Chemotherapeutic agents enhance cell migration and epithelial-to- mesenchymal transition through transient up-regulation of tNOX (ENOX2) protein

Biochimica et Biophysica Acta - General Subjects

Volumn 1820, Issue 11, 2012, Pages 1744-1752

  Su, Yu Ching ^a   Lin, Yu Han ^a   Zeng, Zih Ming ^a   Shao, Kuo Ning ^b   Chueh, Pin Ju ^a  

^a NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^b Taichung Hospital   (Taiwan)

Author keywords

Doxorubicin; Epithelial to mesenchymal transition (EMT); Migration; Tamoxifen; Tumor associated NADH oxidase (tNOX ENOX2)

Indexed keywords

DOXORUBICIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE; TAMOXIFEN; TUMOR ASSOCIATED REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE 2; UNCLASSIFIED DRUG;

ANALYZER; ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CARCINOMA CELL; CELL MIGRATION; CELL TYPE; CONTROLLED STUDY; DOWN REGULATION; EPITHELIAL MESENCHYMAL TRANSITION; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE INDUCTION; GENE OVEREXPRESSION; GENETIC ASSOCIATION; GENETIC CORRELATION; GENETIC GAIN; HUMAN; HUMAN CELL; IN VITRO STUDY; LUNG CARCINOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRANSIENT EXPRESSION; UPREGULATION; WESTERN BLOTTING;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL MOVEMENT; DOXORUBICIN; EPITHELIAL-MESENCHYMAL TRANSITION; HUMANS; MICE; NADH, NADPH OXIDOREDUCTASES; OXIDATIVE STRESS; TAMOXIFEN; UP-REGULATION;

EID: 84864809126     PISSN: 03044165     EISSN: 18728006     Source Type: Journal    
DOI: 10.1016/j.bbagen.2012.07.009     Document Type: Article

References (39)

1. M. Bruno, A.O. Brightman, J. Lawrence, D. Werderitsh, D.M. Morré, and D.J. Morré Stimulation of NADH oxidase activity from rat liver plasma membranes by growth factors and hormones is decreased or absent with hepatoma plasma membranes Biochem. J. 284 Pt 3 1992 625 628
2. P.J. Chueh Cell membrane redox systems and transformation Antioxid. Redox Signal. 2 2000 177 187
3. P.J. Chueh, C. Kim, N. Cho, D.M. Morré, and D.J. Morré Molecular cloning and characterization of a tumor-associated, growth-related, and time-keeping hydroquinone (NADH) oxidase (tNOX) of the HeLa cell surface Biochemistry 41 2002 3732 3741
4. D.J. Morré NADH oxidase: a multifunctional ectoprotein of the eukaryotic cell surface H. Asard, A. Bérczi, R. Caubergs, Plasma Membrane Redox Systems and their Role in Biological Stress and Disease 1998 Kluwer Academic Publishers Dordrecht, the Netherlands 121 1561
5. D.J. Morré, P.J. Chueh, and D.M. Morré Capsaicin inhibits preferentially the NADH oxidase and growth of transformed cells in culture Proc. Natl. Acad. Sci. U. S. A. 92 1995 1831 1835
6. C.F. Chen, S. Huang, S.C. Liu, and P.J. Chueh Effect of polyclonal antisera to recombinant tNOX protein on the growth of transformed cells Biofactors 28 2006 119 133
7. L.C. Mao, H.M. Wang, Y.Y. Lin, T.K. Chang, Y.H. Hsin, and P.J. Chueh Stress-induced down-regulation of tumor-associated NADH oxidase during apoptosis in transformed cells FEBS Lett. 582 2008 3445 3450
8. D.J. Morré, A. Bridge, L.Y. Wu, and D.M. Morré Preferential inhibition by (-)-epigallocatechin-3-gallate of the cell surface NADH oxidase and growth of transformed cells in culture Biochem. Pharmacol. 60 2000 937 946
9. P.J. Chueh, D.J. Morré, F.E. Wilkinson, J. Gibson, and D.M. Morré A 33.5-kDa heat- and protease-resistant NADH oxidase inhibited by capsaicin from sera of cancer patients Arch. Biochem. Biophys. 342 1997 38 47
10. D.J. Morré, and T. Reust A circulating form of NADH oxidase activity responsive to the antitumor sulfonylurea N-4-(methylphenylsulfonyl)- N′-(4-chlorophenyl)urea (LY181984) specific to sera from cancer patients J. Bioenerg. Biomembr. 29 1997 281 289
11. D.J. Morré, S. Caldwell, A. Mayorga, L.Y. Wu, and D.M. Morré NADH oxidase activity from sera altered by capsaicin is widely distributed among cancer patients Arch. Biochem. Biophys. 342 1997 224 230
12. D.J. Morré, P.J. Chueh, K. Yagiz, A. Balicki, C. Kim, and D.M. Morré ECTO-NOX target for the anticancer isoflavene phenoxodiol Oncol. Res. 16 2007 299 312
13. K.L. Hedges, D.M. Morré, L.Y. Wu, and D.J. Morré Adriamycin tolerance in human mesothelioma lines and cell surface NADH oxidase Life Sci. 73 2003 1189 1198
14. D.J. Morré, C. Kim, M. Paulik, D.M. Morré, and W.P. Faulk Is the drug-responsive NADH oxidase of the cancer cell plasma membrane a molecular target for adriamycin? J. Bioenerg. Biomembr. 29 1997 269 280
15. H.M. Wang, S.M. Chuang, Y.C. Su, Y.H. Li, and P.J. Chueh Down-regulation of tumor-associated NADH oxidase, tNOX (ENOX2), enhances capsaicin-induced inhibition of gastric cancer cell growth Cell Biochem. Biophys. 61 2011 355 366
16. S.C. Liu, J.J. Yang, K.N. Shao, and P.J. Chueh RNA interference targeting tNOX attenuates cell migration via a mechanism that involves membrane association of Rac Biochem. Biophys. Res. Commun. 365 2008 672 677
17. P.J. Chueh, L.Y. Wu, D.M. Morré, and D.J. Morré tNOX is both necessary and sufficient as a cellular target for the anticancer actions of capsaicin and the green tea catechin (-)-epigallocatechin-3-gallate Biofactors 20 2004 235 249
18. C.H. Hou, Y.C. Chiang, Y.C. Fong, and C.H. Tang WISP-1 increases MMP-2 expression and cell motility in human chondrosarcoma cells Biochem. Pharmacol. 81 2011 1286 1295
19. M.A. Dwyer, J.D. Joseph, H.E. Wade, M.L. Eaton, R.S. Kunder, D. Kazmin, C.Y. Chang, and D.P. McDonnell WNT11 expression is induced by estrogen-related receptor alpha and beta-catenin and acts in an autocrine manner to increase cancer cell migration Cancer Res. 70 2010 9298 9308
20. H. Wang, M.T. Teh, Y. Ji, V. Patel, S. Firouzabadian, A.A. Patel, J.S. Gutkind, and W.A. Yeudall EPS8 upregulates FOXM1 expression, enhancing cell growth and motility Carcinogenesis 31 2010 1132 1141
21. S. Pendyala, I.A. Gorshkova, P.V. Usatyuk, D. He, A. Pennathur, J.D. Lambeth, V.J. Thannickal, and V. Natarajan Role of Nox4 and Nox2 in hyperoxia-induced reactive oxygen species generation and migration of human lung endothelial cells Antioxid. Redox Signal. 11 2009 747 764
22. Y.F. Kuo, Y.Z. Su, Y.H. Tseng, S.Y. Wang, H.M. Wang, and P.J. Chueh Flavokawain B, a novel chalcone from Alpinia pricei Hayata with potent apoptotic activity: involvement of ROS and GADD153 upstream of mitochondria-dependent apoptosis in HCT116 cells Free Radic. Biol. Med. 49 2010 214 226
23. H.M. Wang, P.J. Chueh, S.P. Chang, C.L. Yang, and K.N. Shao Effect of capsaicin on tNOX (ENOX2) protein expression in stomach cancer cells Biofactors 34 2009 209 217
24. N. Ke, X. Wang, X. Xu, and Y.A. Abassi The xCELLigence system for real-time and label-free monitoring of cell viability Methods Mol. Biol. 740 2011 33 43
25. H. Ungefroren, S. Sebens, S. Groth, F. Gieseler, and F. Fandrich Differential roles of Src in transforming growth factor-ss regulation of growth arrest, epithelial-to-mesenchymal transition and cell migration in pancreatic ductal adenocarcinoma cells Int. J. Oncol. 38 2011 797 805
26. H. Hugo, M.L. Ackland, T. Blick, M.G. Lawrence, J.A. Clements, E.D. Williams, and E.W. Thompson Epithelial-mesenchymal and mesenchymal-epithelial transitions in carcinoma progression J. Cell. Physiol. 213 2007 374 383
27. T.H. Lee, L.Y. Chuang, and W.C. Hung Tamoxifen induces p21WAF1 and p27KIP1 expression in estrogen receptor-negative lung cancer cells Oncogene 18 1999 4269 4274
28. R.L. Sutherland, R.E. Hall, and I.W. Taylor Cell proliferation kinetics of MCF-7 human mammary carcinoma cells in culture and effects of tamoxifen on exponentially growing and plateau-phase cells Cancer Res. 43 1983 3998 4006
29. J.H. Kang, K.H. Song, K.C. Jeong, S. Kim, C. Choi, C.H. Lee, and S.H. Oh Involvement of Cox-2 in the metastatic potential of chemotherapy-resistant breast cancer cells BMC Cancer 11 2011 334
30. J.M. Knowlden, I.R. Hutcheson, H.E. Jones, T. Madden, J.M. Gee, M.E. Harper, D. Barrow, A.E. Wakeling, and R.I. Nicholson Elevated levels of epidermal growth factor receptor/c-erbB2 heterodimers mediate an autocrine growth regulatory pathway in tamoxifen-resistant MCF-7 cells Endocrinology 144 2003 1032 1044
31. S. Cannito, E. Novo, L.V. di Bonzo, C. Busletta, S. Colombatto, and M. Parola Epithelial-mesenchymal transition: from molecular mechanisms, redox regulation to implications in human health and disease Antioxid. Redox Signal. 12 2010 1383 1430
32. T. Finkel Oxidant signals and oxidative stress Curr. Opin. Cell Biol. 15 2003 247 254
33. R.S. Balaban, S. Nemoto, and T. Finkel Mitochondria, oxidants, and aging Cell 120 2005 483 495
34. J.D. Lambeth NOX enzymes and the biology of reactive oxygen Nat. Rev. Immunol. 4 2004 181 189
35. J.S. Kim, E.J. Bak, B.C. Lee, Y.S. Kim, J.B. Park, and I.G. Choi Neuregulin induces HaCaT keratinocyte migration via Rac1-mediated NADPH-oxidase activation J. Cell. Physiol. 226 2011 3014 3021
36. K. Polyak, and R.A. Weinberg Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits Nat. Rev. Cancer 9 2009 265 273
37. W.S. Wu The signaling mechanism of ROS in tumor progression Cancer Metastasis Rev. 25 2006 695 705
38. Z.M. Zeng, S.M. Chuang, T.C. Chang, C.W. Hong, J.C. Chou, J.J. Yang, and P.J. Chueh Phosphorylation of serine-504 of tNOX (ENOX2) modulates cell proliferation and migration in cancer cells Exp. Cell Res. 318 2012 1759 1766
39. N.C. Liu, P.F. Hsieh, M.K. Hsieh, Z.M. Chen, H.L. Cheng, J.W. Liao, and P.J. Chueh Capsaicin-mediated tNOX (ENOX2) up-regulation enhances cell proliferation and migration in vitro and in vivo J. Agric. Food Chem. 60 2012 2758 2765