Anti-interleukin-12/23p40 antibody attenuates chronic rejection of cardiac allografts partly via inhibition γδT cells

Clinical and Experimental Immunology

Volumn 169, Issue 3, 2012, Pages 320-329

  Wang, S ^a   Xu, X ^b   Xie, A ^a   Li, J ^a   Ye, P ^a   Liu, Z ^a   Wu, J ^a   Rui, L ^c   Xia, J ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^c FUWAI HOSPITAL   (China)

Author keywords

Chronic allograft rejection; Cytokines; T cells

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 17; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA; MONOCLONAL ANTIBODY; MONOCYTE CHEMOTACTIC PROTEIN 1; P40 MONOCLONAL ANTIBODY; T LYMPHOCYTE RECEPTOR DELTA CHAIN; T LYMPHOCYTE RECEPTOR GAMMA CHAIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATTENUATION; CARDIAC GRAFT REJECTION; CHRONIC GRAFT REJECTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; ECHOCARDIOGRAPHY; FLOW CYTOMETRY; GRAFT SURVIVAL; HEART TRANSPLANTATION; HISTOPATHOLOGY; IMMUNOFLUORESCENCE TEST; MAJOR HISTOCOMPATIBILITY COMPLEX; MALE; MOUSE; NONHUMAN; PALPATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ASSAY; REAL TIME POLYMERASE CHAIN REACTION; WILD TYPE;

ANIMALS; ANTIBODIES, MONOCLONAL; CHEMOKINES; CYTOKINES; DRUG EVALUATION, PRECLINICAL; FIBROSIS; GRAFT REJECTION; GRAFT SURVIVAL; HEART TRANSPLANTATION; INTERFERON-GAMMA; INTERLEUKIN-12 SUBUNIT P40; INTERLEUKIN-17; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYOCARDIUM; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; SPECIFIC PATHOGEN-FREE ORGANISMS; T-LYMPHOCYTE SUBSETS; TRANSPLANTATION, HETEROTOPIC; TRANSPLANTATION, HOMOLOGOUS;

EID: 84864757908     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2012.04612.x     Document Type: Article

References (40)

1. Taylor DO, Stehlik J, Edwards LB etal. Registry of the International Society for Heart and Lung Transplantation: twenty-sixth official adult heart transplant report-2009. J Heart Lung Transplant 2009; 28:1007-22.
2. Schmauss D, Weis M. Cardiac allograft vasculopathy: recent developments. Circulation 2008; 117:2131-41.
3. Zhou L, Chong MM, Littman DR. Plasticity of CD4+ T cell lineage differentiation. Immunity 2009; 30:646-55.
4. Ingulli E. Mechanism of cellular rejection in transplantation. Pediatr Nephrol 2008; 25:61-74.
5. Wang S, Li J, Xie A etal. Dynamic changes in Th1, Th17, and FoxP3(+) T cells in patients with acute cellular rejection after cardiac transplantation. Clin Transplant 2011; 25:E177-86.
6. Yuan X, Paez-Cortez J, Schmitt-Knosalla I etal. A novel role of CD4 Th17 cells in mediating cardiac allograft rejection and vasculopathy. J Exp Med 2008; 205:3133-44.
7. Cua DJ, Sherlock J, Chen Y etal. Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature 2003; 421:744-8.
8. Macatonia SE, Hosken NA, Litton M etal. Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4+ T cells. J Immunol 1995; 154:5071-9.
9. Ha SJ, Kim DJ, Baek KH, Yun YD, Sung YC. IL-23 induces stronger sustained CTL and Th1 immune responses than IL-12 in hepatitis C virus envelope protein 2 DNA immunization. J Immunol 2004; 172:525-31.
10. Manetti R, Parronchi P, Giudizi MG etal. Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells. J Exp Med 1993; 177:1199-204.
11. Cornelissen F, van Hamburg JP, Lubberts E. The IL-12/IL-23 axis and its role in Th17 cell development, pathology and plasticity in arthritis. Curr Opin Invest Drugs 2009; 10:452-62.
12. Martin B, Hirota K, Cua DJ, Stockinger B, Veldhoen M. Interleukin-17-producing gammadelta T cells selectively expand in response to pathogen products and environmental signals. Immunity 2009; 31:321-30.
13. Benson JM, Sachs CW, Treacy G etal. Therapeutic targeting of the IL-12/23 pathways: generation and characterization of ustekinumab. Nat Biotechnol 2011; 29:615-24.
14. Xie A, Wang S, Zhang K etal. Treatment with interleukin-12/23p40 antibody attenuates acute cardiac allograft rejection. Transplantation 2011; 91:27-34.
15. Corry RJ, Winn HJ, Russell PS. Primarily vascularized allografts of hearts in mice. The role of H-2D, H-2K, and non-H-2 antigens in rejection. Transplantation 1973; 16:343-50.
16. Furukawa Y, Libby P, Stinn JL, Becker G, Mitchell RN. Cold ischemia induces isograft arteriopathy, but does not augment allograft arteriopathy in non-immunosuppressed hosts. Am J Pathol 2002; 160:1077-87.
17. Sayegh MH, Wu Z, Hancock WW etal. Allograft rejection in a new allospecific CD4+ TCR transgenic mouse. Am J Transplant 2003; 3:381-9.
18. Scherrer-Crosbie M, Glysing-Jensen T, Fry SJ etal. Echocardiography improves detection of rejection after heterotopic mouse cardiac transplantation. J Am Soc Echocardiogr 2002; 15:1315-20.
19. Zhou YQ, Bishay R, Feintuch A etal. Morphological and functional evaluation of murine heterotopic cardiac grafts using ultrasound biomicroscopy. Ultrasound Med Biol 2007; 33:870-9.
20. Sutton CE, Lalor SJ, Sweeney CM, Brereton CF, Lavelle EC, Mills KH. Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity. Immunity 2009; 31:331-41.
21. Presky DH, Yang H, Minetti LJ etal. A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits. Proc Natl Acad Sci USA 1996; 93:14002-7.
22. Gandhi M, Alwawi E, Gordon KB. Anti-p40 antibodies ustekinumab and briakinumab: blockade of interleukin-12 and interleukin-23 in the treatment of psoriasis. Semin Cutan Med Surg 2010; 29:48-52.
23. Itoh S, Nakae S, Axtell RC etal. IL-17 contributes to the development of chronic rejection in a murine heart transplant model. J Clin Immunol 2010; 30:235-40.
24. Nagano H, Libby P, Taylor MK etal. Coronary arteriosclerosis after T-cell-mediated injury in transplanted mouse hearts: role of interferon-gamma. Am J Pathol 1998; 152:1187-97.
25. Russell PS, Chase CM, Winn HJ, Colvin RB. Coronary atherosclerosis in transplanted mouse hearts. II. Importance of humoral immunity. J Immunol 1994; 152:5135-41.
26. Kobayashi M, Fitz L, Ryan M etal. Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes. J Exp Med 1989; 170:827-45.
27. Gately MK, Desai BB, Wolitzky AG etal. Regulation of human lymphocyte proliferation by a heterodimeric cytokine, IL-12 (cytotoxic lymphocyte maturation factor). J Immunol 1991; 147:874-82.
28. Uehara S, Chase CM, Kitchens WH etal. NK cells can trigger allograft vasculopathy: the role of hybrid resistance in solid organ allografts. J Immunol 2005; 175:3424-30.
29. Bi EG, Shi W, Zou J etal. IL-12p40 is not required for islet allograft rejection. Acta Pharmacol Sin 2006; 27:1065-70.
30. Oppmann B, Lesley R, Blom B etal. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity 2000; 13:715-25.
31. Parham C, Chirica M, Timans J etal. A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R. J Immunol 2002; 168:5699-708.
32. Acosta-Rodriguez EV, Napolitani G, Lanzavecchia A, Sallusto F. Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells. Nat Immunol 2007; 8:942-9.
33. Cua DJ, Tato CM. Innate IL-17-producing cells: the sentinels of the immune system. Nat Rev Immunol 2010; 10:479-89.
34. Millington TM, Madsen JC. Innate immunity and cardiac allograft rejection. Kidney Int Suppl 2010; 119:S18-21.
35. Curtis MM, Way SS, Wilson CB. IL-23 promotes the production of IL-17 by antigen-specific CD8 T cells in the absence of IL-12 and type-I interferons. J Immunol 2009; 183:381-7.
36. Petermann F, Rothhammer V, Claussen MC etal. Gammadelta T cells enhance autoimmunity by restraining regulatory T cell responses via an interleukin-23-dependent mechanism. Immunity 2010; 33:351-63.
37. Kitchens WH, Chase CM, Uehara S etal. Macrophage depletion suppresses cardiac allograft vasculopathy in mice. Am J Transplant 2007; 7:2675-82.
38. Saeki K, Kanai T, Nakano M etal. CCL2-induced migration and SOCS3-mediated activation of macrophages are involved in cerulein-induced pancreatitis in mice. Gastroenterology 2012; 142:1010-20.
39. Ha SJ, Lee CH, Lee SB etal. A novel function of IL-12p40 as a chemotactic molecule for macrophages. J Immunol 1999; 163:2902-8.
40. Diaz JA, Booth AJ, Lu G, Wood SC, Pinsky DJ, Bishop DK. Critical role for IL-6 in hypertrophy and fibrosis in chronic cardiac allograft rejection. Am J Transplant 2009; 9:1773-83.