메뉴 건너뛰기




Volumn 42, Issue 8, 2012, Pages 2010-2018

IFN-γ receptor deficiency prevents diabetes induction by diabetogenic CD4 +, but not CD8 +, T cells

Author keywords

Autoimmunity; IFN ; NOD mice; T cells; Type 1 diabetes

Indexed keywords

GAMMA INTERFERON; GAMMA INTERFERON RECEPTOR; HERMES ANTIGEN; L SELECTIN;

EID: 84864755068     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201142374     Document Type: Article
Times cited : (30)

References (48)
  • 1
    • 0029030964 scopus 로고
    • T helper cell subsets in insulin-dependent diabetes
    • Katz, J. D., Benoist, C. and Mathis, D., T helper cell subsets in insulin-dependent diabetes. Science 1995. 268: 1185-1188.
    • (1995) Science , vol.268 , pp. 1185-1188
    • Katz, J.D.1    Benoist, C.2    Mathis, D.3
  • 2
    • 67649364114 scopus 로고    scopus 로고
    • The role of inflammation in insulitis and beta-cell loss in type 1 diabetes
    • Eizirik, D. L., Colli, M. L. and Ortis, F., The role of inflammation in insulitis and beta-cell loss in type 1 diabetes. Nat. Rev. Endocrinol. 2009. 5: 219-226.
    • (2009) Nat. Rev. Endocrinol. , vol.5 , pp. 219-226
    • Eizirik, D.L.1    Colli, M.L.2    Ortis, F.3
  • 4
    • 0025981388 scopus 로고
    • Essential role for interferon-gamma and interleukin-6 in autoimmune insulin-dependent diabetes in NOD/Wehi mice
    • Campbell, I. L., Kay, T. W., Oxbrow, L. and Harrison, L. C., Essential role for interferon-gamma and interleukin-6 in autoimmune insulin-dependent diabetes in NOD/Wehi mice. J. Clin. Invest. 1991. 87: 739-742.
    • (1991) J. Clin. Invest. , vol.87 , pp. 739-742
    • Campbell, I.L.1    Kay, T.W.2    Oxbrow, L.3    Harrison, L.C.4
  • 6
    • 0030444632 scopus 로고    scopus 로고
    • The effects of a nonimmunogenic form of murine soluble interferon-gamma receptor on the development of autoimmune diabetes in the NOD mouse
    • Nicoletti, F., Zaccone, P., Di Marco, R., Di Mauro, M., Magro, G., Grasso, S., Mughini, L. et al., The effects of a nonimmunogenic form of murine soluble interferon-gamma receptor on the development of autoimmune diabetes in the NOD mouse. Endocrinology 1996. 137: 5567-5575.
    • (1996) Endocrinology , vol.137 , pp. 5567-5575
    • Nicoletti, F.1    Zaccone, P.2    Di Marco, R.3    Di Mauro, M.4    Magro, G.5    Grasso, S.6    Mughini, L.7
  • 7
    • 0025905091 scopus 로고
    • Characterization of pancreatic T lymphocytes associated with beta cell destruction in the non-obese diabetic (NOD) mouse
    • Kay, T. W., Campbell, I. L. and Harrison, L. C., Characterization of pancreatic T lymphocytes associated with beta cell destruction in the non-obese diabetic (NOD) mouse. J. Autoimmun. 1991. 4: 263-276.
    • (1991) J. Autoimmun. , vol.4 , pp. 263-276
    • Kay, T.W.1    Campbell, I.L.2    Harrison, L.C.3
  • 8
    • 0025108875 scopus 로고
    • Loss of pancreatic islet tolerance induced by beta-cell expression of interferon-gamma
    • Sarvetnick, N., Shizuru, J., Liggitt, D., Martin, L., McIntyre, B., Gregory, A., Parslow, T. et al., Loss of pancreatic islet tolerance induced by beta-cell expression of interferon-gamma. Nature 1990. 346: 844-847.
    • (1990) Nature , vol.346 , pp. 844-847
    • Sarvetnick, N.1    Shizuru, J.2    Liggitt, D.3    Martin, L.4    McIntyre, B.5    Gregory, A.6    Parslow, T.7
  • 9
    • 0036068246 scopus 로고    scopus 로고
    • Interleukin-1 plus gamma-interferon-induced pancreatic beta-cell dysfunction is mediated by beta-cell nitric oxide production
    • Thomas, H. E., Darwiche, R., Corbett, J. A. and Kay, T. W., Interleukin-1 plus gamma-interferon-induced pancreatic beta-cell dysfunction is mediated by beta-cell nitric oxide production. Diabetes 2002. 51: 311-316.
    • (2002) Diabetes , vol.51 , pp. 311-316
    • Thomas, H.E.1    Darwiche, R.2    Corbett, J.A.3    Kay, T.W.4
  • 10
    • 0023779707 scopus 로고
    • Destruction of rat islet cell monolayers by cytokines. Synergistic interactions of interferon-gamma, tumor necrosis factor, lymphotoxin, and interleukin 1
    • Pukel, C., Baquerizo, H. and Rabinovitch, A., Destruction of rat islet cell monolayers by cytokines. Synergistic interactions of interferon-gamma, tumor necrosis factor, lymphotoxin, and interleukin 1. Diabetes 1988. 37: 133-136.
    • (1988) Diabetes , vol.37 , pp. 133-136
    • Pukel, C.1    Baquerizo, H.2    Rabinovitch, A.3
  • 11
    • 24344453811 scopus 로고    scopus 로고
    • Synergistic activation of JNK/SAPK induced by TNF-alpha and IFN-gamma: apoptosis of pancreatic beta-cells via the p53 and ROS pathway
    • Kim, W. H., Lee, J. W., Gao, B. and Jung, M. H., Synergistic activation of JNK/SAPK induced by TNF-alpha and IFN-gamma: apoptosis of pancreatic beta-cells via the p53 and ROS pathway. Cell Signal. 2005. 17: 1516-1532.
    • (2005) Cell Signal. , vol.17 , pp. 1516-1532
    • Kim, W.H.1    Lee, J.W.2    Gao, B.3    Jung, M.H.4
  • 12
    • 0035313059 scopus 로고    scopus 로고
    • IFN-gamma/TNF-alpha synergism as the final effector in autoimmune diabetes: a key role for STAT1/IFN regulatory factor-1 pathway in pancreatic beta cell death
    • Suk, K., Kim, S., Kim, Y. H., Kim, K. A., Chang, I., Yagita, H., Shong, M. et al., IFN-gamma/TNF-alpha synergism as the final effector in autoimmune diabetes: a key role for STAT1/IFN regulatory factor-1 pathway in pancreatic beta cell death. J. Immunol. 2001. 166: 4481-4489.
    • (2001) J. Immunol. , vol.166 , pp. 4481-4489
    • Suk, K.1    Kim, S.2    Kim, Y.H.3    Kim, K.A.4    Chang, I.5    Yagita, H.6    Shong, M.7
  • 13
    • 0023784346 scopus 로고
    • IFN-gamma and tumor necrosis factor-alpha. Cytotoxicity to murine islets of Langerhans
    • Campbell, I. L., Iscaro, A. and Harrison, L. C., IFN-gamma and tumor necrosis factor-alpha. Cytotoxicity to murine islets of Langerhans. J. Immunol. 1988. 141: 2325-2329.
    • (1988) J. Immunol. , vol.141 , pp. 2325-2329
    • Campbell, I.L.1    Iscaro, A.2    Harrison, L.C.3
  • 14
    • 0037603320 scopus 로고    scopus 로고
    • IL-1beta, IFN-gamma and TNF-alpha increase vulnerability of pancreatic beta cells to autoimmune destruction
    • Wachlin, G., Augstein, P., Schroder, D., Kuttler, B., Kloting, I., Heinke, P. and Schmidt, S., IL-1beta, IFN-gamma and TNF-alpha increase vulnerability of pancreatic beta cells to autoimmune destruction. J. Autoimmun. 2003. 20: 303-312.
    • (2003) J. Autoimmun. , vol.20 , pp. 303-312
    • Wachlin, G.1    Augstein, P.2    Schroder, D.3    Kuttler, B.4    Kloting, I.5    Heinke, P.6    Schmidt, S.7
  • 15
    • 34948893439 scopus 로고    scopus 로고
    • Essential role for signal transducer and activator of transcription-1 in pancreatic beta-cell death and autoimmune type 1 diabetes of nonobese diabetic mice
    • Kim, S., Kim, H. S., Chung, K. W., Oh, S. H., Yun, J. W., Im, S. H., Lee, M. et al., Essential role for signal transducer and activator of transcription-1 in pancreatic beta-cell death and autoimmune type 1 diabetes of nonobese diabetic mice. Diabetes 2007. 56: 2561-2568.
    • (2007) Diabetes , vol.56 , pp. 2561-2568
    • Kim, S.1    Kim, H.S.2    Chung, K.W.3    Oh, S.H.4    Yun, J.W.5    Im, S.H.6    Lee, M.7
  • 16
    • 15444380329 scopus 로고    scopus 로고
    • 1,25-Dihydroxyvitamin D3 modulates expression of chemokines and cytokines in pancreatic islets: implications for prevention of diabetes in nonobese diabetic mice
    • Gysemans, C. A., Cardozo, A. K., Callewaert, H., Giulietti, A., Hulshagen, L., Bouillon, R., Eizirik, D. L.et al., 1, 25-Dihydroxyvitamin D3 modulates expression of chemokines and cytokines in pancreatic islets: implications for prevention of diabetes in nonobese diabetic mice. Endocrinology 2005. 146: 1956-1964.
    • (2005) Endocrinology , vol.146 , pp. 1956-1964
    • Gysemans, C.A.1    Cardozo, A.K.2    Callewaert, H.3    Giulietti, A.4    Hulshagen, L.5    Bouillon, R.6    Eizirik, D.L.7
  • 17
    • 0029948898 scopus 로고    scopus 로고
    • Genetic absence of gamma-interferon delays but does not prevent diabetes in NOD mice
    • Hultgren, B., Huang, X., Dybdal, N. and Stewart, T. A., Genetic absence of gamma-interferon delays but does not prevent diabetes in NOD mice. Diabetes 1996. 45: 812-817.
    • (1996) Diabetes , vol.45 , pp. 812-817
    • Hultgren, B.1    Huang, X.2    Dybdal, N.3    Stewart, T.A.4
  • 18
    • 0034175965 scopus 로고    scopus 로고
    • Protection of nonobese diabetic mice from diabetes by gene(s) closely linked to IFN-gamma receptor loci
    • Kanagawa, O., Xu, G., Tevaarwerk, A. and Vaupel, B. A., Protection of nonobese diabetic mice from diabetes by gene(s) closely linked to IFN-gamma receptor loci. J. Immunol. 2000. 164: 3919-3923.
    • (2000) J. Immunol. , vol.164 , pp. 3919-3923
    • Kanagawa, O.1    Xu, G.2    Tevaarwerk, A.3    Vaupel, B.A.4
  • 19
    • 0033669375 scopus 로고    scopus 로고
    • Interferon-gamma receptor signaling is dispensable in the development of autoimmune type 1 diabetes in NOD mice
    • Serreze, D. V., Post, C. M., Chapman, H. D., Johnson, E. A., Lu, B. and Rothman, P. B., Interferon-gamma receptor signaling is dispensable in the development of autoimmune type 1 diabetes in NOD mice. Diabetes 2000. 49: 2007-2011.
    • (2000) Diabetes , vol.49 , pp. 2007-2011
    • Serreze, D.V.1    Post, C.M.2    Chapman, H.D.3    Johnson, E.A.4    Lu, B.5    Rothman, P.B.6
  • 20
    • 0035576007 scopus 로고    scopus 로고
    • IFN-gamma affects homing of diabetogenic T cells
    • Savinov, A. Y., Wong, F. S. and Chervonsky, A. V., IFN-gamma affects homing of diabetogenic T cells. J. Immunol. 2001. 167: 6637-6643.
    • (2001) J. Immunol. , vol.167 , pp. 6637-6643
    • Savinov, A.Y.1    Wong, F.S.2    Chervonsky, A.V.3
  • 22
    • 0032531099 scopus 로고    scopus 로고
    • IFN-gamma action on pancreatic beta cells causes class I MHC upregulation but not diabetes
    • Thomas, H. E., Parker, J. L., Schreiber, R. D. and Kay, T. W., IFN-gamma action on pancreatic beta cells causes class I MHC upregulation but not diabetes. J. Clin. Invest. 1998. 102: 1249-1257.
    • (1998) J. Clin. Invest. , vol.102 , pp. 1249-1257
    • Thomas, H.E.1    Parker, J.L.2    Schreiber, R.D.3    Kay, T.W.4
  • 23
    • 0033579875 scopus 로고    scopus 로고
    • Initiation of autoimmune diabetes by developmentally regulated presentation of islet cell antigens in the pancreatic lymph nodes
    • Hoglund, P., Mintern, J., Waltzinger, C., Heath, W., Benoist, C. and Mathis, D., Initiation of autoimmune diabetes by developmentally regulated presentation of islet cell antigens in the pancreatic lymph nodes. J. Exp. Med. 1999. 189: 331-339.
    • (1999) J. Exp. Med. , vol.189 , pp. 331-339
    • Hoglund, P.1    Mintern, J.2    Waltzinger, C.3    Heath, W.4    Benoist, C.5    Mathis, D.6
  • 24
    • 0026636069 scopus 로고
    • First phase insulin release in the non-obese diabetic mouse: correlation with insulitis, beta cell number and autoantibodies
    • Reddy, S., Liu, W., Thompson, J. M., Bibby, N. J. and Elliott, R. B., First phase insulin release in the non-obese diabetic mouse: correlation with insulitis, beta cell number and autoantibodies. Diabetes Res. Clin. Pract. 1992. 17: 17-25.
    • (1992) Diabetes Res. Clin. Pract. , vol.17 , pp. 17-25
    • Reddy, S.1    Liu, W.2    Thompson, J.M.3    Bibby, N.J.4    Elliott, R.B.5
  • 25
    • 4344675052 scopus 로고    scopus 로고
    • Progression to islet destruction in a cyclophosphamide-induced transgenic model: a microarray overview
    • Matos, M., Park, R., Mathis, D. and Benoist, C., Progression to islet destruction in a cyclophosphamide-induced transgenic model: a microarray overview. Diabetes 2004. 53: 2310-2321.
    • (2004) Diabetes , vol.53 , pp. 2310-2321
    • Matos, M.1    Park, R.2    Mathis, D.3    Benoist, C.4
  • 26
    • 33747673629 scopus 로고    scopus 로고
    • A novel direct competitive repopulation assay for human hematopoietic stem cells using NOD/SCID mice
    • Tatekawa, T., Ogawa, H., Kawakami, M., Oka, Y., Yasukawa, K., Sugiyama, H., Kawase, I. and Soma, T., A novel direct competitive repopulation assay for human hematopoietic stem cells using NOD/SCID mice. Cytotherapy 2006. 8: 390-398.
    • (2006) Cytotherapy , vol.8 , pp. 390-398
    • Tatekawa, T.1    Ogawa, H.2    Kawakami, M.3    Oka, Y.4    Yasukawa, K.5    Sugiyama, H.6    Kawase, I.7    Soma, T.8
  • 27
    • 0025316055 scopus 로고
    • Cytotoxic effects of cytokines on human pancreatic islet cells in monolayer culture
    • Rabinovitch, A., Sumoski, W., Rajotte, R. V. and Warnock, G. L., Cytotoxic effects of cytokines on human pancreatic islet cells in monolayer culture. J. Clin. Endocrinol. Metab. 1990. 71: 152-156.
    • (1990) J. Clin. Endocrinol. Metab. , vol.71 , pp. 152-156
    • Rabinovitch, A.1    Sumoski, W.2    Rajotte, R.V.3    Warnock, G.L.4
  • 29
    • 60749119714 scopus 로고    scopus 로고
    • In vivo effects of cytokines on pancreatic beta-cells in models of type I diabetes dependent on CD4(+) T lymphocytes
    • Angstetra, E., Graham, K. L., Emmett, S., Dudek, N. L., Darwiche, R., Ayala-Perez, R., Allison, J.et al., In vivo effects of cytokines on pancreatic beta-cells in models of type I diabetes dependent on CD4(+) T lymphocytes. Immunol. Cell Biol. 2008. 87: 178-185.
    • (2008) Immunol. Cell Biol. , vol.87 , pp. 178-185
    • Angstetra, E.1    Graham, K.L.2    Emmett, S.3    Dudek, N.L.4    Darwiche, R.5    Ayala-Perez, R.6    Allison, J.7
  • 30
    • 0030779118 scopus 로고    scopus 로고
    • A mechanism for the major histocompatibility complex-linked resistance to autoimmunity
    • Schmidt, D., Verdaguer, J., Averill, N. and Santamaria, P., A mechanism for the major histocompatibility complex-linked resistance to autoimmunity. J. Exp. Med. 1997. 186: 1059-1075.
    • (1997) J. Exp. Med. , vol.186 , pp. 1059-1075
    • Schmidt, D.1    Verdaguer, J.2    Averill, N.3    Santamaria, P.4
  • 32
    • 0033526068 scopus 로고    scopus 로고
    • In autoimmune diabetes the transition from benign to pernicious insulitis requires an islet cell response to tumor necrosis factor alpha
    • Pakala, S. V., Chivetta, M., Kelly, C. B. and Katz, J. D., In autoimmune diabetes the transition from benign to pernicious insulitis requires an islet cell response to tumor necrosis factor alpha. J. Exp. Med. 1999. 189: 1053-1062.
    • (1999) J. Exp. Med. , vol.189 , pp. 1053-1062
    • Pakala, S.V.1    Chivetta, M.2    Kelly, C.B.3    Katz, J.D.4
  • 33
    • 33846630040 scopus 로고    scopus 로고
    • Humanized mice in translational biomedical research
    • Shultz, L. D., Ishikawa, F. and Greiner, D. L., Humanized mice in translational biomedical research. Nat. Rev. Immunol. 2007. 7: 118-130.
    • (2007) Nat. Rev. Immunol. , vol.7 , pp. 118-130
    • Shultz, L.D.1    Ishikawa, F.2    Greiner, D.L.3
  • 34
    • 33750726384 scopus 로고    scopus 로고
    • Allogeneic hematopoietic transplantation and natural killer cell recognition of missing self
    • Ruggeri, L., Aversa, F., Martelli, M. F. and Velardi, A., Allogeneic hematopoietic transplantation and natural killer cell recognition of missing self. Immunol. Rev. 2006. 214: 202-218.
    • (2006) Immunol. Rev. , vol.214 , pp. 202-218
    • Ruggeri, L.1    Aversa, F.2    Martelli, M.F.3    Velardi, A.4
  • 35
    • 34547561721 scopus 로고    scopus 로고
    • Deletion of STAT-1 pancreatic islets protects against streptozotocin-induced diabetes and early graft failure but not against late rejection
    • Callewaert, H. I., Gysemans, C. A., Ladriere, L., D'Hertog, W., Hagenbrock, J., Overbergh, L., Eizirik, D. L.et al., Deletion of STAT-1 pancreatic islets protects against streptozotocin-induced diabetes and early graft failure but not against late rejection. Diabetes 2007. 56: 2169-2173.
    • (2007) Diabetes , vol.56 , pp. 2169-2173
    • Callewaert, H.I.1    Gysemans, C.A.2    Ladriere, L.3    D'Hertog, W.4    Hagenbrock, J.5    Overbergh, L.6    Eizirik, D.L.7
  • 36
    • 0038142707 scopus 로고    scopus 로고
    • Nuclear factor kappaB protects pancreatic beta-cells from tumor necrosis factor-alpha-mediated apoptosis
    • Chang, I., Kim, S., Kim, J. Y., Cho, N., Kim, Y. H., Kim, H. S., Lee, M. K.et al., Nuclear factor kappaB protects pancreatic beta-cells from tumor necrosis factor-alpha-mediated apoptosis. Diabetes 2003. 52: 1169-1175.
    • (2003) Diabetes , vol.52 , pp. 1169-1175
    • Chang, I.1    Kim, S.2    Kim, J.Y.3    Cho, N.4    Kim, Y.H.5    Kim, H.S.6    Lee, M.K.7
  • 37
    • 0033561560 scopus 로고    scopus 로고
    • Pancreatic infiltration but not diabetes occurs in the relative absence of MHC class II-restricted CD4 T cells: studies using NOD/CIITA-deficient mice
    • Mora, C., Wong, F. S., Chang, C. H. and Flavell, R. A., Pancreatic infiltration but not diabetes occurs in the relative absence of MHC class II-restricted CD4 T cells: studies using NOD/CIITA-deficient mice. J. Immunol. 1999. 162: 4576-4588.
    • (1999) J. Immunol. , vol.162 , pp. 4576-4588
    • Mora, C.1    Wong, F.S.2    Chang, C.H.3    Flavell, R.A.4
  • 38
    • 0034677105 scopus 로고    scopus 로고
    • Neonatal tumor necrosis factor alpha promotes diabetes in nonobese diabetic mice by CD154-independent antigen presentation to CD8(+) T cells
    • Green, E. A., Wong, F. S., Eshima, K., Mora, C. and Flavell, R. A., Neonatal tumor necrosis factor alpha promotes diabetes in nonobese diabetic mice by CD154-independent antigen presentation to CD8(+) T cells. J. Exp. Med. 2000. 191: 225-238.
    • (2000) J. Exp. Med. , vol.191 , pp. 225-238
    • Green, E.A.1    Wong, F.S.2    Eshima, K.3    Mora, C.4    Flavell, R.A.5
  • 39
    • 0027367830 scopus 로고
    • Major histocompatibility complex class I molecules are required for the development of insulitis in non-obese diabetic mice
    • Katz, J., Benoist, C. and Mathis, D., Major histocompatibility complex class I molecules are required for the development of insulitis in non-obese diabetic mice. Eur. J. Immunol. 1993. 23: 3358-3360.
    • (1993) Eur. J. Immunol. , vol.23 , pp. 3358-3360
    • Katz, J.1    Benoist, C.2    Mathis, D.3
  • 40
    • 0027378612 scopus 로고
    • Following a diabetogenic T-cell from genesis through pathogenesis
    • Katz, J. D., Wang, B., Haskins, K., Benoist, C. and Mathis, D., Following a diabetogenic T-cell from genesis through pathogenesis. Cell 1993. 74: 1089-1100.
    • (1993) Cell , vol.74 , pp. 1089-1100
    • Katz, J.D.1    Wang, B.2    Haskins, K.3    Benoist, C.4    Mathis, D.5
  • 42
    • 0035879194 scopus 로고    scopus 로고
    • Defective CD8+ T-cell peripheral tolerance in nonobese diabetic mice
    • Kreuwel, H. T., Biggs, J. A., Pilip, I. M., Pamer, E. G., Lo, D. and Sherman, L. A., Defective CD8+ T-cell peripheral tolerance in nonobese diabetic mice. J. Immunol. 2001. 167: 1112-1117.
    • (2001) J. Immunol. , vol.167 , pp. 1112-1117
    • Kreuwel, H.T.1    Biggs, J.A.2    Pilip, I.M.3    Pamer, E.G.4    Lo, D.5    Sherman, L.A.6
  • 43
    • 0037478632 scopus 로고    scopus 로고
    • Identification of the beta cell antigen targeted by a prevalent population of pathogenic CD8+ T cells in autoimmune diabetes
    • Lieberman, S. M., Evans, A. M., Han, B., Takaki, T., Vinnitskaya, Y., Caldwell, J. A., Serreze, D. V.et al., Identification of the beta cell antigen targeted by a prevalent population of pathogenic CD8+ T cells in autoimmune diabetes. Proc. Natl. Acad. Sci. USA 2003. 100: 8384-8388.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 8384-8388
    • Lieberman, S.M.1    Evans, A.M.2    Han, B.3    Takaki, T.4    Vinnitskaya, Y.5    Caldwell, J.A.6    Serreze, D.V.7
  • 44
    • 0029841157 scopus 로고    scopus 로고
    • The role of CD8+ T cells in the initiation of insulin-dependent diabetes mellitus
    • Wang, B., Gonzalez, A., Benoist, C. and Mathis, D., The role of CD8+ T cells in the initiation of insulin-dependent diabetes mellitus. Eur. J. Immunol. 1996. 26: 1762-1769.
    • (1996) Eur. J. Immunol. , vol.26 , pp. 1762-1769
    • Wang, B.1    Gonzalez, A.2    Benoist, C.3    Mathis, D.4
  • 45
    • 38449098081 scopus 로고    scopus 로고
    • Nonobese diabetic (NOD) mice congenic for a targeted deletion of 12/15-lipoxygenase are protected from autoimmune diabetes
    • McDuffie, M., Maybee, N. A., Keller, S. R., Stevens, B. K., Garmey, J. C., Morris, M. A., Kropf, E.et al., Nonobese diabetic (NOD) mice congenic for a targeted deletion of 12/15-lipoxygenase are protected from autoimmune diabetes. Diabetes 2008. 57: 199-208.
    • (2008) Diabetes , vol.57 , pp. 199-208
    • McDuffie, M.1    Maybee, N.A.2    Keller, S.R.3    Stevens, B.K.4    Garmey, J.C.5    Morris, M.A.6    Kropf, E.7
  • 47
    • 0026545730 scopus 로고
    • Intrathymic islet cell transplantation reduces beta-cell autoimmunity and prevents diabetes in NOD/Lt mice
    • Gerling, I. C., Serreze, D. V., Christianson, S. W. and Leiter, E. H., Intrathymic islet cell transplantation reduces beta-cell autoimmunity and prevents diabetes in NOD/Lt mice. Diabetes 1992. 41: 1672-1676.
    • (1992) Diabetes , vol.41 , pp. 1672-1676
    • Gerling, I.C.1    Serreze, D.V.2    Christianson, S.W.3    Leiter, E.H.4
  • 48
    • 0029557950 scopus 로고
    • A new method for isolation of murine islets with markedly improved yields
    • Liu, M. and Shapiro, M. E., A new method for isolation of murine islets with markedly improved yields. Transplant Proc. 1995. 27: 3208-3210.
    • (1995) Transplant Proc. , vol.27 , pp. 3208-3210
    • Liu, M.1    Shapiro, M.E.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.