The effect of simvastatin treatment on behavioral parameters, cognitive performance, and hippocampal morphology in rats fed a standard or a high-fat diet

Behavioural Pharmacology

Volumn 23, Issue 5-6, 2012, Pages 582-592

  Can, Özgür Devrim ^a   Ulupinar, Emel ^b   Özkay, Ümide Demir ^a   Yegin, Bengi ^a   Öztürk, Yusuf ^a  

^a ANADOLU UNIVERSITY   (Turkey)

^b ESKISEHIR OSMANGAZI UNIVERSITY   (Turkey)

Author keywords

Anxiety; Cavalieri volume estimation; depression; hippocampus; maternal high fat diet; Morris water maze; optic fractionator; rat; simvastatin; stereology

Indexed keywords

ANTIDEPRESSANT AGENT; ANXIOLYTIC AGENT; CHOLESTEROL; NOOTROPIC AGENT; SIMVASTATIN; TRIACYLGLYCEROL;

AFFECTIVE PSYCHOSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDEPRESSANT ACTIVITY; ANXIETY; ARTICLE; BEHAVIOR; CHOLESTEROL BLOOD LEVEL; CLINICAL ASSESSMENT; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; DEPRESSION; DRUG EFFECT; EMOTION; EVALUATION; EXAMINATION; FORCED SWIMMING TEST; HIPPOCAMPUS; LIPID DIET; MORPHOLOGY; NONHUMAN; PERINATAL PERIOD; PRENATAL PERIOD; PYRAMIDAL NERVE CELL; RAT; STEREOLOGY; TRANQUILIZING ACTIVITY; TRIACYLGLYCEROL BLOOD LEVEL;

ANIMALS; ANTI-ANXIETY AGENTS; ANTIDEPRESSIVE AGENTS; BEHAVIOR, ANIMAL; COGNITION DISORDERS; DIET, HIGH-FAT; FEMALE; HIPPOCAMPUS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; HYPERTRIGLYCERIDEMIA; LACTATION; MALE; MATERNAL NUTRITIONAL PHYSIOLOGICAL PHENOMENA; NEUROGENESIS; NEURONS; NEUROPROTECTIVE AGENTS; NOOTROPIC AGENTS; PREGNANCY; RATS; RATS, SPRAGUE-DAWLEY; SIMVASTATIN;

EID: 84864872052     PISSN: 09558810     EISSN: 14735849     Source Type: Journal    
DOI: 10.1097/FBP.0b013e328356c3f2     Document Type: Article

References (61)

1. Abildgaard A, Solskov L, Volke V, Harvey BH, Lund S,Wegener G (2011). A highfat diet exacerbates depressive-like behavior in the Flinders Sensitive Line (FSL) rat, a genetic model of depression. Psychoneuroendocrinology 36: 623-633.
2. Akdogan I, Kocamaz E, Kucukatay V, Yonguc NG, Ozdemir MB, Murk W (2011). Hippocampal neuron number loss in rats exposed to ingested sulfite. Toxicol Ind Health 27:771-778.
3. Alexopoulos GS, Meyers BS, Young RC, Campbell S, Silbersweig D, Charlson M (1997). 'Vascular depression' hypothesis. Arch Gen Psychiatry 54:915-922.
4. Alsiö J, Roman E, Olszewski PK, Jonsson P, Fredriksson R, Levine AS, et al. (2009). Inverse association of high-fat diet preference and anxiety-like behavior: a putative role for urocortin 2. Genes Brain Behav 8:193-202.
5. Bannerman DM, Rawlins JN, McHugh SB, Deacon RM, Yee BK, Bast T, et al. (2004). Regional dissociations within the hippocampus-memory and anxiety. Neurosci Biobehav Rev 28:273-283.
6. Bilbo SD, Tsang V (2010). Enduring consequences of maternal obesity for brain inflammation and behavior of offspring. FASEB J 24:2104-2115.
7. Bouilleret V, Ridoux V, Depaulis A, Marescaux C, Nehlig A, Le Gal La Salle G (1999). Recurrent seizures and hippocampal sclerosis following intrahippocampal kainate injection in adult mice: electroencephalography, histopathology and synaptic reorganization similar to mesial temporal lobe epilepsy. Neuroscience 89:717-729.
8. Bouret SG (2010). Role of early hormonal and nutritional experiences in shaping feeding behavior and hypothalamic development. J Nutr 140:653-657.
9. Buchenauer T, Behrendt P, Bode FJ, Horn R, Brabant G, Stephan M, Nave H (2009). Diet induced obesity alters behavior as well as serum levels of corticosterone in F344 rats. Physiol Behav 98:563-569.
10. Can OD, Oztü rk Y, Ozkay UD (2011). Effects of insulin and St John's Wort treatments on anxiety, locomotory activity, depression, and active learning parameters of streptozotocin-diabetic rats. Planta Med 77:1970-1976.
11. Constantinescu E, Safciuc F, Sima AV (2011). A hyperlipidemic diet induces structural changes in cerebral blood vessels. Curr Neurovasc Res 8: 131-144.
12. Cryan JF, Markou A, Lucki I (2002). Assessing antidepressant activity in rodents: recent developments and future needs. Trends Pharmacol Sci 23:238-245.
13. Dalla Y, Singh N, Jaggi AS, Singh D (2010). Memory restorative role of statins in experimental dementia: an evidence of their cholesterol dependent and independent actions. Pharmacol Rep 62:784-796.
14. Del Rosario A, McDermott MM, Panee J (2012). Effects of a high-fat diet and bamboo extract supplement on anxiety-and depression-like neurobehaviours in mice. Br J Nutr 7:1-7.
15. Douma TN, Borre Y, Hendriksen H, Olivier B, Oosting RS (2011). Simvastatin improves learning and memory in control but not in olfactory bulbectomized rats. Psychopharmacology (Berl) 216:537-544.
16. Francis HM, Stevenson RJ (2011). Higher reported saturated fat and refined sugar intake is associated with reduced hippocampal-dependent memory and sensitivity to interoceptive signals. Behav Neurosci 125:943-955.
17. Freeman LR, Granholm AC (2012). Vascular changes in rat hippocampus following a high saturated fat and cholesterol diet. J Cereb Blood Flow Metab 32:643-653.
18. Freeman LR, Haley-Zitlin V, Stevens C, Granholm AC (2011). Diet-induced effects on neuronal and glial elements in the middle-aged rat hippocampus. Nutr Neurosci 14:32-44.
19. Granholm AC, Bimonte-Nelson HA, Moore AB, Nelson ME, Freeman LR, Sambamurti K (2008). Effects of a saturated fat and high cholesterol diet on memory and hippocampal morphology in the middle-aged rat. J Alzheimers Dis 14:133-145.
20. Grü nblatt E, Salkovic-Petrisic M, Osmanovic J, Riederer P, Hoyer S (2007). Brain insulin system dysfunction in streptozotocin intracerebroventricularly treated rats generates hyperphosphorylated tau protein. J Neurochem 101:757-770.
21. Han X, Yang N, Xu Y, Zhu J, Chen Z, Liu Z, et al. (2011). Simvastatin treatment improves functional recovery after experimental spinal cord injury by upregulating the expression of BDNF and GDNF. Neurosci Lett 487:255-259.
22. Karki K, Knight RA, Han Y, Yang D, Zhang J, Ledbetter KA, et al. (2009). Simvastatin and atorvastatin improve neurological outcome after experimental intracerebral hemorrhage. Stroke 40:3384-3389.
23. Kempermann G, Kuhn HG, Gage FH (1997). More hippocampal neurons in adult mice living in an enriched environment. Nature 386:493-495.
24. Kilic FS, Ozatik Y, Kaygsz B, Baydemir C, Erol K (2012). Acute antidepressant and anxiolytic effects of simvastatin and its mechanisms in rats. Neurosciences 17:39-43.
25. Kivipelto M, Helkala EL, Hä nninen T, Laakso MP, Hallikainen M, Alhainen K, et al. (2001). Midlife vascular risk factors and late-life mild cognitive impairment: a population-based study. Neurology 56:1683-1689.
26. Kopelman PG (2000). Obesity as a medical problem. Nature 404:635-643.
27. Li L, Cao D, Kim H, Lester R, Fukuchi K (2006). Simvastatin enhances learning and memory independent of amyloid load in mice. Ann Neurol 60:729-739.
28. Lledo PM, Alonso M, Grubb MS (2006). Adult neurogenesis and functional plasticity in neuronal circuits. Nat Rev Neurosci 7:179-193.
29. Maniam J, Morris MJ (2010a). Palatable cafeteria diet ameliorates anxiety and depression-like symptoms following an adverse early environment. Psychoneuroendocrinology 35:717-728.
30. Maniam J, Morris MJ (2010b). Voluntary exercise and palatable high-fat diet both improve behavioural profile and stress responses in male rats exposed to early life stress: role of hippocampus. Psychoneuroendocrinology 35:1553-1564.
31. Molteni R, Wu AA, Vaynman AS, Ying AZ, Barnarda RJ, Mez-Pinilla FG (2004). Exercise reverses the harmful effects of consumption of a high-fat diet on synaptic and behavioural plasticity associated to the action of brain-derived neurotrophic factor. Neuroscience 123:429-440.
32. Naef L, Moquin L, Dal BG, Giros B, Gratton A,Walker CD (2011). Maternal highfat intake alters presynaptic regulation of dopamine in the nucleus accumbens and increases motivation for fat rewards in the offspring. Neuroscience 176:225-236.
33. Niculescu MD, Lupu DS (2009). High fat diet-induced maternal obesity alters fetal hippocampal development. Int J Dev Neurosci 27:627-633.
34. Park HR, Park M, Choi J, Park KY, Chung HY, Lee J (2010). A high-fat diet impairs neurogenesis: involvement of lipid peroxidation and brain-derived neurotrophic factor. Neurosci Lett 482:235-239.
35. Parle M, Singh N (2007). Reversal of memory deficits by atorvastatin and simvastatin in rats. Yakugaku Zasshi 127:1125-1137.
36. Pawlak R, Skrzypiec A, Sulkowski S, Buczko W (2002). Ethanol-induced neurotoxicity is counterbalanced by increased cell proliferation in mouse dentate gyrus. Neurosci Lett 327:83-86.
37. Porter DW, Irwin N, Flatt PR, Hö lscher C, Gault VA (2011). Prolonged GIP receptor activation improves cognitive function, hippocampal synaptic plasticity and glucose homeostasis in high-fat fed mice. Eur J Pharmacol 650:688-693.
38. Prasad A, Prasad C (1996). Short-term consumption of a diet rich in fat decreases anxiety response in adult male rats. Physiol Behav 60: 1039-1042.
39. Rodriguez JS, Rodríguez-Gonzá lez GL, Reyes-Castro LA, Ibáñ ez C, Ramírez A, Chavira R, et al. (2012). Maternal obesity in the rat programs male offspring exploratory, learning and motivation behavior: prevention by dietary intervention pre-gestation or in gestation. Int J Dev Neurosci 30:75-81.
40. Sampath C, Holbik M, Krenn L, Butterweck V (2011). Anxiolytic effects of fractions obtained from Passiflora incarnata L. in the elevated plus-maze in mice. Phytother Res 25:789-795.
41. Sharma B, Singh N (2011). Attenuation of vascular dementia by sodium butyrate in streptozotocin diabetic rats. Psychopharmacology (Berl) 215:677-687.
42. Shepardson NE, Shankar GM, Selkoe DJ (2011). Cholesterol level and statin use in Alzheimer disease: I. Review of epidemiological and preclinical studies. Arch Neurol 68:1239-1244.
43. Sierra S, Ramos MC, Molina P, Esteo C, Vázquez JA, Burgos JS (2011). Statins as neuroprotectants: a comparative in vitro study of lipophilicity, blood-brainbarrier penetration, lowering of brain cholesterol, and decrease of neuron cell death. J Alzheimers Dis 23:307-318.
44. Stranahan AM, Cutler RG, Button C, Telljohann R, Mattson MP (2011). Dietinduced elevations in serum cholesterol are associated with alterations in hippocampal lipid metabolism and increased oxidative stress. J Neurochem 118:611-615.
45. Sullivan EL, Grayson B, Takahashi D, Robertson N, Maier A, Bethea CL, et al. (2010). Chronic consumption of a high-fat diet during pregnancy causes perturbations in the serotonergic system and increased anxiety-like behavior in nonhuman primate offspring. J Neurosci 30:3826-3830.
46. Sullivan EL, Smith MS, Grove KL (2011). Perinatal exposure to high-fat diet programs energy balance, metabolism and behavior in adulthood. Neuroendocrinology 93:1-8.
47. Tozuka Y, Kumon M,Wada E, Onodera M, Mochizuki H,Wada K (2010). Maternal obesity impairs hippocampal BDNF production and spatial learning performance in young mouse offspring. Neurochem Int 57:235-247.
48. Tufan AC, Akdogan I, Turgut G, Adiguzel E (2008). Increased tunel positive cells in CA1, CA2, and CA3 subfields of rat hippocampus due to copper and ethanol co-exposure. Int J Neurosci 118:647-656.
49. Vorhees CV, Williams MT (2006). Morris water maze: procedures for assessing spatial and related forms of learning and memory. Nat Protoc 1:848-858.
50. Vucetic Z, Kimmel J, Totoki K, Hollenbeck E, Reyes TM (2010). Maternal high-fat diet alters methylation and gene expression of dopamine and opioidrelated genes. Endocrinology 151:4756-4764.
51. Wang H, Lynch JR, Song P, Yang HJ, Yates RB, Mace B, et al. (2007). Simvastatin and atorvastatin improve behavioural outcome, reduce hippocampal degeneration, and improve cerebral blood flow after experimental traumatic brain injury. Exp Neurol 206:59-69.
52. Wang Q, Zengin A, Deng C, Li Y, Newell KA, Yang GY, et al. (2009). High dose of simvastatin induces hyperlocomotive and anxiolytic-like activities: The association with the up-regulation of NMDA receptor binding in the rat brain. Exp Neurol 216:132-138.
53. Wells BG, DiPiro JT, Schwinghammer TL, DiPiro CV (2009). Pharmacotherapy handbook. 7th ed. New York: The McGraw-Hill Companies Inc.
54. West MJ, Slomianka L, Gundersen HJ (1991). Unbiased stereological estimation of the total number of neurons in thesubdivisions of the rat hippocampus using the optical fractionator. Anat Rec 231:482-497.
55. West MJ, Slomanka L (2001). 2-D versus 3-D cell counting-a debate. What is an optical disector? Trends Neurosci 24:374author reply 378-380.
56. White CL, Pistell PJ, Purpera MN, Gupta S, Fernandez-Kim SO, Hise TL, et al. (2009). Effects of high fat diet on Morris maze performance, oxidative stress, and inflammation in rats: contributions of maternal diet. Neurobiol Dis 35: 3-13.
57. Wu A, Ying Z, Gomez-Pinilla F (2004). The interplay between oxidative stress and brain-derived neurotrophic factor modulates the outcome of a saturated fat diet on synaptic plasticity and cognition. Eur J Neurosci 19:1699-1707.
58. Wu H, Lu D, Jiang H, Xiong Y, Qu C, Li B, et al. (2008). Simvastatin-mediated upregulation of VEGF and BDNF, activation of the PI3K/Akt pathway, and increase of neurogenesis are associated with therapeutic improvement after traumatic brain injury. J Neurotrauma 25:130-139.
59. Yamada N, Katsuura G, Ochi Y, Ebihara K, Kusakabe T, Hosoda K, Nakao K (2011). Impaired CNS leptin action is implicated in depression associated with obesity. Endocrinology 152:2634-2643.
60. Young-Xu Y, Chan KA, Liao JK, Ravid S, Blatt CM (2003). Long-term statin use and psychological well-being. J Am Coll Cardiol 42:690-697.
61. Zanoli LP, Rivasi M, Zavatti M, Brusiani F, Baraldi M (2005). New insight in the neuropharmacological activity of Humulus lupulus. J Ethnopharmacol 102:102-106.