Nitric oxide up-regulates DNA-binding activity of nuclear factor-κB in macrophages stimulated with silica and inflammatory stimulants

Molecular and Cellular Biochemistry

Volumn 215, Issue 1-2, 2000, Pages 1-9

  Kang, J L ^a   Lee, K ^a   Castranova, V ^b  

^a Ewha Womans University School of Medicine   (South Korea)

^b NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH   (United States)

Author keywords

Macrophages; Nitric oxide; Nuclear factor kappa B; Silica; Transcription factor

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; GENISTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LINSIDOMINE; LIPOPOLYSACCHARIDE; METALLOPORPHYRIN; MURAMYL DIPEPTIDE; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; N(G) NITROARGININE METHYL ESTER; N6 (1 IMINOETHYL)LYSINE; NITRIC OXIDE; NITROPRUSSIDE SODIUM; PROTEIN KINASE C INHIBITOR; PROTEIN TYROSINE KINASE; REACTIVE OXYGEN METABOLITE; SILICON DIOXIDE; STAUROSPORINE; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; AUTORADIOGRAPHY; CELL CULTURE; CELL PROLIFERATION; CONTROLLED STUDY; DNA BINDING; DOSE RESPONSE; ELECTROPHORETIC MOBILITY; INFLAMMATION; LUNG ALVEOLUS MACROPHAGE; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; PATHOGENESIS; PERITONEUM MACROPHAGE; PNEUMOCONIOSIS; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SILICOSIS;

ACETYLMURAMYL-ALANYL-ISOGLUTAMINE; ADJUVANTS, IMMUNOLOGIC; ANIMALS; CELL LINE; CELL NUCLEUS; CELLS, CULTURED; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; GENISTEIN; ISOQUINOLINES; LIPOPOLYSACCHARIDES; LYSINE; MACROPHAGES; MACROPHAGES, ALVEOLAR; MALE; MICE; MOLSIDOMINE; NF-KAPPA B; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRITES; NITROPRUSSIDE; PHAGOCYTOSIS; PROTEIN BINDING; PROTEIN KINASE C; PROTEIN-TYROSINE KINASES; RATS; RATS, SPRAGUE-DAWLEY; SILICON DIOXIDE; STAUROSPORINE; SULFONAMIDES; TYRPHOSTINS; UP-REGULATION;

ANIMALIA;

EID: 0034507984     PISSN: 03008177     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1026581301366     Document Type: Article

References (37)

1. Diseases associated with exposure to silica and non-fibrous silicate minerals
2. Silica and lung cancer
3. Carcinogenesis by crystalline silica: Animal, cellular, and molecular studies
4. How silicosis and coal workers' pneumoconiosis develop: A cellular assessment
5. Reactive oxygen species and silica-induced carcinogenesis
6. New insights into the role of nuclear factor-κB, a ubiquitous transcription factor in the initiation of diseases
7. A pivotal transcription factor in chronic inflammatory diseases
8. IκB: A specific inhibitor of the NF-κB transcription factor
9. Role of hydroxyl radical in silica-induced NF-κB activation in macrophages
10. Silica-induced nuclear factor-κB activation: Involvement of reactive oxygen species and protein tyrosine kinase activation
11. Silica-induced pulmonary inflammation in rats: Activation of NF-kappa B and its suppression by dexamethasone
12. Oxidant release from pulmonary phagocytes
13. Antioxidant properties of aspirin: Characterization of the ability of aspirin to inhibit silica-induced lipid peroxidation, DNA damage, NF-κB activation and TNFα production
14. Intratracheal instillation of silica up-regulates inducible nitric oxide synthase gene expression and increases nitric oxide production in alveolar macrophages and neutrophils
15. Inducible nitric oxide synthase mRNA expression and nitric oxide production in silica-induced acute inflammatory lung injury
16. Comparison of inducible nitric oxide synthase gene expression and lung inflammation following intratracheal instillation of silica, coal, carbonyl iron, or titanium dioxide in rats
17. Dependence and reversal of nitric oxide production on NF-κB in silica and lipopolysaccharide-induced macrophages
18. Activation of human peripheral blood mononuclear cells by nitric oxide-generating compounds
19. Factors which affect superoxide anion release from rat alveolar macrophages
20. Pulmonary responses of guinea pigs to consecutive exposures to cotton dust
21. Human T-cell leukemia virus type I Tax activation of NF-κB/Rel involves phosphorylation and degradation of IκB and Rel A(p65)-mediated induction of the c-rel gene
22. Regulation of nitric oxide production by rat alveolar macrophages in response to silica exposure
23. Metalloporphyrins inhibit nitric oxide-dependent cGMP formation in vivo
24. Regulation of soluble guanylate cyclase activity by porphyrins and metalloporphyrins
25. Characterization of the cytoprotective action of peroxynitrite decomposition catalysts
26. Co-stimulatory effect of nitric oxide on endothelial NF-kappa B implies a physiological self-amplifying mechanism
27. A role for oxygen radicals as second messengers
28. Nitric oxide signaling: A possible role for G proteins
29. ras
30. Essential role of NF-kappa B activation in silica-induced inflammatory mediator production in macrophages
31. Nitric oxide blocks nuclear factor kappa B activation in alveolar macrophages
32. Induction and stabilization of IκBα by nitric oxide mediates inhibition of NF-κB
33. Inhibition of NF-κB DNA binding by nitric oxide
34. Dual effect of nitric oxide donors on cyclooxygenase-2 expression in human mesangial cells
35. Enhancement of nitric oxide production by pulmonary cells following silica exposure
36. Quantifying cellular oxidative stress by dichlorofluorescein assay using microplate reader
37. Administration of SIN-1 induces guinea pig airway hyperresponsiveness through inactivation of airway neutral endopeptidase