Self-assembling nanocomposites for protein delivery: Supramolecular interactions between PEG-cholane and rh-G-CSF

Journal of Controlled Release

Volumn 162, Issue 1, 2012, Pages 176-184

  Salmaso, Stefano ^a   Bersani, Sara ^a   Mastrotto, Francesca ^a   Tonon, Giancarlo ^b   Schrepfer, Rodolfo ^b   Genovese, Stefano ^c   Caliceti, Paolo ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b Bio Ker   (Italy)

^c IRCCS MULTIMEDICA   (Italy)

Author keywords

Amphiphilic polymers; Granulocyte colony stimulating factor; Nanocomposites; Poly(ethylene glycol); Protein delivery; Supramolecular association

Indexed keywords

AFFINITY CONSTANTS; AMPHIPHILIC POLYMERS; BIOCONJUGATES; CYTOKINES; GEL PERMEATION; GRANULOCYTE-COLONY STIMULATING FACTOR; IN-VITRO; IN-VIVO; ISOTHERMAL TITRATION CALORIMETRY; MICELLE SIZE; MULTI-MODAL; NANOCOMPLEXES; POLYMER INTERACTIONS; PROTEIN DELIVERY; PROTEIN LOADINGS; RELATIVE BIOAVAILABILITY; SCATTERING ANALYSIS; SECONDARY STRUCTURES; SELF-ASSEMBLING; SPECTROSCOPIC STUDIES; SUPRAMOLECULAR ASSOCIATION; SUPRAMOLECULAR INTERACTIONS; WHITE BLOOD CELLS;

BIOACTIVITY; CALORIMETERS; CALORIMETRY; ISOTHERMS; MOLECULAR WEIGHT; NANOCOMPOSITES; POLYETHYLENE GLYCOLS; POLYMERS; SPECTROSCOPIC ANALYSIS; SUPRAMOLECULAR CHEMISTRY; TITRATION;

PROTEINS;

CHOLANE DERIVATIVE; CHOLANIC ACID DERIVATIVE; MACROGOL; MONOMETHOXY POLY(ETHYLENE GLYCOL); NANOCOMPOSITE; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BIOLOGICAL ACTIVITY; CHEMICAL STRUCTURE; CIRCULAR DICHROISM; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG CONJUGATION; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG FORMULATION; DRUG HALF LIFE; GEL PERMEATION CHROMATOGRAPHY; ISOTHERMAL TITRATION CALORIMETRY; LIGHT SCATTERING; MALE; MAXIMUM PLASMA CONCENTRATION; MICELLE; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECONDARY STRUCTURE; RAT; SPECTROSCOPY; SUPRAMOLECULAR CHEMISTRY; SYNTHESIS; TIME TO MAXIMUM PLASMA CONCENTRATION;

ADMINISTRATION, INTRAVENOUS; ANIMALS; CHOLANES; CIRCULAR DICHROISM; DELAYED-ACTION PREPARATIONS; GRANULOCYTE COLONY-STIMULATING FACTOR; HUMANS; INJECTIONS, SUBCUTANEOUS; LEUKOCYTE COUNT; MALE; NANOCOMPOSITES; POLYETHYLENE GLYCOLS; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT PROTEINS;

EID: 84864716257     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2012.06.018     Document Type: Article

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