-
1
-
-
0032851160
-
Functions of cell surface heparan sulfate proteoglycans
-
Bernfield M., Gotte M., Park P., Reizes O., Fitzgerald M., Lincecum J., et al. Functions of cell surface heparan sulfate proteoglycans. Annu Rev Biochem 68 (1999) 729-777
-
(1999)
Annu Rev Biochem
, vol.68
, pp. 729-777
-
-
Bernfield, M.1
Gotte, M.2
Park, P.3
Reizes, O.4
Fitzgerald, M.5
Lincecum, J.6
-
2
-
-
0031657808
-
Matrix proteoglycans: from molecular design to cellular function
-
Iozzo R. Matrix proteoglycans: from molecular design to cellular function. Annu Rev Biochem 67 (1998) 609-652
-
(1998)
Annu Rev Biochem
, vol.67
, pp. 609-652
-
-
Iozzo, R.1
-
4
-
-
0030018209
-
Involvement of heparan sulfate and related molecules in sequestration and growth promoting activity of fibroblast growth factor
-
Vlodavsky I., Miao H., Medalion B., Danagher P., and Ron D. Involvement of heparan sulfate and related molecules in sequestration and growth promoting activity of fibroblast growth factor. Cancer Metastasis Rev 15 (1996) 177-186
-
(1996)
Cancer Metastasis Rev
, vol.15
, pp. 177-186
-
-
Vlodavsky, I.1
Miao, H.2
Medalion, B.3
Danagher, P.4
Ron, D.5
-
6
-
-
0034904048
-
Molecular properties and involvement of heparanase in cancer metastasis and angiogenesis
-
Vlodavsky I., and Friedmann Y. Molecular properties and involvement of heparanase in cancer metastasis and angiogenesis. J Clin Invest 108 (2001) 341-347
-
(2001)
J Clin Invest
, vol.108
, pp. 341-347
-
-
Vlodavsky, I.1
Friedmann, Y.2
-
7
-
-
34247637147
-
Heparanase: a target for drug discovery in cancer and inflammation
-
McKenzie E. Heparanase: a target for drug discovery in cancer and inflammation. Br J Pharmacol 151 (2007) 1-14
-
(2007)
Br J Pharmacol
, vol.151
, pp. 1-14
-
-
McKenzie, E.1
-
8
-
-
0041659176
-
Heterodimer formation is essential for heparanase enzymatic activity
-
Levy-Adam F., Miao H., Heinrikson R., Vlodavsky I., and Ilan N. Heterodimer formation is essential for heparanase enzymatic activity. Biochem Biophys Res Commun 308 (2003) 885-891
-
(2003)
Biochem Biophys Res Commun
, vol.308
, pp. 885-891
-
-
Levy-Adam, F.1
Miao, H.2
Heinrikson, R.3
Vlodavsky, I.4
Ilan, N.5
-
9
-
-
1242307804
-
Mechanism of activation of human heparanase investigated by protein engineering
-
Nardella C., Lahm A., Pallaoro M., Brunetti M., Vannini A., and Steinkuhler C. Mechanism of activation of human heparanase investigated by protein engineering. Biochemistry 43 (2004) 1862-1873
-
(2004)
Biochemistry
, vol.43
, pp. 1862-1873
-
-
Nardella, C.1
Lahm, A.2
Pallaoro, M.3
Brunetti, M.4
Vannini, A.5
Steinkuhler, C.6
-
10
-
-
0034719130
-
Identification of active-site residues of the pro-metastatic endoglycosidase heparanase
-
Hulett M., Hornby J., Ohms S., Zuegg J., Freeman C., Gready J., et al. Identification of active-site residues of the pro-metastatic endoglycosidase heparanase. Biochemistry 39 (2000) 15659-15667
-
(2000)
Biochemistry
, vol.39
, pp. 15659-15667
-
-
Hulett, M.1
Hornby, J.2
Ohms, S.3
Zuegg, J.4
Freeman, C.5
Gready, J.6
-
11
-
-
17144415530
-
Site-directed mutagenesis, proteolytic cleavage, and activation of human proheparanase
-
Abboud-Jarrous G., Rangini-Guetta Z., Aingorn H., Atzmon R., Elgavish S., Peretz T., et al. Site-directed mutagenesis, proteolytic cleavage, and activation of human proheparanase. J Biol Chem 280 (2005) 13568-13575
-
(2005)
J Biol Chem
, vol.280
, pp. 13568-13575
-
-
Abboud-Jarrous, G.1
Rangini-Guetta, Z.2
Aingorn, H.3
Atzmon, R.4
Elgavish, S.5
Peretz, T.6
-
12
-
-
33748683743
-
Regulation, function and clinical significance of heparanase in cancer metastasis and angiogenesis
-
Ilan N., Elkin M., and Vlodavsky I. Regulation, function and clinical significance of heparanase in cancer metastasis and angiogenesis. Int J Biochem Cell Biol 38 (2006) 2018-2039
-
(2006)
Int J Biochem Cell Biol
, vol.38
, pp. 2018-2039
-
-
Ilan, N.1
Elkin, M.2
Vlodavsky, I.3
-
13
-
-
4143083982
-
Heparanase as a molecular target of cancer chemotherapy
-
Simizu S., Ishida K., and Osada H. Heparanase as a molecular target of cancer chemotherapy. Cancer Sci 95 (2004) 553-558
-
(2004)
Cancer Sci
, vol.95
, pp. 553-558
-
-
Simizu, S.1
Ishida, K.2
Osada, H.3
-
14
-
-
0035405778
-
Heparanase as mediator of angiogenesis: mode of action
-
Elkin M., Ilan N., Ishai-Michaeli R., Friedmann Y., Papo O., Pecker I., et al. Heparanase as mediator of angiogenesis: mode of action. FASEB J 15 (2001) 1661-1663
-
(2001)
FASEB J
, vol.15
, pp. 1661-1663
-
-
Elkin, M.1
Ilan, N.2
Ishai-Michaeli, R.3
Friedmann, Y.4
Papo, O.5
Pecker, I.6
-
15
-
-
2542494203
-
Heparanase induces endothelial cell migration via protein kinase B/Akt activation
-
Gingis-Velitski S., Zetser A., Flugelman M., Vlodavsky I., and Ilan N. Heparanase induces endothelial cell migration via protein kinase B/Akt activation. J Biol Chem 279 (2004) 23536-23541
-
(2004)
J Biol Chem
, vol.279
, pp. 23536-23541
-
-
Gingis-Velitski, S.1
Zetser, A.2
Flugelman, M.3
Vlodavsky, I.4
Ilan, N.5
-
16
-
-
32944479184
-
Heparanase induces vascular endothelial growth factor expression: correlation with p38 phosphorylation levels and Src activation
-
Zetser A., Bashenko Y., Edovitsky E., Levy-Adam F., Vlodavsky I., and Ilan N. Heparanase induces vascular endothelial growth factor expression: correlation with p38 phosphorylation levels and Src activation. Cancer Res 66 (2006) 1455-1463
-
(2006)
Cancer Res
, vol.66
, pp. 1455-1463
-
-
Zetser, A.1
Bashenko, Y.2
Edovitsky, E.3
Levy-Adam, F.4
Vlodavsky, I.5
Ilan, N.6
-
17
-
-
32344434119
-
An ELISA method for the detection and quantification of human heparanase
-
Shafat I., Zcharia E., Nisman B., Nadir Y., Nakhoul F., Vlodavsky I., et al. An ELISA method for the detection and quantification of human heparanase. Biochem Biophys Res Commun 341 (2006) 958-963
-
(2006)
Biochem Biophys Res Commun
, vol.341
, pp. 958-963
-
-
Shafat, I.1
Zcharia, E.2
Nisman, B.3
Nadir, Y.4
Nakhoul, F.5
Vlodavsky, I.6
-
18
-
-
0032879625
-
Inhibition of heparanase activity and tumor metastasis by laminarin sulfate and synthetic phosphorothioate oligodeoxynucleotides
-
Miao H., Elkin M., Aingorn E., Ishai-Michaeli R., Stein C., and Vlodavsky I. Inhibition of heparanase activity and tumor metastasis by laminarin sulfate and synthetic phosphorothioate oligodeoxynucleotides. Int J Cancer 83 (1999) 424-431
-
(1999)
Int J Cancer
, vol.83
, pp. 424-431
-
-
Miao, H.1
Elkin, M.2
Aingorn, E.3
Ishai-Michaeli, R.4
Stein, C.5
Vlodavsky, I.6
-
19
-
-
0033565247
-
Identification of sulfated oligosaccharide-based inhibitors of tumor growth and metastasis using novel in vitro assays for angiogenesis and heparanase activity
-
Parish C., Freeman C., Brown K., Francis D., and Cowden W. Identification of sulfated oligosaccharide-based inhibitors of tumor growth and metastasis using novel in vitro assays for angiogenesis and heparanase activity. Cancer Res 59 (1999) 3433-3441
-
(1999)
Cancer Res
, vol.59
, pp. 3433-3441
-
-
Parish, C.1
Freeman, C.2
Brown, K.3
Francis, D.4
Cowden, W.5
-
20
-
-
0028675219
-
Inhibition of tumor metastasis by heparanase inhibiting species of heparin
-
Vlodavsky I., Mohsen M., Lider O., Svahn C., Ekre H., Vigoda M., et al. Inhibition of tumor metastasis by heparanase inhibiting species of heparin. Invasion Metastasis 14 (1994) 290-302
-
(1994)
Invasion Metastasis
, vol.14
, pp. 290-302
-
-
Vlodavsky, I.1
Mohsen, M.2
Lider, O.3
Svahn, C.4
Ekre, H.5
Vigoda, M.6
-
21
-
-
0033057962
-
Mammalian heparanase: gene cloning, expression and function in tumor progression and metastasis
-
Vlodavsky I., Friedmann Y., Elkin M., Aingorn H., Atzmon R., Ishai-Michaeli R., et al. Mammalian heparanase: gene cloning, expression and function in tumor progression and metastasis. Nat Med 5 (1999) 793-802
-
(1999)
Nat Med
, vol.5
, pp. 793-802
-
-
Vlodavsky, I.1
Friedmann, Y.2
Elkin, M.3
Aingorn, H.4
Atzmon, R.5
Ishai-Michaeli, R.6
-
22
-
-
0037162555
-
Cell surface expression and secretion of heparanase markedly promote tumor angiogenesis and metastasis
-
Goldshmidt O., Zcharia E., Abramovitch R., Metzger S., Aingorn H., Friedmann Y., et al. Cell surface expression and secretion of heparanase markedly promote tumor angiogenesis and metastasis. Proc Natl Acad Sci U S A 99 (2002) 10031-10036
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 10031-10036
-
-
Goldshmidt, O.1
Zcharia, E.2
Abramovitch, R.3
Metzger, S.4
Aingorn, H.5
Friedmann, Y.6
-
23
-
-
4344598247
-
Heparanase gene silencing, tumor invasiveness, angiogenesis, and metastasis
-
Edovitsky E., Elkin M., Zcharia E., Peretz T., and Vlodavsky I. Heparanase gene silencing, tumor invasiveness, angiogenesis, and metastasis. J Natl Cancer Inst 96 (2004) 1219-1230
-
(2004)
J Natl Cancer Inst
, vol.96
, pp. 1219-1230
-
-
Edovitsky, E.1
Elkin, M.2
Zcharia, E.3
Peretz, T.4
Vlodavsky, I.5
-
24
-
-
0037711133
-
Heparanase mediates cell adhesion independent of its enzymatic activity
-
Goldshmidt O., Zcharia E., Cohen M., Aingorn H., Cohen I., Nadav L., et al. Heparanase mediates cell adhesion independent of its enzymatic activity. FASEB J 17 (2003) 1015-1025
-
(2003)
FASEB J
, vol.17
, pp. 1015-1025
-
-
Goldshmidt, O.1
Zcharia, E.2
Cohen, M.3
Aingorn, H.4
Cohen, I.5
Nadav, L.6
-
25
-
-
33750075728
-
Heparanase induces tissue factor expression in vascular endothelial and cancer cells
-
Nadir Y., Brenner B., Zetser A., Ilan N., Shafat I., Zcharia E., et al. Heparanase induces tissue factor expression in vascular endothelial and cancer cells. J Thromb Haemost 4 (2006) 2443-2451
-
(2006)
J Thromb Haemost
, vol.4
, pp. 2443-2451
-
-
Nadir, Y.1
Brenner, B.2
Zetser, A.3
Ilan, N.4
Shafat, I.5
Zcharia, E.6
-
26
-
-
25844507098
-
Cellular uptake of mammalian heparanase precursor involves low density lipoprotein receptor-related proteins, mannose 6-phosphate receptors, and heparan sulfate proteoglycans
-
Vreys V., Delande N., Zhang Z., Coomans C., Roebroek A., Durr J., et al. Cellular uptake of mammalian heparanase precursor involves low density lipoprotein receptor-related proteins, mannose 6-phosphate receptors, and heparan sulfate proteoglycans. J Biol Chem 280 (2005) 33141-33148
-
(2005)
J Biol Chem
, vol.280
, pp. 33141-33148
-
-
Vreys, V.1
Delande, N.2
Zhang, Z.3
Coomans, C.4
Roebroek, A.5
Durr, J.6
-
27
-
-
34147166702
-
The effect of low-molecular-weight heparin on cancer survival. A systematic review and meta-analysis of randomized trials
-
Lazo-Langner A., Goss G., Spaans J., and Rodger M. The effect of low-molecular-weight heparin on cancer survival. A systematic review and meta-analysis of randomized trials. J Thromb Haemost 5 (2007) 729-737
-
(2007)
J Thromb Haemost
, vol.5
, pp. 729-737
-
-
Lazo-Langner, A.1
Goss, G.2
Spaans, J.3
Rodger, M.4
-
28
-
-
17144385138
-
Randomized comparison of low molecular weight heparin and coumarin derivatives on the survival of patients with cancer and venous thromboembolism
-
Lee A., Rickles F., Julian J., Gent M., Baker R., Bowden C., et al. Randomized comparison of low molecular weight heparin and coumarin derivatives on the survival of patients with cancer and venous thromboembolism. J Clin Oncol 23 (2005) 2123-2129
-
(2005)
J Clin Oncol
, vol.23
, pp. 2123-2129
-
-
Lee, A.1
Rickles, F.2
Julian, J.3
Gent, M.4
Baker, R.5
Bowden, C.6
-
29
-
-
0034700438
-
Prognosis of cancers associated with venous thromboembolism
-
Sorensen H., Mellemkjaer L., Olsen J., and Baron J. Prognosis of cancers associated with venous thromboembolism. N Engl J Med 343 (2000) 1846-1850
-
(2000)
N Engl J Med
, vol.343
, pp. 1846-1850
-
-
Sorensen, H.1
Mellemkjaer, L.2
Olsen, J.3
Baron, J.4
-
30
-
-
0035853111
-
Heparin and cancer revisited: mechanistic connections involving platelets, P-selectin, carcinoma mucins, and tumor metastasis
-
Borsig L., Wong R., Feramisco J., Nadeau D., Varki N., and Varki A. Heparin and cancer revisited: mechanistic connections involving platelets, P-selectin, carcinoma mucins, and tumor metastasis. Proc Natl Acad Sci USA 98 (2001) 3352-3357
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 3352-3357
-
-
Borsig, L.1
Wong, R.2
Feramisco, J.3
Nadeau, D.4
Varki, N.5
Varki, A.6
-
31
-
-
35948980396
-
P-selectin- and heparanase-dependent antimetastatic activity of non-anticoagulant heparins
-
[Jun 8; Epub ahead of print.]
-
Hostettler N., Naggi A., Torri G., Ishai-Michaeli R., Casu B., Vlodavsky I., et al. P-selectin- and heparanase-dependent antimetastatic activity of non-anticoagulant heparins. FASEB J (2007) [Jun 8; Epub ahead of print.]
-
(2007)
FASEB J
-
-
Hostettler, N.1
Naggi, A.2
Torri, G.3
Ishai-Michaeli, R.4
Casu, B.5
Vlodavsky, I.6
-
32
-
-
0023193233
-
Inhibition of heparanase-mediated degradation of extracellular matrix heparan sulfate by non-anticoagulant heparin species
-
Bar-Ner M., Eldor A., Wasserman L., Matzner Y., Cohen I., Fuks Z., et al. Inhibition of heparanase-mediated degradation of extracellular matrix heparan sulfate by non-anticoagulant heparin species. Blood 70 (1987) 551-557
-
(1987)
Blood
, vol.70
, pp. 551-557
-
-
Bar-Ner, M.1
Eldor, A.2
Wasserman, L.3
Matzner, Y.4
Cohen, I.5
Fuks, Z.6
-
33
-
-
20144388264
-
Modulation of the heparanase-inhibiting activity of heparin through selective desulfation, graded N-acetylation, and glycol splitting
-
Naggi A., Casu B., Perez M., Torri G., Cassinelli G., Penco S., et al. Modulation of the heparanase-inhibiting activity of heparin through selective desulfation, graded N-acetylation, and glycol splitting. J Biol Chem 280 (2005) 12103-12113
-
(2005)
J Biol Chem
, vol.280
, pp. 12103-12113
-
-
Naggi, A.1
Casu, B.2
Perez, M.3
Torri, G.4
Cassinelli, G.5
Penco, S.6
-
34
-
-
34447287858
-
Heparanase: structure, biological functions, and inhibition by heparin-derived mimetics of heparan sulfate
-
Vlodavsky I., Ilan N., Naggi A., and Casu B. Heparanase: structure, biological functions, and inhibition by heparin-derived mimetics of heparan sulfate. Curr Pharmacol Design 13 (2007) 2057-2073
-
(2007)
Curr Pharmacol Design
, vol.13
, pp. 2057-2073
-
-
Vlodavsky, I.1
Ilan, N.2
Naggi, A.3
Casu, B.4
-
35
-
-
7944230119
-
Heparan sulfate proteoglycans and heparanase partners in osteolytic tumor growth and metastasis
-
Sanderson R., Yang Y., Suva L., and Kelly T. Heparan sulfate proteoglycans and heparanase partners in osteolytic tumor growth and metastasis. Matrix Biol 23 (2004) 341-352
-
(2004)
Matrix Biol
, vol.23
, pp. 341-352
-
-
Sanderson, R.1
Yang, Y.2
Suva, L.3
Kelly, T.4
-
36
-
-
34548836012
-
The syndecan-1 heparan sulfate proteoglycan is a viable target for myeloma therapy
-
[May 29; Epub ahead of print.]
-
Yang Y., Macleod V., Dai Y., Khotskaya-Sample Y., Shriver Z., Venkataraman G., et al. The syndecan-1 heparan sulfate proteoglycan is a viable target for myeloma therapy. Blood (2007) [May 29; Epub ahead of print.]
-
(2007)
Blood
-
-
Yang, Y.1
Macleod, V.2
Dai, Y.3
Khotskaya-Sample, Y.4
Shriver, Z.5
Venkataraman, G.6
-
37
-
-
0024021040
-
Conformational flexibility: a new concept for explaining binding and biological properties of iduronic acid-containing glycosaminoglycans
-
Casu B., Petitou M., Provasoli M., and Sinäy P. Conformational flexibility: a new concept for explaining binding and biological properties of iduronic acid-containing glycosaminoglycans. Trends Biochem Sci 13 (1988) 221-225
-
(1988)
Trends Biochem Sci
, vol.13
, pp. 221-225
-
-
Casu, B.1
Petitou, M.2
Provasoli, M.3
Sinäy, P.4
-
38
-
-
0036687864
-
Active conformations of glycosaminoglycans. NMR determination of the conformation of heparin sequences complexed with antithrombin and fibroblast growth factors in solution
-
Hricovini M., Guerrini M., Bisio A., Torri G., Naggi A., and Casu B. Active conformations of glycosaminoglycans. NMR determination of the conformation of heparin sequences complexed with antithrombin and fibroblast growth factors in solution. Semin Thromb Hemost 28 (2002) 325-334
-
(2002)
Semin Thromb Hemost
, vol.28
, pp. 325-334
-
-
Hricovini, M.1
Guerrini, M.2
Bisio, A.3
Torri, G.4
Naggi, A.5
Casu, B.6
-
39
-
-
20144376911
-
Identification and characterization of heparin/heparan sulfate binding domains of the endoglycosidase heparanase
-
Levy-Adam F., Abboud-Jarrous G., Guerrini M., Beccati D., Vlodavsky I., and Ilan N. Identification and characterization of heparin/heparan sulfate binding domains of the endoglycosidase heparanase. J Biol Chem 280 (2005) 20457-20466
-
(2005)
J Biol Chem
, vol.280
, pp. 20457-20466
-
-
Levy-Adam, F.1
Abboud-Jarrous, G.2
Guerrini, M.3
Beccati, D.4
Vlodavsky, I.5
Ilan, N.6
-
41
-
-
0141819106
-
Tissue factor, thrombin, and cancer
-
Rickles F., Patierno S., and Fernandez P. Tissue factor, thrombin, and cancer. Chest 124 (2003) 58S-68S
-
(2003)
Chest
, vol.124
-
-
Rickles, F.1
Patierno, S.2
Fernandez, P.3
-
42
-
-
0026722647
-
Expression of heparanase by platelets and circulating cells of the immune system: possible involvement in diapedesis and extravasation
-
Vlodavsky I., Eldor A., Haimovitz-Friedman A., Matzner Y., Ishai-Michaeli R., Lider O., et al. Expression of heparanase by platelets and circulating cells of the immune system: possible involvement in diapedesis and extravasation. Invasion Metastasis 12 (1992) 112-127
-
(1992)
Invasion Metastasis
, vol.12
, pp. 112-127
-
-
Vlodavsky, I.1
Eldor, A.2
Haimovitz-Friedman, A.3
Matzner, Y.4
Ishai-Michaeli, R.5
Lider, O.6
-
43
-
-
1642355132
-
Induction of tissue factor expression in human monocytic cells by protease inhibitors through activating activator protein-1 (AP-1) with phosphorylation of Jun-N-terminal kinase and p38
-
Ohsawa M., Koyama T., Nara N., and Hirosawa S. Induction of tissue factor expression in human monocytic cells by protease inhibitors through activating activator protein-1 (AP-1) with phosphorylation of Jun-N-terminal kinase and p38. Thromb Res 112 (2003) 313-320
-
(2003)
Thromb Res
, vol.112
, pp. 313-320
-
-
Ohsawa, M.1
Koyama, T.2
Nara, N.3
Hirosawa, S.4
-
44
-
-
0027935431
-
Tissue factor controls the balance of angiogenic and antiangiogenic properties of tumor cells in mice
-
Zhang Y., Deng Y., Luther T., Muller M., Ziegler R., Waldherr R., et al. Tissue factor controls the balance of angiogenic and antiangiogenic properties of tumor cells in mice. J Clin Invest 94 (1994) 1320-1327
-
(1994)
J Clin Invest
, vol.94
, pp. 1320-1327
-
-
Zhang, Y.1
Deng, Y.2
Luther, T.3
Muller, M.4
Ziegler, R.5
Waldherr, R.6
-
45
-
-
0023768277
-
Differentiating human leukemia cells express heparanase that degrades heparan sulfate in subendothelial extracellular matrix
-
Yahalom J., Fibach E., Bar-Tana R., Fuks Z., and Vlodavsky I. Differentiating human leukemia cells express heparanase that degrades heparan sulfate in subendothelial extracellular matrix. Leuk Res 12 (1988) 711-717
-
(1988)
Leuk Res
, vol.12
, pp. 711-717
-
-
Yahalom, J.1
Fibach, E.2
Bar-Tana, R.3
Fuks, Z.4
Vlodavsky, I.5
-
46
-
-
33645983628
-
Heparanase neutralizes the anticoagulation properties of heparin and low-molecular-weight heparin
-
Nasser N., Sarig G., Brenner B., Nevo E., Goldshmidt O., Zcharia E., et al. Heparanase neutralizes the anticoagulation properties of heparin and low-molecular-weight heparin. J Thromb Haemost 4 (2006) 560-565
-
(2006)
J Thromb Haemost
, vol.4
, pp. 560-565
-
-
Nasser, N.1
Sarig, G.2
Brenner, B.3
Nevo, E.4
Goldshmidt, O.5
Zcharia, E.6
|