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Volumn 36, Issue 8, 2012, Pages 1040-1046

Leanness in postnatally nutritionally programmed rats is associated with increased sensitivity to leptin and a melanocortin receptor agonist and decreased sensitivity to neuropeptide y

Author keywords

alpha melanocortin agonist (MTII); hypothalamus; leptin sensitivity; neuropeptide Y (NPY); postnatal nutrition

Indexed keywords

LEPTIN; MELANOCORTIN RECEPTOR; MELANOCORTIN RECEPTOR AGONIST; MELANOCORTIN RECEPTOR AGONIST MTII; NEUROPEPTIDE Y; UNCLASSIFIED DRUG;

EID: 84864705036     PISSN: 03070565     EISSN: 14765497     Source Type: Journal    
DOI: 10.1038/ijo.2011.226     Document Type: Article
Times cited : (14)

References (55)
  • 1
    • 15544369982 scopus 로고    scopus 로고
    • Developmental origins of the metabolic syndrome: Prediction, plasticity, and programming
    • DOI 10.1152/physrev.00053.2003
    • McMillen IC, Robinson JS. Developmental origins of the metabolic syndrome: prediction, plasticity, and programming. Physiol Rev2005; 85: 571-633. (Pubitemid 40404637)
    • (2005) Physiological Reviews , vol.85 , Issue.2 , pp. 571-633
    • McMillen, I.C.1    Robinson, J.S.2
  • 3
    • 0017305263 scopus 로고
    • Obesity in young men after famine exposure in utero and early infancy
    • Ravelli GP, Stein ZA, Susser MW. Obesity in young men after famine exposure in utero and early infancy. N Engl J Med 1976; 295: 349-353.
    • (1976) N Engl J Med , vol.295 , pp. 349-353
    • Ravelli, G.P.1    Stein, Z.A.2    Susser, M.W.3
  • 5
    • 85028288395 scopus 로고    scopus 로고
    • Size at birth and early childhood growth in relation to maternal smoking, parity and infant breast-feeding: Longitudinal birth cohort study and analysis
    • DOI 10.1203/01.PDR.0000036602.81878.6D
    • Ong KK, Preece MA, Emmett PM, Ahmed ML, Dunger DB. Size at birth and early childhood growth in relation to maternal smoking, parity and infant breast-feeding: longitudinal birth cohort study and analysis. Pediatr Res 2002; 52: 863-867. (Pubitemid 35379465)
    • (2002) Pediatric Research , vol.52 , Issue.6 , pp. 863-867
    • Ong, K.K.L.1    Preece, M.A.2    Emmett, P.M.3    Ahmed, M.L.4    Dunger, D.B.5
  • 7
    • 0842328994 scopus 로고    scopus 로고
    • Catch-up growth and obesity in male mice
    • Ozanne SE, Hales CN. Lifespan: catch-up growth and obesity in male mice. Nature 2004; 427: 411-412. (Pubitemid 38168484)
    • (2004) Nature , vol.427 , Issue.6973 , pp. 411-412
    • Ozanne, S.E.1    Hales, C.N.2
  • 8
    • 67749120742 scopus 로고    scopus 로고
    • Programming of hypothalamic neuropeptide gene expression in rats by maternal dietary protein content during pregnancy and lactation
    • Cripps RL, Martin-Gronert MS, Archer ZA, Hales CN, Mercer JG, Ozanne SE. Programming of hypothalamic neuropeptide gene expression in rats by maternal dietary protein content during pregnancy and lactation. Clin Sci (Lond) 2009; 117: 85-93.
    • (2009) Clin Sci (Lond) , vol.117 , pp. 85-93
    • Cripps, R.L.1    Martin-Gronert, M.S.2    Archer, Z.A.3    Hales, C.N.4    Mercer, J.G.5    Ozanne, S.E.6
  • 9
    • 51049114465 scopus 로고    scopus 로고
    • Early undernutrition leads to long-lasting reductions in body weight and adiposity whereas increased intake increases cardiac fibrosis in male rats
    • Velkoska E, Cole TJ, Dean RG, Burrell LM, Morris MJ. Early undernutrition leads to long-lasting reductions in body weight and adiposity whereas increased intake increases cardiac fibrosis in male rats. J Nutr 2008; 138: 1622-1627.
    • (2008) J Nutr , vol.138 , pp. 1622-1627
    • Velkoska, E.1    Cole, T.J.2    Dean, R.G.3    Burrell, L.M.4    Morris, M.J.5
  • 11
    • 49349085690 scopus 로고    scopus 로고
    • Neonatal food restriction permanently alters rat body dimensions and energy intake
    • Remmers F, Fodor M, Delemarre-van de Waal HA. Neonatal food restriction permanently alters rat body dimensions and energy intake. Physiol Behav 2008; 95: 208-215.
    • (2008) Physiol Behav , vol.95 , pp. 208-215
    • Remmers, F.1    Fodor, M.2    Delemarre-Van De Waal, H.A.3
  • 12
    • 66149148733 scopus 로고    scopus 로고
    • Early life origins of obesity: Role of hypothalamic programming
    • Bouret SG. Early life origins of obesity: role of hypothalamic programming. J Pediatr Gastroenterol Nutr 2009; 48 (Suppl 1): S31-S38.
    • (2009) J Pediatr Gastroenterol Nutr , vol.48 , Issue.SUPPL. 1
    • Bouret, S.G.1
  • 14
    • 34347208695 scopus 로고    scopus 로고
    • Melanocortinergic activation by melanotan II inhibits feeding and increases uncoupling protein 1 messenger ribonucleic acid in the developing rat
    • DOI 10.1210/en.2007-0184
    • Glavas MM, Joachim SE, Draper SJ, Smith MS, Grove KL. Melanocortinergic activation by melanotan II inhibits feeding and increases uncoupling protein 1 messenger ribonucleic acid in the developing rat. Endocrinology 2007; 148: 3279-3287. (Pubitemid 46996975)
    • (2007) Endocrinology , vol.148 , Issue.7 , pp. 3279-3287
    • Glavas, M.M.1    Joachim, S.E.2    Draper, S.J.3    Smith, M.S.4    Grove, K.L.5
  • 15
    • 33845609117 scopus 로고    scopus 로고
    • Increased maternal nutrition alters development of the appetite-regulating network in the brain
    • Muhlhausler BS, Adam CL, Findlay PA, Duffield JA, McMillen IC. Increased maternal nutrition alters development of the appetite-regulating network in the brain. FASEBJ2006; 20: 1257-1259.
    • (2006) FASEBJ , vol.20 , pp. 1257-1259
    • Muhlhausler, B.S.1    Adam, C.L.2    Findlay, P.A.3    Duffield, J.A.4    McMillen, I.C.5
  • 16
    • 38549134585 scopus 로고    scopus 로고
    • Maternal perinatal undernutrition drastically reduces postnatal leptin surge and affects the development of arcuate nucleus proopiomelanocortin neurons in neonatal male rat pups
    • DOI 10.1210/en.2007-1263
    • Delahaye F, Breton C, Risold PY, Enache M, Dutriez-Casteloot I, Laborie C et al. Maternal perinatal undernutrition drastically reduces postnatal leptin surge and affects the development of arcuate nucleus proopiomelanocortin neurons in neonatal male rat pups. Endocrinology 2008; 149: 470-475. (Pubitemid 351159317)
    • (2008) Endocrinology , vol.149 , Issue.2 , pp. 470-475
    • Delahaye, F.1    Breton, C.2    Risold, P.-Y.3    Enache, M.4    Dutriez-Casteloot, I.5    Laborie, C.6    Lesage, J.7    Vieau, D.8
  • 17
    • 54349098711 scopus 로고    scopus 로고
    • Maternal and postnatal overnutrition differentially impact appetite regulators and fuel metabolism
    • Chen H, Simar D, Lambert K, Mercier J, Morris MJ. Maternal and postnatal overnutrition differentially impact appetite regulators and fuel metabolism. Endocrinology 2008; 149: 5348-5356.
    • (2008) Endocrinology , vol.49 , pp. 5348-5356
    • Chen, H.1    Simar, D.2    Lambert, K.3    Mercier, J.4    Morris, M.J.5
  • 19
    • 0021867618 scopus 로고
    • Bregma, lambda and the interaural midpoint in stereotaxic surgery with rats of different sex, strain and weight
    • DOI 10.1016/0165-0270(85)90026-3
    • Paxinos G, Watson C, Pennisi M, Topple A. Bregma, lambda and the interaural midpoint in stereotaxic surgery with rats of different sex, strain and weight. J Neurosci Methods 1985; 13: 139-143. (Pubitemid 15008633)
    • (1985) Journal of Neuroscience Methods , vol.13 , Issue.2 , pp. 139-143
    • Paxinos, G.1    Watson, C.2    Pennisi, M.3    Topple, A.4
  • 22
    • 0034881262 scopus 로고    scopus 로고
    • Central melanocortin system modulates energy intake and expenditure of obese and lean Zucker rats
    • Hwa JJ, Ghibaudi L, Gao J, Parker EM. Central melanocortin system modulates energy intake and expenditure of obese and lean Zucker rats. Am J Physiol Regul Integr Comp Physiol 2001; 281: R444-R451.
    • (2001) Am J Physiol Regul Integr Comp Physiol , vol.281
    • Hwa, J.J.1    Ghibaudi, L.2    Gao, J.3    Parker, E.M.4
  • 23
    • 0033785930 scopus 로고    scopus 로고
    • The effect of leptin on luteinizing hormone release is exerted in the zona incerta and mediated by melanin-concentrating hormone
    • Murray JF, Mercer JG, Adan RA, Datta JJ, Aldairy C, Moar KM et al. The effect of leptin on luteinizing hormone release is exerted in the zona incerta and mediated by melanin-concentrating hormone. J Neuroendocrinol 2000; 12: 1133-1139.
    • (2000) J Neuroendocrinol , vol.12 , pp. 1133-1139
    • Murray, J.F.1    Mercer, J.G.2    Adan, R.A.3    Datta, J.J.4    Aldairy, C.5    Moar, K.M.6
  • 24
    • 0036460449 scopus 로고    scopus 로고
    • Hypothalamic bHLH transcription factors are novel candidates in the regulation of energy balance
    • DOI 10.1046/j.1460-9568.2002.01894.x
    • Nilaweera KN, Ellis C, Barrett P, Mercer JG, Morgan PJ. Hypothalamic bHLH transcription factors are novel candidates in the regulation of energy balance. Eur J Neurosci 2002; 15: 644-650. (Pubitemid 35471933)
    • (2002) European Journal of Neuroscience , vol.15 , Issue.4 , pp. 644-650
    • Nilaweera, K.N.1    Ellis, C.2    Barrett, P.3    Mercer, J.G.4    Morgan, P.J.5
  • 25
    • 0024463970 scopus 로고
    • A complete protocol for in situ hybridization of messenger RNAs in brain and other tissues with radiolabeled single-stranded RNA probes
    • Simmons DM, Arriza JL, Swanson LW. A complete protocol for in situ hybridization of messenger RNAs in brain and other tissues with radio-labelled single-stranded RNA probes. J Histotechnol 1989; 12: 169-181. (Pubitemid 19246678)
    • (1989) Journal of Histotechnology , vol.12 , Issue.3 , pp. 169-181
    • Simmons, D.M.1    Arriza, J.L.2    Swanson, L.W.3
  • 27
    • 77954694568 scopus 로고    scopus 로고
    • Identification of the global transcriptomic response of the hypothalamic arcuate nucleus to fasting and leptin
    • Jovanovic Z, Tung YC, Lam BY, O'Rahilly S, Yeo GS. Identification of the global transcriptomic response of the hypothalamic arcuate nucleus to fasting and leptin. J Neuroendocrinol 2010; 22: 915-925.
    • (2010) J Neuroendocrinol , vol.22 , pp. 915-925
    • Jovanovic, Z.1    Tung, Y.C.2    Lam, B.Y.3    O'Rahilly, S.4    Yeo, G.S.5
  • 28
    • 46349107528 scopus 로고    scopus 로고
    • Hypothalamic neuropeptide expression of juvenile and middle-aged rats after early postnatal food restriction
    • DOI 10.1210/en.2007-1388
    • Remmers F, Verhagen LA, Adan RA, Delemarre-van de Waal HA. Hypothalamic neuropeptide expression ofjuvenile and middle-aged rats after early postnatal food restriction. Endocrinology 2008; 149: 3617-3625. (Pubitemid 351919583)
    • (2008) Endocrinology , vol.149 , Issue.7 , pp. 3617-3625
    • Remmers, F.1    Verhagen, L.A.2    Adan, R.A.3    Delemarre-Van De Waal, H.A.4
  • 29
    • 0034733888 scopus 로고    scopus 로고
    • Investigation of the melanocyte stimulating hormones on food intakeLack of evidence to support a role for the melanocortin-3-receptor
    • DOI 10.1016/S0006-8993(00)02386-6, PII S0006899300023866
    • Abbott CR, Rossi M, Kim M, AlAhmed SH,Taylor GM, Ghatei MA etal. Investigation of the melanocyte stimulating hormones on food intake. Lack of evidence to support a role for the melanocortin-3-receptor. Brain Res 2000; 869: 203-210. (Pubitemid 30345791)
    • (2000) Brain Research , vol.869 , Issue.1-2 , pp. 203-210
    • Abbott, C.R.1    Rossi, M.2    Kim, M.-S.3    Alahmed, S.H.4    Taylor, G.M.5    Ghatei, M.A.6    Smith, D.M.7    Bloom, S.R.8
  • 31
    • 0036226005 scopus 로고    scopus 로고
    • Central leptin gene delivery evokes persistent leptin signal transduction in young and aged-obese rats but physiological responses become attenuated over time in aged-obese rats
    • DOI 10.1016/S0028-3908(02)00003-5, PII S0028390802000035
    • Scarpace PJ, Matheny M, Zhang Y,Tumer N, Frase CD, ShekEW etal. Central leptin gene delivery evokes persistent leptin signal transduction in young and aged-obese rats but physiological responses become attenuated over time in aged-obese rats. Neuropharmacology 2002; 42: 548-561. (Pubitemid 34304247)
    • (2002) Neuropharmacology , vol.42 , Issue.4 , pp. 548-561
    • Scarpace, P.J.1    Matheny, M.2    Zhang, Y.3    Tumer, N.4    Frase, C.D.5    Shek, E.W.6    Hong, B.7    Prima, V.8    Zolotukhin, S.9
  • 32
    • 18844367781 scopus 로고    scopus 로고
    • Central regulation of energy balance: Inputs, outputs and leptin resistance
    • DOI 10.1079/PNS2004407
    • Arch Jr. Central regulation of energy balance: inputs, outputs and leptin resistance. Proc Nutr Soc 2005; 64: 39-46. (Pubitemid 40685750)
    • (2005) Proceedings of the Nutrition Society , vol.64 , Issue.1 , pp. 39-46
    • Arch, J.R.S.1
  • 33
    • 33847319765 scopus 로고    scopus 로고
    • Diet-induced obesity causes severe but reversible leptin resistance in arcuate melanocortin neurons
    • Enriori PJ, Evans AE, Sinnayah P, Jobst EE, Tonelli-Lemos L, Billes SK et al. Diet-induced obesity causes severe but reversible leptin resistance in arcuate melanocortin neurons. CellMetab 2007; 5: 181-194.
    • (2007) CellMetab , vol.5 , pp. 181-194
    • Enriori, P.J.1    Evans, A.E.2    Sinnayah, P.3    Jobst, E.E.4    Tonelli-Lemos, L.5    Billes, S.K.6
  • 34
    • 0035895826 scopus 로고    scopus 로고
    • Enhanced inhibitory feeding response to alpha-melanocyte stimulating hormone in the diet-induced obese rat
    • DOI 10.1016/S0006-8993(00)03246-7, PII S0006899300032467
    • Hansen MJ, Ball MJ, Morris MJ. Enhanced inhibitory feeding response to alpha-melanocyte stimulating hormone in the diet-induced obese rat Brain Res 2001; 892: 130-137. (Pubitemid 32126576)
    • (2001) Brain Research , vol.892 , Issue.1 , pp. 130-137
    • Hansen, M.J.1    Ball, M.J.2    Morris, M.J.3
  • 35
    • 0038168650 scopus 로고    scopus 로고
    • Leptin-induced leptin resistant rats exhibit enhanced responses to the melanocortin agonist MT II
    • DOI 10.1016/S0028-3908(03)00158-8
    • Scarpace PJ, Matheny M, Zolotukhin S, Tumer N, Zhang Y. Leptin-induced leptin resistant rats exhibit enhanced responses to the melanocortin agonist II MT. Neuropharmacology 2003; 45: 211-219. (Pubitemid 36782534)
    • (2003) Neuropharmacology , vol.45 , Issue.2 , pp. 211-219
    • Scarpace, P.J.1    Matheny, M.2    Zolotukhin, S.3    Tumer, N.4    Zhang, Y.5
  • 36
    • 4043154233 scopus 로고    scopus 로고
    • Unabated anorexic and enhanced thermogenic responses to melanotan II in diet-induced obese rats despite reduced melanocortin 3 and 4 receptor expression
    • DOI 10.1677/joe.0.1820123
    • Li G, Zhang Y, Wilsey JT, Scarpace PJ. Unabated anorexic and enhanced thermo-genic responses to melanotan II in diet-induced obese rats despite reduced melanocortin 3 and 4 receptor expression. J Endocrinol 2004; 182: 123-132. (Pubitemid 39076908)
    • (2004) Journal of Endocrinology , vol.182 , Issue.1 , pp. 123-132
    • Li, G.1    Zhang, Y.2    Wilsey, J.T.3    Scarpace, P.J.4
  • 37
    • 4644359357 scopus 로고    scopus 로고
    • Aged-obese rats exhibit robust responses to a melanocortin agonist and antagonist despite leptin resistance
    • DOI 10.1016/j.neurobiolaging.2004.02.012, PII S0197458004001125
    • Zhang Y, Matheny M, Tumer N, Scarpace PJ. Aged-obese rats exhibit robust responses to a melanocortin agonist and antagonist despite leptin resistance. Neurobiol Aging 2004; 25: 1349-1360. (Pubitemid 39299173)
    • (2004) Neurobiology of Aging , vol.25 , Issue.10 , pp. 1349-1360
    • Zhang, Y.1    Matheny, M.2    Tumer, N.3    Scarpace, P.J.4
  • 39
    • 1042266534 scopus 로고    scopus 로고
    • Adaptive responses in hypothalamic neuropeptide Y in the face of prolonged high-fat feeding in the rat
    • Hansen MJ, Jovanovska V, Morris MJ. Adaptive responses in hypothalamic neuropeptide Y in the face of prolonged high-fat feeding in the rat. J Neurochem 2004; 88: 909-916. (Pubitemid 38199312)
    • (2004) Journal of Neurochemistry , vol.88 , Issue.4 , pp. 909-916
    • Hansen, M.J.1    Jovanovska, V.2    Morris, M.J.3
  • 40
    • 0026575399 scopus 로고
    • Spare receptors for beta-adrenoceptor-mediated positive inotropic effects of catecholamines in the human heart
    • Brown L, Deighton NM, Bals S, Sohlmann W, Zerkowski HR, Michel MC et al. Spare receptors for beta-adrenoceptor-mediated positive inotropic effects of catecholamines in the human heart. J Cardiovasc Pharmacol 1992; 19: 222-232.
    • (1992) J Cardiovasc Pharmacol , vol.19 , pp. 222-232
    • Brown, L.1    Deighton, N.M.2    Bals, S.3    Sohlmann, W.4    Zerkowski, H.R.5    Michel, M.C.6
  • 41
    • 0030775971 scopus 로고    scopus 로고
    • Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus
    • Schwartz MW, Seeley RJ, Woods SC, Weigle DS, Campfield LA, Burn P et al. Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus. Diabetes 1997; 46: 2119-2123. (Pubitemid 27512108)
    • (1997) Diabetes , vol.46 , Issue.12 , pp. 2119-2123
    • Schwartz, M.W.1    Seeley, R.J.2    Woods, S.C.3    Weigle, D.S.4    Campfield, L.A.5    Burn, P.6    Baskin, D.G.7
  • 42
    • 0031888157 scopus 로고    scopus 로고
    • Hypothalamic pro-opiomelanocortin mRNA is reduced by fasting in ob/ob and db/db mice, but is stimulated by leptin
    • Mizuno TM, Kleopoulos SP, Bergen HT, Roberts JL, Priest CA, Mobbs CV. Hypothalamic pro-opiomelanocortin mRNA is reduced by fasting and corrected in ob/ob and db/db mice, but is stimulated by leptin. Diabetes 1998; 47: 294-297. (Pubitemid 28079992)
    • (1998) Diabetes , vol.47 , Issue.2 , pp. 294-297
    • Mizuno, T.M.1    Kleopoulos, S.P.2    Bergen, H.T.3    Roberts, J.L.4    Priest, C.A.5    Mobbs, C.V.6
  • 43
    • 0031766974 scopus 로고    scopus 로고
    • Fate of leptin after intracerebroventricular injection into the mouse brain
    • DOI 10.1210/en.139.11.4556
    • Maness LM, Kastin AJ, Farrell CL, Banks WA. Fate of leptin after intracerebroven-tricular injection into the mouse brain. Endocrinology 1998; 139: 4556-4562. (Pubitemid 28487772)
    • (1998) Endocrinology , vol.139 , Issue.11 , pp. 4556-4562
    • Maness, L.M.1    Kastin, A.J.2    Farrell, C.L.3    Banks, W.A.4
  • 44
    • 37649024725 scopus 로고    scopus 로고
    • The effect of intraperitoneal administration of leptin on short-term food intake in rats
    • Patel JD, Ebenezer IS. The effect of intraperitoneal administration of leptin on short-term food intake in rats. Eur J Pharmacol 2008; 580: 143-152.
    • (2008) Eur J Pharmacol , vol.580 , pp. 143-152
    • Patel, J.D.1    Ebenezer, I.S.2
  • 46
    • 34547235565 scopus 로고    scopus 로고
    • Leptin inhibits gastric emptying in rats: Role of CCK receptors and vagal afferent fibers
    • Cakir B, Kasimay O, Devseren E, Yegen BC. Leptin inhibits gastric emptying in rats: role of CCK receptors and vagal afferent fibers. Physiol Res 2007; 56: 315-322.
    • (2007) Physiol Res , vol.56 , pp. 315-322
    • Cakir, B.1    Kasimay, O.2    Devseren, E.3    Yegen, B.C.4
  • 47
    • 33745142241 scopus 로고    scopus 로고
    • Characterization of leptin-responsive neurons in the caudal brainstem
    • DOI 10.1210/en.2005-0877
    • Ellacott KL, Halatchev IG, Cone RD. Characterization of leptin-responsive neurons in the caudal brainstem. Endocrinology 2006; 147: 3190-3195. (Pubitemid 43901109)
    • (2006) Endocrinology , vol.147 , Issue.7 , pp. 3190-3195
    • Ellacott, K.L.J.1    Halatchev, I.G.2    Cone, R.D.3
  • 48
    • 0032796613 scopus 로고    scopus 로고
    • Effects of central and peripheral injection of leptin on food intake and on brain fos expression in the Otsuka Long-Evans Tokushima Fatty rat with hyperleptinaemia
    • DOI 10.1046/j.1365-2826.1999.00368.x
    • Niimi M, Sato M, Yokote R, Tada S, Takahara J. Effects of central and peripheral injection of leptin on food intake and on brain Fos expression in the otsuka long-evans tokushima fatty rat with hyperleptinaemia. J Neuroendocrinol 1999; 11: 605-611. (Pubitemid 29338676)
    • (1999) Journal of Neuroendocrinology , vol.11 , Issue.8 , pp. 605-611
    • Niimi, M.1    Sato, M.2    Yokote, R.3    Tada, S.4    Takahara, J.5
  • 49
    • 77956046109 scopus 로고    scopus 로고
    • Large litter rearing enhances leptin sensitivity and protects selectively bred diet-induced obese rats from becoming obese
    • Patterson CM, Bouret SG, Park S, Irani BG, Dunn-Meynell AA, Levin BE. Large litter rearing enhances leptin sensitivity and protects selectively bred diet-induced obese rats from becoming obese. Endocrinology 2010; 151: 4270-4279.
    • (2010) Endocrinology , vol.151 , pp. 4270-4279
    • Patterson, C.M.1    Bouret, S.G.2    Park, S.3    Irani, B.G.4    Dunn-Meynell, A.A.5    Levin, B.E.6
  • 51
    • 64149099887 scopus 로고    scopus 로고
    • Three weeks of postweaning exercise in DIO rats produces prolonged increases in central leptin sensitivity and signaling
    • Patterson CM, Bouret SG, Dunn-Meynell AA, Levin BE. Three weeks of postweaning exercise in DIO rats produces prolonged increases in central leptin sensitivity and signaling. Am J Physiol Regul Integr Comp Physiol 2009; 296: R537-R548.
    • (2009) Am J Physiol Regul Integr Comp Physiol , vol.296
    • Patterson, C.M.1    Bouret, S.G.2    Dunn-Meynell, A.A.3    Levin, B.E.4
  • 52
    • 0021327519 scopus 로고
    • Exercise and detraining: Effect on food intake, adiposity and lipogenesis in Osborne-Mendel rats made obese by a high fat diet
    • Applegate EA, Upton DE, Stern JS. Exercise and detraining: effect on food intake, adiposity and lipogenesis in Osborne-Mendel rats made obese by a high fat diet. J Nutr 1984; 114: 447-459. (Pubitemid 14192388)
    • (1984) Journal of Nutrition , vol.114 , Issue.2 , pp. 447-459
    • Applegate, E.A.1    Upton, D.E.2    Stern, J.S.3


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