Phthalates stimulate the epithelial to mesenchymal transitionthrough an HDAC6-dependent mechanism in human breastepithelial stem cells

Toxicological Sciences

Volumn 128, Issue 2, 2012, Pages 365-376

  Hsieh, Tsung Hua ^a   Tsai, Cheng Fang ^a   Hsu, Chia Yi ^a   Kuo, Po Lin ^a,b   Lee, Jau Nan ^a,c   Chai, Chee Yin ^a,c   Hou, Ming Feng ^c,d   Chang, Chia Cheng ^e   Long, Cheng Yu ^a   Ko, Ying Chin ^a   Tsai, Eing Mei ^a,c  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^b KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^c KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^d NATIONAL SUN YAT SEN UNIVERSITY   (Taiwan)

^e MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

AP 2a; EMT; Environmental hormone; HDAC6; Phthalates

Indexed keywords

BETA CATENIN; COMPLEMENTARY DNA; CYCLIC AMP DEPENDENT PROTEIN KINASE; EPIDERMAL GROWTH FACTOR RECEPTOR; ESTRADIOL; ESTROGEN RECEPTOR; GLYCOGEN SYNTHASE KINASE 3BETA; HISTONE DEACETYLASE 6; MESSENGER RNA; PHTHALIC ACID; PHTHALIC ACID BENZYL BUTYL ESTER; PHTHALIC ACID DIBUTYL ESTER; SHORT HAIRPIN RNA; SMALL INTERFERING RNA;

ARTICLE; BREAST CANCER; CANCER RISK; CANCER STEM CELL; CELL MIGRATION; ENZYME ACTIVATION; EPITHELIAL MESENCHYMAL TRANSITION; EPITHELIUM CELL; FLOW CYTOMETRY; LUNG METASTASIS; METASTASIS; NUCLEOTIDE SEQUENCE; PROMOTER REGION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STEM CELL; TRANSCRIPTION INITIATION; WESTERN BLOTTING;

ANIMALS; BASE SEQUENCE; BETA CATENIN; DNA PRIMERS; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; FLOW CYTOMETRY; HISTONE DEACETYLASES; HUMANS; MAMMARY GLANDS, HUMAN; MICE; MICE, NUDE; PHTHALIC ACIDS; PROMOTER REGIONS, GENETIC; PROTEIN PHOSPHATASE 1; PROTO-ONCOGENE PROTEINS C-AKT; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STEM CELLS; TRANSCRIPTION FACTOR AP-2;

EID: 84864700324     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfs163     Document Type: Article

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