Effect of a selective progesterone receptor modulator on induction of apoptosis in uterine fibroids in vivo

International Journal of Endocrinology

Volumn 2012, Issue , 2012, Pages

  Horak, Petr ^a   Mara, Michal ^a   Dundr, Pavel ^a   Kubinova, Kristyna ^a   Kuzel, David ^a   Hudecek, Robert ^b   Chmel, Roman ^a  

^a CHARLES UNIVERSITY   (Czech Republic)

^b UNIVERSITY HOSPITAL BRNO   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

AVIDIN; BIOTIN; CASPASE 3; CASPASE 3 ANTIBODY; ENZYME ANTIBODY; FERROUS SULFATE; TRIPTORELIN; ULIPRISTAL; UNCLASSIFIED DRUG;

ADULT; APOPTOSIS; ARTICLE; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; FEMALE; HORMONAL THERAPY; HUMAN; HUMAN TISSUE; HYSTERECTOMY; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; MYOMECTOMY; PREMENOPAUSE; PRIORITY JOURNAL; PROTEIN CLEAVAGE; TREATMENT DURATION; UTERUS MYOMA;

EID: 84864913327     PISSN: 16878337     EISSN: 16878345     Source Type: Journal    
DOI: 10.1155/2012/436174     Document Type: Article

References (47)

1. Wallach E. E., Vlahos N. F., Uterine myomas: an overview of development, clinical features, and management Obstetrics and Gynecology 2004 104 2 393 406 (Pubitemid 40458890)
2. Arici A., Sozen I., Expression, menstrual cycle-dependent activation, and bimodal mitogenic effect of transforming growth factor- 1 in human myometrium and leiomyoma American Journal of Obstetrics and Gynecology 2003 188 1 76 83 (Pubitemid 36135601)
3. Marshall L. M., Spiegelman D., Barbieri R. L., Goldman M. B., Manson J. E., Colditz G. A., Willett W. C., Hunter D. J., Variation in the incidence of uterine leiomyoma among premenopausal women by age and race Obstetrics and Gynecology 1997 90 6 967 973 (Pubitemid 27510139)
4. Maruo T., Matsuo H., Shimomura Y., Kurachi O., Gao Z., Nakago S., Yamada T., Chen W., Wang J., Effects of progesterone on growth factor expression in human uterine leiomyoma Steroids 2003 68 1013 817 824 (Pubitemid 37532405)
5. Sozen I., Arici A., Cellular biology of myomas: interaction of sex steroids with cytokines and growth factors Obstetrics and Gynecology Clinics of North America 2006 33 1 41 58
6. Toro J. R., Nickerson M. L., Wei M. H., Warren M. B., Glenn G. M., Turner M. L., Stewart L., Duray P., Tourre O., Sharma N., Choyke P., Stratton P., Merino M., Walther M. M., Linehan W. M., Schmidt L. S., Zbar B., Mutations in the fumarate hydratase gene cause hereditary leiomyomatosis and renal cell cancer in families in North America American Journal of Human Genetics 2003 73 1 95 106 (Pubitemid 36793783)
7. Walker C. L., Role of hormonal and reproductive factors in the etiology and treatment of uterine leiomyoma Recent Progress in Hormone Research 2002 57 277 294
8. Nieman L. K., Blocker W., Nansel T., Mahoney S., Reynolds J., Blithe D., Wesley R., Armstrong A., Efficacy and tolerability of CDB-2914 treatment for symptomatic uterine fibroids: a randomized, double-blind, placebo-controlled, phase IIb study Fertility and Sterility 2011 95 2 767.e2 772.e2
9. Wilkens J., Chwalisz K., Han C., Walker J., Cameron I. T., Ingamells S., Lawrence A. C., Lumsden M. A., Hapangama D., Williams A. R. W., Critchley H. O. D., Effects of the selective progesterone receptor modulator asoprisnil on uterine artery blood flow, ovarian activity, and clinical symptoms in patients with uterine leiomyomata scheduled for hysterectomy Journal of Clinical Endocrinology and Metabolism 2008 93 12 4664 4671
10. Chen W., Ohara N., Wang J., Xu Q., Liu J., Morikawa A., Sasaki H., Yoshida S., Demanno D. A., Chwalisz K., Maruo T., A novel selective progesterone receptor modulator asoprisnil (J867) inhibits proliferation and induces apoptosis in cultured human uterine leiomyoma cells in the absence of comparable effects on myometrial cells Journal of Clinical Endocrinology and Metabolism 2006 91 4 1296 1304
11. Donnez J., Tatarchuk T. F., Bouchard P., Ulipristal acetate versus placebo for fibroid treatment prior to surgery The New England Journal of Medicine 2012 366 5 409 420
12. Higham J. M., O'Brien P. M. S., Shaw R. W., Assessment of menstrual blood loss using a pictorial chart British Journal of Obstetrics and Gynaecology 1990 97 8 734 739 (Pubitemid 20263124)
13. Janssen C. A. H., Scholten P. C., Heintz A. P. M., A simple visual assessment technique to discriminate between menorrhagia and normal menstrual blood loss Obstetrics and Gynecology 1995 85 6 977 982
14. Burroughs K. D., Fuchs-Young R., Davis B., Walker C. L., Altered hormonal responsiveness of proliferation and apoptosis during myometrial maturation and the development of uterine leiomyomas in the rat Biology of Reproduction 2000 63 5 1322 1330
15. Khan K. N., Kitajima M., Hiraki K., Fujishita A., Sekine I., Ishimaru T., Masuzaki H., Changes in tissue inflammation, angiogenesis and apoptosis in endometriosis, adenomyosis and uterine myoma after GnRH agonist therapy Human Reproduction 2010 25 3 642 653
16. Liu W. M., Laparoscopic bipolar coagulation of uterine vessels to treat symptomatic leiomyomas Journal of the American Association of Gynecologic Laparoscopists 2000 7 1 125 129
17. Ravina J. H., Herbreteau D., Ciraru-Vigneron N., Bouret J. M., Houdart E., Aymard A., Merland J. J., Arterial embolisation to treat uterine myomata The Lancet 1995 346 8976 671 672
18. Recaldini C., Carrafiello G., Lagan D., Cuffari S., Bergamini V., Ghezzi F., Fugazzola C., Percutaneous sonographically guided radiofrequency ablation of medium-sized fibroids: feasibility study American Journal of Roentgenology 2007 189 6 1303 1306 (Pubitemid 350174783)
19. Stewart E. A., Gedroyc W. M. W., Tempany C. M. C., Quade B. J., Inbar Y., Ehrenstein T., Shushan A., Hindley J. T., Goldin R. D., David M., Sklair M., Rabinovici J., Focused ultrasound treatment of uterine fibroid tumors: safety and feasibility of a noninvasive thermoablative technique American Journal of Obstetrics and Gynecology 2003 189 1 48 54 (Pubitemid 36886523)
20. Eisinger S. H., Meldrum S., Fiscella K., Le Roux H. D., Guzick D. S., Low-dose mifepristone for uterine leiomyomata Obstetrics and Gynecology 2003 101 2 243 250 (Pubitemid 36170124)
21. Chegini N., Ma C., Tang X. M., Williams R. S., Effects of GnRH analogues, add-back steroid therapy, antiestrogen and antiprogestins on leiomyoma and myometrial smooth muscle cell growth and transforming growth factor- expression Molecular Human Reproduction 2002 8 12 1071 1078 (Pubitemid 36032844)
22. Maruo T., Ohara N., Matsuo H., Xu Q., Chen W., Sitruk-Ware R., Johansson E. D. B., Effects of levonorgestrel-releasing IUS and progesterone receptor modulator PRM CDB-2914 on uterine leiomyomas Contraception 2007 75 6 S99 S103
23. Olive D. L., Lindheim S. R., Pritts E. A., Non-surgical management of leiomyoma: impact on fertility Current Opinion in Obstetrics and Gynecology 2004 16 3 239 243 (Pubitemid 38703839)
24. Rackow B. W., Arici A., Options for medical treatment of myomas Obstetrics and Gynecology Clinics of North America 2006 33 1 97 113
25. Shozu M., Murakami K., Segawa T., Kasai T., Inoue M., Successful treatment of a symptomatic uterine leiomyoma in a perimenopausal woman with a nonsteroidal aromatase inhibitor Fertility and Sterility 2003 79 3 628 631 (Pubitemid 36293465)
26. De Leo V., Morgante G., La Marca A., Concetta Musacchio M., Sorace M., Cavicchioli C., Petraglia F., A benefit-risk assessment of medical treatment for uterine leiomyomas Drug Safety 2002 25 11 759 779 (Pubitemid 35178633)
27. Golan A., Bukovsky I., Pansky M., Schneider D., Weinraub Z., Caspi E., Pre-operative gonadotrophin-releasing hormone agonist treatment in surgery for uterine leiomyomata Human Reproduction 1993 8 3 450 452 (Pubitemid 23106827)
28. Lethaby A., Vollenhoven B., Sowter M., Efficacy of pre-operative gonadotrophin hormone releasing analogues for women with uterine fibroids undergoing hysterectomy or myomectomy: a systematic review An International Journal of Obstetrics and Gynaecology 2002 109 10 1097 1108 (Pubitemid 35287078)
29. Manyonda I., Sinthamoney E., Belli A. M., Controversies and challenges in the modern management of uterine fibroids An International Journal of Obstetrics and Gynaecology 2004 111 2 95 102 (Pubitemid 38186796)
30. Fujimoto J., Ichigo S., Hori M., Nishigaki M., Tamaya T., Expression of progesterone receptor form A and B mRNAs in gynecologic malignant tumors Tumor Biology 1995 16 4 254 260
31. Chrapusta S., Sieinski W., Konopka B., Szamborski J., Paszko Z., Estrogen and progestin receptor levels in uterine leiomyomata: relation to the tumour histology and the phase of menstrual cycle European Journal of Gynaecological Oncology 1990 11 5 381 387
32. Kawaguchi K., Fujii S., Konishi I., Nanbu Y., Nonogaki H., Mori T., Mitotic activity in uterine leiomyomas during the menstrual cycle American Journal of Obstetrics and Gynecology 1989 160 3 637 641 (Pubitemid 19092150)
33. DeManno D., Elger W., Garg R., Lee R., Schneider B., Hess-Stumpp H., Schubert G., Chwalisz K., Asoprisnil (J867): a selective progesterone receptor modulator for gynecological therapy Steroids 2003 68 1013 1019 1032 (Pubitemid 37532427)
34. Murphy A. A., Morales A. J., Kettel L. M., Yen S. S. C., Regression of uterine leiomyomata to the antiprogesterone RU486: dose- response effect Fertility and Sterility 1995 64 1 187 190
35. Bagaria M., Suneja A., Vaid N. B., Guleria K., Mishra K., Low-dose mifepristone in treatment of uterine leiomyoma: a randomised double-blind placebo-controlled clinical trial Australian and New Zealand Journal of Obstetrics and Gynaecology 2009 49 1 77 83
36. Wilkens J., Williams A. R. W., Chwalisz K., Han C., Cameron I. T., Critchley H. O. D., Effect of asoprisnil on uterine proliferation markers and endometrial expression of the tumour suppressor gene, PTEN Human Reproduction 2009 24 5 1036 1044
37. Williams A. R. W., Critchley H. O. D., Osei J., Ingamells S., Cameron I. T., Han C., Chwalisz K., The effects of the selective progesterone receptor modulator asoprisnil on the morphology of uterine tissues after 3 months treatment in patients with symptomatic uterine leiomyomata Human Reproduction 2007 22 6 1696 1704 (Pubitemid 47061342)
38. Maruo T., Ohara N., Yoshida S., Nakabayashi K., Sasaki H., Xu Q., Chen W., Yamada H., Translational research with progesterone receptor modulator motivated by the use of levonorgestrel-releasing intrauterine system Contraception 2010 82 5 435 441
39. Yin P., Lin Z., Cheng Y. H., Marsh E. E., Utsunomiya H., Ishikawa H., Xue Q., Reierstad S., Innes J., Thung S., Kim J. J., Xu E., Bulun S. E., Progesterone receptor regulates Bcl-2 gene expression through direct binding to its promoter region in uterine leiomyoma cells Journal of Clinical Endocrinology and Metabolism 2007 92 11 4459 4466 (Pubitemid 350074770)
40. Yoshida S., Ohara N., Xu Q., Chen W., Wang J., Nakabayashi K., Sasaki H., Morikawa A., Maruo T., Cell-type specific actions of progesterone receptor modulators in the regulation of uterine leiomyoma growth Seminars in Reproductive Medicine 2010 28 3 260 273
41. Martel K. M., Ko A. C., Christman G. M., Stribley J. M., Apoptosis in human uterine leiomyomas Seminars in Reproductive Medicine 2004 22 2 91 103 (Pubitemid 38691952)
42. Duan W. R., Gamer D. S., Williams S. D., Funckes-Shippy C. L., Spath I. S., Blomme E. A. G., Comparison of immunohistochemistry for activated caspase-3 and cleaved cytokeratin 18 with the TUNEL method for quantification of apoptosis in histological sections of PC-3 subcutaneous xenografts Journal of Pathology 2003 199 2 221 228 (Pubitemid 36176028)
43. Donnez J., Tomaszewski J., Vzquez F., PEARL II Study Group. Ulipristal acetate versus leuprolide acetate for uterine fibroids The New England Journal of Medicine 2012 366 421 432
44. Committee on Gynecologic Practice, American College of Obstetricians, Gynecologists: ACOG Committee Opinion, Uterine artery embolization Obstetrics Gynecology 2004 103 403 404
45. Kuzel D., Mara M., Horak P., Kubinova K., Maskova J., Dundr P., Cindr J., Comparative outcomes of hysteroscopic examinations performed after uterine artery embolization or laparoscopic uterine artery occlusion to treat leiomyomas Fertility and Sterility 2011 95 6 2143 2145
46. Homer H., Saridogan E., Uterine artery embolization for fibroids is associated with an increased risk of miscarriage Fertility and Sterility 2010 94 1 324 330
47. Park K. H., Kim J. Y., Shin J. S., Kwon J. Y., Koo J. S., Jeong K. A., Cho N. H., Bai S. W., Lee B. S., Treatment outcomes of uterine artery embolization and laparoscopic uterine artery ligation for uterine myoma Yonsei Medical Journal 2003 44 4 694 702