Fraxinellone inhibits lipopolysaccharide-induced inducible nitric oxide synthase and cyclooxygenase-2 expression by negatively regulating nuclear factor-kappa B in RAW 264.7 macrophages cells

Biological and Pharmaceutical Bulletin

Volumn 32, Issue 6, 2009, Pages 1062-1068

  Kim, Jong Hwan ^a   Park, Young Mi ^a   Shin, Ji Sun ^a   Park, Seung Jae ^a   Choi, Jung Hye ^a   Jung, Hyun Ju ^b   Park, Hee Juhn ^c   Lee, Kyung Tae ^a  

^a Kyung Hee University   (South Korea)

^b Wonkwang University   (South Korea)

^c Sangji University   (South Korea)

Author keywords

Cyclooxygenase 2; Dictamnus dasycarpus; Fraxinellone; Inducible nitric oxide synthase; Nuclear factor B

Indexed keywords

ANTIINFLAMMATORY AGENT; CYCLOOXYGENASE 2; FRAXINELLONE; HERBACEOUS AGENT; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; LIMONOID; LIPOPOLYSACCHARIDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; MITOGEN ACTIVATED PROTEIN KINASE KINASE 7; MITOGEN ACTIVATED PROTEIN KINASE P38; PROSTAGLANDIN E2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BARK; BINDING AFFINITY; DICTAMNUS; DNA BINDING; DOSE RESPONSE; DOWN REGULATION; DRUG MECHANISM; DRUG STRUCTURE; IMMUNOPRECIPITATION; INFLAMMATION; MACROPHAGE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; BENZOFURANS; BLOTTING, WESTERN; CELL LINE; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; DICTAMNUS; DINOPROSTONE; ELECTROPHORETIC MOBILITY SHIFT ASSAY; ENZYME INHIBITORS; IMMUNOPRECIPITATION; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PLANT ROOTS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 66649137173     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.32.1062     Document Type: Article

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