Disrupting the Interaction Between HOX and PBX Causes Necrotic and Apoptotic Cell Death in the Renal Cancer Lines CaKi-2 and 769-P

Journal of Urology

Volumn 180, Issue 5, 2008, Pages 2196-2201

  Shears, Liesl ^a   Plowright, Lynn ^a   Harrington, Kevin ^a   Pandha, Hardev S ^a   Morgan, Richard ^a  

^a UNIVERSITY OF SURREY   (United Kingdom)

Author keywords

apoptosis; gene expression; kidney; kidney neoplasms; transcription factors

Indexed keywords

ANNEXIN; CASPASE; HOX PROTEIN; PROPIDIUM IODIDE; PROTEIN CXR9; PROTEIN HXR9; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR PBX1; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CANCER CELL; CELL SURVIVAL; CONTROLLED STUDY; DIMERIZATION; ENZYME ACTIVITY; GENE CONTROL; GENE EXPRESSION; GENE INTERACTION; GENE TARGETING; HUMAN; HUMAN CELL; KIDNEY CANCER; MICROARRAY ANALYSIS; MOUSE; NECROSIS; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

ANIMALS; APOPTOSIS; CARCINOMA, RENAL CELL; CELL DEATH; CELL LINE, TUMOR; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, HOMEOBOX; KIDNEY NEOPLASMS; MICE; NECROSIS; REFERENCE VALUES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, NEOPLASM; SENSITIVITY AND SPECIFICITY; TRANSCRIPTION FACTORS;

EID: 53449098713     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.juro.2008.07.018     Document Type: Article

References (20)

1. Morgan R. Hox genes: a continuation of embryonic patterning?. Trends Genet 22 (2006) 67
2. Hoegg S., and Meyer A. Hox clusters as models for vertebrate genome evolution. Trends Genet 21 (2005) 421
3. Eklund E.A. The role of HOX genes in malignant myeloid disease. Curr Opin Hematol 14 (2007) 85
4. Morgan R., Pirard P., Shears S., Sohal S., Pettengell R., and Pandha H.S. Antagonism of HOX/PBX dimer formation blocks the in vivo proliferation of melanoma. Cancer Res 67 (2007) 5806
5. Chang C.P., Brocchieri L., Shen W.F., Largman C., and Cleary M.L. Pbx modulation of Hox homeodomain amino-terminal arms establishes different DNA-binding specificities across the Hox locus. Mol Cell Biol 16 (1996) 1734
6. Piper D.E., Batchelor A.H., Chang C.P., Cleary M.L., and Wolberger C. Structure of a HoxB1-Pbx1 heterodimer bound to DNA: role of the hexapeptide and a fourth homeodomain helix in complex formation. Cell 96 (1999) 587
7. Bradshaw A.D., Francki A., Motamed K., Howe C., and Sage E.H. Primary mesenchymal cells isolated from SPARC-null mice exhibit altered morphology and rates of proliferation. Mol Biol Cell 10 (1999) 1569
8. Williams R.D., Elliott A.Y., Stein N., and Fraley E.E. In vitro cultivation of human renal cell cancer. I. Establishment of cells in culture. In Vitro 12 (1976) 623
9. Fogh J. Cultivation, characterization, and identification of human tumor cells with emphasis on kidney, testis, and bladder tumors. Natl Cancer Inst Monogr 49 (1978) 5
10. Koopman G., Reutelingsperger C.P., Kuijten G.A., Keehnen R.M., Pals S.T., and van Oers M.H. Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis. Blood 84 (1994) 1415
11. Fleischmann A., Jochum W., Eferl R., Witowsky J., and Wagner E.F. Rhabdomyosarcoma development in mice lacking Trp53 and Fos: tumor suppression by the Fos protooncogene. Cancer Cell 4 (2003) 477
12. Kalra N., and Kumar V. c-Fos is a mediator of the c-myc-induced apoptotic signaling in serum-deprived hepatoma cells via the p38 mitogen-activated protein kinase pathway. J Biol Chem 279 (2004) 25313
13. Mikula M., Gotzmann J., Fischer A.N., Wolschek M.F., Thallinger C., Schulte-Hermann R., et al. The proto-oncoprotein c-Fos negatively regulates hepatocellular tumorigenesis. Oncogene 22 (2003) 6725
14. Ducruet A.P., Vogt A., Wipf P., and Lazo J.S. Dual specificity protein phosphatases: therapeutic targets for cancer and Alzheimer's disease. Annu Rev Pharmacol Toxicol 45 (2005) 725
15. Wek R.C., Jiang H.Y., and Anthony T.G. Coping with stress: eIF2 kinases and translational control. Biochem Soc Trans 3 (2006) 7
16. Yan C., Lu D., Hai T., and Boyd D.D. Activating transcription factor 3, a stress sensor, activates p53 by blocking its ubiquitination. EMBO J 24 (2005) 2425
17. Yan C., and Boyd D.D. ATF3 regulates the stability of p53: a link to cancer. Cell Cycle 5 (2006) 926
18. Lu D., Wolfgang C.D., and Hai T. Activating transcription factor 3, a stress-inducible gene, suppresses Ras-stimulated tumorigenesis. J Biol Chem 281 (2006) 10473
19. Scharnhorst V., Menke A.L., Attema J., Haneveld J.K., Riteco N., van Steenbrugge G.J., et al. EGR-1 enhances tumor growth and modulates the effect of the Wilms' tumor 1 gene products on tumorigenicity. Oncogene 19 (2000) 791
20. Ikemoto S., Narita K., Yoshida N., Wada S., Kishimoto T., Sugimura K., et al. Effects of tumor necrosis factor alpha in renal cell carcinoma. Oncol Rep 10 (2003) 1947