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Vercellini P, Trespidi L, Zaina B, et al. Gonadotropin-releasing hormone agonist treatment before abdominal myomectomy: a controlled trial. Fertil Steril 2003; 79:1390-1395. This study used a properly sized cohort to answer an important issue, namely the value of GnRHa prior to myomectomy.
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Bozzini N, Rodrigues CJ, Petti DA, et al. Effects of treatment with gonadotropin releasing hormone agonist on the uterine leiomyomata structure. Acta Obstet Gynecol Scand 2003; 82:330-334.
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Chegini N, Kornberg L. Gonadotropin releasing hormone analogue therapy alters signal transduction pathways involving mitogen-activated protein and focal adhesion kinases in leiomyoma. J Soc Gynecol Invest 2003; 10:21-26. This paper, along with the two below, begins to elucidate the intracellular mechanisms by which GnRHa works to reduce myoma size.
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Chegini N, Ma C, Tang XM, Williams RS. Effects of GnRH analogues, 'add-back' steroid therapy, antiestrogen and antiprogestins on leiomyoma and myometrial smooth muscle cell growth and transforming growth factor-beta expression. Mol Hum Reprod 2002; 12:1071-1078.
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Chegini N, Verala J, Luo X, et al. Gene expression profile of leiomyoma and myometrium and the effect of gonadotropin releasing hormone analogue therapy. J Soc Gynecol Invest 2003; 10:161-171. This paper describes an interesting use of gene microarrays to look for intracellular mechanisms associated with drug use.
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J Soc Gynecol Invest
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Chegini, N.1
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La Marca A, Musacchio MC, Morgante G, et al. Hemodynamic effect of danazol therapy in women with uterine leiomyomata. Fertil Steril 2003; 79:1240-1242.
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Eisinger SH, Meldrum S, Fiscella K, le Roux HD, Guzick DS. Low-dose mifepristone for uterine leiomyomata. Obstet Gynecol 2003; 101:243-250. This is the first large single armed trial of what is likely to be a number of studies on selective progesterone receptor modulators on fibroids.
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Palomba S, Russo T, Orio F, et al. Effectiveness of combined GnRH analogue plus raloxifene administration in the treatment of uterine leiomyomas: a prospective, randomized, single-blind, placebo-controlled clinical trial. Hum Reprod 2002; 17:3213-3219.
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Shozu M, Murakami K, Segawa T, et al. Successful treatment of a symptomatic uterine leiomyoma in a perimenopausal woman with a nonsteroidal aromatase inhibitor. Fertil Steril 2003; 79:628-631.
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Grigorieva V, Chen-Mok M, Tarasova M, Mikhailov A. Use of a levonorgestrel-releasing intrauterine system to treat bleeding related to uterine leiomyomas. Fertil Steril 2003; 79:1194-1198.
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Pinto I, Chimeno P, Romo A, et al. Uterine fibroids: uterine artery embolization versus abdominal hysterectomy for treatment: a prospective, randomized and controlled clinical trial. Radiology 2003; 226:425-431. This was the first randomized trial to compare hysterectomy and UAE. While the design was not ideal and the size of the study was probably too small, the results do provide important comparative insights between the two treatments.
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Radiology
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Pinto, I.1
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Pron G, Bennett J, Common A, et al. The Ontario fibroid embolization trial. Part 2. Uterine fibroid reduction and symptom relief after uterine artery embolization for fibroids. Fertil Steril 2003; 79:120-127. This and other publications by this collaborative group are the first providing prospective, multicenter information regarding UAE. The large numbers allow subgroup analyses that will aid in determining applicability of UAE to individual patients.
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Fertil Steril
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Pron, G.1
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Ryu RK, Siddiqi A, Omary RA, et al. Sonography of delayed effects of uterine artery embolization on ovarian arterial perfusion and function. AJR Am J Roentgenol 2003; 181:89-92.
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Tropeano G, Litwicka K, Di Stasi C, et al. Permanent amenorrhea associated with endometrial atrophy after uterine artery embolization for symptomatic uterine fibroids. Fertil Steril 2003; 79:132-135. This is the first report of a chilling side effect for women wishing to retain fertility after UAE.
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Fertil Steril
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Payne JF, Haney AF. Serious complications of uterine artery embolization for conservative treatment of fibroids. Fertil Steril 2003; 79:128-131.
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Am J Surg Pathol
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Fogt F, Hinds N, Zimmerman RL. Histologic features of uterine leiomyomata treated with microsphere embolization. Obstet Gynecol 2003; 102:600-602.
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Pelage J-P, Le Dref O, Beregi J-P, et al. Limited uterine artery embolization with tris-acryl gelatin microspheres for uterine fibroids. J Vasc Interv Radiol 2003; 14:15-20. This paper is a primer on microsphere usage in UAE and what is desirable.
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J Vasc Interv Radiol
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Pelage, J.-P.1
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Zupi E, Pocek M, Dauri M, et al. Selective uterine artery embolization in the management of uterine myomas. Fertil Steril 2003; 79:107-111. This technique may become more popular for single fibroid patients.
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Fertil Steril
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