Spray drying from organic solvents to prepare nanoporous/nanoparticulate microparticles of protein: Excipient composites designed for oral inhalation

Journal of Pharmacy and Pharmacology

Volumn 64, Issue 9, 2012, Pages 1275-1290

  NíÓgáin, Orla ^a   Tajber, Lidia ^a   Corrigan, Owen I ^a   Healy, Anne Marie ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

inhalation; nanoporous nanoparticulate microparticles; spray drying; trypsin

Indexed keywords

2 HYDROXYPROPYL BETA CYCLODEXTRIN; ACETIC ACID DERIVATIVE; EXCIPIENT; METHANOL; N BUTYL ACETATE; ORGANIC SOLVENT; RAFFINOSE; TREHALOSE; TRYPSIN; UNCLASSIFIED DRUG; WATER;

AEROSOL; ARTICLE; CHEMICAL ANALYSIS; CONTROLLED STUDY; DENSITY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG DESIGN; DRUG FORMULATION; DRUG SOLUBILITY; DRUG STABILITY; DRUG STORAGE; HUMIDITY; IN VITRO STUDY; INFRARED SPECTROSCOPY; INHALATIONAL DRUG ADMINISTRATION; MATERIAL STATE; NANOPOROUS NANOPARTICULATE MICROPARTICLE; PHYSICAL CHEMISTRY; POWDER; PROTEIN FUNCTION; PROTEIN SECONDARY STRUCTURE; SCANNING ELECTRON MICROSCOPY; SPRAY DRYING; STORAGE TEMPERATURE; THERMOGRAVIMETRY; X RAY DIFFRACTION;

ADMINISTRATION, INHALATION; ADMINISTRATION, ORAL; AEROSOLS; BETA-CYCLODEXTRINS; DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; DRUG STORAGE; ENZYME STABILITY; EXCIPIENTS; HUMANS; MICROSPHERES; NANOPARTICLES; PARTICLE SIZE; POWDERS; PROTEIN CONFORMATION; SOLUBILITY; SOLVENTS; SURFACE PROPERTIES; TRYPSIN; WATER;

EID: 84864688167     PISSN: 00223573     EISSN: 20427158     Source Type: Journal    
DOI: 10.1111/j.2042-7158.2012.01488.x     Document Type: Article

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