Coronary arteriosclerosis after T-cell-mediated injury in transplanted mouse hearts: Role of interferon-γ

American Journal of Pathology

Volumn 152, Issue 5, 1998, Pages 1187-1197

  Nagano, Hiroaki ^a   Libby, Peter ^a   Taylor, Marta K ^a   Hasegawa, Satoru ^a   Stinn, Jennifer L ^a   Becker, Gerold ^a   Tilney, Nicholas L ^a   Mitchell, Richard N ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; GAMMA INTERFERON; INTERCELLULAR ADHESION MOLECULE 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; VASCULAR CELL ADHESION MOLECULE 1;

ALLOGRAFT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DAMAGE; CONTROLLED STUDY; CORONARY ARTERY ATHEROSCLEROSIS; FLOW CYTOMETRY; GRAFT REJECTION; GRAFT SURVIVAL; HEART TRANSPLANTATION; IMMUNOHISTOCHEMISTRY; IMMUNOSUPPRESSIVE TREATMENT; MOUSE; NATURAL KILLER CELL; NONHUMAN; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CORONARY ARTERIOSCLEROSIS; FEMALE; FLOW CYTOMETRY; GRAFT REJECTION; GRAFT SURVIVAL; HEART TRANSPLANTATION; HISTOCOMPATIBILITY ANTIGENS CLASS II; IMMUNOHISTOCHEMISTRY; IMMUNOSUPPRESSION; INTERCELLULAR ADHESION MOLECULE-1; INTERFERON TYPE II; LYMPHOCYTE DEPLETION; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; TRANSPLANTATION, HOMOLOGOUS; VASCULAR CELL ADHESION MOLECULE-1;

EID: 0031946190     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (52)

1. Uretsky BF, Murali S, Reddy PS, Rabin B, Lee A, Griffith BP, Hardesty RL, Trento A, Bahnson HT: Development of coronary artery disease in cardiac patients receiving immunosuppressive therapy with cyclosporin and prednisone. Circulation 1987, 76:827-834
2. Paul LC, Fellstrom B. Chronic vascular rejection of the heart and the kidney. Have rational treatment options emerged? Transplantation 1992, 53:1169-1179
3. Hosenpud JD, Shipley GD, Wagner CR: Cardiac allograft vasculopathy: current concepts, recent developments, and future directions. J Heart Lung Transplant 1992, 11:9-23
4. Russell ME, Fujita M, Masek MA, Rowan RA, Billingham ME: Cardiac graft vascular disease: nonselective involvement of large and small vessels Transplantation 1993, 56:1599-1601
5. Libby P, Salomon RN, Payne DD, Schoen FJ, Pober JS: Functions of vascular wall cells related to development of transplantation-associated coronary arteriosclerosis. Transplant Proc 1989, 21:3677-3684
6. Hauptman PJ, Davis SF, Miller L, Yeung AC: The role of nonimmune risk factors in the development and progression of graft arteriosclerosis: preliminary insights from a multicenter intravascular ultrasound study. J Heart Lung Transplant 1995, 14:S238-S242
7. Libby P: Transplantation-associated arteriosclerosis: possible mechanisms. Transplantation Biology: Cellular and Molecular Aspects. Edited by Tilney NL, Strom TB, Paul LC. Philadelphia, Lippincott-Raven, 1996, pp 577-586
8. Salomon RN, Hughes CCW, Schoen FJ, Payne DD, Pober JS, Libby P: Human coronary transplantation-associated arteriosclerosis. Am J Pathol 1991, 138:791-798
9. Dumont FJ, Dijkmans R, Palfee RGE, Boldtz RD, Coker L: Selective up-regulation by interferons-γ of surface molecules of Ly-6 complex in resting T cells. The Ly-6A/E and TAP antigens are preferentially enhanced. Eur J Immunol 1987, 17:1183-1191
10. Barr C, Sanders GF: Interferon-γ-inducible regulation of the human invariant chain. J Biol Chem 1991, 266:3475-3481
11. 2-microglobulin gene expression in human neuronal cells: factor binding to conserved cis-acting regulatory sequences correlates with expression of the gene. J Immunol 1993, 150:3300-3310
12. Dustin ML, Rothlein R, Bhan AK, Dinarello CA, Springer TA: Induction of IL-1 and interferon-γ: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1). J Immunol 1986, 137:245-254
13. Nagano H, Mitchell RN, Taylor MK, Hasegawa S, Tilney NL, Libby P: Interferon-γ deficiency prevents coronary arteriosclerosis but not myocardial rejection in transplanted mouse heart. J Clin Invest 1997, 100:550-557
14. Liu G, Butany J: Morphology of graft arteriosclerosis in cardiac transplant recipients. Hum Pathol 1992, 23:763-773
15. Zerbe T, Utemsky B, Kormos R, Armitage J, Wolyn T, Griffith B: Graft atherosclerosis: effects of cellular reaction and human lymphocyte antigen J Heart Lung Transplant 1992, 11:S104-S110
16. Nakagawa T, Sukohva GK, Rabkin E, Winters GL, Schoen FJ, Libby P: Acute rejection accelerates graft coronary disease in transplanted rabbit hearts. Circulation 1995, 92:987-993
17. Hauptman PJ, Nakagawa T, Tanaka H, Libby P: Acute rejection: culprit or coincidence in the pathogenesis of cardiac graft vascular disease? J Heart Lung Transplant 1995, 14:S173-S180
18. Dalton DK, Pitts-Meek S, Keshav S, Figari IS, Bradley A, Stewart TA: Multiple defects of immune cell function in mice with disrupted interferon-γ genes. Science 1993, 259:1739-1742
19. Corry RJ, Winn HJ, Russell PS: Primary vascularized allografts of hearts in mice. Transplantation 1973, 16:344-350
20. Hsu SM, Raine L, Fanger H: The use of antiavidin antibody and avidin-biotin-peroxidase complex in immunoperoxidase techniques. Am J Clin Pathol 1981, 75:816-821
21. Billingham ME, Cary NRB, Hammond ME, Kemnitz J, Marboe C, McCallister HA, Snovar DC, Winters GL, Zerbe A: A working formulation for the standardization of nomenclature in the diagnosis of heart and lung rejection: Heart Rejection Study Group. J Heart Lung Transplant 1990, 9:587-593
22. Saleem S, Konieczny BT, Lowry RP, Baddoura FK, Lakkis FG: Acute rejection of vascularized heart allografts in the absence of IFNγ. Transplantation 1996, 62:1908-1911
23. Russell ME, Fujita M, Masek MA, Billingham ME: Cardiac allograft vascular disease. Transplantation 1993, 56:762-763
24. Addonizio LJ, Hsu DT, Douglas JF, Kichuk MR, Michler RE, Quaegebeur JM, Smith CR, Rose EA: Decreasing incidence of coronary disease in pediatric cardiac transplant recipients using increased immunosuppression. Circulation 1993, 88:224-229
25. Libby P, Tanaka H: The pathogenesis of coronary arteriosclerosis ("chronic rejection") in transplanted hearts. Clin Transplant 1994, 8-327-332
26. Geerling RA, DeBruin RWF, Scheringa M, Bonthuis F, Jeekei J, Ijzermans JNM, Marquet RL: Suppression of acute rejection prevents graft arteriosclerosis after allogeneic aorta transplantation in the rat. Transplantation 1994, 58:1258-1263
27. Tullius SG, WW Hancock, Heemann U, Azuma H, Tilney NL: Reversibility of chronic renal allograft rejection: critical effect of time after transplantation suggests both host immune dependent and independent phases of progressive injury. Transplantation 1994, 58:93-99
28. Izutani H, Miyagawa S, Shirakura R, Matsumiya G, Nakata S, Shimazaki Y, Matsuda H: Evidence that graft coronary arteriosclerosis begins in the early phase after transplantation and progresses without chronic immunoreaction. Transplantation 1995, 60:1073-1079
29. Hullett DA, Geraghty JG, Stoltenberg RL, Sollinger HW: The impact of acute rejection on the development of intimai hyperplasia associated with chronic rejection. Transplantation 1996, 62:1842-1846
30. Russell ME, Hancock WW, Akalin E, Wallace AF, Glysing-Jensen T, Willett TA, Sayegh MH: Chronic cardiac reaction in the Lew to F344 rat model. Blockade of CD28-B7 costimulation by CTLA4Ig modulates T cell and macrophage activation. J Clin Invest 1996, 97:833-838
31. Shi C, Lee W, He Q, Zhang D, Fletcher DL Jr, Newell JB, Harber E: The immunological basis of transplant-associated arteriosclerosis. Proc Natl Acad Sci USA 1996, 93:4051-4056
32. Gajewski TF, Fitch FW: Anti-proliferative effect of IFN-γ in immune regulation. I. IFN-γ inhibits the proliferation of Th2 but not Th1 murine helper T lymphocyte genes. J Immunol 1988, 140:4245-4252
33. Liu Y, Janeway CA Jr: Interferon-γ plays a critical role in induced cell death of effector T cell: a possible third mechanism of self-tolerance. J Exp Med 1990, 172:1735-1739
34. Bucy RP, Hanto DW, Berens E, Schreiber RD: Lack of an obligate role of IFN-γ in the primary in vitro mixed lymphocyte response. J Immunol 1988, 140:1148-1152
35. Nathan CF, Murray HW, Wiebe ME, Rubin BY: Identification of interferon-γ as the lymphokine that activates human macrophage oxidative metabolism and antimicrobial activity. J Exp Med 1983, 158:670-689
36. Boehm U, Klamp T, Groot M, Howard JC: Cellular responses to interferon-γ Annu Rev Immunol 1997, 15:749-795
37. Rosa F, Fellous M: The effect of γ-interferon on MHC antigens. Immunol Today 1984, 5:261-262
38. Skoskiewicz MJ, Colvin RB, Schneeberger EE, Russell PS: Wide spread and selective induction of major histocompatibility complex-determined antigens in vivo by γ interferon. J Exp Med 1985, 162: 1645-1664
39. Collins T, Lapierre LA, Fiers W, Strominger JL, Pober JS: Recombinant human tumor necrosis factor increases mRNA levels and surface expression of HLA-A, B antigens in vascular endothelial cells and dermal fibroblasts in vivo. Proc Natl Acad Sci USA 1986, 83:446-450
40. Misinovski B, Urdal D, Gallatin WM: IL-4 acts synergistically with IL-1β to promote lymphocyte adhesion to microvascular endothelium by induction of vascular cell adhesion molecule-1. J Immunol 1990, 145:2886-2895
41. Thornhill MH, Wellicome SM, Mahiouz DL, Lanchbury JSS, Kyan-Aung U, Haskard DO: Tumor necrosis factor combines with IL-4 or IFN-γ to selectively enhance endothelial cells for T cells: the contribution of vascular cell adhesion molecule-1-dependent and -independent binding mechanisms. J Immunol 1991, 146:592-598
42. Thornhill MH, Haskard DO: IL-4 regulates endothelial cell activation by IL-1, tumor necrosis factor, or IFN-γ. J Immunol 1990, 145:865-872
43. Thornhill MH, Kyan-Aung U, Haskard DO: IL-4 increases human endothelial adhesiveness for T cells but not for neutrophils. J Immunol 1990, 144:3060-3065
44. Pober JS, Gimbrone MA Jr, Lapierre LA, Mendrick DL, Fiers W, Rothlein R, Springer TA: Overlapping patterns of activation of human endothelial cells by interleukin 1, tumor necrosis factor, and murine interferon. J Immunol 1986, 137:1893-1896
45. Tanaka H, Sukhova GK, Swanson SJ, Cybulsky MI, Schoen FJ, Libby P: Endothelial and smooth muscle cells express leukocyte adhesion molecules heterogeneously during acute rejection of rabbit cardiac allografts. Am J Pathol 1994, 144:938-951
46. Ardehali A, Laks H, Drinkwater DC, Ziv E, Drake TA: Vascular cell adhesion molecule-1 is induced on vascular endothelia and medial smooth muscle cells in experimental cardiac allograft vasculopathy. Circulation 1995, 92:450-456
47. Tanaka H, Sukhova GK, Libby P: Interaction of the allogeneic state and hypercholesterolemia in arterial lesion formation in experimental cardiac allografts. Arterioscler Thromb 1994, 14:734-745
48. Pelletier RP, Ohye RG, Vanbuskirk A, Sedmak DD, Kincade P, Ferguson RM, Orosz CG: Importance of endothelial VCAM-1 for inflammatory leukocytic infiltration in vivo. J Immunol 1992, 149:2473-2481
49. Isobe M, Yagita H, Okumura K, Ihara A: Specific acceptance of cardiac allograft after treatment with antibodies to ICAM-1 and LFA-1. Science 1992, 255:1125-1127
50. Russell PS, Chase CM, Colvin RB: Coronary atherosclerosis in transplanted mouse hearts. IV. Effects of treatment with monoclonal antibodies to intracellular adhesion molecule-1 and leukocyte function-associated antigen-1. Transplantation 1995, 60:724-729
51. Orosz CG, Ohye RG, Pelletier RP, Vanbuskirk A, Huang E, Morgan C, Kincade P, Ferguson RM: Treatment of anti-vascular cell adhesion molecule 1 monoclonal antibody induces long-term murine cardiac allograft acceptance. Transplantation 1993, 56:453-460
52. Sadahiro M, McDonald TO, Allen MD: Reduction in cellular and vascular rejection by blocking leukocyte adhesion molecule receptors. Am J Pathol 1993, 142:675-683