Reactive diafiltration for assembly and formulation of virus-like particles

Biochemical Engineering Journal

Volumn 68, Issue , 2012, Pages 120-128

  Liew, Mervyn W O ^a   Chuan, Yap P ^a   Middelberg, Anton P J ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Bioprocess design; Downstream processing; Process integration; Scale up; Self assembly; Virus like particles

Indexed keywords

BIOPROCESS DESIGN; DOWNSTREAM-PROCESSING; PROCESS INTEGRATION; SCALE-UP; VIRUS-LIKE PARTICLES;

DIALYSIS; MANUFACTURE; OPTIMIZATION; SELF ASSEMBLY; VIRUSES;

ASSEMBLY;

CALCIUM ION;

ARTICLE; CONTROLLED STUDY; DIAFILTRATION; DIALYSIS; METHODOLOGY; NONHUMAN; PRIORITY JOURNAL; PROCESS OPTIMIZATION; QUANTITATIVE ANALYSIS; VIRUS LIKE AGENT;

BACTERIA (MICROORGANISMS);

EID: 84864823463     PISSN: 1369703X     EISSN: 1873295X     Source Type: Journal    
DOI: 10.1016/j.bej.2012.07.009     Document Type: Article

References (44)

1. Jilg W., Schmidt M., Zoulek G., Lorbeer B., Wilske B., Deinhardt F. Clinical evaluation of a recombinant hepatitis B vaccine. Lancet 1984, 324:1174-1175.
2. Villa L.L., Costa R.L.R., Petta C.A., Andrade R.P., Ault K.A., Giuliano A.R., Wheeler C.M., Koutsky L.A., Malm C., Lehtinen M., Skjeldestad F.E., Olsson S.E., Steinwall M., Brown D.R., Kurman R., Ronnett B.M., Stoler M.H., Ferenczy A., Harper D.M., Tamms G.M., Yu J., Lupinacci L., Railkar R., Taddeo F.J., Jansen K.U., Esser M.T., Sings H.L., Saah A.J. Prophylactic quadrivalent human papillomavirus (types 6, 11, 16, and 18) L1 virus-like particle vaccine in young women: a randomised double-blind placebo-controlled multicentre phase II efficacy trial. Lancet Oncol. 2005, 6:271-278.
3. Buckland B.C. The process development challenge for a new vaccine. Nat. Med. 2005, 11:S16-S19.
4. Pattenden L.K., Middelberg A.P.J., Niebert M., Lipin D.I. Towards the preparative and large-scale precision manufacture of virus-like particles. Trends Biotechnol. 2005, 23:523-529.
5. Josefsberg J.O., Buckland B. Vaccine process technology. Biotechnol. Bioeng. 2012, 109:1443-1460.
6. Roldão A., Mellado M.C.M., Castilho L.R., Carrondo M.J.T., Alves P.M. Virus-like particles in vaccine development. Expert Rev. Vaccines 2010, 9:1149-1176.
7. Rollié S., Mangold M., Sundmacher K. Designing biological systems: systems engineering meets synthetic biology. Chem. Eng. Sci. 2012, 69:1-29.
8. Palomares L.A., Ramírez O.T. Challenges for the production of virus-like particles in insect cells: the case of rotavirus-like particles. Biochem. Eng. J. 2009, 45:158-167.
9. Liew M.W.O., Chuan Y.P., Middelberg A.P.J. High-yield and scalable cell-free assembly of virus-like particles by dilution. Biochem. Eng. J. 2012, 67:88-96.
10. Kirnbauer R., Booy F., Cheng N., Lowy D.R., Schiller J.T. Papillomavirus L1 major capsid protein self-assembles into virus-like particles that are highly immunogenic. Proc. Natl. Acad. Sci. U. S. A. 1992, 89:12180-12184.
11. Hofmann K.J., Cook J.C., Joyce J.G., Brown D.R., Schultz L.D., George H.A., Rosolowsky M., Fife K.H., Jansen K.U. Sequence determination of human papillomavirus type 6A and assembly of virus-like particles in Saccharomyces-cerevisiae. Virology 1995, 209:506-518.
12. Mach H., Volkin D.B., Troutman R.D., Wang B., Luo Z., Jansen K.U., Shi L. Disassembly and reassembly of yeast-derived recombinant human papillomavirus virus-like particles (HPV VLPs). J. Pharm. Sci. 2006, 95:2195-2206.
13. Bundy B.C., Franciszkowicz M.J., Swartz J.R. Escherichia coli-based cell-free synthesis of virus-like particles. Biotechnol. Bioeng. 2008, 100:28-37.
14. Middelberg A.P.J., Rivera-Hernandez T., Wibowo N., Lua L.H.L., Fan Y., Magor G., Chang C., Chuan Y.P., Good M.F., Batzloff M.R. A microbial platform for rapid and low-cost virus-like particle and capsomere vaccines. Vaccine 2011, 29:7154-7162.
15. Salunke D.M., Caspar D.L.D., Garcea R.L. Self-assembly of purified polyomavirus capsid protein-VP1. Cell 1986, 46:895-904.
16. Chuan Y.P., Lua L.H.L., Middelberg A.P.J. High-level expression of soluble viral structural protein in Escherichia coli. J. Biotechnol. 2008, 134:64-71.
17. Liew M.W.O., Rajendran A., Middelberg A.P.J. Microbial production of virus-like particle vaccine protein at gram-per-litre levels. J. Biotechnol. 2010, 150:224-231.
18. Ding Y., Chuan Y.P., He L.Z., Middelberg A.P.J. Modeling the competition between aggregation and self-assembly during virus-like particle processing. Biotechnol. Bioeng. 2010, 107:550-560.
19. 2+-triggered switch in the thermodynamic attraction between structural protein capsomeres. J. R. Soc. Interface 2010, 7:409-421.
20. Gleiter S., Lilie H. Coupling of antibodies via protein Z on modified polyoma virus-like particles. Protein Sci. 2001, 10:434-444.
21. Rayment I., Baker T.S., Caspar D.L.D., Murakami W.T. Polyoma-virus capsid structure at 22.5-A resolution. Nature 1982, 295:110-115.
22. Salunke D.M., Caspar D.L.D., Garcea R.L. Polymorphism in the assembly of polyomavirus capsid protein VP1. Biophys. J. 1989, 56:887-900.
23. Hanslip S.J., Zaccai N.R., Middelberg A.P.J., Falconer R.J. Assembly of human papillomavirus type-16 virus-like particles: multifactorial study of assembly and competing aggregation. Biotechnol. Prog. 2006, 22:554-560.
24. vanReis R., Goodrich E.M., Yson C.L., Frautschy L.N., Dzengeleski S., Lutz H. Linear scale ultrafiltration. Biotechnol. Bioeng. 1997, 55:737-746.
25. Russell B.J., Velez J.O., Laven J.J., Johnson A.J., Chang G.-J.J., Johnson B.W. A comparison of concentration methods applied to non-infectious flavivirus recombinant antigens for use in diagnostic serological assays. J. Virol. Methods 2007, 145:62-70.
26. Wickramasinghe S.R., Kalbfuss B., Zimmermann A., Thom V., Reichl U. Tangential flow microfiltration and ultrafiltration for human influenza A virus concentration and purification. Biotechnol. Bioeng. 2005, 92:199-208.
27. Chen X.S., Casini G., Harrison S.C., Garcea R.L. Papillomavirus capsid protein expression in Escherichia coli: purification and assembly of HPV11 and HPV16 L1. J. Mol. Biol. 2001, 307:173-182.
28. Wibowo N., Chuan Y.P., Lua L.H.L., Middelberg A.P.J. Modular engineering of a microbially-produced viral capsomere vaccine for influenza. Chem. Eng. Sci. 2012, 10.1016/j.ces.2012.04.001.
29. Lipin D.I., Lua L.H.L., Middelberg A.P.J. Quaternary size distribution of soluble aggregates of glutathione-S-transferase-purified viral protein as determined by asymmetrical flow field flow fractionation and dynamic light scattering. J. Chromatogr. A 2008, 1190:204-214.
30. Yuan Y., Shane E., Oliver C.N. Reversed-phase high-performance liquid chromatography of virus-like particles. J. Chromatogr. A 1998, 816:21-28.
31. Chuan Y.P., Fan Y.Y., Lua L., Middelberg A.P.J. Quantitative analysis of virus-like particle size and distribution by field-flow fractionation. Biotechnol. Bioeng. 2008, 99:1425-1433.
32. Lo C.T., Jahn A., Locascio L.E., Vreeland W.N. Controlled self-assembly of monodisperse niosomes by microfluidic hydrodynamic focusing. Langmuir 2010, 26:8559-8566.
33. ElSawy K.M., Caves L.S.D., Twarock R. Polyomaviridae assembly polymorphism from an energy landscape perspective. Comput. Math. Methods Med. 2008, 9:245-256.
34. Kim K.J., Chen V., Fane A.G. Some factors determining protein aggregation during ultrafiltration. Biotechnol. Bioeng. 1993, 42:260-265.
35. Zlotnick A., Johnson J.M., Wingfield P.W., Stahl S.J., Endres D. A theoretical model successfully identifies features of hepatitis B virus capsid assembly. Biochemistry 1999, 38:14644-14652.
36. Adamec T., Palkova Z., Velkova K., Stokrova J., Forstova J. Point mutation in calcium-binding domain of mouse polyomavirus VP1 protein does not prevent virus-like particle formation, but changes VP1 interactions with Saccharomyces cerevisiae cell structures. FEMS Yeast Res. 2005, 5:331-340.
37. Schmidt U., Rudolph R., Bohm G. Mechanism of assembly of recombinant murine polyomavirus-like particles. J. Virol. 2000, 74:1658-1662.
38. Nilsson J., Miyazaki N., Xing L., Wu B.M., Hammar L., Li T.C., Takeda N., Miyamura T., Cheng R.H. Structure and assembly of a T=1 virus-like particle in BK polyomavirus. J. Virol. 2005, 79:5337-5345.
39. Chen P.L., Wang M.L., Ou W.C., Lii C.K., Chen L.S., Chang D.C. Disulfide bonds stabilize JC virus capsid-like structure by protecting calcium ions from chelation. FEBS Lett. 2001, 500:109-113.
40. Yin Y., Zhang J., Dong D.Y., Liu S.L., Guo Q., Song X.H., Li G.L., Fu L., Xu J.J., Chen W. Chimeric hepatitis B virus core particles carrying an epitope of anthrax protective antigen induce protective immunity against Bacillus anthracis. Vaccine 2008, 26:5814-5821.
41. Gedvilaite A., Zvirbliene A., Staniulis Z., Sasnauskas K., Kruger D.H., Ulrich R. Segments of puumala hantavirus nucleocapsid protein inserted into chimeric polyomavirus-derived virus-like particles induce a strong immune response in mice. Viral Immunol. 2004, 17:51-68.
42. Yamanaka S., Hashimoto M., Tobe M., Kobayashi K., Sekizawa J., Nishimura M. A simple method for screening assessment of acute toxicity of chemicals. Arch. Toxicol. 1990, 64:262-268.
43. Shi L., Sanyal G., Ni A., Luo Z., Doshna S., Wang B., Graham T.L., Wang N., Volkin D.B. Stabilization of human papillomavirus virus-like particles by non-ionic surfactants. J. Pharm. Sci. 2005, 94:1538-1551.
44. 2+-EDTA interactions: calorimetric study. Biophys. Chem. 1999, 79:117-127.