Role of antibody-mediated tumor targeting and route of administration in nanoparticle tumor accumulation in vivo

Molecular Pharmaceutics

Volumn 9, Issue 8, 2012, Pages 2168-2179

  Chattopadhyay, Niladri ^a   Fonge, Humphrey ^a   Cai, Zhongli ^a   Scollard, Deborah ^a   Lechtman, Eli ^b   Done, Susan J ^b,e   Pignol, Jean Philippe ^b,c   Reilly, Raymond M ^a,b,d  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c SUNNYBROOK RESEARCH INSTITUTE   (Canada)

^d UNIVERSITY HEALTH NETWORK   (Canada)

^e PRINCESS MARGARET HOSPITAL   (Canada)

Author keywords

antibody; biodistribution; HER2; ICP MS; imaging; intratumoral; lymph node; microSPECT; nanoparticles; pharmacokinetics

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR 2; FC RECEPTOR; GADOLINIUM CHLORIDE; GOLD NANOPARTICLE; GOLD NANOPARTICLE INDIUM 111; INDIUM 111; NANOMATERIAL; PEGYLATED GOLD NANOPARTICLE INDIUM 111; RITUXIMAB; TRASTUZUMAB; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTORADIOGRAPHY; COMPUTER ASSISTED TOMOGRAPHY; CONJUGATION; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; GENE TARGETING; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; INTERNALIZATION; LIVER; MOUSE; NONHUMAN; PRIORITY JOURNAL; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; SPLEEN; TRANSMISSION ELECTRON MICROSCOPY;

ANIMALS; ANTIBODIES; ANTIBODIES, MONOCLONAL, HUMANIZED; ANTIBODIES, MONOCLONAL, MURINE-DERIVED; BREAST NEOPLASMS; CELL LINE, TUMOR; FEMALE; GADOLINIUM; GOLD; HUMANS; LYMPH NODES; METAL NANOPARTICLES; MICE; MICE, NUDE; MICROSCOPY, ELECTRON, TRANSMISSION; RECEPTOR, ERBB-2;

EID: 84864672239     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp300016p     Document Type: Article

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