Altered BCR signalling quality predisposes to autoimmune disease and a pre-diabetic state

EMBO Journal

Volumn 31, Issue 15, 2012, Pages 3363-3374

  Königsberger, Sebastian ^a   Prodöhl, Jan ^a   Stegner, David ^b   Weis, Vanessa ^a   Andreas, Martin ^a   Stehling, Martin ^a   Schumacher, Theresa ^a,c   Böhmer, Ruben ^a   Thielmann, Ina ^b   Van Eeuwijk, Judith M M ^b   Nieswandt, Bernhard ^b   Kiefer, Friedemann ^a  

^a MAX PLANCK INSTITUTE FOR MOLECULAR BIOMEDICINE   (Germany)

^b UNIVERSITY OF WÜRZBURG   (Germany)

^c UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

Author keywords

autoimmunity; B cell; Syk; Zap 70

Indexed keywords

B LYMPHOCYTE RECEPTOR; CALCIUM ION; COMPLEMENT COMPONENT C3; COMPLEMENT COMPONENT C4; CREATINE; FC RECEPTOR; GLUCOSE; INSULIN ANTIBODY; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN KINASE SYK; PROTEIN KINASE ZAP 70;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY PRODUCTION; ARTICLE; AUTOIMMUNE DISEASE; B LYMPHOCYTE; CALCIUM TRANSPORT; CELL ACTIVATION; CELL SURVIVAL; CONTROLLED STUDY; CREATINE KINASE BLOOD LEVEL; DISEASE PREDISPOSITION; ENDOCYTOSIS; ENZYME PHOSPHORYLATION; GLOMERULONEPHRITIS; GLUCOSE BLOOD LEVEL; IMPAIRED GLUCOSE TOLERANCE; IN VIVO STUDY; MACROPHAGE; MOUSE; NEUTROPHIL; NONHUMAN; NUCLEOTIDE SEQUENCE; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; THROMBOCYTE ACTIVATION; UREA NITROGEN BLOOD LEVEL; WILD TYPE;

ANIMALS; AUTOIMMUNE DISEASES; B-LYMPHOCYTES; CELLS, CULTURED; GENE KNOCK-IN TECHNIQUES; GENE REARRANGEMENT, B-LYMPHOCYTE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; PREDIABETIC STATE; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS C-BCR; SIGNAL TRANSDUCTION; ZAP-70 PROTEIN-TYROSINE KINASE;

MUS;

EID: 84864885609     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/emboj.2012.169     Document Type: Article

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