Notoginsenoside Ft1 promotes angiogenesis via HIF-1α mediated VEGF secretion and the regulation of PI3K/AKT and Raf/MEK/ERK signaling pathways

Biochemical Pharmacology

Volumn 84, Issue 6, 2012, Pages 784-792

  Shen, Kaikai ^a   Ji, Lili ^a,b   Gong, Chenyuan ^a   Ma, Yibo ^a   Yang, Li ^a,b   Fan, Yi ^c   Hou, Maoqi ^a   Wang, Zhengtao ^a,b  

^a SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^b Shanghai R and D Centre for Standardization of Chinese Medicines   (China)

^c LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Angiogenesis; Hypoxia inducible factor 1 (HIF 1 ); Notoginsenoside Ft1 (Ft1); Vascular endothelial growth factor (VEGF); Wound healing

Indexed keywords

ANGIOGENESIS MODULATOR; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MAMMALIAN TARGET OF RAPAMYCIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; NOTOGINSENOSIDE FT1; PHOSPHATIDYLINOSITOL 3 KINASE; RAF PROTEIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; VASCULOTROPIN; WOUND HEALING PROMOTING AGENT;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; CYTOPLASM; DRUG DOSE REDUCTION; DRUG MEGADOSE; DRUG STRUCTURE; ENZYME PHOSPHORYLATION; GENE EXPRESSION; GENE SILENCING; GENE TRANSLOCATION; HUMAN; HUMAN CELL; INJURY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PUNCHED HOLE INJURY; SIGNAL TRANSDUCTION; UMBILICAL VEIN ENDOTHELIAL CELL;

ANGIOGENESIS INDUCING AGENTS; ANIMALS; CELL MOVEMENT; CELL SURVIVAL; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MALE; MAP KINASE SIGNALING SYSTEM; MICE; MICE, INBRED BALB C; NEOVASCULARIZATION, PHYSIOLOGIC; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-RAF; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; RNA, MESSENGER; RNA, SMALL INTERFERING; SAPONINS; SIGNAL TRANSDUCTION; SKIN; TOR SERINE-THREONINE KINASES; VASCULAR ENDOTHELIAL GROWTH FACTOR A; WOUND HEALING;

EID: 84864927637     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2012.05.024     Document Type: Article

References (37)

1. P. Gal, T. Vasilenko, M. Kostelnikova, J. Jakubco, I. Kovac, and F. Sabol Open wound healing in vivo: monitoring binding and presence of adhesion/growth-regulatory galectins in rat skin during the course of complete re-epithelialization Acta Histochem Cytochem 44 2011 191 199
2. G.C. Gurtner, S. Werner, Y. Barrandon, and M.T. Longaker Wound repair and regeneration Nature 453 2008 314 321
3. S.A. Eming, B. Brachvogel, and M. Odorisio Koch Regulation of angiogenesis: wound healing as a model Prog Histochem Cytochem 42 2007 115 170
4. T.A. Wilqus, and L.A. Dipietro Complex roles for VEGF in dermal wound healing J Invest Dermatol 132 2012 493 494
5. Q.S. Chen Pharmacological studies on notoginseng saponins isolated from the fibrous root of Panax notoginseng Zhong Yao Tong Bao 12 1987 45 47
6. T.B. Ng Pharmacological activity of sanchi ginseng (Panax notoginseng) J Pharm Pharmacol 58 2006 1007 1019
7. S.J. Hong, J.B. Wang, Y. Zhang, G. Hu, H.C. Lin, and S.W. Seto Angiogenic effect of saponin extract from Panax notoginseng on HUVECs in vitro and zebrafish in vivo Phytother Res 23 2009 677 686
8. P.Y. Yue, D.Y. Wong, W.Y. Ha, M.C. Fung, N.K. Mak, and H.W. Yeung Elucidation of the mechanisms underlying the angiogenic effects of ginsenoside Rg(1) in vivo and in vitro Angiogenesis 8 2005 205 216
9. L.W. Cheung, K.W. Leung, C.K. Wong, R.N. Wong, and A.S. Wong Ginsenoside-Rg1 induces angiogenesis via non-genomic crosstalk of glucocorticoid receptor and fibroblast growth factor receptor-1 Cardiovasc Res 89 2011 419 425
10. K.W. Leung, H.M. Ng, M.K. Tang, C.C. Wong, R.N. Wong, and A.S. Wong Ginsenoside-Rg1 mediates a hypoxia-independent upregulation of hypoxia-inducible factor-1α to promote angiogenesis Angiogenesis 14 2011 515 522
11. Y.C. Huang, C.T. Chen, S.C. Chen, P.H. Lai, H.C. Liang, and Y. Chang A natural compound (ginsenoside Re) isolated from Panax ginseng as a novel angiogenic agent for tissue regeneration Pharm Res 22 2005 636 646
12. K. Kawahira, M. Sumiyoshi, M. Sakanaka, and Y. Kimura Effects of ginsenoside Rb1 at low doses on histamine, substance P, and monocyte chemoattractant protein 1 in the burn wound areas during the process of acute burn wound repair J Ethnopharmacol 117 2008 278 284
13. Y. Kimura, M. Sumiyoshi, K. Kawahira, and M. Sakanaka Effects of ginseng saponins isolated from Red Ginseng roots on burn wound healing in mice Br J Pharmacol 148 2006 860 870
14. J.T. Chen, H.Z. Li, D. Wang, Y.J. Zhang, and C.R. Yang New dammarane monodesmosides from the acidic deglycosylation of notoginseng-leaf saponins Helv Chim Acta 89 2006 1442 1448
15. V. Marin, G. Kaplanski, S. Gres, C. Famarier, and P. Bonqrand Endothelial cell culture: protocol to obtain and cultivate human umbilical endothelial cells J Immunol Methods 254 2001 183 190
16. G.A. McMahon, E. Petitclerc, S. Stefansson, E. Smith, M.K. Wong, and R.J. Westrick Plasminogen activator inhibit-1 regulates tumor growth and angiogenesis J Biol Chem 276 2001 33964 33968
17. C.H. Cho, H.K. Sung, K.T. Kim, H.G. Cheon, G.T. Oh, and H.J. Hong COMP-angiopoietin-1 promotes wound healing through enhanced angiogenesis, lymphangiogenesis, and blood flow in a diabetic mouse model Proc Natl Acad Sci USA 103 2006 4946 4951
18. D. Altavilla, A. Saitta, D. Cucinotta, M. Galeano, B. Deodato, and M. Colonna Inhibition of lipid peroxidation restores impaired vascular endothelial growth factor expression and stimulates wound healing and angiognenesis in the genetically diabetes mouse Diabetes 50 2001 667 674
19. M. Przybylski A review of the current research on the role of bFGF and VEGF in angiogenesis J Wound Care 18 2009 516 519
20. P. Bao, A. Kodra, M. Tomic-Canic, M.S. Golinko, H.P. Ehrlich, and H. Brem The role of vascular endothelial growth factor in wound healing J Surg Res 153 2009 347 358
21. T. Odorisio, F. Cianfarani, C.M. Failla, and G. Zambruno The placenta growth factor in skin angiogenesis J Dermatol Sci 41 2006 11 19
22. G. Pages, and J. Pouyssequr Transcriptional regulation of the vascular endothelial growth factor gene - a concert of activating factors Cardiovasc Res 65 2005 564 573
23. D. Shweiki, A. Ltin, D. Soffer, and E. Keshet Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis Nature 359 1992 843 845
24. M.J. Gray, J. Zhang, L.M. Ellis, G.L. Semenza, D.B. Evans, and S.S. Watowich HIF-1alpha, STAT3, CBP/p300 and Ref-1/APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas Oncogene 24 2005 3110 3120
25. E. Zelzer, Y. Levy, C. Kahana, B.Z. Shilo, M. Rubinstein, and B. Cohen Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1alpha/ARNT EMBO J 17 1998 5084 5094
26. R.L. Bilton, and G.W. Booker The subtle side to hypoxia inducible factor (HIFalpha) regulation Eur J Biochem 270 2003 791 798
27. A.G. Bader, S. Kang, L. Zhao, and P.K. Voqt Oncogenic PI3K deregulates transcription and translation Nat Rev Cancer 5 2005 921 929
28. J. Karar, and A. Maity PI3K/AKT/mTOR pathway in angiogenesis Front Mol Neurosci 4 2011 1 8
29. C.C. Hudson, M. Liu, G.G. Chiang, D.M. Otterness, D.C. Loomis, and F. Kaper Regulation of hypoxia-inducible factor 1 alpha expression and function by the mammalian target of rapamycin Mol Cell Biol 22 2002 7004 7014
30. C.X. Bian, Z. Shi, Q. Meng, Y. Jiang, L.Z. Liu, and B.H. Jiang P70S6K 1 regulation of angiogenesis through VEGF and HIF-1α expression Biochem Biophys Res Commun 398 2010 395 399
31. J.D. Hood, R. Frausto, W.B. Kiosses, M.A. Schwartz, and D.A. Cheresh Differential alphav integrin-mediated Ras-ERK signaling during two pathways of angiogenesis J Cell Biol 162 2003 933 943
32. G. Han, F. Li, P. Ten Dijke, and X.J. Wang Temporal smad transgene induction in mouse epidermis accelerates skin wound healing Am J Pathol 179 2011 1768 1779
33. S.M. Chim, A. Qin, J. Tickner, N. Pavlos, T. Davey, and H. Wang EGFL6 promotes endothelial cell migration and angiogenesis through the activation of extracellular signal-regulated kinase J Biol Chem 286 2011 22035 22046
34. W.S. Kim, Y.J. Yang, H.G. Min, M.G. Song, J.S. Lee, and K.Y. Park Accelerated wound healing by S-methylmethionine sulfonium: evidence of dermal fibroblast activation via the ERK1/2 pathway Pharmacology 85 2010 68 76
35. J. Lee, K.B. Roh, S.C. Kim, J. Lee, and D. Park Soy peptide-induced stem cell proliferation: involvement of ERK and TGF-β1 J Nutr Biochem 2012 10.1016/j.jnutbio.2011.08.003
36. M.C. Mendoza, E.E. Er, and J. Blenis The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation Trends Biochem Sci 36 2011 320 328
37. C.H. Squarize, R.M. Castilho, T.H. Buqqe, and J.S. Gutkind Accelerated wound healing by mTOR activation in genetically defined mouse models PLoS One 5 2010 e10643