ^a   Soulier, Jean Louis ^a   Rodrigo, Jordi ^a   Desvergne, Audrey ^b   Leblanc, Karine ^a   Bernadat, Guillaume ^a   Crousse, Benoit ^a   Reboud Ravaux, Micheèle ^b   Ongeri, Sandrine ^a  

^a UNIVERSITÉ PARIS SUD   (France)

^b SORBONNE UNIVERSITÉ   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; CARBONYLHYDRAZIDE DERIVATIVE; HUMAN IMMUNODEFICIENCY VIRUS PROTEINASE; HYDROGEN; OLIGOHYDRAZIDE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DIMERIZATION; DRUG STRUCTURE; DRUG SYNTHESIS; HYDROGEN BOND; HYDROPHOBICITY; PROTEIN PROTEIN INTERACTION;

ENZYME ASSAYS; FLUOROMETRY; HIV PROTEASE; HIV PROTEASE INHIBITORS; HYDRAZINES; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; KINETICS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MUTATION; NAPHTHALENES; PEPSIN A; PEPTIDOMIMETICS; PROTEIN MULTIMERIZATION; RENIN; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84864957267     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm300181j     Document Type: Article

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