Design and characterization of HER-2-targeted gold nanoparticles for enhanced X-radiation treatment of locally advanced breast cancer

Molecular Pharmaceutics

Volumn 7, Issue 6, 2010, Pages 2194-2206

  Chattopadhyay, Niladri ^a   Cai, Zhongli ^a   Pignol, Jean Philippe ^b,c   Keller, Brian ^b   Lechtman, Eli ^b   Bendayan, Reina ^a   Reilly, Raymond M ^a,b,d  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c SUNNYBROOK RESEARCH INSTITUTE   (Canada)

^d UNIVERSITY HEALTH NETWORK   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

2 PYRIDYLDISULFIDE POLYETHYLENE GLYCOL N HYDROXYSUCCINIMIDE; EPIDERMAL GROWTH FACTOR RECEPTOR 2; GOLD NANOPARTICLE; HISTONE H2AX; IODINE 123; MACROGOL DERIVATIVE; RADIOSENSITIZING AGENT; TRASTUZUMAB; TRASTUZUMAB 2 PYRIDYLDISULFIDE POLYETHYLENE GLYCOL N HYDROXYSUCCINIMIDE GOLD NANOPARTICLE CONJUGATE; UNCLASSIFIED DRUG;

ADVANCED CANCER; ARTICLE; BREAST CANCER; CANCER RADIOTHERAPY; CONJUGATION; CONTROLLED STUDY; DNA DAMAGE; DOUBLE STRANDED DNA BREAK; DRUG DESIGN; DRUG STRUCTURE; FLOW CYTOMETRY; GENE OVEREXPRESSION; GENE TARGETING; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE; IMMUNOGOLD ELECTRON MICROSCOPY; IMMUNOREACTIVITY; INTERNALIZATION; MOLECULAR WEIGHT; NANOTECHNOLOGY; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RADIOSENSITIZATION; SPECTROPHOTOMETRY; X RAY;

ANTIBODIES, MONOCLONAL; ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; DISEASE PROGRESSION; DOSE-RESPONSE RELATIONSHIP, RADIATION; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; GOLD; HUMANS; METAL NANOPARTICLES; MODELS, BIOLOGICAL; NANOTECHNOLOGY; NEOPLASM RECURRENCE, LOCAL; POLYETHYLENE GLYCOLS; RADIATION-SENSITIZING AGENTS; RECEPTOR, ERBB-2; X-RAYS;

EID: 78649929751     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp100207t     Document Type: Article

References (50)

1. Fisher, B.; Anderson, S.; Bryant, J.; Margolese, R. G.; Deutsch, M.; Fisher, E. R.; Jeong, J.-H.; Wolmark, N. Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer N. Engl. J. Med. 2002, 347, 1233-1241
2. Sawaki, M.; Ito, Y.; Akiyama, F.; Tokudome, N.; Horii, R.; Mizunuma, N.; Takahashi, S.; Horikoshi, N.; Imai, T.; Nakao, A.; Kasumi, F.; Sakamoto, G.; Hatake, K. High prevalence of HER-2/neu and p53 overexpression in inflammatory breast cancer Breast Cancer 2006, 13, 172-178
3. Charafe-Jauffret, E.; Tarpin, C.; Bardou, V.-J.; Bertucci, F.; Ginestier, C.; Braud, A.-C.; Puig, B.; Geneix, J.; Hassoun, J.; Bimbaum, D.; Jacquemier, J.; Viens, P. Immunophenotypic analysis of inflammatory breast cancers: Identification of an 'inflammatory signature' J. Pathol. 2004, 202, 265-273 (Pubitemid 38325235)
4. Herold, D. M.; Das, I. J.; Stobbe, C. C.; Iyer, R. V.; Chapman, J. D. Gold microspheres: A selective technique for producing biologically effective dose enhancement Int. J. Radiat. Biol. 2000, 76, 1357-1364
5. Hainfeld, J. F.; Slatkin, D. N.; Smilowitz, H. M. The use of gold nanoparticles to enhance radiotherapy in mice Phys. Med. Biol. 2004, 49, N309-N315
6. Kong, T.; Zeng, J.; Yang, J.; Yao, Y.; Wang, X.; Li, P.; Yang, A.; Roa, W.; Xing, J.; Chen, J. Surface modifications of gold-nanoparticles to enhance radiation cytotoxicity. 2007 IEEE/NIH Life Science Systems and Applications Workshop, LISA; 2008; pp 265 - 268
7. Zheng, Y.; Hunting, D. J.; Ayotte, P.; Sanche, L. Radiosensitization of DNA by gold nanoparticles irradiated with high-energy electrons Radiat. Res. 2008, 169, 19-27
8. Howell, R. W. Auger processes in the 21st century Int. J. Radiat. Biol. 2008, 84, 959-975
9. Larson, D.; Bodell, W. J.; Ling, C.; Phillips, T. L.; Schell, M.; Shrieve, D.; Troxel, T. Auger electron contribution to bromodeoxyuridine cellular radiosensitization Int. J. Radiat. Oncol. Biol. Phys. 1989, 16, 171-176
10. Pignol, J.-P.; Rakovitch, E.; Beachey, D.; Le Sech, C. Clinical significance of atomic inner shell ionization (ISI) and Auger cascade for radiosensitization using IUdR, BUdR, platinum salts, or gadolinium porphyrin compounds Int. J. Radiat. Oncol. Biol. Phys. 2003, 55, 1082-1091
11. Spiers, W. Br. J. Radiol. 1949, 22, 512
12. Takakura, T. Auger effects on bromo-deoxyuridine-monophosphate irradiated with monochromatic X-rays around bromine K-absorption edge Radiat. Environ. Biophys. 1989, 28, 177-184
13. Hainfeld, J. F.; Dilmanian, F. A.; Slatkin, D. N.; Smilowitz, H. M. Radiotherapy enhancement with gold nanoparticles J. Pharm. Pharmacol. 2008, 60, 977-985
14. Kurfurst, M. M. Detection and molecular weight determination of polyethylene glycol- modified hirudin by staining after sodium dodecyl sulfate-polyacrylamide gel electrophoresis Anal. Biochem. 1992, 200, 244-248
15. McLarty, K.; Reilly, R. M. Molecular imaging as a tool for personalized and targeted anticancer therapy Clin. Pharmacol. Ther. 2007, 81, 420-424
16. Chithrani, B. D.; Ghazani, A. A.; Chan, W. C. W. Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells Nano Lett. 2006, 6, 662-668
17. Liu, J.; Hu, W.; Chen, H.; Ni, Q.; Xu, H.; Yang, X. Isotretinoin-loaded solid lipid nanoparticles with skin targeting for topical delivery Int. J. Pharm. 2007, 328, 191-195
18. Liu, Y.; Shipton, M. K.; Ryan, J.; Kaufman, E. D.; Franzen, S.; Feldheim, D. L. Synthesis, stability, and cellular internalization of gold nanoparticles containing mixed peptide-poly(ethylene glycol) monolayers Anal. Chem. 2007, 79, 2221-2229
19. Zhang, D.; Neumann, O.; Wang, H.; Yuwono, V. M.; Barhoumi, A.; Perham, M.; Hartgerink, J. D.; Wittung-Stafshede, P.; Halas, N. J. Gold nanoparticles can induce the formation of protein-based aggregates at physiological pH Nano Lett. 2009, 9, 666-671
20. Shenoy, D.; Fu, W.; Li, J.; Crasto, C.; Jones, G.; DiMarzio, C.; Sridhar, S.; Amiji, M. Surface functionalization of gold nanoparticles using hetero-bifunctional poly(ethylene glycol) spacer for intracellular tracking and delivery Int. J. Nanomed. 2006, 1, 51-57
21. Qian, X.; Peng, X. H.; Ansari, D. O.; Yin-Goen, Q.; Chen, G. Z.; Shin, D. M.; Yang, L.; Young, A. N.; Wang, M. D.; Nie, S. In vivo tumor targeting and spectroscopic detection with surface-enhanced Raman nanoparticle tags Nat. Biotechnol. 2008, 26, 83-90
22. Peng, M.; Litman, R.; Jin, Z.; Fong, G.; Cantor, S. B. BACH1 is a DNA repair protein supporting BRCA1 damage response Oncogene 2006, 25, 2245-2253
23. Cai, Z.; Vallis, K. A.; Reilly, R. M. Computational analysis of the number, area and density of γ-H2AX foci in breast cancer cells exposed to 111In-DTPA-hEGF or γ-rays using ImageJ software Int. J. Radiat. Biol. 2009, 85, 262-271
24. Casey, J. L.; Pedley, R. B.; King, D. J.; Boden, R.; Chapman, A. P.; Yarranton, G. T.; Begent, R. H. J. Improved tumour targeting of di-Fab' fragments modified with polyethylene glycol Tumor Targeting 1999, 4, 235-244
25. Chapman, A. P. PEGylated antibodies and antibody fragments for improved therapy: A review Adv. Drug Delivery Rev. 2002, 54, 531-545
26. Kitamura, K.; Takahashi, T.; Yamaguchi, T.; Noguchi, A.; Noguchi, A.; Takashina, K.-i.; Tsurumi, H.; Inagake, M.; Toyokuni, T.; Hakomori, S.-i. Chemical engineering of the monoclonal antibody A7 by polyethylene glycol for targeting cancer chemotherapy Cancer Res. 1991, 51, 4310-4315
27. Kitamura, K.; Takahashi, T.; Takashina, K.; Yamaguchi, T.; Noguchi, A.; Tsurumi, H.; Toyokuni, T.; Hakomori, S. Polyethylene glycol modification of the monoclonal antibody A7 enhances its tumor localization Biochem. Biophys. Res. Commun. 1990, 171, 1387-1394
28. Pedley, R. B.; Boden, J. A.; Boden, R.; Begent, R. H. J.; Turner, A.; Haines, A. M. R.; King, D. J. The potential for enhanced tumour localisation by poly(ethylene glycol) modification of anti-CEA antibody Br. J. Cancer 1994, 70, 1126-1130
29. Suzuki, T.; Wu, D.; Schlachetzki, F.; Jian, Y. L.; Boado, R. J.; Pardridge, W. M. Imaging endogenous gene expression in brain cancer in vivo with 111In-peptide nucleic acid antisense radiopharmaceuticals and brain drug-targeting technology J. Nucl. Med. 2004, 45, 1766-1775
30. 111In-trastuzumab (Herceptin) Fab fragments Nucl. Med. Biol. 2005, 32, 51-58 (Pubitemid 40187381)
31. Kelley, R. F.; O'Connell, M. P. Thermodynamic analysis of an antibody functional epitope Biochemistry (N.Y.) 1993, 32, 6828-6835
32. Hermanson, G. Bioconjugate Techniques.: Elsevier: Netherlands, 2008; pp 1323.
33. Bhattacharya, R.; Patra, C. R.; Earl, A.; Wang, S.; Katarya, A.; Lu, L.; Kizhakkedathu, J. N.; Yaszemski, M. J.; Greipp, P. R.; Mukhopadhyay, D.; Mukherjee, P. Attaching folic acid on gold nanoparticles using noncovalent interaction via different polyethylene glycol backbones and targeting of cancer cells Nanomed. Nanotechnol. Biol. Med. 2007, 3, 224-238
34. Costantini, D. L.; Chan, C.; Cai, Z.; Vallis, K. A.; Reilly, R. M. 111In-labeled trastuzumab (Herceptin) modified with nuclear localization sequences (NLS): An auger electron-emitting radiotherapeutic agent for HER2/neu-amplified breast cancer J. Nucl. Med. 2007, 48, 1357-1368
35. Melancon, M. P.; Lu, W.; Yang, Z.; Zhang, R.; Cheng, Z.; Elliot, A. M.; Stafford, J.; Olson, T.; Zhang, J. Z.; Li, C. In vitro and in vivo targeting of hollow gold nanoshells directed at epidermal growth factor receptor for photothermal ablation therapy Mol. Cancer Ther. 2008, 7, 1730-1739
36. Eck, W.; Craig, G.; Sigdel, A.; Ritter, G.; Old, L. J.; Tang, L.; Brennan, M. F.; Allen, P. J.; Mason, M. D. PEGylated gold nanoparticles conjugated to monoclonal F19 antibodies as targeted labeling agents for human pancreatic carcinoma tissue ACS Nano 2008, 2, 2263-2272
37. Grabar, K. C.; Griffith Freeman, R.; Hommer, M. B.; Natan, M. J. Preparation and characterization of Au colloid monolayers Anal. Chem. 1995, 67, 735-743
38. Lowery, A. R.; Gobin, A. M.; Day, E. S.; Halas, N. J.; West, J. L. Immunonanoshells for targeted photothermal ablation of tumor cells Int. J. Nanomed. 2006, 1, 149-154
39. Cantarero, L. A.; Butler, J. E.; Osborne, J. W. The adsorptive characteristics of proteins for polystyrene and their significance in solid-phase immunoassays Anal. Biochem. 1980, 105, 375-382
40. Liu, Y.; Liu, Y.; Mernaugh, R. L.; Zeng, X. Single chain fragment variable recombinant antibody functionalized gold nanoparticles for a highly sensitive colorimetric immunoassay Biosens. Bioelectron. 2009, 24, 2853-2857
41. Hong, S.; Leroueil, P. R.; Majoros, I. J.; Orr, B. G.; Baker, J. R., Jr.; Banaszak Holl, M. M. The binding avidity of a nanoparticle-based multivalent targeted drug delivery platform Chem. Biol. 2007, 14, 107-115
42. Ehrenberg, M. S.; Friedman, A. E.; Finkelstein, J. N.; Oberdörster, G.; McGrath, J. L. The influence of protein adsorption on nanoparticle association with cultured endothelial cells Biomaterials 2009, 30, 603-610
43. Göppert, T. M.; Müller, R. H. Polysorbate-stabilized solid lipid nanoparticles as colloidal carriers for intravenous targeting of drugs to the brain: Comparison of plasma protein adsorption patterns J. Drug Targeting 2005, 13, 179-187
44. Rubin, I.; Yarden, Y. The basic biology of HER2 Ann. Oncol. 2001, 12, S3-S8
45. Hainfeld, J. F.; Slatkin, D. N.; Focella, T. M.; Smilowitz, H. M. Gold nanoparticles: A new X-ray contrast agent Br. J. Radiol. 2006, 79, 248-253
46. Roberts, W. G.; Hasan, T. Tumor-secreted vascular permeability factor/vascular endothelial growth factor influences photosensitizer uptake Cancer Res. 1993, 53, 153-157
47. In 2010 Genitourinary Cancers Symposium [Conference Proceedings]; March 5-7, 2010; San Francisco, CA, USA; American Society of Clinical Oncology; 2010; p 126.
48. Rahman, W. N.; Bishara, N.; Ackerly, T.; He, C. F.; Jackson, P.; Wong, C.; Davidson, R.; Geso, M. Enhancement of radiation effects by gold nanoparticles for superficial radiation therapy Nanomed.: Nanotechnol., Biol., Med. 2009, 5, 136-142
49. Peer, D.; Karp, J. M.; Hong, S.; Farokhzad, O. C.; Margalit, R.; Langer, R. Nanocarriers as an emerging platform for cancer therapy Nat. Nanotechnol. 2007, 2, 751-760
50. Kong, T.; Zeng, J.; Wang, X.; Yang, X.; Yang, J.; McQuarrie, S.; McEwan, A.; Roa, W.; Chen, J.; Xing, J. Z. Enhancement of radiation cytotoxicity in breast-cancer cells by localized attachment of gold nanoparticles Small 2008, 4, 1537-1543