Discovery of potent inhibitors of human and mouse fatty acid amide hydrolases

Journal of Medicinal Chemistry

Volumn 55, Issue 15, 2012, Pages 6898-6915

  Butini, Stefania ^a,b   Brindisi, Margherita ^a,b   Gemma, Sandra ^a,b   Minetti, Patrizia ^c   Cabri, Walter ^c   Gallo, Grazia ^c   Vincenti, Silvia ^c   Talamonti, Emanuela ^d,e   Borsini, Franco ^c   Caprioli, Antonio ^c   Stasi, Maria Antonietta ^c   Di Serio, Stefano ^c   Ros, Sindu ^a,b   Borrelli, Giuseppe ^a,b   Maramai, Samuele ^a,b   Fezza, Filomena ^d,e   Campiani, Giuseppe ^a,b   MacCarrone, Mauro ^e,f  

^a European Research Centre for Drug Discovery and Development (NatSynDrugs)   (Italy)

^b UNIVERSITY OF SIENA   (Italy)

^c Sigma Tau SpA   (Italy)

^d UNIVERSITY OF ROME TOR VERGATA   (Italy)

^e EUROPEAN BRAIN RESEARCH INSTITUTE   (Italy)

^f Dipartimento di Scienze   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

1 BENZYL 2 (3 METHOXYPHENYL) 5 METHYL N (5 PHENYLHEXYL) 1H PYRROLE 3 CARBOXAMIDE; 1 BENZYL 2 (3 METHOXYPHENYL) 5 METHYL N (5 PHENYLPENTYL) 1H PYRROLE 3 CARBOXAMIDE; [3 (3 CARBAMOYL 1H PYRROL 1 YL)PHENOXYCARBONYL] 1 UNDEC 10 YNYLAMINE; [3 (3 CARBAMOYL 1H PYRROL 1 YL)PHENOXYCARBONYL](6 PHENYLHEXYL)AMINE; [3 (3 CARBAMOYL 1H PYRROL 1 YL)PHENOXYCARBONYL][2 (2 PHENOXYETHOXY)ETHYL]AMINE; [3 (3 CARBAMOYL 1H PYRROL 1 YL)PHENOXYCARBONYL][2 [2 (2 FLUOROPHENOXY)ETHOXY]ETHYL]AMINE; [3 (3 CARBAMOYL 1H PYRROL 1 YL)PHENOXYCARBONYL][2 [2 (2,4 DIFLUOROPHENOXY)ETHOXY]ETHYL]AMINE; [3 (3 CARBAMOYL 1H PYRROL 1 YL)PHENOXYCARBONYL][2 [2 (2,4,6 TRIFLUOROPHENOXY)ETHOXY]ETHYL]AMINE; [3 (3 CARBAMOYL 1H PYRROL 1 YL)PHENOXYCARBONYL][2 [2 (4 FLUOROPHENOXY)ETHOXY]ETHYL]AMINE; [3 (3 CARBAMOYL 1H PYRROL 1 YL)PHENOXYCARBONYL]BUTYLAMINE; [3 (3 CARBAMOYL 1H PYRROL 1 YL)PHENOXYCARBONYL]CYCLOHEXYLAMINE; [3 (3 CARBAMOYL 5 METHYLFURAN 2 YL)PHENOXYCARBONYL](6 PHENYLHEXYL)AMINE; [3 (3 CARBAMOYL 5 METHYLFURAN 2 YL)PHENOXYCARBONYL]BUTYLAMINE; [3 (3 CARBAMOYL 5 METHYLFURAN 2 YL)PHENOXYCARBONYL]CYCLOHEXYLAMINE; [3 (3 CARBAMOYL 5 METHYLTHIOPHEN 2 YL)PHENOXYCARBONYL](6 PHENYLHEXYL)AMINE; [3 (3 CARBAMOYL 5 METHYLTHIOPHEN 2 YL)PHENOXYCARBONYL]BUTYLAMINE; [3 (3 CARBAMOYL 5 METHYLTHIOPHEN 2 YL)PHENOXYCARBONYL]CYCLOHEXYLAMINE; [3 (4 CARBAMOYL 5 METHYLFURAN 2 YL)PHENOXYCARBONYL](6 PHENYLHEXYL)AMINE; [3 (4 CARBAMOYL 5 METHYLFURAN 2 YL)PHENOXYCARBONYL]BUTYLAMINE; [3 (4 CARBAMOYL 5 METHYLFURAN 2 YL)PHENOXYCARBONYL]CYCLOHEXYLAMINE; [3 [3 (6 PHENYLHEXYLCARBAMOYL) 1 BENZYL 5 METHYL 1H PYRROL 2 YL]PHENOXYCARBONYL]CYCLOHEXYLAMINE; [3 [[3 (6 PHENYLHEXYLOXY)CARBONYL] 1H PYRROL 1 YL]PHENOXYCARBONYL)BUTYLAMINE; [3 [[3 (6 PHENYLHEXYLOXY)CARBONYL] 1H PYRROL 1 YL]PHENOXYCARBONYL)CYCLOHEXYLAMINE; [3 [[3 (UNDEC 10 YNYLOXY)CARBONYL] 1H PYRROL 1 YL]PHENOXYCARBONYL)(6 PHENYLHEXYL)AMINE; [3 [[3 (UNDEC 10 YNYLOXY)CARBONYL] 1H PYRROL 1 YL]PHENOXYCARBONYL)BUTYLAMINE; [3 [[3 (UNDEC 10 YNYLOXY)CARBONYL] 1H PYRROL 1 YL]PHENOXYCARBONYL)CYCLOHEXYLAMINE; FATTY ACID AMIDASE; FATTY ACID AMIDASE INHIBITOR; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG METABOLISM; DRUG POTENCY; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; HYPERALGESIA; KERATINOCYTE; MOLECULAR INTERACTION; MOUSE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; TRANQUILIZING ACTIVITY;

AMIDOHYDROLASES; ANALGESICS; ANIMALS; BRAIN; CHO CELLS; CRICETINAE; CRICETULUS; CYCLOHEXANES; ETHER-A-GO-GO POTASSIUM CHANNELS; FURANS; HUMANS; HYPERALGESIA; MAZE LEARNING; MICE; MODELS, MOLECULAR; PAIN THRESHOLD; PYRROLES; RATS; RECOMBINANT PROTEINS; STEREOTYPED BEHAVIOR; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES;

EID: 84864927691     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm300689c     Document Type: Article

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